메뉴 건너뛰기




Volumn 28, Issue 3, 2014, Pages 507-517

Immunotherapy for chronic lymphocytic leukemia in the era of BTK inhibitors

Author keywords

Adoptive immunotherapy; Allogeneic hematopoietic cell transplantation; Bruton's Tyrosine Kinase; Chimeric antigen receptor therapy; Ibrutinib

Indexed keywords

ALEMTUZUMAB; BRUTON TYROSINE KINASE INHIBITOR; IBRUTINIB; LENALIDOMIDE; MONOCLONAL ANTIBODY; OBINUTUZUMAB; OFATUMUMAB; RITUXIMAB; TUMOR VACCINE;

EID: 84895796894     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2013.311     Document Type: Review
Times cited : (22)

References (119)
  • 1
    • 77949424964 scopus 로고    scopus 로고
    • Changing paradigms in the treatment of chronic lymphocytic leukemia
    • Foon KA, Hallek MJ. Changing paradigms in the treatment of chronic lymphocytic leukemia. Leukemia 2010; 24: 500-511.
    • (2010) Leukemia , vol.24 , pp. 500-511
    • Foon, K.A.1    Hallek, M.J.2
  • 2
    • 79952093131 scopus 로고    scopus 로고
    • Update on therapy of chronic lymphocytic leukemia
    • Gribben JG, O'Brien S. Update on therapy of chronic lymphocytic leukemia. J Clin Oncol 2011; 29: 544-550.
    • (2011) J Clin Oncol , vol.29 , pp. 544-550
    • Gribben, J.G.1    O'Brien, S.2
  • 4
    • 36048932506 scopus 로고    scopus 로고
    • Evolving role of monoclonal antibodies in the treatment of chronic lymphocytic leukemia
    • Kharfan-Dabaja MA, Fahed R, Hussein M, Santos ES. Evolving role of monoclonal antibodies in the treatment of chronic lymphocytic leukemia. Expert Opin Investig Drugs 2007; 16: 1799-1815.
    • (2007) Expert Opin Investig Drugs , vol.16 , pp. 1799-1815
    • Kharfan-Dabaja, M.A.1    Fahed, R.2    Hussein, M.3    Santos, E.S.4
  • 5
    • 84881267213 scopus 로고    scopus 로고
    • Ibrutinib (PCI-32765) in chronic lymphocytic leukemia
    • Jain N, O'Brien S. Ibrutinib (PCI-32765) in chronic lymphocytic leukemia. Hematol Oncol Clin North Am 2013; 27: 851-860.
    • (2013) Hematol Oncol Clin North Am , vol.27 , pp. 851-860
    • Jain, N.1    O'Brien, S.2
  • 6
    • 79953655788 scopus 로고    scopus 로고
    • CAL-101 An isoform-selective inhibitor of phosphatidylinositol 3-kinase P110{delta}, demonstrates clinical activity and pharmacodynamic effects in patients with relapsed or refractory chronic lymphocytic leukemia
    • Furman RR, Byrd JC, Brown JR, Coutre SE, Benson Jr DM, Wagner-Johnston ND et al. CAL-101, An isoform-selective inhibitor of phosphatidylinositol 3-kinase P110{delta}, demonstrates clinical activity and pharmacodynamic effects in patients with relapsed or refractory chronic lymphocytic leukemia. ASH Ann Meet Abstr 2010; 116: 55.
    • (2010) ASH Ann Meet Abstr , vol.116 , pp. 55
    • Furman, R.R.1    Byrd, J.C.2    Brown, J.R.3    Coutre, S.E.4    Benson Jr., D.M.5    Wagner-Johnston, N.D.6
  • 7
    • 23044510136 scopus 로고    scopus 로고
    • Early results of a chemoimmunotherapy regimen of fludarabine, cyclophosphamide, and rituximab as initial therapy for chronic lymphocytic leukemia
    • Keating MJ, O'Brien S, Albitar M, Lerner S, Plunkett W, Giles F et al. Early results of a chemoimmunotherapy regimen of fludarabine, cyclophosphamide, and rituximab as initial therapy for chronic lymphocytic leukemia. J Clin Oncol 2005; 23: 4079-4088.
    • (2005) J Clin Oncol , vol.23 , pp. 4079-4088
    • Keating, M.J.1    O'Brien, S.2    Albitar, M.3    Lerner, S.4    Plunkett, W.5    Giles, F.6
  • 8
    • 77957664665 scopus 로고    scopus 로고
    • Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: A randomised, open-label, phase 3 trial
    • Hallek M, Fischer K, Fingerle-Rowson G, Fink AM, Busch R, Mayer J et al. Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: A randomised, open-label, phase 3 trial. Lancet 2010; 376: 1164-1174.
    • (2010) Lancet , vol.376 , pp. 1164-1174
    • Hallek, M.1    Fischer, K.2    Fingerle-Rowson, G.3    Fink, A.M.4    Busch, R.5    Mayer, J.6
  • 10
    • 54449093967 scopus 로고    scopus 로고
    • Five-year follow-up of patients with advanced chronic lymphocytic leukemia treated with allogeneic hematopoietic cell transplantation after nonmyeloablative conditioning
    • Sorror ML, Storer BE, Sandmaier BM, Maris M, Shizuru J, Maziarz R et al. Five-year follow-up of patients with advanced chronic lymphocytic leukemia treated with allogeneic hematopoietic cell transplantation after nonmyeloablative conditioning. J Clin Oncol 2008; 26: 4912-4920.
    • (2008) J Clin Oncol , vol.26 , pp. 4912-4920
    • Sorror, M.L.1    Storer, B.E.2    Sandmaier, B.M.3    Maris, M.4    Shizuru, J.5    Maziarz, R.6
  • 11
    • 47549085972 scopus 로고    scopus 로고
    • Quantitative MRD monitoring identifies distinct GVL response patterns after allogeneic stem cell transplantation for chronic lymphocytic leukemia: Results from the GCLLSG CLL3X trial
    • Ritgen M, Bottcher S, Stilgenbauer S, Bunjes D, Schubert J, Cohen S et al. Quantitative MRD monitoring identifies distinct GVL response patterns after allogeneic stem cell transplantation for chronic lymphocytic leukemia: Results from the GCLLSG CLL3X trial. Leukemia 2008; 22: 1377-1386.
    • (2008) Leukemia , vol.22 , pp. 1377-1386
    • Ritgen, M.1    Bottcher, S.2    Stilgenbauer, S.3    Bunjes, D.4    Schubert, J.5    Cohen, S.6
  • 12
    • 77957743452 scopus 로고    scopus 로고
    • Allogeneic stem cell transplantation provides durable disease control in poor-risk chronic lymphocytic leukemia: Long-Term clinical and MRD results of the German CLL Study Group CLL3X trial
    • Dreger P, Dohner H, Ritgen M, Bottcher S, Busch R, Dietrich S et al. Allogeneic stem cell transplantation provides durable disease control in poor-risk chronic lymphocytic leukemia: Long-Term clinical and MRD results of the German CLL Study Group CLL3X trial. Blood 2010; 116: 2438-2447.
    • (2010) Blood , vol.116 , pp. 2438-2447
    • Dreger, P.1    Dohner, H.2    Ritgen, M.3    Bottcher, S.4    Busch, R.5    Dietrich, S.6
  • 13
    • 84873567955 scopus 로고    scopus 로고
    • Long-Term follow-up of reduced-intensity allogeneic stem cell transplantation for chronic lymphocytic leukemia: Prognostic model to predict outcome
    • Brown JR, Kim HT, Armand P, Cutler C, Fisher DC, Ho V et al. Long-Term follow-up of reduced-intensity allogeneic stem cell transplantation for chronic lymphocytic leukemia: Prognostic model to predict outcome. Leukemia 2013; 27: 362-369.
    • (2013) Leukemia , vol.27 , pp. 362-369
    • Brown, J.R.1    Kim, H.T.2    Armand, P.3    Cutler, C.4    Fisher, D.C.5    Ho, V.6
  • 14
    • 83255164801 scopus 로고    scopus 로고
    • Hematopoietic stem cell allografting for chronic lymphocytic leukemia: A focus on reduced-intensity conditioning regimens
    • Kharfan-Dabaja MA, Bazarbachi A. Hematopoietic stem cell allografting for chronic lymphocytic leukemia: A focus on reduced-intensity conditioning regimens. Cancer Control 2012; 19: 68-75.
    • (2012) Cancer Control , vol.19 , pp. 68-75
    • Kharfan-Dabaja, M.A.1    Bazarbachi, A.2
  • 15
    • 84860433198 scopus 로고    scopus 로고
    • Bruton tyrosine kinase (BTK) and its role in B-cell malignancy
    • Buggy JJ, Elias L. Bruton tyrosine kinase (BTK) and its role in B-cell malignancy. Int Rev Immunol 2012; 31: 119-132.
