메뉴 건너뛰기




Volumn 28, Issue 3, 2014, Pages 566-576

CXCR4-SERINE339 regulates cellular adhesion, retention and mobilization, and is a marker for poor prognosis in acute myeloid leukemia

Author keywords

AML; CXCR4; Homing; Resistance; Retention; Serine339

Indexed keywords

BIOLOGICAL MARKER; CHEMOKINE RECEPTOR CXCR4; MUTANT PROTEIN; PLERIXAFOR;

EID: 84895785740     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2013.201     Document Type: Article
Times cited : (33)

References (41)
  • 1
    • 0033524834 scopus 로고    scopus 로고
    • Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4.
    • Peled A, Petit I, Kollet O, Magid M, Ponomaryov T, Byk T et al. Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4. Science 1999; 283: 845-848.
    • (1999) Science , vol.283 , pp. 845-848
    • Peled, A.1    Petit, I.2    Kollet, O.3    Magid, M.4    Ponomaryov, T.5    Byk, T.6
  • 2
    • 13744255245 scopus 로고    scopus 로고
    • CXCR4 regulates migration and development of human acute myelogenous leukemia stem cells in transplanted NOD/SCID mice
    • Tavor S, Petit I, Porozov S, Avigdor A, Dar A, Leider-Trejo L et al. CXCR4 regulates migration and development of human acute myelogenous leukemia stem cells in transplanted NOD/SCID mice. Cancer Res 2004; 64: 2817-2824.
    • (2004) Cancer Res , vol.64 , pp. 2817-2824
    • Tavor, S.1    Petit, I.2    Porozov, S.3    Avigdor, A.4    Dar, A.5    Leider-Trejo, L.6
  • 3
    • 65549096796 scopus 로고    scopus 로고
    • The biology of CCR5 and CXCR4
    • Alkhatib G. The biology of CCR5 and CXCR4. Curr Opin HIV AIDS 2009; 4: 96-103.
    • (2009) Curr Opin HIV AIDS , vol.4 , pp. 96-103
    • Alkhatib, G.1
  • 5
    • 3142620882 scopus 로고    scopus 로고
    • Relation between CXCR-4 expression Flt3 mutations, and unfavorable prognosis of adult acute myeloid leukemia
    • Rombouts EJ, Pavic B, Lowenberg B, Ploemacher RE. Relation between CXCR-4 expression, Flt3 mutations, and unfavorable prognosis of adult acute myeloid leukemia. Blood 2004; 104: 550-557.
    • (2004) Blood , vol.104 , pp. 550-557
    • Rombouts, E.J.1    Pavic, B.2    Lowenberg, B.3    Ploemacher, R.E.4
  • 6
    • 33846241600 scopus 로고    scopus 로고
    • CXCR4 is a prognostic marker in acute myelogenous leukemia
    • Spoo AC, Lubbert M, Wierda WG, Burger JA. CXCR4 is a prognostic marker in acute myelogenous leukemia. Blood 2007; 109: 786-791.
    • (2007) Blood , vol.109 , pp. 786-791
    • Spoo, A.C.1    Lubbert, M.2    Wierda, W.G.3    Burger, J.A.4
  • 8
    • 0032563291 scopus 로고    scopus 로고
    • G protein-coupled receptors III New roles for receptor kinases and beta-Arrestins in receptor signaling and desensitization
    • Lefkowitz RJ. G protein-coupled receptors. III. New roles for receptor kinases and beta-Arrestins in receptor signaling and desensitization. J Biol Chem 1998; 273: 18677-18680.
    • (1998) J Biol Chem , vol.273 , pp. 18677-18680
    • Lefkowitz, R.J.1
  • 10
    • 0033519236 scopus 로고    scopus 로고
    • B cell antigen receptor engagement inhibits stromal cell-derived factor (SDF)-1alpha chemotaxis and promotes protein kinase C (PKC)-induced internalization of CXCR4
    • Guinamard R, Signoret N, Ishiai M, Marsh M, Kurosaki T, Ravetch JV. B cell antigen receptor engagement inhibits stromal cell-derived factor (SDF)-1alpha chemotaxis and promotes protein kinase C (PKC)-induced internalization of CXCR4. J Exp Med 1999; 189: 1461-1466.
