The strategy to improve gene transfection efficiency and biocompatibility of hyperbranched PAMAM with the cooperation of PEGylated hyperbranched PAMAM

International Journal of Pharmaceutics

Volumn 465, Issue 1-2, 2014, Pages 112-119

  Sun, Yangfei ^a   Jiao, Yunfeng ^b   Wang, Yang ^b   Lu, Daru ^a   Yang, Wuli ^b  

^a FUDAN UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

Author keywords

Cytotoxicity; Gene delivery; Hyperbranched polyamidoamine; Mixture system; PEGylation

Indexed keywords

DENDRIMER; MACROGOL; POLYAMIDOAMINE; PLASMID DNA; BIOMATERIAL; DNA; ENHANCED GREEN FLUORESCENT PROTEIN; GREEN FLUORESCENT PROTEIN; MACROGOL DERIVATIVE; PAMAM STARBURST; PEG-PAMAM;

ARTICLE; BIOCOMPATIBILITY; CELL SURVIVAL; CELL VIABILITY; CYTOTOXICITY; ENCAPSULATION; FLOW CYTOMETRY; GENE DELIVERY SYSTEM; GENE TARGETING; HYDRODYNAMICS; IN VITRO GENE TRANSFER; NONVIRAL GENE THERAPY; PRIORITY JOURNAL; ZETA POTENTIAL; COMPARATIVE STUDY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VIVO GENE TRANSFER; NONVIRAL GENE DELIVERY SYSTEM; ONE POT SYNTHESIS; ACTIVE TRANSPORT; BIOSYNTHESIS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HEK293 CELL LINE; METABOLISM; PROCEDURES; SYNTHESIS; TOXICITY;

ACTIVE TRANSPORT, CELL NUCLEUS; BIOCOMPATIBLE MATERIALS; CELL SURVIVAL; DENDRIMERS; DNA; GENE EXPRESSION REGULATION; GREEN FLUORESCENT PROTEINS; HEK293 CELLS; HUMANS; MOLECULAR STRUCTURE; POLYETHYLENE GLYCOLS; TRANSFECTION;

EID: 84895885775     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.02.018     Document Type: Article

References (30)