    • (2012) Int Rev Immunol , vol.31 , pp. 119-132
    • Buggy, J.J.1    Elias, L.2
  • 16
    • 77955625479 scopus 로고    scopus 로고
    • The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy
    • Honigberg LA, Smith AM, Sirisawad M, Verner E, Loury D, Chang B et al. The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc Natl Acad Sci U S A 2010; 107: 13075-13080.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 13075-13080
    • Honigberg, L.A.1    Smith, A.M.2    Sirisawad, M.3    Verner, E.4    Loury, D.5    Chang, B.6
  • 17
    • 84889100379 scopus 로고    scopus 로고
    • Final results of a phase I study of idelalisib (GSE1101) a selective inhibitor of PI3K {delta}, in patients with relapsed or refractory CLL
    • 15 suppl
    • Brown JR, Furman RR, Flinn I, Coutre SE, Wagner-Johnston ND, Kahl BS et al. Final results of a phase I study of idelalisib (GSE1101) a selective inhibitor of PI3K {delta}, in patients with relapsed or refractory CLL. ASCO Meeting Abstracts 2013; 31(15-suppl): 7003.
    • (2013) ASCO Meeting Abstracts , vol.31 , pp. 7003
    • Brown, J.R.1    Furman, R.R.2    Flinn, I.3    Coutre, S.E.4    Wagner-Johnston, N.D.5    Kahl, B.S.6
  • 18
    • 80051720194 scopus 로고    scopus 로고
    • Chimeric antigen receptormodified T cells in chronic lymphoid leukemia
    • Porter DL, Levine BL, Kalos M, Bagg A, June CH. Chimeric antigen receptormodified T cells in chronic lymphoid leukemia. N Engl J Med 2011; 365: 725-733.
    • (2011) N Engl J Med , vol.365 , pp. 725-733
    • Porter, D.L.1    Levine, B.L.2    Kalos, M.3    Bagg, A.4    June, C.H.5
  • 19
    • 79955980426 scopus 로고    scopus 로고
    • In vitro and in vivo model of a novel immunotherapy approach for chronic lymphocytic leukemia by anti-CD23 chimeric antigen receptor
    • Giordano Attianese GM, Marin V, Hoyos V, Savoldo B, Pizzitola I, Tettamanti S et al. In vitro and in vivo model of a novel immunotherapy approach for chronic lymphocytic leukemia by anti-CD23 chimeric antigen receptor. Blood 2011; 117: 4736-4745.
    • (2011) Blood , vol.117 , pp. 4736-4745
    • Giordano Attianese, G.M.1    Marin, V.2    Hoyos, V.3    Savoldo, B.4    Pizzitola, I.5    Tettamanti, S.6
  • 20
    • 23044501404 scopus 로고    scopus 로고
    • Chemoimmunotherapy with fludarabine, cyclophosphamide, and rituximab for relapsed and refractory chronic lymphocytic leukemia
    • Wierda W, O'Brien S, Wen S, Faderl S, Garcia-Manero G, Thomas D et al. Chemoimmunotherapy with fludarabine, cyclophosphamide, and rituximab for relapsed and refractory chronic lymphocytic leukemia. J Clin Oncol 2005; 23: 4070-4078.
    • (2005) J Clin Oncol , vol.23 , pp. 4070-4078
    • Wierda, W.1    O'Brien, S.2    Wen, S.3    Faderl, S.4    Garcia-Manero, G.5    Thomas, D.6
  • 21
    • 84877624236 scopus 로고    scopus 로고
    • Chemoimmunotherapy with GA101 plus chlorambucil in patients with chronic lymphocytic leukemia and comorbidity: Results of the CLL11 (BO21004) safety run-in
    • Goede V, Fischer K, Busch R, Jaeger U, Dilhuydy MS, Wickham N et al. Chemoimmunotherapy with GA101 plus chlorambucil in patients with chronic lymphocytic leukemia and comorbidity: Results of the CLL11 (BO21004) safety run-in. Leukemia 2013; 27: 1172-1174.
    • (2013) Leukemia , vol.27 , pp. 1172-1174
    • Goede, V.1    Fischer, K.2    Busch, R.3    Jaeger, U.4    Dilhuydy, M.S.5    Wickham, N.6
  • 22
    • 84871249105 scopus 로고    scopus 로고
    • Fludarabine and cyclophosphamide in combination with alemtuzumab in patients with primary high-risk, relapsed or refractory chronic lymphocytic leukemia
    • Elter T, James R, Busch R, Winkler D, Ritgen M, Bottcher S et al. Fludarabine and cyclophosphamide in combination with alemtuzumab in patients with primary high-risk, relapsed or refractory chronic lymphocytic leukemia. Leukemia 2012; 26: 2549-2552.
    • (2012) Leukemia , vol.26 , pp. 2549-2552
    • Elter, T.1    James, R.2    Busch, R.3    Winkler, D.4    Ritgen, M.5    Bottcher, S.6
  • 23
    • 33846258434 scopus 로고    scopus 로고
    • Combination chemoimmunotherapy with pentostatin, cyclophosphamide, and rituximab shows significant clinical activity with low accompanying toxicity in previously untreated B chronic lymphocytic leukemia
    • Kay NE, Geyer SM, Call TG, Shanafelt TD, Zent CS, Jelinek DF et al. Combination chemoimmunotherapy with pentostatin, cyclophosphamide, and rituximab shows significant clinical activity with low accompanying toxicity in previously untreated B chronic lymphocytic leukemia. Blood 2007; 109: 405-411.
    • (2007) Blood , vol.109 , pp. 405-411
    • Kay, N.E.1    Geyer, S.M.2    Call, T.G.3    Shanafelt, T.D.4    Zent, C.S.5    Jelinek, D.F.6
  • 24
    • 33645732715 scopus 로고    scopus 로고
    • Pentostatin, cyclophosphamide, and rituximab is an active, well-Tolerated regimen for patients with previously treated chronic lymphocytic leukemia
    • Lamanna N, Kalaycio M, Maslak P, Jurcic JG, Heaney M, Brentjens R et al. Pentostatin, cyclophosphamide, and rituximab is an active, well-Tolerated regimen for patients with previously treated chronic lymphocytic leukemia. J Clin Oncol 2006; 24: 1575-1581.
    • (2006) J Clin Oncol , vol.24 , pp. 1575-1581
    • Lamanna, N.1    Kalaycio, M.2    Maslak, P.3    Jurcic, J.G.4    Heaney, M.5    Brentjens, R.6
  • 25
    • 70350132633 scopus 로고    scopus 로고
    • Rituximab in combination with high-dose methylprednisolone for the treatment of chronic lymphocytic leukemia
    • Castro JE, James DF, Sandoval-Sus JD, Jain S, Bole J, Rassenti L et al. Rituximab in combination with high-dose methylprednisolone for the treatment of chronic lymphocytic leukemia. Leukemia 2009; 23: 1779-1789.
    • (2009) Leukemia , vol.23 , pp. 1779-1789
    • Castro, J.E.1    James, D.F.2    Sandoval-Sus, J.D.3    Jain, S.4    Bole, J.5    Rassenti, L.6
  • 28
    • 84871831846 scopus 로고    scopus 로고
    • Ofatumumab is more efficient than rituximab in lysing B chronic lymphocytic leukemia cells in whole blood and in combination with chemotherapy
    • Bologna L, Gotti E, Da Roit F, Intermesoli T, Rambaldi A, Introna M et al. Ofatumumab is more efficient than rituximab in lysing B chronic lymphocytic leukemia cells in whole blood and in combination with chemotherapy. J Immunol 2013; 190: 231-239.
    • (2013) J Immunol , vol.190 , pp. 231-239
    • Bologna, L.1    Gotti, E.2    Da Roit, F.3    Intermesoli, T.4    Rambaldi, A.5    Introna, M.6
  • 29
    • 77950502126 scopus 로고    scopus 로고
    • Ofatumumab as single-Agent CD20 immunotherapy in fludarabine-refractory chronic lymphocytic leukemia
    • Wierda WG, Kipps TJ, Mayer J, Stilgenbauer S, Williams CD, Hellmann A et al. Ofatumumab as single-Agent CD20 immunotherapy in fludarabine-refractory chronic lymphocytic leukemia. J Clin Oncol 2010; 28: 1749-1755.
    • (2010) J Clin Oncol , vol.28 , pp. 1749-1755
    • Wierda, W.G.1    Kipps, T.J.2    Mayer, J.3    Stilgenbauer, S.4    Williams, C.D.5    Hellmann, A.6
  • 30
    • 81055148076 scopus 로고    scopus 로고
    • Ofatumumab is active in patients with fludarabine-refractory CLL irrespective of prior rituximab: Results from the phase 2 international study
    • Wierda WG, Padmanabhan S, Chan GW, Gupta IV, Lisby S, Osterborg A. Ofatumumab is active in patients with fludarabine-refractory CLL irrespective of prior rituximab: Results from the phase 2 international study. Blood 2011; 118: 5126-5129.
