-
1
-
-
0033524834
-
Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4.
-
Peled A, Petit I, Kollet O, Magid M, Ponomaryov T, Byk T et al. Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4. Science 1999; 283: 845-848.
-
(1999)
Science
, vol.283
, pp. 845-848
-
-
Peled, A.1
Petit, I.2
Kollet, O.3
Magid, M.4
Ponomaryov, T.5
Byk, T.6
-
2
-
-
13744255245
-
CXCR4 regulates migration and development of human acute myelogenous leukemia stem cells in transplanted NOD/SCID mice
-
Tavor S, Petit I, Porozov S, Avigdor A, Dar A, Leider-Trejo L et al. CXCR4 regulates migration and development of human acute myelogenous leukemia stem cells in transplanted NOD/SCID mice. Cancer Res 2004; 64: 2817-2824.
-
(2004)
Cancer Res
, vol.64
, pp. 2817-2824
-
-
Tavor, S.1
Petit, I.2
Porozov, S.3
Avigdor, A.4
Dar, A.5
Leider-Trejo, L.6
-
3
-
-
65549096796
-
The biology of CCR5 and CXCR4
-
Alkhatib G. The biology of CCR5 and CXCR4. Curr Opin HIV AIDS 2009; 4: 96-103.
-
(2009)
Curr Opin HIV AIDS
, vol.4
, pp. 96-103
-
-
Alkhatib, G.1
-
5
-
-
3142620882
-
Relation between CXCR-4 expression Flt3 mutations, and unfavorable prognosis of adult acute myeloid leukemia
-
Rombouts EJ, Pavic B, Lowenberg B, Ploemacher RE. Relation between CXCR-4 expression, Flt3 mutations, and unfavorable prognosis of adult acute myeloid leukemia. Blood 2004; 104: 550-557.
-
(2004)
Blood
, vol.104
, pp. 550-557
-
-
Rombouts, E.J.1
Pavic, B.2
Lowenberg, B.3
Ploemacher, R.E.4
-
6
-
-
33846241600
-
CXCR4 is a prognostic marker in acute myelogenous leukemia
-
Spoo AC, Lubbert M, Wierda WG, Burger JA. CXCR4 is a prognostic marker in acute myelogenous leukemia. Blood 2007; 109: 786-791.
-
(2007)
Blood
, vol.109
, pp. 786-791
-
-
Spoo, A.C.1
Lubbert, M.2
Wierda, W.G.3
Burger, J.A.4
-
7
-
-
85014207179
-
Migratory behavior of leukemic cells from acute myeloid leukemia patients
-
Voermans C, van Heese WP, de Jong I, Gerritsen WR, van Der Schoot CE. Migratory behavior of leukemic cells from acute myeloid leukemia patients. Leukemia 2002; 16: 650-657.
-
(2002)
Leukemia
, vol.16
, pp. 650-657
-
-
Voermans, C.1
Van Heese, W.P.2
De Jong, I.3
Gerritsen, W.R.4
Van Der Schoot, C.E.5
-
8
-
-
0032563291
-
G protein-coupled receptors III New roles for receptor kinases and beta-Arrestins in receptor signaling and desensitization
-
Lefkowitz RJ. G protein-coupled receptors. III. New roles for receptor kinases and beta-Arrestins in receptor signaling and desensitization. J Biol Chem 1998; 273: 18677-18680.
-
(1998)
J Biol Chem
, vol.273
, pp. 18677-18680
-
-
Lefkowitz, R.J.1
-
10
-
-
0033519236
-
B cell antigen receptor engagement inhibits stromal cell-derived factor (SDF)-1alpha chemotaxis and promotes protein kinase C (PKC)-induced internalization of CXCR4
-
Guinamard R, Signoret N, Ishiai M, Marsh M, Kurosaki T, Ravetch JV. B cell antigen receptor engagement inhibits stromal cell-derived factor (SDF)-1alpha chemotaxis and promotes protein kinase C (PKC)-induced internalization of CXCR4. J Exp Med 1999; 189: 1461-1466.