    • (1999) J Exp Med , vol.189 , pp. 1461-1466
    • Guinamard, R.1    Signoret, N.2    Ishiai, M.3    Marsh, M.4    Kurosaki, T.5    Ravetch, J.V.6
  • 11
    • 34250839661 scopus 로고    scopus 로고
    • Control of receptor internalization, signaling level, and precise arrival at the target in guided cell migration
    • Minina S, Reichman-Fried M, Raz E. Control of receptor internalization, signaling level, and precise arrival at the target in guided cell migration. Curr Biol 2007; 17: 1164-1172.
    • (2007) Curr Biol , vol.17 , pp. 1164-1172
    • Minina, S.1    Reichman-Fried, M.2    Raz, E.3
  • 12
    • 0032742818 scopus 로고    scopus 로고
    • Trafficking of the HIV coreceptor CXCR4. Role of arrestins and identification of residues in the c-Terminal tail that mediate receptor internalization
    • Orsini MJ, Parent JL, Mundell SJ, Marchese A, Benovic JL. Trafficking of the HIV coreceptor CXCR4. Role of arrestins and identification of residues in the c-Terminal tail that mediate receptor internalization. J Biol Chem 1999; 274: 31076-31086.
    • (1999) J Biol Chem , vol.274 , pp. 31076-31086
    • Orsini, M.J.1    Parent, J.L.2    Mundell, S.J.3    Marchese, A.4    Benovic, J.L.5
  • 13
    • 77951230331 scopus 로고    scopus 로고
    • Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling
    • Busillo JM, Armando S, Sengupta R, Meucci O, Bouvier M, Benovic JL. Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling. J Biol Chem 2010; 285: 7805-7817.
    • (2010) J Biol Chem , vol.285 , pp. 7805-7817
    • Busillo, J.M.1    Armando, S.2    Sengupta, R.3    Meucci, O.4    Bouvier, M.5    Benovic, J.L.6
  • 14
    • 69549086437 scopus 로고    scopus 로고
    • Dissection of PIM serine/threonine kinases in FLT3-ITD-induced leukemogenesis reveals PIM1 as regulator of CXCL12-CXCR4-mediated homing and migration
    • Grundler R, Brault L, Gasser C, Bullock AN, Dechow T, Woetzel S et al. Dissection of PIM serine/threonine kinases in FLT3-ITD-induced leukemogenesis reveals PIM1 as regulator of CXCL12-CXCR4-mediated homing and migration. J Exp Med 2009; 206: 1957-1970.
    • (2009) J Exp Med , vol.206 , pp. 1957-1970
    • Grundler, R.1    Brault, L.2    Gasser, C.3    Bullock, A.N.4    Dechow, T.5    Woetzel, S.6
  • 15
    • 84864326041 scopus 로고    scopus 로고
    • PIM kinases are progression markers and emerging therapeutic targets in diffuse large B-cell lymphoma
    • Brault L, Menter T, Obermann EC, Knapp S, Thommen S, Schwaller J et al. PIM kinases are progression markers and emerging therapeutic targets in diffuse large B-cell lymphoma. Br J Cancer 2012; 107: 491-500.
    • (2012) Br J Cancer , vol.107 , pp. 491-500
    • Brault, L.1    Menter, T.2    Obermann, E.C.3    Knapp, S.4    Thommen, S.5    Schwaller, J.6
  • 16
    • 15244351083 scopus 로고    scopus 로고
    • Coordinate dual-gene transgenesis by lentiviral vectors carrying synthetic bidirectional promoters
    • Amendola M, Venneri MA, Biffi A, Vigna E, Naldini L. Coordinate dual-gene transgenesis by lentiviral vectors carrying synthetic bidirectional promoters. Nat Biotechnol 2005; 23: 108-116.
    • (2005) Nat Biotechnol , vol.23 , pp. 108-116
    • Amendola, M.1    Venneri, M.A.2    Biffi, A.3    Vigna, E.4    Naldini, L.5
  • 17
    • 77949423437 scopus 로고    scopus 로고
    • Functional characterization of high levels of meningioma 1 as collaborating oncogene in acute leukemia
    • Liu T, Jankovic D, Brault L, Ehret S, Baty F, Stavropoulou V et al. Functional characterization of high levels of meningioma 1 as collaborating oncogene in acute leukemia. Leukemia 2010; 24: 601-612.
    • (2010) Leukemia , vol.24 , pp. 601-612
    • Liu, T.1    Jankovic, D.2    Brault, L.3    Ehret, S.4    Baty, F.5    Stavropoulou, V.6
  • 18
    • 0018473622 scopus 로고
    • Distribution of the bone marrow cells in the skeleton of mice
    • Shaposhnikov VL. [Distribution of the bone marrow cells in the skeleton of mice]. Biull Eksp Biol Med 1979; 87: 483-485.
