-
1
-
-
84861203302
-
EGFR-mutated oncogene-addicted non-small cell lung cancer: current trends and future prospects
-
Soria J.C., Mok T.S., Cappuzzo F., Janne P.A. EGFR-mutated oncogene-addicted non-small cell lung cancer: current trends and future prospects. Cancer Treat Rev 2012, 38:416-430.
-
(2012)
Cancer Treat Rev
, vol.38
, pp. 416-430
-
-
Soria, J.C.1
Mok, T.S.2
Cappuzzo, F.3
Janne, P.A.4
-
2
-
-
69949162760
-
Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
-
Mok T.S., Wu Y.L., Thongprasert S., Yang C.H., Chu D.T., Saijo N., et al. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med 2009, 361:947-957.
-
(2009)
N Engl J Med
, vol.361
, pp. 947-957
-
-
Mok, T.S.1
Wu, Y.L.2
Thongprasert, S.3
Yang, C.H.4
Chu, D.T.5
Saijo, N.6
-
3
-
-
22044445517
-
Erlotinib in previously treated non-small-cell lung cancer
-
Shepherd F.A., Rodrigues Pereira J., Ciuleanu T., Tan E.H., Hirsh V., et al. Erlotinib in previously treated non-small-cell lung cancer. N Engl J Med 2005, 353:123-132.
-
(2005)
N Engl J Med
, vol.353
, pp. 123-132
-
-
Shepherd, F.A.1
Rodrigues Pereira, J.2
Ciuleanu, T.3
Tan, E.H.4
Hirsh, V.5
-
4
-
-
84857502654
-
Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial
-
Rosell R., Carcereny E., Gervais R., Vergnenegre A., Massuti B., Felip E., et al. Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial. Lancet Oncol 2012, 13:239-246.
-
(2012)
Lancet Oncol
, vol.13
, pp. 239-246
-
-
Rosell, R.1
Carcereny, E.2
Gervais, R.3
Vergnenegre, A.4
Massuti, B.5
Felip, E.6
-
5
-
-
79953118839
-
Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors
-
75ra26
-
Sequist L.V., Waltman B.A., Dias-Santagata D., Digumarthy S., Turke A.B., Fidias P., et al. Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors. Sci Transl Med 2011, 3. 75ra26.
-
(2011)
Sci Transl Med
, vol.3
-
-
Sequist, L.V.1
Waltman, B.A.2
Dias-Santagata, D.3
Digumarthy, S.4
Turke, A.B.5
Fidias, P.6
-
6
-
-
40049099220
-
The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP
-
Yun C.H., Mengwasser K.E., Toms A.V., Woo M.S., Greulich H., Wong K.K., et al. The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP. Proc Natl Acad Sci U S A 2008, 105:2070-2075.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 2070-2075
-
-
Yun, C.H.1
Mengwasser, K.E.2
Toms, A.V.3
Woo, M.S.4
Greulich, H.5
Wong, K.K.6
-
7
-
-
21144439000
-
Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib
-
Kwak E.L., Sordella R., Bell D.W., Godin-Heymann N., Okimoto R.A., Brannigan B.W., et al. Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib. Proc Natl Acad Sci U S A 2005, 102:7665-7670.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 7665-7670
-
-
Kwak, E.L.1
Sordella, R.2
Bell, D.W.3
Godin-Heymann, N.4
Okimoto, R.A.5
Brannigan, B.W.6
-
8
-
-
19744364796
-
Structural bioinformatics-based design of selective, irreversible kinase inhibitors
-
Cohen M.S., Zhang C., Shokat K.M., Taunton J. Structural bioinformatics-based design of selective, irreversible kinase inhibitors. Science 2005, 308:1318-1321.
-
(2005)
Science
, vol.308
, pp. 1318-1321
-
-
Cohen, M.S.1
Zhang, C.2
Shokat, K.M.3
Taunton, J.4
-
10
-
-
37549061078
-
PF00299804, an irreversible pan-ERBB inhibitor, is effective in lung cancer models with EGFR and ERBB2 mutations that are resistant to gefitinib
-
Engelman J.A., Zejnullahu K., Gale C.M., Lifshits E., Gonzales A.J., Shimamura T., et al. PF00299804, an irreversible pan-ERBB inhibitor, is effective in lung cancer models with EGFR and ERBB2 mutations that are resistant to gefitinib. Cancer Res 2007, 67:11924-11932.
-
(2007)
Cancer Res
, vol.67
, pp. 11924-11932
-
-
Engelman, J.A.1
Zejnullahu, K.2
Gale, C.M.3
Lifshits, E.4
Gonzales, A.J.5
Shimamura, T.6
-
11
-
-
49149118719
-
BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models
-
Li D., Ambrogio L., Shimamura T., Kubo S., Takahashi M., Chirieac L.R., et al. BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models. Oncogene 2008, 27:4702-4711.