-
(1999)
J Exp Med
, vol.189
, pp. 1461-1466
-
-
Guinamard, R.1
Signoret, N.2
Ishiai, M.3
Marsh, M.4
Kurosaki, T.5
Ravetch, J.V.6
-
11
-
-
34250839661
-
Control of receptor internalization, signaling level, and precise arrival at the target in guided cell migration
-
Minina S, Reichman-Fried M, Raz E. Control of receptor internalization, signaling level, and precise arrival at the target in guided cell migration. Curr Biol 2007; 17: 1164-1172.
-
(2007)
Curr Biol
, vol.17
, pp. 1164-1172
-
-
Minina, S.1
Reichman-Fried, M.2
Raz, E.3
-
12
-
-
0032742818
-
Trafficking of the HIV coreceptor CXCR4. Role of arrestins and identification of residues in the c-Terminal tail that mediate receptor internalization
-
Orsini MJ, Parent JL, Mundell SJ, Marchese A, Benovic JL. Trafficking of the HIV coreceptor CXCR4. Role of arrestins and identification of residues in the c-Terminal tail that mediate receptor internalization. J Biol Chem 1999; 274: 31076-31086.
-
(1999)
J Biol Chem
, vol.274
, pp. 31076-31086
-
-
Orsini, M.J.1
Parent, J.L.2
Mundell, S.J.3
Marchese, A.4
Benovic, J.L.5
-
13
-
-
77951230331
-
Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling
-
Busillo JM, Armando S, Sengupta R, Meucci O, Bouvier M, Benovic JL. Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling. J Biol Chem 2010; 285: 7805-7817.
-
(2010)
J Biol Chem
, vol.285
, pp. 7805-7817
-
-
Busillo, J.M.1
Armando, S.2
Sengupta, R.3
Meucci, O.4
Bouvier, M.5
Benovic, J.L.6
-
14
-
-
69549086437
-
Dissection of PIM serine/threonine kinases in FLT3-ITD-induced leukemogenesis reveals PIM1 as regulator of CXCL12-CXCR4-mediated homing and migration
-
Grundler R, Brault L, Gasser C, Bullock AN, Dechow T, Woetzel S et al. Dissection of PIM serine/threonine kinases in FLT3-ITD-induced leukemogenesis reveals PIM1 as regulator of CXCL12-CXCR4-mediated homing and migration. J Exp Med 2009; 206: 1957-1970.
-
(2009)
J Exp Med
, vol.206
, pp. 1957-1970
-
-
Grundler, R.1
Brault, L.2
Gasser, C.3
Bullock, A.N.4
Dechow, T.5
Woetzel, S.6
-
15
-
-
84864326041
-
PIM kinases are progression markers and emerging therapeutic targets in diffuse large B-cell lymphoma
-
Brault L, Menter T, Obermann EC, Knapp S, Thommen S, Schwaller J et al. PIM kinases are progression markers and emerging therapeutic targets in diffuse large B-cell lymphoma. Br J Cancer 2012; 107: 491-500.
-
(2012)
Br J Cancer
, vol.107
, pp. 491-500
-
-
Brault, L.1
Menter, T.2
Obermann, E.C.3
Knapp, S.4
Thommen, S.5
Schwaller, J.6
-
16
-
-
15244351083
-
Coordinate dual-gene transgenesis by lentiviral vectors carrying synthetic bidirectional promoters
-
Amendola M, Venneri MA, Biffi A, Vigna E, Naldini L. Coordinate dual-gene transgenesis by lentiviral vectors carrying synthetic bidirectional promoters. Nat Biotechnol 2005; 23: 108-116.
-
(2005)
Nat Biotechnol
, vol.23
, pp. 108-116
-
-
Amendola, M.1
Venneri, M.A.2
Biffi, A.3
Vigna, E.4
Naldini, L.5
-
17
-
-
77949423437
-
Functional characterization of high levels of meningioma 1 as collaborating oncogene in acute leukemia
-
Liu T, Jankovic D, Brault L, Ehret S, Baty F, Stavropoulou V et al. Functional characterization of high levels of meningioma 1 as collaborating oncogene in acute leukemia. Leukemia 2010; 24: 601-612.