    • (2011) Blood , vol.118 , pp. 5126-5129
    • Wierda, W.G.1    Padmanabhan, S.2    Chan, G.W.3    Gupta, I.V.4    Lisby, S.5    Osterborg, A.6
  • 31
    • 79959190996 scopus 로고    scopus 로고
    • Chemoimmunotherapy with O-FC in previously untreated patients with chronic lymphocytic leukemia
    • Wierda WG, Kipps TJ, Durig J, Griskevicius L, Stilgenbauer S, Mayer J et al. Chemoimmunotherapy with O-FC in previously untreated patients with chronic lymphocytic leukemia. Blood 2011; 117: 6450-6458.
    • (2011) Blood , vol.117 , pp. 6450-6458
    • Wierda, W.G.1    Kipps, T.J.2    Durig, J.3    Griskevicius, L.4    Stilgenbauer, S.5    Mayer, J.6
  • 32
    • 79955979273 scopus 로고    scopus 로고
    • Novel type II anti-CD20 monoclonal antibody (GA101) evokes homotypic adhesion and actin-dependent, lysosome-mediated cell death in B-cell malignancies
    • Alduaij W, Ivanov A, Honeychurch J, Cheadle EJ, Potluri S, Lim SH et al. Novel type II anti-CD20 monoclonal antibody (GA101) evokes homotypic adhesion and actin-dependent, lysosome-mediated cell death in B-cell malignancies. Blood 2011; 117: 4519-4529.
    • (2011) Blood , vol.117 , pp. 4519-4529
    • Alduaij, W.1    Ivanov, A.2    Honeychurch, J.3    Cheadle, E.J.4    Potluri, S.5    Lim, S.H.6
  • 33
    • 78651354250 scopus 로고    scopus 로고
    • Comparison of the in vitro effects of the anti-CD20 antibodies rituximab and GA101 on chronic lymphocytic leukaemia cells
    • Patz M, Isaeva P, Forcob N, Muller B, Frenzel LP, Wendtner CM et al. Comparison of the in vitro effects of the anti-CD20 antibodies rituximab and GA101 on chronic lymphocytic leukaemia cells. Br J Haematol 2011; 152: 295-306.
    • (2011) Br J Haematol , vol.152 , pp. 295-306
    • Patz, M.1    Isaeva, P.2    Forcob, N.3    Muller, B.4    Frenzel, L.P.5    Wendtner, C.M.6
  • 35
    • 84887058701 scopus 로고    scopus 로고
    • Obinutuzumab (GA101) plus chlorambucil (Clb) or rituximab (R) plus Clb versus Clb alone in patients with chronic lymphocytic leukemia (CLL) and preexisting medical conditions (comorbidities): Final stage 1 results of the CLL11 (BO21004) phase III trial
    • 15 suppl
    • Goede V, Fischer K, Humphrey K, Asikanius E, Busch R, Engelke A et al. Obinutuzumab (GA101) plus chlorambucil (Clb) or rituximab (R) plus Clb versus Clb alone in patients with chronic lymphocytic leukemia (CLL) and preexisting medical conditions (comorbidities): Final stage 1 results of the CLL11 (BO21004) phase III trial. ASCO Meeting Abstracts 2013; 31(15-suppl): 7004.
    • (2013) ASCO Meeting Abstracts , vol.31 , pp. 7004
    • Goede, V.1    Fischer, K.2    Humphrey, K.3    Asikanius, E.4    Busch, R.5    Engelke, A.6
  • 36
    • 0024204319 scopus 로고
    • Remission induction in non-Hodgkin lymphoma with reshaped human monoclonal antibody CAMPATH-1H
    • Hale G, Dyer MJ, Clark MR, Phillips JM, Marcus R, Riechmann L et al. Remission induction in non-Hodgkin lymphoma with reshaped human monoclonal antibody CAMPATH-1H. Lancet 1988; 2: 1394-1399.
    • (1988) Lancet , vol.2 , pp. 1394-1399
    • Hale, G.1    Dyer, M.J.2    Clark, M.R.3    Phillips, J.M.4    Marcus, R.5    Riechmann, L.6
  • 38
    • 4844229401 scopus 로고    scopus 로고
    • Rituximab and alemtuzumab induce a nonclassic, caspase-independent apoptotic pathway in B-lymphoid cell lines and in chronic lymphocytic leukemia cells
    • Stanglmaier M, Reis S, Hallek M. Rituximab and alemtuzumab induce a nonclassic, caspase-independent apoptotic pathway in B-lymphoid cell lines and in chronic lymphocytic leukemia cells. Ann Hematol 2004; 83: 634-645.
    • (2004) Ann Hematol , vol.83 , pp. 634-645
    • Stanglmaier, M.1    Reis, S.2    Hallek, M.3
  • 39
    • 0023691376 scopus 로고
    • Importance of antigen specificity for complementmediated lysis by monoclonal antibodies
    • Bindon CI, Hale G, Waldmann H. Importance of antigen specificity for complementmediated lysis by monoclonal antibodies. Eur J Immunol 1988; 18: 1507-1514.
    • (1988) Eur J Immunol , vol.18 , pp. 1507-1514
    • Bindon, C.I.1    Hale, G.2    Waldmann, H.3
  • 40
    • 37649004407 scopus 로고    scopus 로고
    • Alemtuzumab compared with chlorambucil as first-line therapy for chronic lymphocytic leukemia
    • Hillmen P, Skotnicki AB, Robak T, Jaksic B, Dmoszynska A, Wu J et al. Alemtuzumab compared with chlorambucil as first-line therapy for chronic lymphocytic leukemia. J Clin Oncol 2007; 25: 5616-5623.
    • (2007) J Clin Oncol , vol.25 , pp. 5616-5623
    • Hillmen, P.1    Skotnicki, A.B.2    Robak, T.3    Jaksic, B.4    Dmoszynska, A.5    Wu, J.6
  • 41
    • 0037092951 scopus 로고    scopus 로고
    • Therapeutic role of alemtuzumab (Campath-1H) in patients who have failed fludarabine: Results of a large international study
    • Keating MJ, Flinn I, Jain V, Binet JL, Hillmen P, Byrd J et al. Therapeutic role of alemtuzumab (Campath-1H) in patients who have failed fludarabine: Results of a large international study. Blood 2002; 99: 3554-3561.
    • (2002) Blood , vol.99 , pp. 3554-3561
    • Keating, M.J.1    Flinn, I.2    Jain, V.3    Binet, J.L.4    Hillmen, P.5    Byrd, J.6
  • 42
    • 0030897222 scopus 로고    scopus 로고
    • Phase II multicenter study of human CD52 antibody in previously treated chronic lymphocytic leukemia. European study group of CAMPATH-1H treatment in chronic lymphocytic leukemia
    • Osterborg A, Dyer MJ, Bunjes D, Pangalis GA, Bastion Y, Catovsky D et al. Phase II multicenter study of human CD52 antibody in previously treated chronic lymphocytic leukemia. European study group of CAMPATH-1H treatment in chronic lymphocytic leukemia. J Clin Oncol 1997; 15: 1567-1574.
    • (1997) J Clin Oncol , vol.15 , pp. 1567-1574
    • Osterborg, A.1    Dyer, M.J.2    Bunjes, D.3    Pangalis, G.A.4    Bastion, Y.5    Catovsky, D.6
  • 43
    • 0037106502 scopus 로고    scopus 로고
    • Alemtuzumab in previously treated chronic lymphocytic leukemia patients who also had received fludarabine
    • Rai KR, Freter CE, Mercier RJ, Cooper MR, Mitchell BS, Stadtmauer EA et al. Alemtuzumab in previously treated chronic lymphocytic leukemia patients who also had received fludarabine. J Clin Oncol 2002; 20: 3891-3897.
    • (2002) J Clin Oncol , vol.20 , pp. 3891-3897
    • Rai, K.R.1    Freter, C.E.2    Mercier, R.J.3    Cooper, M.R.4    Mitchell, B.S.5    Stadtmauer, E.A.6
  • 44
    • 77449133613 scopus 로고    scopus 로고
    • Phase 1/2 study of lumiliximab combined with fludarabine, cyclophosphamide, and rituximab in patients with relapsed or refractory chronic lymphocytic leukemia
    • Byrd JC, Kipps TJ, Flinn IW, Castro J, Lin TS, Wierda W et al. Phase 1/2 study of lumiliximab combined with fludarabine, cyclophosphamide, and rituximab in patients with relapsed or refractory chronic lymphocytic leukemia. Blood 2010; 115: 489-495.
    • (2010) Blood , vol.115 , pp. 489-495
    • Byrd, J.C.1    Kipps, T.J.2    Flinn, I.W.3    Castro, J.4    Lin, T.S.5    Wierda, W.6
  • 45
    • 84857996061 scopus 로고    scopus 로고
    • Action of novel CD37 antibodies on chronic lymphocytic leukemia cells
    • Krause G, Patz M, Isaeva P, Wigger M, Baki I, Vondey V et al. Action of novel CD37 antibodies on chronic lymphocytic leukemia cells. Leukemia 2012; 26: 546-549.
    • (2012) Leukemia , vol.26 , pp. 546-549
    • Krause, G.1    Patz, M.2    Isaeva, P.3    Wigger, M.4    Baki, I.5    Vondey, V.6
  • 46
    • 24944581157 scopus 로고    scopus 로고
    • Preclinical antilymphoma activity of a humanized anti-CD40 monoclonal antibody, SGN-40
    • Law CL, Gordon KA, Collier J, Klussman K, McEarchern JA, Cerveny CG et al. Preclinical antilymphoma activity of a humanized anti-CD40 monoclonal antibody, SGN-40. Cancer Res 2005; 65: 8331-8338.