    • (1979) Biull Eksp Biol Med , vol.87 , pp. 483-485
    • Shaposhnikov, V.L.1
  • 19
    • 80755140039 scopus 로고    scopus 로고
    • P53 independent epigenetic-differentiation treatment in xenotransplant models of acute myeloid leukemia
    • Ng KP, Ebrahem Q, Negrotto S, Mahfouz RZ, Link KA, Hu Z et al. p53 independent epigenetic-differentiation treatment in xenotransplant models of acute myeloid leukemia. Leukemia 2011; 25: 1739-1750.
    • (2011) Leukemia , vol.25 , pp. 1739-1750
    • Ng, K.P.1    Ebrahem, Q.2    Negrotto, S.3    Mahfouz, R.Z.4    Link, K.A.5    Hu, Z.6
  • 20
    • 67650367598 scopus 로고    scopus 로고
    • Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML
    • Zeng Z, Shi YX, Samudio IJ, Wang RY, Ling X, Frolova O et al. Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML. Blood 2009; 113: 6215-6224.
    • (2009) Blood , vol.113 , pp. 6215-6224
    • Zeng, Z.1    Shi, Y.X.2    Samudio, I.J.3    Wang, R.Y.4    Ling, X.5    Frolova, O.6
  • 22
    • 79960257171 scopus 로고    scopus 로고
    • In situ RHAMM protein expression in acute myeloid leukemia blasts suggests poor overall survival
    • Tzankov A, Strasser U, Dirnhofer S, Menter T, Arber C, Jotterand M et al. In situ RHAMM protein expression in acute myeloid leukemia blasts suggests poor overall survival. Ann Hematol 2011; 90: 901-909.
    • (2011) Ann Hematol , vol.90 , pp. 901-909
    • Tzankov, A.1    Strasser, U.2    Dirnhofer, S.3    Menter, T.4    Arber, C.5    Jotterand, M.6
  • 23
    • 0032550179 scopus 로고    scopus 로고
    • Cytoplasmic tail phosphorylation of the alpha-factor receptor is required for its ubiquitination and internalization
    • Hicke L, Zanolari B, Riezman H. Cytoplasmic tail phosphorylation of the alpha-factor receptor is required for its ubiquitination and internalization. J Cell Biol 1998; 141: 349-358.
    • (1998) J Cell Biol , vol.141 , pp. 349-358
    • Hicke, L.1    Zanolari, B.2    Riezman, H.3
  • 24
    • 0344286482 scopus 로고    scopus 로고
    • Cluster of differentiation antigen 4 (CD4) endocytosis and adaptor complex binding require activation of the CD4 endocytosis signal by serine phosphorylation
    • Pitcher C, Honing S, Fingerhut A, Bowers K, Marsh M. Cluster of differentiation antigen 4 (CD4) endocytosis and adaptor complex binding require activation of the CD4 endocytosis signal by serine phosphorylation. Mol Biol Cell 1999; 10: 677-691.
    • (1999) Mol Biol Cell , vol.10 , pp. 677-691
    • Pitcher, C.1    Honing, S.2    Fingerhut, A.3    Bowers, K.4    Marsh, M.5
  • 25
    • 2642710893 scopus 로고    scopus 로고
    • The chemokine receptor CXCR-4 is expressed on CD34þ hematopoietic progenitors and leukemic cells and mediates transendothelial migration induced by stromal cell-derived factor-1
    • Mohle R, Bautz F, Rafii S, Moore MA, Brugger W, Kanz L. The chemokine receptor CXCR-4 is expressed on CD34þ hematopoietic progenitors and leukemic cells and mediates transendothelial migration induced by stromal cell-derived factor-1. Blood 1998; 91: 4523-4530.
    • (1998) Blood , vol.91 , pp. 4523-4530
    • Mohle, R.1    Bautz, F.2    Rafii, S.3    Moore, M.A.4    Brugger, W.5    Kanz, L.6
  • 28
    • 77449127999 scopus 로고    scopus 로고
    • Delivery of microRNA-126 by apoptotic bodies induces CXCL12-dependent vascular protection
    • Zernecke A, Bidzhekov K, Noels H, Shagdarsuren E, Gan L, Denecke B et al. Delivery of microRNA-126 by apoptotic bodies induces CXCL12-dependent vascular protection. Sci Signal 2009; 2: Ra81.