-
(2008)
Oncogene
, vol.27
, pp. 4702-4711
-
-
Li, D.1
Ambrogio, L.2
Shimamura, T.3
Kubo, S.4
Takahashi, M.5
Chirieac, L.R.6
-
12
-
-
2542582261
-
Antitumor activity of HKI-272, an orally active, irreversible inhibitor of the HER-2 tyrosine kinase
-
Rabindran S.K., Discafani C.M., Rosfjord E.C., Baxter M., Floyd M.B., Golas J., et al. Antitumor activity of HKI-272, an orally active, irreversible inhibitor of the HER-2 tyrosine kinase. Cancer Res 2004, 64:3958-3965.
-
(2004)
Cancer Res
, vol.64
, pp. 3958-3965
-
-
Rabindran, S.K.1
Discafani, C.M.2
Rosfjord, E.C.3
Baxter, M.4
Floyd, M.B.5
Golas, J.6
-
13
-
-
84867621201
-
Target binding properties and cellular activity of afatinib (BIBW 2992), an irreversible ErbB family blocker
-
Solca F., Dahl G., Zoephel A., Bader G., Sanderson M., Klein C., et al. Target binding properties and cellular activity of afatinib (BIBW 2992), an irreversible ErbB family blocker. J Pharmacol Exp Ther 2012, 343:342-350.
-
(2012)
J Pharmacol Exp Ther
, vol.343
, pp. 342-350
-
-
Solca, F.1
Dahl, G.2
Zoephel, A.3
Bader, G.4
Sanderson, M.5
Klein, C.6
-
14
-
-
38049038935
-
A phase I dose escalation study of BIBW 2992, an irreversible dual inhibitor of epidermal growth factor receptor 1 (EGFR) and 2 (HER2) tyrosine kinase in a 2-week on, 2-week off schedule in patients with advanced solid tumours
-
Eskens F.A., Mom C.H., Planting A.S., Gietema J.A., Amelsberg A., Huisman H., et al. A phase I dose escalation study of BIBW 2992, an irreversible dual inhibitor of epidermal growth factor receptor 1 (EGFR) and 2 (HER2) tyrosine kinase in a 2-week on, 2-week off schedule in patients with advanced solid tumours. Br J Cancer 2008, 98:80-85.
-
(2008)
Br J Cancer
, vol.98
, pp. 80-85
-
-
Eskens, F.A.1
Mom, C.H.2
Planting, A.S.3
Gietema, J.A.4
Amelsberg, A.5
Huisman, H.6
-
15
-
-
33751421795
-
A phase I dose escalation study of BIBW 2992, an irreversible dual EGFR/HER2 receptor tyrosine kinase inhibitor, in a 3 week on 1 week off schedule in patients with advanced solid tumors
-
Lewis N.J.M., Amelsberg A., Cohen R.B., Stopfer P., Hwang J., Malik S. A phase I dose escalation study of BIBW 2992, an irreversible dual EGFR/HER2 receptor tyrosine kinase inhibitor, in a 3 week on 1 week off schedule in patients with advanced solid tumors. J Clin Oncol 2006, 18S.
-
(2006)
J Clin Oncol
-
-
Lewis, N.J.M.1
Amelsberg, A.2
Cohen, R.B.3
Stopfer, P.4
Hwang, J.5
Malik, S.6
-
16
-
-
77957585027
-
Phase I trial of the irreversible EGFR and HER2 kinase inhibitor BIBW 2992 in patients with advanced solid tumors
-
Yap T.A., Vidal L., Adam J., Stephens P., Spicer J., Shaw H., et al. Phase I trial of the irreversible EGFR and HER2 kinase inhibitor BIBW 2992 in patients with advanced solid tumors. J Clin Oncol 2010, 28:3965-3972.
-
(2010)
J Clin Oncol
, vol.28
, pp. 3965-3972
-
-
Yap, T.A.1
Vidal, L.2
Adam, J.3
Stephens, P.4
Spicer, J.5
Shaw, H.6
-
17
-
-
84859795661
-
Phase I study of continuous afatinib (BIBW 2992) in patients with advanced non-small cell lung cancer after prior chemotherapy/erlotinib/gefitinib (LUX-Lung 4)
-
Murakami H., Tamura T., Takahashi T., Nokihara H., Naito T., Nakamura Y., et al. Phase I study of continuous afatinib (BIBW 2992) in patients with advanced non-small cell lung cancer after prior chemotherapy/erlotinib/gefitinib (LUX-Lung 4). Cancer Chemother Pharmacol 2012, 69:891-899.
-
(2012)
Cancer Chemother Pharmacol
, vol.69
, pp. 891-899
-
-
Murakami, H.1
Tamura, T.2
Takahashi, T.3
Nokihara, H.4
Naito, T.5
Nakamura, Y.6
-
18
-
-
84859793822
-
Afatinib pharmacokinetics and metabolism after oral administration to healthy male volunteers
-
Stopfer P., Marzin K., Narjes H., Gansser D., Shahidi M., Uttereuther-Fischer M., Ebner T. Afatinib pharmacokinetics and metabolism after oral administration to healthy male volunteers. Cancer Chemother Pharmacol 2012, 69:1051-1061.