    • (2005) Cancer Res , vol.65 , pp. 8331-8338
    • Law, C.L.1    Gordon, K.A.2    Colli, J.3    Klussman, K.4    McEarchern, J.A.5    Cerveny, C.G.6
  • 47
    • 60749120363 scopus 로고    scopus 로고
    • The humanized CD40 antibody SGN-40 demonstrates pre-clinical activity that is enhanced by lenalidomide in chronic lymphocytic leukaemia
    • Lapalombella R, Gowda A, Joshi T, Mehter N, Cheney C, Lehman A et al. The humanized CD40 antibody SGN-40 demonstrates pre-clinical activity that is enhanced by lenalidomide in chronic lymphocytic leukaemia. Br J Haematol 2009; 144: 848-855.
    • (2009) Br J Haematol , vol.144 , pp. 848-855
    • Lapalombella, R.1    Gowda, A.2    Joshi, T.3    Mehter, N.4    Cheney, C.5    Lehman, A.6
  • 48
    • 84873078001 scopus 로고    scopus 로고
    • A phase 1, open-label, multi-center, multiple-dose, dose-escalation study of MDX-1342 in patients with CD19-positive refractory/relapsed chronic lymphocytic leukemia
    • Camacho LH, Joyce R, Brown JR, Chanan-Khan A, Amrein PC, Assad A et al. A phase 1, open-label, multi-center, multiple-dose, dose-escalation study of MDX-1342 in patients with CD19-positive refractory/relapsed chronic lymphocytic leukemia. ASH Annual Meeting Abstracts 2009; 114: 3425.
    • (2009) ASH Annual Meeting Abstracts , vol.114 , pp. 3425
    • Camacho, L.H.1    Joyce, R.2    Brown, J.R.3    Chanan-Khan, A.4    Amrein, P.C.5    Assad, A.6
  • 49
    • 33750634293 scopus 로고    scopus 로고
    • Characterization of a humanized IgG4 anti-HLA-DR monoclonal antibody that lacks effector cell functions but retains direct antilymphoma activity and increases the potency of rituximab
    • Stein R, Qu Z, Chen S, Solis D, Hansen HJ, Goldenberg DM. Characterization of a humanized IgG4 anti-HLA-DR monoclonal antibody that lacks effector cell functions but retains direct antilymphoma activity and increases the potency of rituximab. Blood 2006; 108: 2736-2744.
    • (2006) Blood , vol.108 , pp. 2736-2744
    • Stein, R.1    Qu, Z.2    Chen, S.3    Solis, D.4    Hansen, H.J.5    Goldenberg, D.M.6
  • 50
    • 34247639475 scopus 로고    scopus 로고
    • CD200 expression on tumor cells suppresses antitumor immunity: New approaches to cancer immunotherapy
    • Kretz-Rommel A, Qin F, Dakappagari N, Ravey EP, McWhirter J, Oltean D et al. CD200 expression on tumor cells suppresses antitumor immunity: New approaches to cancer immunotherapy. J Immunol 2007; 178: 5595-5605.
    • (2007) J Immunol , vol.178 , pp. 5595-5605
    • Kretz-Rommel, A.1    Qin, F.2    Dakappagari, N.3    Ravey, E.P.4    McWhirter, J.5    Oltean, D.6
  • 51
    • 46749132717 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia T cells show impaired immunological synapse formation that can be reversed with an immunomodulating drug
    • Ramsay AG, Johnson AJ, Lee AM, Gorgun G, Le Dieu R, Blum W et al. Chronic lymphocytic leukemia T cells show impaired immunological synapse formation that can be reversed with an immunomodulating drug. J Clin Invest 2008; 118: 2427-2437.
    • (2008) J Clin Invest , vol.118 , pp. 2427-2437
    • Ramsay, A.G.1    Johnson, A.J.2    Lee, A.M.3    Gorgun, G.4    Le Dieu, R.5    Blum, W.6
  • 52
    • 84865165316 scopus 로고    scopus 로고
    • Multiple inhibitory ligands induce impaired T-cell immunologic synapse function in chronic lymphocytic leukemia that can be blocked with lenalidomide: Establishing a reversible immune evasion mechanism in human cancer
    • Ramsay AG, Clear AJ, Fatah R, Gribben JG. Multiple inhibitory ligands induce impaired T-cell immunologic synapse function in chronic lymphocytic leukemia that can be blocked with lenalidomide: Establishing a reversible immune evasion mechanism in human cancer. Blood 2012; 120: 1412-1421.
    • (2012) Blood , vol.120 , pp. 1412-1421
    • Ramsay, A.G.1    Clear, A.J.2    Fatah, R.3    Gribben, J.G.4
  • 53
    • 80053130680 scopus 로고    scopus 로고
    • New insights into the T cell synapse from single molecule techniques
    • Dustin ML, Depoil D. New insights into the T cell synapse from single molecule techniques. Nat Rev Immunol 2011; 11: 672-684.
    • (2011) Nat Rev Immunol , vol.11 , pp. 672-684
    • Dustin, M.L.1    Depoil, D.2
  • 54
    • 79952769640 scopus 로고    scopus 로고
    • Single-Agent lenalidomide in the treatment of previously untreated chronic lymphocytic leukemia
    • Chen CI, Bergsagel PL, Paul H, Xu W, Lau A, Dave N et al. Single-Agent lenalidomide in the treatment of previously untreated chronic lymphocytic leukemia. J Clin Oncol 2011; 29: 1175-1181.
    • (2011) J Clin Oncol , vol.29 , pp. 1175-1181
    • Chen, C.I.1    Bergsagel, P.L.2    Paul, H.3    Xu, W.4    Lau, A.5    Dave, N.6
  • 55
    • 84880276168 scopus 로고    scopus 로고
    • Long-Term repair of T-cell synapse activity in a phase II trial of chemoimmunotherapy followed by lenalidomide consolidation in previously untreated chronic lymphocytic leukemia (CLL
    • Shanafelt TD, Ramsay AG, Zent CS, Leis JF, Tun HW, Call TG et al. Long-Term repair of T-cell synapse activity in a phase II trial of chemoimmunotherapy followed by lenalidomide consolidation in previously untreated chronic lymphocytic leukemia (CLL). Blood 2013; 121: 4137-4141.
    • (2013) Blood , vol.121 , pp. 4137-4141
    • Shanafelt, T.D.1    Ramsay, A.G.2    Zent, C.S.3    Leis, J.F.4    Tun, H.W.5    Call, T.G.6
  • 56
    • 58149399362 scopus 로고    scopus 로고
    • Lenalidomide down-regulates the CD20 antigen and antagonizes direct and antibody-dependent cellular cytotoxicity of rituximab on primary chronic lymphocytic leukemia cells
    • Lapalombella R, Yu B, Triantafillou G, Liu Q, Butchar JP, Lozanski G et al. Lenalidomide down-regulates the CD20 antigen and antagonizes direct and antibody-dependent cellular cytotoxicity of rituximab on primary chronic lymphocytic leukemia cells. Blood 2008; 112: 5180-5189.
    • (2008) Blood , vol.112 , pp. 5180-5189
    • Lapalombella, R.1    Yu, B.2    Triantafillou, G.3    Liu, Q.4    Butchar, J.P.5    Lozanski, G.6
  • 57
    • 84875451856 scopus 로고    scopus 로고
    • Phase II study of lenalidomide and rituximab as salvage therapy for patients with relapsed or refractory chronic lymphocytic leukemia
    • Badoux XC, Keating MJ, Wen S, Wierda WG, O'Brien SM, Faderl S et al. Phase II study of lenalidomide and rituximab as salvage therapy for patients with relapsed or refractory chronic lymphocytic leukemia. J Clin Oncol 2013; 31: 584-591.
    • (2013) J Clin Oncol , vol.31 , pp. 584-591
    • Badoux, X.C.1    Keating, M.J.2    Wen, S.3    Wierda, W.G.4    O'Brien, S.M.5    Faderl, S.6
  • 58
    • 80053350801 scopus 로고    scopus 로고
    • Lenalidomide as initial therapy of elderly patients with chronic lymphocytic leukemia
    • Badoux XC, Keating MJ, Wen S, Lee BN, Sivina M, Reuben J et al. Lenalidomide as initial therapy of elderly patients with chronic lymphocytic leukemia. Blood 2011; 118: 3489-3498.
    • (2011) Blood , vol.118 , pp. 3489-3498
    • Badoux, X.C.1    Keating, M.J.2    Wen, S.3    Lee, B.N.4    Sivina, M.5    Reuben, J.6
  • 59
    • 64749086917 scopus 로고    scopus 로고
    • Stem cell transplantation in chronic lymphocytic leukemia
    • 1 Suppl
    • Gribben JG. Stem cell transplantation in chronic lymphocytic leukemia. Biol Blood Marrow Transplant 2009; 15(1 Suppl): 53-58.