    • (2009) Sci Signal , vol.2
    • Zernecke, A.1    Bidzhekov, K.2    Noels, H.3    Shagdarsuren, E.4    Gan, L.5    Denecke, B.6
  • 29
    • 84861316751 scopus 로고    scopus 로고
    • Bone marrow stromal cells modulate mouse ENT1 activity and protect leukemia cells from cytarabine induced apoptosis
    • Macanas-Pirard P, Leisewitz A, Broekhuizen R, Cautivo K, Barriga FM, Leisewitz F et al. Bone marrow stromal cells modulate mouse ENT1 activity and protect leukemia cells from cytarabine induced apoptosis. PLoS One 2012; 7: E37203.
    • (2012) PLoS One , vol.7
    • Macanas-Pirard, P.1    Leisewitz, A.2    Broekhuizen, R.3    Cautivo, K.4    Barriga, F.M.5    Leisewitz, F.6
  • 30
    • 33947200199 scopus 로고    scopus 로고
    • Overexpression of CXCR4 predicts adverse overall and event-free survival in patients with unmutated FLT3 acute myeloid leukemia with normal karyotype
    • Konoplev S, Rassidakis GZ, Estey E, Kantarjian H, Liakou CI, Huang X et al. Overexpression of CXCR4 predicts adverse overall and event-free survival in patients with unmutated FLT3 acute myeloid leukemia with normal karyotype. Cancer 2007; 109: 1152-1156.
    • (2007) Cancer , vol.109 , pp. 1152-1156
    • Konoplev, S.1    Rassidakis, G.Z.2    Estey, E.3    Kantarjian, H.4    Liakou, C.I.5    Huang, X.6
  • 32
    • 10744223652 scopus 로고    scopus 로고
    • Engraftment of acute myeloid leukemia in NOD/SCID mice is independent of CXCR4 and predicts poor patient survival
    • Monaco G, Konopleva M, Munsell M, Leysath C, Wang RY, Jackson CE et al. Engraftment of acute myeloid leukemia in NOD/SCID mice is independent of CXCR4 and predicts poor patient survival. Stem Cells 2004; 22: 188-201.
    • (2004) Stem Cells , vol.22 , pp. 188-201
    • Monaco, G.1    Konopleva, M.2    Munsell, M.3    Leysath, C.4    Wang, R.Y.5    Jackson, C.E.6
  • 33
    • 29244445813 scopus 로고    scopus 로고
    • Widespread CXCR4 activation in astrocytomas revealed by phospho-CXCR4-specific antibodies
    • Woerner BM, Warrington NM, Kung AL, Perry A, Rubin JB. Widespread CXCR4 activation in astrocytomas revealed by phospho-CXCR4-specific antibodies. Cancer Res 2005; 65: 11392-11399.
    • (2005) Cancer Res , vol.65 , pp. 11392-11399
    • Woerner, B.M.1    Warrington, N.M.2    Kung, A.L.3    Perry, A.4    Rubin, J.B.5
  • 34
    • 80053896956 scopus 로고    scopus 로고
    • Phosphorylated CXCR4 is associated with poor survival in adults with B-Acute lymphoblastic leukemia
    • Konoplev S, Jorgensen JL, Thomas DA, Lin E, Burger J, Kantarjian HM et al. Phosphorylated CXCR4 is associated with poor survival in adults with B-Acute lymphoblastic leukemia. Cancer 2011; 117: 31.
    • (2011) Cancer , vol.117 , pp. 31
    • Konoplev, S.1    Jorgensen, J.L.2    Thomas, D.A.3    Lin, E.4    Burger, J.5    Kantarjian, H.M.6
  • 35
    • 15244361356 scopus 로고    scopus 로고
    • Enhanced function with decreased internalization of carboxy-Terminus truncated CXCR4 responsible for WHIM syndrome
    • Kawai T, Choi U, Whiting-Theobald NL, Linton GF, Brenner S, Sechler JM et al. Enhanced function with decreased internalization of carboxy-Terminus truncated CXCR4 responsible for WHIM syndrome. Exp Hematol 2005; 33: 460-468.
