Discovery of 1,3,4-oxidiazole scaffold compounds as inhibitors of superoxide dismutase expression

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 6, 2014, Pages 1532-1537

  Lukas, Thomas J ^a   Schiltz, Gary E ^b   Arrat, Hasan ^d   Scheidt, Karl ^b,c   Siddique, Teepu ^d  

^a NORTHWESTERN UNIVERSITY   (United States)

^b Center for Molecular Innovation and Drug Discovery   (United States)

^c Department of Chemistry Center for Molecular Innovation and Drug Discovery Silverman Hall ^*  (United States)

^d NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Amyotrophic lateral sclerosis; Chemical synthesis; Hit to lead; Inhibitor; Pharmacokinetics; Superoxide dismutase; Transgenic mouse

Indexed keywords

1,3,4 OXADIAZOLE DERIVATIVE; COPPER ZINC SUPEROXIDE DISMUTASE; MUTANT PROTEIN; PROTEIN KINASE INHIBITOR; SUPEROXIDE DISMUTASE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; AUTOSOMAL DOMINANT DISORDER; BRAIN TISSUE; CHRONIC DISEASE; CONTROLLED STUDY; DRUG DESIGN; DRUG SCREENING; GENE MUTATION; IN VITRO STUDY; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SPINAL CORD; STRUCTURE ACTIVITY RELATION;

MUS MUSCULUS; TOXOPHORA;

AMYOTROPHIC LATERAL SCLEROSIS; CHEMICAL SYNTHESIS; HIT-TO-LEAD; INHIBITOR; PHARMACOKINETICS; SUPEROXIDE DISMUTASE; TRANSGENIC MOUSE;

ANIMALS; CELL LINE; DRUG EVALUATION, PRECLINICAL; GENE EXPRESSION REGULATION; MICE; OXADIAZOLES; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP; SUPEROXIDE DISMUTASE;

EID: 84895779541     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.01.078     Document Type: Article

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