    • (2009) Biol Blood Marrow Transplant , vol.15 , pp. 53-58
    • Gribben, J.G.1
  • 60
    • 79959485796 scopus 로고    scopus 로고
    • Autologous stem cell transplantation as a first-line treatment strategy for chronic lymphocytic leukemia: A multicenter randomized controlled trial from the SFGM-TC and GFLLC
    • Sutton L, Chevret S, Tournilhac O, Divine M, Leblond V, Corront B et al. Autologous stem cell transplantation as a first-line treatment strategy for chronic lymphocytic leukemia: A multicenter, randomized, controlled trial from the SFGM-TC and GFLLC. Blood 2011; 117: 6109-6119.
    • (2011) Blood , vol.117 , pp. 6109-6119
    • Sutton, L.1    Chevret, S.2    Tournilhac, O.3    Divine, M.4    Leblond, V.5    Corront, B.6
  • 61
    • 34848893310 scopus 로고    scopus 로고
    • Systematic review of high dose chemotherapy and autologous haematopoietic stem cell transplantation for chronic lymphocytic leukaemia what is the published evidence?
    • Kharfan-Dabaja MA, Kumar A, Behera M, Djulbegovic B. Systematic review of high dose chemotherapy and autologous haematopoietic stem cell transplantation for chronic lymphocytic leukaemia: What is the published evidence?. Br J Haematol 2007; 139: 234-242.
    • (2007) Br J Haematol , vol.139 , pp. 234-242
    • Kharfan-Dabaja, M.A.1    Kumar, A.2    Behera, M.3    Djulbegovic, B.4
  • 62
    • 13344287042 scopus 로고    scopus 로고
    • HLA-identical sibling bone marrow transplantation in younger patients with chronic lymphocytic leukemia
    • European Group for Blood and Marrow Transplantation and the International Bone Marrow Transplant Registry
    • Michallet M, Archimbaud E, Bandini G, Rowlings PA, Deeg HJ, Gahrton G et al. HLA-identical sibling bone marrow transplantation in younger patients with chronic lymphocytic leukemia. European Group for Blood and Marrow Transplantation and the International Bone Marrow Transplant Registry. Ann Intern Med 1996; 124: 311-315.
    • (1996) Ann Intern Med , vol.124 , pp. 311-315
    • Michallet, M.1    Archimbaud, E.2    Bandini, G.3    Rowlings, P.A.4    Deeg, H.J.5    Gahrton, G.6
  • 64
    • 27744580700 scopus 로고    scopus 로고
    • Myeloablative allografting for chronic lymphocytic leukemia: Evidence for a potent graft-versus-leukemia effect associated with graft-versus-host disease
    • Toze CL, Galal A, Barnett MJ, Shepherd JD, Conneally EA, Hogge DE et al. Myeloablative allografting for chronic lymphocytic leukemia: Evidence for a potent graft-versus-leukemia effect associated with graft-versus-host disease. Bone Marrow Transplant 2005; 36: 825-830.
    • (2005) Bone Marrow Transplant , vol.36 , pp. 825-830
    • Toze, C.L.1    Galal, A.2    Barnett, M.J.3    Shepherd, J.D.4    Conneally, E.A.5    Hogge, D.E.6
  • 65
    • 20844436596 scopus 로고    scopus 로고
    • Reduced-intensity conditioning lowers treatment-related mortality of allogeneic stem cell transplantation for chronic lymphocytic leukemia: A population-matched analysis
    • Dreger P, Brand R, Milligan D, Corradini P, Finke J, Lambertenghi Deliliers G et al. Reduced-intensity conditioning lowers treatment-related mortality of allogeneic stem cell transplantation for chronic lymphocytic leukemia: A population-matched analysis. Leukemia 2005; 19: 1029-1033.
    • (2005) Leukemia , vol.19 , pp. 1029-1033
    • Dreger, P.1    Brand, R.2    Milligan, D.3    Corradini, P.4    Finke, J.5    Lambertenghi Deliliers, G.6
  • 66
    • 84865997474 scopus 로고    scopus 로고
    • Comparing efficacy of reduced-Toxicity allogeneic hematopoietic cell transplantation with conventional chemo-(immuno) therapy in patients with relapsed or refractory CLL: A Markov decision analysis
    • Kharfan-Dabaja MA, Pidala J, Kumar A, Terasawa T, Djulbegovic B. Comparing efficacy of reduced-Toxicity allogeneic hematopoietic cell transplantation with conventional chemo-(immuno) therapy in patients with relapsed or refractory CLL: A Markov decision analysis. Bone Marrow Transplant 2012; 47: 1164-1170.
    • (2012) Bone Marrow Transplant , vol.47 , pp. 1164-1170
    • Kharfan-Dabaja, M.A.1    Pidala, J.2    Kumar, A.3    Terasawa, T.4    Djulbegovic, B.5
  • 67
    • 84883532609 scopus 로고    scopus 로고
    • Autologous CLL cell vaccination early after transplant induces leukemia-specific T cells
    • Burkhardt UE, Hainz U, Stevenson K, Goldstein NR, Pasek M, Naito M et al. Autologous CLL cell vaccination early after transplant induces leukemia-specific T cells. J Clin Invest 2013; 123: 3756-3765.
    • (2013) J Clin Invest , vol.123 , pp. 3756-3765
    • Burkhardt, U.E.1    Hainz, U.2    Stevenson, K.3    Goldstein, N.R.4    Pasek, M.5    Naito, M.6
  • 68
    • 84877282791 scopus 로고    scopus 로고
    • Efficacy of adoptive immunotherapy with donor lymphocyte infusion in relapsed lymphoid malignancies
    • El-Jurdi N, Reljic T, Kumar A, Pidala J, Bazarbachi A, Djulbegovic B et al. Efficacy of adoptive immunotherapy with donor lymphocyte infusion in relapsed lymphoid malignancies. Immunotherapy 2013; 5: 457-466.
    • (2013) Immunotherapy , vol.5 , pp. 457-466
    • El-Jurdi, N.1    Reljic, T.2    Kumar, A.3    Pidala, J.4    Bazarbachi, A.5    Djulbegovic, B.6
  • 69
    • 77956535599 scopus 로고    scopus 로고
    • Redirecting T-cell specificity by introducing a tumorspecific chimeric antigen receptor
    • Jena B, Dotti G, Cooper LJ. Redirecting T-cell specificity by introducing a tumorspecific chimeric antigen receptor. Blood 2010; 116: 1035-1044.
    • (2010) Blood , vol.116 , pp. 1035-1044
    • Jena, B.1    Dotti, G.2    Cooper, L.J.3
  • 70
    • 84877669593 scopus 로고    scopus 로고
    • The basic principles of chimeric antigen receptor design
    • Sadelain M, Brentjens R, Riviere I. The basic principles of chimeric antigen receptor design. Cancer Discov 2013; 3: 388-398.
    • (2013) Cancer Discov , vol.3 , pp. 388-398
    • Sadelain, M.1    Brentjens, R.2    Riviere, I.3
  • 71
    • 27744566329 scopus 로고    scopus 로고
    • A chimeric T cell antigen receptor that augments cytokine release and supports clonal expansion of primary human T cells
    • Pule MA, Straathof KC, Dotti G, Heslop HE, Rooney CM, Brenner MK. A chimeric T cell antigen receptor that augments cytokine release and supports clonal expansion of primary human T cells. Mol Ther 2005; 12: 933-941.
    • (2005) Mol Ther , vol.12 , pp. 933-941
    • Pule, M.A.1    Straathof, K.C.2    Dotti, G.3    Heslop, H.E.4    Rooney, C.M.5    Brenner, M.K.6
  • 72
    • 84860333968 scopus 로고    scopus 로고
    • CD20-specific adoptive immunotherapy for lymphoma using a chimeric antigen receptor with both CD28 and 4-1BB domains: Pilot clinical trial results
    • Till BG, Jensen MC, Wang J, Qian X, Gopal AK, Maloney DG et al. CD20-specific adoptive immunotherapy for lymphoma using a chimeric antigen receptor with both CD28 and 4-1BB domains: Pilot clinical trial results. Blood 2012; 119: 3940-3950.
    • (2012) Blood , vol.119 , pp. 3940-3950
    • Till, B.G.1    Jensen, M.C.2    Wang, J.3    Qian, X.4    Gopal, A.K.5    Maloney, D.G.6
  • 73
    • 84878547375 scopus 로고    scopus 로고
    • Manufacture of clinical-grade CD19-specific T cells stably expressing chimeric antigen receptor using Sleeping Beauty system and artificial antigen presenting cells
    • Singh H, Figliola MJ, Dawson MJ, Olivares S, Zhang L, Yang G et al. Manufacture of clinical-grade CD19-specific T cells stably expressing chimeric antigen receptor using Sleeping Beauty system and artificial antigen presenting cells. PLoS ONE 2013; 8: E64138.