    • (2005) Exp Hematol , vol.33 , pp. 460-468
    • Kawai, T.1    Choi, U.2    Whiting-Theobald, N.L.3    Linton, G.F.4    Brenner, S.5    Sechler, J.M.6
  • 36
    • 80054823348 scopus 로고    scopus 로고
    • Chemokine CXCL12 uses CXCR4 and a signaling core formed by bifunctional Akt, extracellular signal-regulated kinase (ERK)1/2, and mammalian target of rapamycin complex 1 (mTORC1) proteins to control chemotaxis and survival simultaneously in mature dendritic cells
    • Delgado-Martin C, Escribano C, Pablos JL, Riol-Blanco L, Rodriguez-Fernandez JL. Chemokine CXCL12 uses CXCR4 and a signaling core formed by bifunctional Akt, extracellular signal-regulated kinase (ERK)1/2, and mammalian target of rapamycin complex 1 (mTORC1) proteins to control chemotaxis and survival simultaneously in mature dendritic cells. J Biol Chem 2011; 286: 37222-37236.
    • (2011) J Biol Chem , vol.286 , pp. 37222-37236
    • Delgado-Martin, C.1    Escribano, C.2    Pablos, J.L.3    Riol-Blanco, L.4    Rodriguez-Fernandez, J.L.5
  • 37
    • 77954763320 scopus 로고    scopus 로고
    • Migration of human umbilical cord blood mesenchymal stem cells mediated by stromal cell-derived factor-1/CXCR4 axis via Akt ERK, and p38 signal transduction pathways
    • Ryu CH, Park SA, Kim SM, Lim JY, Jeong CH, Jun JA et al. Migration of human umbilical cord blood mesenchymal stem cells mediated by stromal cell-derived factor-1/CXCR4 axis via Akt, ERK, and p38 signal transduction pathways. Biochem Biophys Res Commun 2010; 398: 105-110.
    • (2010) Biochem Biophys Res Commun , vol.398 , pp. 105-110
    • Ryu, C.H.1    Park, S.A.2    Kim, S.M.3    Lim, J.Y.4    Jeong, C.H.5    Jun, J.A.6
  • 38
    • 33846106798 scopus 로고    scopus 로고
    • WHIM syndrome myelokathexis reproduced in the NOD/SCID mouse xenotransplant model engrafted with healthy human stem cells transduced with C-Terminus-Truncated CXCR4
    • Kawai T, Choi U, Cardwell L, DeRavin SS, Naumann N, Whiting-Theobald NL et al. WHIM syndrome myelokathexis reproduced in the NOD/SCID mouse xenotransplant model engrafted with healthy human stem cells transduced with C-Terminus-Truncated CXCR4. Blood 2007; 109: 78-84.
    • (2007) Blood , vol.109 , pp. 78-84
    • Kawai, T.1    Choi, U.2    Cardwell, L.3    DeRavin, S.S.4    Naumann, N.5    Whiting-Theobald, N.L.6
  • 39
    • 84878529330 scopus 로고    scopus 로고
    • CXCR4 downregulation of let-7a drives chemoresistance in acute myeloid leukemia
    • Chen Y, Jacamo R, Konopleva M, Garzon R, Croce C, Andreeff M. CXCR4 downregulation of let-7a drives chemoresistance in acute myeloid leukemia. J Clin Invest 2013; 123: 2395-2407.
    • (2013) J Clin Invest , vol.123 , pp. 2395-2407
    • Chen, Y.1    Jacamo, R.2    Konopleva, M.3    Garzon, R.4    Croce, C.5    Andreeff, M.6
  • 40
    • 67650410440 scopus 로고    scopus 로고
    • Chemosensitization of acute myeloid leukemia (AML) following mobilization by the CXCR4 antagonist AMD3100
    • Nervi B, Ramirez P, Rettig MP, Uy GL, Holt MS, Ritchey JK et al. Chemosensitization of acute myeloid leukemia (AML) following mobilization by the CXCR4 antagonist AMD3100. Blood 2009; 113: 6206-6214.
    • (2009) Blood , vol.113 , pp. 6206-6214
    • Nervi, B.1    Ramirez, P.2    Rettig, M.P.3    Uy, G.L.4    Holt, M.S.5    Ritchey, J.K.6
  • 41
    • 84860349448 scopus 로고    scopus 로고
    • A phase 1/2 study of chemosensitization with the CXCR4 antagonist plerixafor in relapsed or refractory acute myeloid leukemia
    • Uy GL, Rettig MP, Motabi IH, McFarland K, Trinkaus KM, Hladnik LM et al. A phase 1/2 study of chemosensitization with the CXCR4 antagonist plerixafor in relapsed or refractory acute myeloid leukemia. Blood 2012; 119: 3917-3924..
    • (2012) Blood , vol.119 , pp. 3917-3924
    • Uy, G.L.1    Rettig, M.P.2    Motabi, I.H.3    McFarland, K.4    Trinkaus, K.M.5    Hladnik, L.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.