1. R.H. Buckley Gene therapy for SCID-a complication after remarkable progress Lancet 360 2002 1185 1186
2. C.Z. Bai, S. Choi, K. Nam, S. An, and J.S. Park Arginine modified PAMAM dendrimer for interferon beta gene delivery to malignant glioma International Journal of Pharmaceutics 445 2013 79 87
3. L. Cao, W.L. Yang, C.C. Wang, and S.K. Fu Synthesis and striking fluorescence properties of hyperbranched poly(amido amine) Journal of Macromolecular Science Part A 44 2007 417 424
4. A.S. Chauhan, N.K. Jain, and P.V. Diwan Pre-clinical and behavioural toxicity profile of PAMAM dendrimers in mice Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences 466 2010 1535 1550
5. J. Chen, J. Guo, B.S. Chang, and W.L. Yang Blue-emitting PEGylated hyperbranched PAMAM: transformation of cross-linked micelles to hollow spheres controlled by the PEG grafting density Colloid and Polymer Science 290 2012 517 524
6. M.J. Cloninger Biological applications of dendrimers Current Opinion in Chemical Biology 6 2002 742 748
7. S.C. De Smedt, J. Demeester, and W.E. Hennink Cationic polymer based gene delivery systems Pharmaceutical Research 17 2000 113 126
8. H. Debus, P. Baumhof, J. Probst, and T. Kissel Delivery of messenger RNA using poly(ethylene imine)-poly(ethylene glycol)-copolymer blends for polyplex formation: biophysical characterization and in vitro transfection properties Journal of Controlled Release 148 2010 334 343
9. N. Daneshvar PAMAM dendrimer roles in gene delivery methods and stem cell research Cytotherapy 15 2013 S15
10. K. Fant, E.K. Eshjorner, A. Jenkins, M.C. Grossel, P. Lincoln, and B. Norden Effects of PEGylation and acetylation of PAMAM dendrimers on DNA binding, cytotoxicity and in vitro transfection efficiency Molecular Pharmaceutics 7 2010 1734 1746
11. D. Fischer, Y.X. Li, B. Ahlemeyer, J. Krieglstein, and T. Kissel In vitro cytotoxicity testing of polycations: influence of polymer structure on cell viability and hemolysis Biomaterials 24 2003 1121 1131
12. M. Giacca, and S. Zacchigna Virus-mediated gene delivery for human gene therapy Journal of Controlled Release 161 2012 377 388
13. D. Ibraheem, A. Elaissari, and H. Fessi Gene therapy and DNA delivery systems International Journal of Pharmaceutics 459 2014 70 83
14. R. Jevprasesphant, J. Penny, R. Jalal, D. Attwood, N.B. McKeown, and A. D'Emanuele The influence of surface modification on the cytotoxicity of PAMAM dendrimers International Journal of Pharmaceutics 252 2003 263 266
15. M.L. Ji, W.L. Yang, Q.G. Ren, and D.R. Lu Facile phase transfer of hydrophobic nanoparticles with poly(ethylene glycol) grafted hyperbranched poly (amido amine) Nanotechnology 20 2009 75101
16. Y. Kim, A.M. Klutz, and K.A. Jacobson Systematic investigation of polyamidoamine dendrimers surface-modified with poly(ethylene glycol) for drug delivery applications: synthesis, characterization, and evaluation of cytotoxicity Bioconjugate Chemistry 19 2008 1660 1672
17. R.B. Kolhatkar, K.M. Kitchens, P.W. Swaan, and H. Ghandehari Surface acetylation of polyamidoamine (PAMAM) dendrimers decreases cytotoxicity while maintaining membrane permeability Bioconjugate Chemistry 18 2007 2054 2060
18. C.C. Lee, Mac Kay, J.A. Frechet, J.M. Szoka, and Designing dendrimers for biological applications Nature Biotechnology 23 2005 1517 1526
19. D. Luo, K. Haverstick, N. Belcheva, E. Han, and W.M. Saltzman Poly(ethylene glycol)-conjugated PAMAM dendrimer for biocompatible, high-efficiency DNA delivery Macromolecules 35 2002 3456 3462
20. D. Luo, and W.M. Saltzman Synthetic DNA delivery systems Nature Biotechnology 18 2000 33 37
21. 125I-labelled polyamidoamine dendrimers in vivo" [Journal of Controlled Release 65 (2000) 133-148] Journal of Controlled Release 68 2000 299 302
22. E. Marshall Gene therapy death prompts review of adenovirus vector Science 286 1999 2244 2245
23. J.C. Roberts, M.K. Bhalgat, and R.T. Zera Preliminary biological evaluation of polyamidoamine (PAMAM) Starburst(TM) dendrimers Journal of Biomedical Materials Research 30 1996 53 65
24. S.J. Son, G.S. Yu, Y.H. Choe, Y.J. Kim, E. Lee, J.S. Park, and J.S. Choi PAMAM dendrimers conjugated with l-arginine and gamma-aminobutyric acid as novel polymeric gene delivery carriers Bulletin of the Korean Chemical Society 34 2013 579 584
25. D. Shcharbin, A. Shakhbazau, and M. Bryszewska Poly(amidoamine) dendrimer complexes as a platform for gene delivery Expert Opinion on Drug Delivery 10 2013 1687 1698
26. V. Shah, O. Taratula, O.B. Garbuzenko, M.L. Patil, R. Savla, M. Zhang, and T. Minko Genotoxicity of different nanocarriers: possible modifications for the delivery of nucleic acids Current Drug Discovery Technologies 10 2013 8 15
27. D.A. Tomalia, and J.M.J. Frechet Discovery of dendrimers and dendritic polymers: a brief historical perspective Journal of Polymer Science: Polymer Chemistry 40 2002 2719 2728
28. Y.A. Yue, F. Jin, R. Deng, J.G. Cai, Y.C. Chen, M.C.M. Lin, H.F. Kung, and C. Wu Revisit complexation between DNA and polyethylenimine Journal of Controlled Release 155 2011 67 76
29. K. Zhu, C. Guo, H. Lai, W.L. Yang, and C. Wang Novel hyperbranched polyamidoamine nanoparticle based gene delivery: transfection, cytotoxicity and in vitro evaluation International Journal of Pharmaceutics 423 2012 378 383
30. K. Zhu, C.F. Guo, H. Lai, W.L. Yang, Y. Xia, D. Zhao, and C.S. Wang Novel hyperbranched polyamidoamine nanoparticles for transfecting skeletal myoblasts with vascular endothelial growth factor gene for cardiac repair Journal of Materials Science Materials in Medicine 22 2011 2477 2485