    • (2013) PLoS ONE , vol.8
    • Singh, H.1    Figliola, M.J.2    Dawson, M.J.3    Olivares, S.4    Zhang, L.5    Yang, G.6
  • 74
    • 84877626190 scopus 로고    scopus 로고
    • Clinical application of Sleeping Beauty and artificial antigen presenting cells to genetically modify T cells from peripheral and umbilical cord blood
    • Huls MH, Figliola MJ, Dawson MJ, Olivares S, Kebriaei P, Shpall EJ et al. Clinical application of Sleeping Beauty and artificial antigen presenting cells to genetically modify T cells from peripheral and umbilical cord blood. J Vis Exp 2013; 72: E50070.
    • (2013) J Vis Exp , vol.72
    • Huls, M.H.1    Figliola, M.J.2    Dawson, M.J.3    Olivares, S.4    Kebriaei, P.5    Shpall, E.J.6
  • 75
    • 50549096284 scopus 로고    scopus 로고
    • Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cells
    • Till BG, Jensen MC, Wang J, Chen EY, Wood BL, Greisman HA et al. Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cells. Blood 2008; 112: 2261-2271.
    • (2008) Blood , vol.112 , pp. 2261-2271
    • Till, B.G.1    Jensen, M.C.2    Wang, J.3    Chen, E.Y.4    Wood, B.L.5    Greisman, H.A.6
  • 76
    • 84876005284 scopus 로고    scopus 로고
    • CD19-Targeted T cells rapidly induce molecular remissions in adults with chemotherapyrefractory acute lymphoblastic leukemia
    • 177ra138
    • Brentjens RJ, Davila ML, Riviere I, Park J, Wang X, Cowell LG et al. CD19-Targeted T cells rapidly induce molecular remissions in adults with chemotherapyrefractory acute lymphoblastic leukemia. Sci Transl Med 2013; 5: 177ra138.
    • (2013) Sci Transl Med , vol.5
    • Brentjens, R.J.1    Davila, M.L.2    Riviere, I.3    Park, J.4    Wang, X.5    Cowell, L.G.6
  • 77
    • 80051775476 scopus 로고    scopus 로고
    • T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia
    • 95ra73
    • Kalos M, Levine BL, Porter DL, Katz S, Grupp SA, Bagg A et al. T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia. Sci Transl Med 2011; 3: 95ra73.
    • (2011) Sci Transl Med , vol.3
    • Kalos, M.1    Levine, B.L.2    Porter, D.L.3    Katz, S.4    Grupp, S.A.5    Bagg, A.6
  • 78
    • 84890827981 scopus 로고    scopus 로고
    • Donor-derived cd19-Targeted t cells cause regression of malignancy persisting after allogeneic hematopoietic stem cell transplantation
    • E-pub Ahead Of Print 20 September 2013 doi:10.1182/blood-2013-08-519413
    • Kochenderfer JN, Dudley ME, Carpenter RO, Kassim SH, Rose JJ, Telford WG et al. Donor-derived CD19-Targeted T cells cause regression of malignancy persisting after allogeneic hematopoietic stem cell transplantation. Blood 2013; e-pub ahead of print 20 September 2013; doi:10.1182/blood-2013-08-519413.
    • (2013) Blood
    • Kochenderfer, J.N.1    Dudley, M.E.2    Carpenter, R.O.3    Kassim, S.H.4    Rose, J.J.5    Telford, W.G.6
  • 79
    • 80455179612 scopus 로고    scopus 로고
    • Safety and persistence of adoptively transferred autologous CD19-Targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias
    • Brentjens RJ, Riviere I, Park JH, Davila ML, Wang X, Stefanski J et al. Safety and persistence of adoptively transferred autologous CD19-Targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias. Blood 2011; 118: 4817-4828.
    • (2011) Blood , vol.118 , pp. 4817-4828
    • Brentjens, R.J.1    Riviere, I.2    Park, J.H.3    Davila, M.L.4    Wang, X.5    Stefanski, J.6
  • 81
    • 77950480974 scopus 로고    scopus 로고
    • Treatment of chronic lymphocytic leukemia with genetically targeted autologous T cells: Case report of an unforeseen adverse event in a phase I clinical trial
    • Brentjens R, Yeh R, Bernal Y, Riviere I, Sadelain M. Treatment of chronic lymphocytic leukemia with genetically targeted autologous T cells: Case report of an unforeseen adverse event in a phase I clinical trial. Mol Ther 2010; 18: 666-668.
    • (2010) Mol Ther , vol.18 , pp. 666-668
    • Brentjens, R.1    Yeh, R.2    Bernal, Y.3    Riviere, I.4    Sadelain, M.5
  • 82
    • 84863337890 scopus 로고    scopus 로고
    • B-cell depletion and remissions of malignancy along with cytokine-Associated toxicity in a clinical trial of anti-CD19 chimeric-Antigen-receptor-Transduced T cells
    • Kochenderfer JN, Dudley ME, Feldman SA, Wilson WH, Spaner DE, Maric I et al. B-cell depletion and remissions of malignancy along with cytokine-Associated toxicity in a clinical trial of anti-CD19 chimeric-Antigen-receptor-Transduced T cells. Blood 2012; 119: 2709-2720.
    • (2012) Blood , vol.119 , pp. 2709-2720
    • Kochenderfer, J.N.1    Dudley, M.E.2    Feldman, S.A.3    Wilson, W.H.4    Spaner, D.E.5    Maric, I.6
  • 83
    • 84886397930 scopus 로고    scopus 로고
    • Anti-PD-1 antibody therapy potently enhances the eradication of established tumors by gene-modified T cells
    • John LB, Devaud C, Duong CM, Yong C, Beavis PA, Haynes NM et al. Anti-PD-1 antibody therapy potently enhances the eradication of established tumors by gene-modified T cells. Clin Cancer Res 2013; 19: 3153-3164.
    • (2013) Clin Cancer Res , vol.19 , pp. 3153-3164
    • John, L.B.1    Devaud, C.2    Duong, C.M.3    Yong, C.4    Beavis, P.A.5    Haynes, N.M.6
  • 84
    • 84879480191 scopus 로고    scopus 로고
    • Receptor affinity and extracellular domain modifications affect tumor recognition by ROR1-specific chimeric antigen receptor T cells
    • Hudecek M, Lupo-Stanghellini MT, Kosasih PL, Sommermeyer D, Jensen MC, Rader C et al. Receptor affinity and extracellular domain modifications affect tumor recognition by ROR1-specific chimeric antigen receptor T cells. Clin Cancer Res 2013; 19: 3153-3164.
    • (2013) Clin Cancer Res , vol.19 , pp. 3153-3164
    • Hudecek, M.1    Lupo-Stanghellini, M.T.2    Kosasih, P.L.3    Sommermeyer, D.4    Jensen, M.C.5    Rader, C.6
  • 85
    • 42949121156 scopus 로고    scopus 로고
    • Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a
    • Fukuda T, Chen L, Endo T, Tang L, Lu D, Castro JE et al. Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a. Proc Natl Acad Sci USA 2008; 105: 3047-3052.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 3047-3052
    • Fukuda, T.1    Chen, L.2    Endo, T.3    Tang, L.4    Lu, D.5    Castro, J.E.6
  • 86
    • 0035859199 scopus 로고    scopus 로고
    • Hematopoietic stem-cell transplants using umbilical-cord blood
    • Gluckman E. Hematopoietic stem-cell transplants using umbilical-cord blood. N Engl J Med 2001; 344: 1860-1861.
    • (2001) N Engl J Med , vol.344 , pp. 1860-1861
    • Gluckman, E.1
  • 87
    • 84880259968 scopus 로고    scopus 로고
    • Generation of multi-leukemia antigen-specific T cells to enhance the graft-versus-leukemia effect after allogeneic stem cell transplant
    • Weber G, Gerdemann U, Caruana I, Savoldo B, Hensel NF, Rabin KR et al. Generation of multi-leukemia antigen-specific T cells to enhance the graft-versus-leukemia effect after allogeneic stem cell transplant. Leukemia 2013; 27: 1538-1547.
    • (2013) Leukemia , vol.27 , pp. 1538-1547
    • Weber, G.1    Gerdemann, U.2    Caruana, I.3    Savoldo, B.4    Hensel, N.F.5    Rabin, K.R.6
  • 88
    • 84862586155 scopus 로고    scopus 로고
    • Gene immunotherapy of chronic lymphocytic leukemia: A phase I study of intranodally injected adenovirus expressing a chimeric CD154 molecule
    • Castro JE, Melo-Cardenas J, Urquiza M, Barajas-Gamboa JS, Pakbaz RS, Kipps TJ. Gene immunotherapy of chronic lymphocytic leukemia: A phase I study of intranodally injected adenovirus expressing a chimeric CD154 molecule. Cancer Res 2012; 72: 2937-2948.
    • (2012) Cancer Res , vol.72 , pp. 2937-2948
    • Castro, J.E.1    Melo-Cardenas, J.2    Urquiza, M.3    Barajas-Gamboa, J.S.4    Pakbaz, R.S.5    Kipps, T.J.6
  • 90
    • 84870734255 scopus 로고    scopus 로고
    • Emerging role of kinase-Targeted strategies in chronic lymphocytic leukemia
    • Wiestner A. Emerging role of kinase-Targeted strategies in chronic lymphocytic leukemia. Blood 2012; 120: 4684-4691.
