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Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 16, 2013, Pages 4627-4632

Discovery and optimisation of 1-hydroxyimino-3,3-diphenylpropanes, a new class of orally active GPBAR1 (TGR5) agonists

(15) Dehmlow, Henrietta a Alvarez Sánchez, Rubén a Bachmann, Stephan a Bissantz, Caterina a Bliss, Fritz a Conde Knape, Karin a Graf, Martin a Martin, Rainer E a Obst Sander, Ulrike a Raab, Susanne a Richter, Hans G F a Sewing, Sabine a Sprecher, Urs a Ullmer, Christoph a Mattei, Patrizio a

a F HOFFMANN LA ROCHE LTD (Switzerland)

Author keywords

Chemical probe; GLP 1; GPBAR1; PYY; TGR5

Indexed keywords

1 HYDROXYIMINO 3, 3 DIPHENYLPROPANE DERIVATIVE; G PROTEIN COUPLED BILE ACID RECEPTOR 1; G PROTEIN COUPLED RECEPTOR; GLUCAGON LIKE PEPTIDE 1; OXIME DERIVATIVE; PEPTIDE YY; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; GLUCOSE BLOOD LEVEL; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIPOPHILICITY; MALE; MOUSE; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; POSTPRANDIAL STATE; PROCESS OPTIMIZATION; PROTEIN SECRETION; STRUCTURE ACTIVITY RELATION;

CHEMICAL PROBE; GLP-1; GPBAR1; PYY; TGR5;

ADMINISTRATION, ORAL; ANIMALS; BLOOD GLUCOSE; DRUG DISCOVERY; INHIBITORY CONCENTRATION 50; MICE; MOLECULAR STRUCTURE; OXIMES; PROPANE; RECEPTORS, G-PROTEIN-COUPLED;

MUS;

EID: 84880611045 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2013.06.017 Document Type: Article

Times cited : (11)

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