-
(2010)
Leukemia
, vol.24
, pp. 601-612
-
-
Liu, T.1
Jankovic, D.2
Brault, L.3
Ehret, S.4
Baty, F.5
Stavropoulou, V.6
-
18
-
-
0018473622
-
Distribution of the bone marrow cells in the skeleton of mice
-
Shaposhnikov VL. [Distribution of the bone marrow cells in the skeleton of mice]. Biull Eksp Biol Med 1979; 87: 483-485.
-
(1979)
Biull Eksp Biol Med
, vol.87
, pp. 483-485
-
-
Shaposhnikov, V.L.1
-
19
-
-
80755140039
-
P53 independent epigenetic-differentiation treatment in xenotransplant models of acute myeloid leukemia
-
Ng KP, Ebrahem Q, Negrotto S, Mahfouz RZ, Link KA, Hu Z et al. p53 independent epigenetic-differentiation treatment in xenotransplant models of acute myeloid leukemia. Leukemia 2011; 25: 1739-1750.
-
(2011)
Leukemia
, vol.25
, pp. 1739-1750
-
-
Ng, K.P.1
Ebrahem, Q.2
Negrotto, S.3
Mahfouz, R.Z.4
Link, K.A.5
Hu, Z.6
-
20
-
-
67650367598
-
Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML
-
Zeng Z, Shi YX, Samudio IJ, Wang RY, Ling X, Frolova O et al. Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML. Blood 2009; 113: 6215-6224.
-
(2009)
Blood
, vol.113
, pp. 6215-6224
-
-
Zeng, Z.1
Shi, Y.X.2
Samudio, I.J.3
Wang, R.Y.4
Ling, X.5
Frolova, O.6
-
21
-
-
77953063372
-
Expression of pSTAT5 predicts FLT3 internal tandem duplications in acute myeloid leukemia
-
Obermann EC, Arber C, Jotterand M, Tichelli A, Hirschmann P, Tzankov A. Expression of pSTAT5 predicts FLT3 internal tandem duplications in acute myeloid leukemia. Ann Hematol 2010; 89: 663-669.
-
(2010)
Ann Hematol
, vol.89
, pp. 663-669
-
-
Obermann, E.C.1
Arber, C.2
Jotterand, M.3
Tichelli, A.4
Hirschmann, P.5
Tzankov, A.6
-
22
-
-
79960257171
-
In situ RHAMM protein expression in acute myeloid leukemia blasts suggests poor overall survival
-
Tzankov A, Strasser U, Dirnhofer S, Menter T, Arber C, Jotterand M et al. In situ RHAMM protein expression in acute myeloid leukemia blasts suggests poor overall survival. Ann Hematol 2011; 90: 901-909.
-
(2011)
Ann Hematol
, vol.90
, pp. 901-909
-
-
Tzankov, A.1
Strasser, U.2
Dirnhofer, S.3
Menter, T.4
Arber, C.5
Jotterand, M.6
-
23
-
-
0032550179
-
Cytoplasmic tail phosphorylation of the alpha-factor receptor is required for its ubiquitination and internalization
-
Hicke L, Zanolari B, Riezman H. Cytoplasmic tail phosphorylation of the alpha-factor receptor is required for its ubiquitination and internalization. J Cell Biol 1998; 141: 349-358.
-
(1998)
J Cell Biol
, vol.141
, pp. 349-358
-
-
Hicke, L.1
Zanolari, B.2
Riezman, H.3
-
24
-
-
0344286482
-
Cluster of differentiation antigen 4 (CD4) endocytosis and adaptor complex binding require activation of the CD4 endocytosis signal by serine phosphorylation
-
Pitcher C, Honing S, Fingerhut A, Bowers K, Marsh M. Cluster of differentiation antigen 4 (CD4) endocytosis and adaptor complex binding require activation of the CD4 endocytosis signal by serine phosphorylation. Mol Biol Cell 1999; 10: 677-691.