    • (2012) Blood , vol.120 , pp. 4684-4691
    • Wiestner, A.1
  • 91
    • 79959404661 scopus 로고    scopus 로고
    • Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765
    • Herman SE, Gordon AL, Hertlein E, Ramanunni A, Zhang X, Jaglowski S et al. Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765. Blood 2011; 117: 6287-6296.
    • (2011) Blood , vol.117 , pp. 6287-6296
    • Herman, S.E.1    Gordon, A.L.2    Hertlein, E.3    Ramanunni, A.4    Zhang, X.5    Jaglowski, S.6
  • 92
    • 84881225049 scopus 로고    scopus 로고
    • Targeting BTK with ibrutinib in relapsed or refractory mantle-cell lymphoma
    • Wang ML, Rule S, Martin P, Goy A, Auer R, Kahl BS et al. Targeting BTK with ibrutinib in relapsed or refractory mantle-cell lymphoma. N Engl J Med 2013; 369: 507-516.
    • (2013) N Engl J Med , vol.369 , pp. 507-516
    • Wang, M.L.1    Rule, S.2    Martin, P.3    Goy, A.4    Auer, R.5    Kahl, B.S.6
  • 93
    • 84863011553 scopus 로고    scopus 로고
    • The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo
    • Ponader S, Chen SS, Buggy JJ, Balakrishnan K, Gandhi V, Wierda WG et al. The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo. Blood 2012; 119: 1182-1189.
    • (2012) Blood , vol.119 , pp. 1182-1189
    • Ponader, S.1    Chen, S.S.2    Buggy, J.J.3    Balakrishnan, K.4    Gandhi, V.5    Wierda, W.G.6
  • 94
    • 84875771550 scopus 로고    scopus 로고
    • The Btk Inhibitor ibrutinib (PCI-32765) in combination with rituximab is well tolerated and displays profound activity in high-risk chronic lymphocytic leukemia (CLL) patients
    • Burger JA, Keating MJ, Wierda WG, Hoellenriegel J, Ferrajoli A, Faderl S et al. The Btk Inhibitor ibrutinib (PCI-32765) in combination with rituximab is well tolerated and displays profound activity in high-risk chronic lymphocytic leukemia (CLL) patients. ASH Annual Meeting Abstracts 2012; 120: 187.
    • (2012) ASH Annual Meeting Abstracts , vol.120 , pp. 187
    • Burger, J.A.1    Keating, M.J.2    Wierda, W.G.3    Hoellenriegel, J.4    Ferrajoli, A.5    Faderl, S.6
  • 95
    • 84867853067 scopus 로고    scopus 로고
    • A phase Ib/II study evaluating activity and tolerability of BTK inhibitor PCI-32765 and ofatumumab in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and related diseases
    • 15 suppl
    • Jaglowski SM, Jones JA, Flynn JM, Andritsos LA, Maddocks KJ, Blum KA et al. A phase Ib/II study evaluating activity and tolerability of BTK inhibitor PCI-32765 and ofatumumab in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and related diseases. ASCO Meeting Abstracts 2012; 30(15-suppl): 6508.
    • (2012) ASCO Meeting Abstracts , vol.30 , pp. 6508
    • Jaglowski, S.M.1    Jones, J.A.2    Flynn, J.M.3    Andritsos, L.A.4    Maddocks, K.J.5    Blum, K.A.6
  • 96
    • 84895795259 scopus 로고    scopus 로고
    • The Bruton's tyrosine kinase (BTK) inhibitor ibrutinib combined with bendamustine and rituximab is active and tolerable in patients with relapsed/refractory CLL, interim results of a phase IB/II study
    • Brown JBJ, Flinn I, Barr P, Burger J, Navarro T. The Bruton's tyrosine kinase (BTK) inhibitor ibrutinib combined with bendamustine and rituximab is active and tolerable in patients with relapsed/refractory CLL, interim results of a phase IB/II study. Haematologica 2012 17th Congress of the European Hematology Association Abstract 0543 2012.
    • (2012) Haematologica 2012 17th Congress of the European Hematology Association Abstract , vol.543
    • Brown, J.B.J.1    Flinn, I.2    Barr, P.3    Burger, J.4    Navarro, T.5
  • 97
    • 84891373612 scopus 로고    scopus 로고
    • Use of tumor genomic profiling to reveal mechanisms of resistance to the BTK inhibitor ibrutinib in chronic lymphocytic leukemia (CLL
    • 15 suppl
    • Chang BY, Furman RR, Zapatka M, Barrientos JC, Li D, Steggerda S et al. Use of tumor genomic profiling to reveal mechanisms of resistance to the BTK inhibitor ibrutinib in chronic lymphocytic leukemia (CLL). ASCO Meeting Abstracts 2013; 31(15-suppl): 7014.
    • (2013) ASCO Meeting Abstracts , vol.31 , pp. 7014
    • Chang, B.Y.1    Furman, R.R.2    Zapatka, M.3    Barrientos, J.C.4    Li, D.5    Steggerda, S.6
  • 98
    • 27744549869 scopus 로고    scopus 로고
    • Allogeneic transplant with reduced intensity conditioning regimens may overcome the poor prognosis of B-Cell chronic lymphocytic leukemia with unmutated immunoglobulin variable heavy-chain gene and chromosomal abnormalities (11q- and 17p)
    • Caballero D, Garcia-Marco JA, Martino R, Mateos V, Ribera JM, Sarra J et al. Allogeneic transplant with reduced intensity conditioning regimens may overcome the poor prognosis of B-cell chronic lymphocytic leukemia with unmutated immunoglobulin variable heavy-chain gene and chromosomal abnormalities (11q- and 17p-). Clin Cancer Res 2005; 11: 7757-7763.
    • (2005) Clin Cancer Res , vol.11 , pp. 7757-7763
    • Caballero, D.1    Garcia-Marco, J.A.2    Martino, R.3    Mateos, V.4    Ribera, J.M.5    Sarra, J.6
  • 99
    • 55549097826 scopus 로고    scopus 로고
    • Allogeneic hematopoietic stem-Cell transplantation for chronic lymphocytic leukemia with 17p deletion: A retrospective European Group for blood and marrow transplantation analysis
    • Schetelig J, van Biezen A, Brand R, Caballero D, Martino R, Itala M et al. Allogeneic hematopoietic stem-cell transplantation for chronic lymphocytic leukemia with 17p deletion: A retrospective European Group for blood and marrow transplantation analysis. J Clin Oncol 2008; 26: 5094-5100.
    • (2008) J Clin Oncol , vol.26 , pp. 5094-5100
    • Schetelig, J.1    Van Biezen, A.2    Brand, R.3    Caballero, D.4    Martino, R.5    Itala, M.6
  • 100
    • 84867889132 scopus 로고    scopus 로고
    • Phase Ib trial of AVL-292, a covalent inhibitor of Bruton's tyrosine kinase (Btk) in chronic lymphocytic leukemia (CLL) and B-non-Hodgkin lymphoma (B-NHL
    • 15 suppl
    • Brown JR, Sharman JP, Harb WA, Kelly KR, Schreeder MT, Sweetenham JW et al. Phase Ib trial of AVL-292, a covalent inhibitor of Bruton's tyrosine kinase (Btk), in chronic lymphocytic leukemia (CLL) and B-non-Hodgkin lymphoma (B-NHL). ASCO Meeting Abstracts 2012; 30(15-suppl): 8032.
    • (2012) ASCO Meeting Abstracts , vol.30 , pp. 8032
    • Brown, J.R.1    Sharman, J.P.2    Harb, W.A.3    Kelly, K.R.4    Schreeder, M.T.5    Sweetenham, J.W.6
  • 102
    • 84875774940 scopus 로고    scopus 로고
    • Phosphoinositide 30-kinase inhibition in chronic lymphocytic leukemia
    • Davids MS, Brown Jr. Phosphoinositide 30-kinase inhibition in chronic lymphocytic leukemia. Hematol Oncol Clin North Am 2013; 27: 329-339.
    • (2013) Hematol Oncol Clin North Am , vol.27 , pp. 329-339
    • Davids, M.S.1    Brown, J.R.2
  • 103
    • 80053345977 scopus 로고    scopus 로고
    • The phosphoinositide 30-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia
    • Hoellenriegel J, Meadows SA, Sivina M, Wierda WG, Kantarjian H, Keating MJ et al. The phosphoinositide 30-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia. Blood 2011; 118: 3603-3612.
    • (2011) Blood , vol.118 , pp. 3603-3612
    • Hoellenriegel, J.1    Meadows, S.A.2    Sivina, M.3    Wierda, W.G.4    Kantarjian, H.5    Keating, M.J.6
  • 104
    • 84889100529 scopus 로고    scopus 로고
    • Update on a phase I study of the selective PI3K{delta} inhibitor idelalisib (GS-1101) in combination with rituximab and/or bendamustine in patients with relapsed or refractory CLL
    • 15 suppl
    • Barrientos JC, Furman RR, Leonard J, Flinn I, Rai KR, De Vos S et al. Update on a phase I study of the selective PI3K{delta} inhibitor idelalisib (GS-1101) in combination with rituximab and/or bendamustine in patients with relapsed or refractory CLL. ASCO Meeting Abstracts 2013; 31(15-suppl): 7017.
