Glycogen synthase kinase-3 inhibition reduces ischemic cerebral damage, restores impaired mitochondrial biogenesis and prevents ROS production

Journal of Neurochemistry

Volumn 116, Issue 6, 2011, Pages 1148-1159

  Valerio, Alessandra ^a   Bertolotti, Paola ^a,b   Delbarba, Andrea ^a,b   Perego, Carlo ^c   Dossena, Marta ^a,b   Ragni, Maurizio ^b   Spano, Pierfranco ^a   Carruba, Michele O ^b,d   De Simoni, Maria Grazia ^c   Nisoli, Enzo ^b,d  

^a UNIVERSITY OF BRESCIA   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^d ISTITUTO AUXOLOGICO ITALIANO   (Italy)

Author keywords

cerebral ischemia; glycogen synthase kinase 3; mitochondrial biogenesis; PGC 1 ; reactive oxygen species

Indexed keywords

2 (2,4 DICHLOROPHENYL) 3 (1 METHYL 3 INDOLYL)MALEIMIDE; COPPER ZINC SUPEROXIDE DISMUTASE; CYTOCHROME C; CYTOCHROME C OXIDASE; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3ALPHA; GLYCOGEN SYNTHASE KINASE 3BETA; LACTATE DEHYDROGENASE; MANGANESE SUPEROXIDE DISMUTASE; MITOCHONDRIAL DNA; MITOCHONDRIAL TRANSCRIPTION FACTOR A; NUCLEAR RESPIRATORY FACTOR 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; BINDING SITE; BIOGENESIS; BRAIN INFARCTION; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG MECHANISM; EMBRYO; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; FEMALE; IN VITRO STUDY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; UPREGULATION;

ANIMALS; ANOXIA; BIOGENESIS; CELLS, CULTURED; CEREBRAL CORTEX; DISEASE MODELS, ANIMAL; DNA, MITOCHONDRIAL; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYO, MAMMALIAN; ENZYME INHIBITORS; GLUCOSE; GLYCOGEN SYNTHASE KINASE 3; HIGH MOBILITY GROUP PROTEINS; INDOLES; INFARCTION, MIDDLE CEREBRAL ARTERY; L-LACTATE DEHYDROGENASE; MALEIMIDES; MICE; MITOCHONDRIA; MUTATION; NEURONS; NUCLEAR RESPIRATORY FACTOR 1; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; TRANSFECTION;

MUS;

EID: 79952369773     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2011.07171.x     Document Type: Article

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