-
(1999)
Mol Biol Cell
, vol.10
, pp. 677-691
-
-
Pitcher, C.1
Honing, S.2
Fingerhut, A.3
Bowers, K.4
Marsh, M.5
-
25
-
-
2642710893
-
The chemokine receptor CXCR-4 is expressed on CD34þ hematopoietic progenitors and leukemic cells and mediates transendothelial migration induced by stromal cell-derived factor-1
-
Mohle R, Bautz F, Rafii S, Moore MA, Brugger W, Kanz L. The chemokine receptor CXCR-4 is expressed on CD34þ hematopoietic progenitors and leukemic cells and mediates transendothelial migration induced by stromal cell-derived factor-1. Blood 1998; 91: 4523-4530.
-
(1998)
Blood
, vol.91
, pp. 4523-4530
-
-
Mohle, R.1
Bautz, F.2
Rafii, S.3
Moore, M.A.4
Brugger, W.5
Kanz, L.6
-
26
-
-
0037438505
-
Role of the intracellular domains of CXCR4 in SDF-1-mediated signaling
-
Roland J, Murphy BJ, Ahr B, Robert-Hebmann V, Delauzun V, Nye KE et al. Role of the intracellular domains of CXCR4 in SDF-1-mediated signaling. Blood 2003; 101: 399-406.
-
(2003)
Blood
, vol.101
, pp. 399-406
-
-
Roland, J.1
Murphy, B.J.2
Ahr, B.3
Robert-Hebmann, V.4
Delauzun, V.5
Nye, K.E.6
-
27
-
-
14344275786
-
The human hematopoietic stem cell compartment is heterogeneous for CXCR4 expression
-
Rosu-Myles M, Gallacher L, Murdoch B, Hess DA, Keeney M, Kelvin D et al. The human hematopoietic stem cell compartment is heterogeneous for CXCR4 expression. Proc Natl Acad Sci USA 2000; 97: 14626-14631.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 14626-14631
-
-
Rosu-Myles, M.1
Gallacher, L.2
Murdoch, B.3
Hess, D.A.4
Keeney, M.5
Kelvin, D.6
-
28
-
-
77449127999
-
Delivery of microRNA-126 by apoptotic bodies induces CXCL12-dependent vascular protection
-
Zernecke A, Bidzhekov K, Noels H, Shagdarsuren E, Gan L, Denecke B et al. Delivery of microRNA-126 by apoptotic bodies induces CXCL12-dependent vascular protection. Sci Signal 2009; 2: Ra81.
-
(2009)
Sci Signal
, vol.2
-
-
Zernecke, A.1
Bidzhekov, K.2
Noels, H.3
Shagdarsuren, E.4
Gan, L.5
Denecke, B.6
-
29
-
-
84861316751
-
Bone marrow stromal cells modulate mouse ENT1 activity and protect leukemia cells from cytarabine induced apoptosis
-
Macanas-Pirard P, Leisewitz A, Broekhuizen R, Cautivo K, Barriga FM, Leisewitz F et al. Bone marrow stromal cells modulate mouse ENT1 activity and protect leukemia cells from cytarabine induced apoptosis. PLoS One 2012; 7: E37203.
-
(2012)
PLoS One
, vol.7
-
-
Macanas-Pirard, P.1
Leisewitz, A.2
Broekhuizen, R.3
Cautivo, K.4
Barriga, F.M.5
Leisewitz, F.6
-
30
-
-
33947200199
-
Overexpression of CXCR4 predicts adverse overall and event-free survival in patients with unmutated FLT3 acute myeloid leukemia with normal karyotype
-
Konoplev S, Rassidakis GZ, Estey E, Kantarjian H, Liakou CI, Huang X et al. Overexpression of CXCR4 predicts adverse overall and event-free survival in patients with unmutated FLT3 acute myeloid leukemia with normal karyotype. Cancer 2007; 109: 1152-1156.