    • (2013) ASCO Meeting Abstracts , vol.31 , pp. 7017
    • Barrientos, J.C.1    Furman, R.R.2    Leonard, J.3    Flinn, I.4    Rai, K.R.5    De Vos, S.6
  • 105
    • 84889096434 scopus 로고    scopus 로고
    • A phase II study of the selective phosphatidylinositol 3-kinase delta (PI3K{delta} inhibitor idelalisib (GS-1101) in combination with rituximab (R) in treatment-naive patients (pts) 4&65 years with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL
    • 15 suppl
    • O'Brien SM, Lamanna N, Kipps TJ, Flinn I, Zelenetz AD, Burger JA et al. A phase II study of the selective phosphatidylinositol 3-kinase delta (PI3K{delta}) inhibitor idelalisib (GS-1101) in combination with rituximab (R) in treatment-naive patients (pts) 4&65 years with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). ASCO Meeting Abstracts 2013; 31(15-suppl): 7005.
    • (2013) ASCO Meeting Abstracts , vol.31 , pp. 7005
    • O'Brien, S.M.1    Lamanna, N.2    Kipps, T.J.3    Flinn, I.4    Zelenetz, A.D.5    Burger, J.A.6
  • 106
    • 0037204949 scopus 로고    scopus 로고
    • B cell antigen receptor signaling: Roles in cell development and disease
    • Gauld SB, Dal Porto JM, Cambier JC. B cell antigen receptor signaling: Roles in cell development and disease. Science 2002; 296: 1641-1642.
    • (2002) Science , vol.296 , pp. 1641-1642
    • Gauld, S.B.1    Dal Porto, J.M.2    Cambier, J.C.3
  • 107
    • 77951002653 scopus 로고    scopus 로고
    • Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia
    • Friedberg JW, Sharman J, Sweetenham J, Johnston PB, Vose JM, Lacasce A et al. Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia. Blood 2010; 115: 2578-2585.
    • (2010) Blood , vol.115 , pp. 2578-2585
    • Friedberg, J.W.1    Sharman, J.2    Sweetenham, J.3    Johnston, P.B.4    Vose, J.M.5    Lacasce, A.6
  • 108
    • 84871236598 scopus 로고    scopus 로고
    • The novel cyclin-dependent kinase inhibitor dinaciclib (SCH727965) promotes apoptosis and abrogates microenvironmental cytokine protection in chronic lymphocytic leukemia cells
    • Johnson AJ, Yeh YY, Smith LL, Wagner AJ, Hessler J, Gupta S et al. The novel cyclin-dependent kinase inhibitor dinaciclib (SCH727965) promotes apoptosis and abrogates microenvironmental cytokine protection in chronic lymphocytic leukemia cells. Leukemia 2012; 26: 2554-2557.
    • (2012) Leukemia , vol.26 , pp. 2554-2557
    • Johnson, A.J.1    Yeh, Y.Y.2    Smith, L.L.3    Wagner, A.J.4    Hessler, J.5    Gupta, S.6
  • 109
    • 79955757849 scopus 로고    scopus 로고
    • Update on the phase I study of the cyclin dependent kinase inhibitor dinaciclib (SCH 727965) in patients with relapsed or refractory chronic lymphocytic leukemia (CLL): Confirmation of clinical activity and feasibility of long-Term administration
    • Flynn JM, Jones JA, Andritsos L, Blum KA, Johnson AJ, Hessler J et al. Update on the phase I study of the cyclin dependent kinase inhibitor dinaciclib (SCH 727965) in patients with relapsed or refractory chronic lymphocytic leukemia (CLL): Confirmation of clinical activity and feasibility of long-Term administration. ASH Annual Meeting Abstracts 2010; 116: 1396.
    • (2010) ASH Annual Meeting Abstracts , vol.116 , pp. 1396
    • Flynn, J.M.1    Jones, J.A.2    Andritsos, L.3    Blum, K.A.4    Johnson, A.J.5    Hessler, J.6
  • 110
    • 84867229264 scopus 로고    scopus 로고
    • A pilot phase II study of the lyn kinase inhibitor bafetinib in patients with relapsed or refractory B cell chronic lymphocytic leukemia
    • Kadia T, Delioukina ML, Kantarjian HM, Keating MJ, Wierda WG, Burger JA et al. A pilot phase II study of the lyn kinase inhibitor bafetinib in patients with relapsed or refractory B cell chronic lymphocytic leukemia. ASH Annual Meeting Abstracts 2011; 118: 2858.
    • (2011) ASH Annual Meeting Abstracts , vol.118 , pp. 2858
    • Kadia, T.1    Delioukina, M.L.2    Kantarjian, H.M.3    Keating, M.J.4    Wierda, W.G.5    Burger, J.A.6
  • 112
    • 52049122208 scopus 로고    scopus 로고
    • Clinical and therapeutic implications of the mutational status of IgVH in patients with chronic lymphocytic leukemia
    • Kharfan-Dabaja MA, Chavez JC, Khorfan KA, Pinilla-Ibarz J. Clinical and therapeutic implications of the mutational status of IgVH in patients with chronic lymphocytic leukemia. Cancer 2008; 113: 897-906.
    • (2008) Cancer , vol.113 , pp. 897-906
    • Kharfan-Dabaja, M.A.1    Chavez, J.C.2    Khorfan, K.A.3    Pinilla-Ibarz, J.4
  • 113
    • 79960036578 scopus 로고    scopus 로고
    • Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia
    • Puente XS, Pinyol M, Quesada V, Conde L, Ordonez GR, Villamor N et al. Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia. Nature 2011; 475: 101-105.
    • (2011) Nature , vol.475 , pp. 101-105
    • Puente, X.S.1    Pinyol, M.2    Quesada, V.3    Conde, L.4    Ordonez, G.R.5    Villamor, N.6
  • 114
    • 0028987180 scopus 로고
    • P53 gene deletion predicts for poor survival and non-response to therapy with purine analogs in chronic B-cell leukemias
    • Dohner H, Fischer K, Bentz M, Hansen K, Benner A, Cabot G et al. p53 gene deletion predicts for poor survival and non-response to therapy with purine analogs in chronic B-cell leukemias. Blood 1995; 85: 1580-1589.
    • (1995) Blood , vol.85 , pp. 1580-1589
    • Dohner, H.1    Fischer, K.2    Bentz, M.3    Hansen, K.4    Benner, A.5    Cabot, G.6
  • 115
    • 0027436745 scopus 로고
    • P53 gene mutation in B-cell chronic lymphocytic leukemia is associated with drug resistance and is independent of MDR1/MDR3 gene expression
    • el Rouby S, Thomas A, Costin D, Rosenberg CR, Potmesil M, Silber R et al. p53 gene mutation in B-cell chronic lymphocytic leukemia is associated with drug resistance and is independent of MDR1/MDR3 gene expression. Blood 1993; 82: 3452-3459.
    • (1993) Blood , vol.82 , pp. 3452-3459
    • Rouby, S.1    Thomas, A.2    Costin, D.3    Rosenberg, C.R.4    Potmesil, M.5    Silber, R.6
  • 116
    • 0037850927 scopus 로고    scopus 로고
    • Mutation of p53 and consecutive selective drug resistance in B-CLL occurs as a consequence of prior DNA-damaging chemotherapy
    • Sturm I, Bosanquet AG, Hermann S, Guner D, Dorken B, Daniel PT. Mutation of p53 and consecutive selective drug resistance in B-CLL occurs as a consequence of prior DNA-damaging chemotherapy. Cell Death Differ 2003; 10: 477-484.
    • (2003) Cell Death Differ , vol.10 , pp. 477-484
    • Sturm, I.1    Bosanquet, A.G.2    Hermann, S.3    Guner, D.4    Dorken, B.5    Daniel, P.T.6
  • 117
    • 33845543049 scopus 로고    scopus 로고
    • Indications for allogeneic stem cell transplantation in chronic lymphocytic leukemia: The EBMT transplant consensus
    • Dreger P, Corradini P, Kimby E, Michallet M, Milligan D, Schetelig J et al. Indications for allogeneic stem cell transplantation in chronic lymphocytic leukemia: The EBMT transplant consensus. Leukemia 2007; 21: 12-17.
    • (2007) Leukemia , vol.21 , pp. 12-17
    • Dreger, P.1    Corradini, P.2    Kimby, E.3    Michallet, M.4    Milligan, D.5    Schetelig, J.6
  • 119
    • 84881293044 scopus 로고    scopus 로고
    • Challenges of creating effective chimeric antigen receptors for cancer therapy
    • Sentman CL. Challenges of creating effective chimeric antigen receptors for cancer therapy. Immunotherapy 2013; 5: 783-785..
    • (2013) Immunotherapy , vol.5 , pp. 783-785
    • Sentman, C.L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.