-
(2007)
Cancer
, vol.109
, pp. 1152-1156
-
-
Konoplev, S.1
Rassidakis, G.Z.2
Estey, E.3
Kantarjian, H.4
Liakou, C.I.5
Huang, X.6
-
31
-
-
63349108695
-
Prognostic value of CXCR4 and FAK expression in acute myelogenous leukemia
-
Tavernier-Tardy E, Cornillon J, Campos L, Flandrin P, Duval A, Nadal N et al. Prognostic value of CXCR4 and FAK expression in acute myelogenous leukemia. Leuk Res 2009; 33: 764-768.
-
(2009)
Leuk Res
, vol.33
, pp. 764-768
-
-
Tavernier-Tardy, E.1
Cornillon, J.2
Campos, L.3
Flandrin, P.4
Duval, A.5
Nadal, N.6
-
32
-
-
10744223652
-
Engraftment of acute myeloid leukemia in NOD/SCID mice is independent of CXCR4 and predicts poor patient survival
-
Monaco G, Konopleva M, Munsell M, Leysath C, Wang RY, Jackson CE et al. Engraftment of acute myeloid leukemia in NOD/SCID mice is independent of CXCR4 and predicts poor patient survival. Stem Cells 2004; 22: 188-201.
-
(2004)
Stem Cells
, vol.22
, pp. 188-201
-
-
Monaco, G.1
Konopleva, M.2
Munsell, M.3
Leysath, C.4
Wang, R.Y.5
Jackson, C.E.6
-
33
-
-
29244445813
-
Widespread CXCR4 activation in astrocytomas revealed by phospho-CXCR4-specific antibodies
-
Woerner BM, Warrington NM, Kung AL, Perry A, Rubin JB. Widespread CXCR4 activation in astrocytomas revealed by phospho-CXCR4-specific antibodies. Cancer Res 2005; 65: 11392-11399.
-
(2005)
Cancer Res
, vol.65
, pp. 11392-11399
-
-
Woerner, B.M.1
Warrington, N.M.2
Kung, A.L.3
Perry, A.4
Rubin, J.B.5
-
34
-
-
80053896956
-
Phosphorylated CXCR4 is associated with poor survival in adults with B-Acute lymphoblastic leukemia
-
Konoplev S, Jorgensen JL, Thomas DA, Lin E, Burger J, Kantarjian HM et al. Phosphorylated CXCR4 is associated with poor survival in adults with B-Acute lymphoblastic leukemia. Cancer 2011; 117: 31.
-
(2011)
Cancer
, vol.117
, pp. 31
-
-
Konoplev, S.1
Jorgensen, J.L.2
Thomas, D.A.3
Lin, E.4
Burger, J.5
Kantarjian, H.M.6
-
35
-
-
15244361356
-
Enhanced function with decreased internalization of carboxy-Terminus truncated CXCR4 responsible for WHIM syndrome
-
Kawai T, Choi U, Whiting-Theobald NL, Linton GF, Brenner S, Sechler JM et al. Enhanced function with decreased internalization of carboxy-Terminus truncated CXCR4 responsible for WHIM syndrome. Exp Hematol 2005; 33: 460-468.
-
(2005)
Exp Hematol
, vol.33
, pp. 460-468
-
-
Kawai, T.1
Choi, U.2
Whiting-Theobald, N.L.3
Linton, G.F.4
Brenner, S.5
Sechler, J.M.6
-
36
-
-
80054823348
-
Chemokine CXCL12 uses CXCR4 and a signaling core formed by bifunctional Akt, extracellular signal-regulated kinase (ERK)1/2, and mammalian target of rapamycin complex 1 (mTORC1) proteins to control chemotaxis and survival simultaneously in mature dendritic cells
-
Delgado-Martin C, Escribano C, Pablos JL, Riol-Blanco L, Rodriguez-Fernandez JL. Chemokine CXCL12 uses CXCR4 and a signaling core formed by bifunctional Akt, extracellular signal-regulated kinase (ERK)1/2, and mammalian target of rapamycin complex 1 (mTORC1) proteins to control chemotaxis and survival simultaneously in mature dendritic cells. J Biol Chem 2011; 286: 37222-37236.
-
(2011)
J Biol Chem
, vol.286
, pp. 37222-37236
-
-
Delgado-Martin, C.1
Escribano, C.2
Pablos, J.L.3
Riol-Blanco, L.4
Rodriguez-Fernandez, J.L.5
-
37
-
-
77954763320
-
Migration of human umbilical cord blood mesenchymal stem cells mediated by stromal cell-derived factor-1/CXCR4 axis via Akt ERK, and p38 signal transduction pathways
-
Ryu CH, Park SA, Kim SM, Lim JY, Jeong CH, Jun JA et al. Migration of human umbilical cord blood mesenchymal stem cells mediated by stromal cell-derived factor-1/CXCR4 axis via Akt, ERK, and p38 signal transduction pathways. Biochem Biophys Res Commun 2010; 398: 105-110.
-
(2010)
Biochem Biophys Res Commun
, vol.398
, pp. 105-110
-
-
Ryu, C.H.1
Park, S.A.2
Kim, S.M.3
Lim, J.Y.4
Jeong, C.H.5
Jun, J.A.6
-
38
-
-
33846106798
-
WHIM syndrome myelokathexis reproduced in the NOD/SCID mouse xenotransplant model engrafted with healthy human stem cells transduced with C-Terminus-Truncated CXCR4
-
Kawai T, Choi U, Cardwell L, DeRavin SS, Naumann N, Whiting-Theobald NL et al. WHIM syndrome myelokathexis reproduced in the NOD/SCID mouse xenotransplant model engrafted with healthy human stem cells transduced with C-Terminus-Truncated CXCR4. Blood 2007; 109: 78-84.
-
(2007)
Blood
, vol.109
, pp. 78-84
-
-
Kawai, T.1
Choi, U.2
Cardwell, L.3
DeRavin, S.S.4
Naumann, N.5
Whiting-Theobald, N.L.6
-
39
-
-
84878529330
-
CXCR4 downregulation of let-7a drives chemoresistance in acute myeloid leukemia
-
Chen Y, Jacamo R, Konopleva M, Garzon R, Croce C, Andreeff M. CXCR4 downregulation of let-7a drives chemoresistance in acute myeloid leukemia. J Clin Invest 2013; 123: 2395-2407.
-
(2013)
J Clin Invest
, vol.123
, pp. 2395-2407
-
-
Chen, Y.1
Jacamo, R.2
Konopleva, M.3
Garzon, R.4
Croce, C.5
Andreeff, M.6
-
40
-
-
67650410440
-
Chemosensitization of acute myeloid leukemia (AML) following mobilization by the CXCR4 antagonist AMD3100
-
Nervi B, Ramirez P, Rettig MP, Uy GL, Holt MS, Ritchey JK et al. Chemosensitization of acute myeloid leukemia (AML) following mobilization by the CXCR4 antagonist AMD3100. Blood 2009; 113: 6206-6214.
-
(2009)
Blood
, vol.113
, pp. 6206-6214
-
-
Nervi, B.1
Ramirez, P.2
Rettig, M.P.3
Uy, G.L.4
Holt, M.S.5
Ritchey, J.K.6
-
41
-
-
84860349448
-
A phase 1/2 study of chemosensitization with the CXCR4 antagonist plerixafor in relapsed or refractory acute myeloid leukemia
-
Uy GL, Rettig MP, Motabi IH, McFarland K, Trinkaus KM, Hladnik LM et al. A phase 1/2 study of chemosensitization with the CXCR4 antagonist plerixafor in relapsed or refractory acute myeloid leukemia. Blood 2012; 119: 3917-3924..
-
(2012)
Blood
, vol.119
, pp. 3917-3924
-
-
Uy, G.L.1
Rettig, M.P.2
Motabi, I.H.3
McFarland, K.4
Trinkaus, K.M.5
Hladnik, L.M.6
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