-
(2012)
Cancer Chemother Pharmacol
, vol.69
, pp. 1051-1061
-
-
Stopfer, P.1
Marzin, K.2
Narjes, H.3
Gansser, D.4
Shahidi, M.5
Uttereuther-Fischer, M.6
Ebner, T.7
-
19
-
-
84868506607
-
Clinical perspectives for irreversible tyrosine kinase inhibitors in cancer
-
Carmi C., Mor M., Petronini P.G., Alfieri R.R. Clinical perspectives for irreversible tyrosine kinase inhibitors in cancer. Biochem Pharmacol 2012, 84:12.
-
(2012)
Biochem Pharmacol
, vol.84
, pp. 12
-
-
Carmi, C.1
Mor, M.2
Petronini, P.G.3
Alfieri, R.R.4
-
20
-
-
84862785051
-
Afatinib versus placebo for patients with advanced, metastatic non-small-cell lung cancer after failure of erlotinib, gefitinib, or both, and one or two lines of chemotherapy (LUX-Lung 1): a phase 2b/3 randomised trial
-
Miller V.A., Hirsh V., Cadranel J., Chen Y.M., Park K., Kim S.W., et al. Afatinib versus placebo for patients with advanced, metastatic non-small-cell lung cancer after failure of erlotinib, gefitinib, or both, and one or two lines of chemotherapy (LUX-Lung 1): a phase 2b/3 randomised trial. Lancet Oncol 2012, 13:528-538.
-
(2012)
Lancet Oncol
, vol.13
, pp. 528-538
-
-
Miller, V.A.1
Hirsh, V.2
Cadranel, J.3
Chen, Y.M.4
Park, K.5
Kim, S.W.6
-
21
-
-
84862819699
-
Afatinib for patients with lung adenocarcinoma and epidermal growth factor receptor mutations (LUX-Lung 2): a phase 2 trial
-
Yang J.C., Shih J.Y., Su W.C., Hsia T.C., Tsai C.M., Ou S.H., et al. Afatinib for patients with lung adenocarcinoma and epidermal growth factor receptor mutations (LUX-Lung 2): a phase 2 trial. Lancet Oncol 2012, 13:539-548.
-
(2012)
Lancet Oncol
, vol.13
, pp. 539-548
-
-
Yang, J.C.1
Shih, J.Y.2
Su, W.C.3
Hsia, T.C.4
Tsai, C.M.5
Ou, S.H.6
-
22
-
-
84866655838
-
LUX-Lung 3: A randomized, open-label, phase III study of afatinib versus pemetrexed and cisplatin as first-line treatment for patients with advanced adenocarcinoma of the lung harboring EGFR-activating mutations
-
(abstr LBA7500)
-
Yang J.C.-H., Schuler M.H., Yamamoto N., O'Byrne K.J., Hirsh V., Mok T., Geater S.L., et al. LUX-Lung 3: A randomized, open-label, phase III study of afatinib versus pemetrexed and cisplatin as first-line treatment for patients with advanced adenocarcinoma of the lung harboring EGFR-activating mutations. J Clin Oncol 2012, 30. (abstr LBA7500).
-
(2012)
J Clin Oncol
, vol.30
-
-
Yang, J.C.-H.1
Schuler, M.H.2
Yamamoto, N.3
O'Byrne, K.J.4
Hirsh, V.5
Mok, T.6
Geater, S.L.7
-
23
-
-
84867078536
-
Interim analysis of afatinib monotherapy in patients with metastatic NSCLC progressing after chemotherapy and erlotinib/gefitinib (E/G) in a trial of afatinib plus paclitaxel versus investigator's choice chemotherapy following progression on afatinib monotherapy
-
(abstr 7557)
-
Martin H., Schuler D.P., Yang J.C.-H., Kim J.-H., De Marinis F., Chen Y.-M., et al. Interim analysis of afatinib monotherapy in patients with metastatic NSCLC progressing after chemotherapy and erlotinib/gefitinib (E/G) in a trial of afatinib plus paclitaxel versus investigator's choice chemotherapy following progression on afatinib monotherapy. J Clin Oncol 2012, 30. (abstr 7557).
-
(2012)
J Clin Oncol
, vol.30
-
-
Martin, H.1
Schuler, D.P.2
Yang, J.C.-H.3
Kim, J.-H.4
De Marinis, F.5
Chen, Y.-M.6
-
24
-
-
84879890269
-
Afatinib monotherapy in patients with metastatic squamous cell carcinoma of the lung progressing after erlotinib/gefitinib (E/G) and chemotherapy: interim subset analysis from a phase III trial
-
(abstr 7558)
-
Kim F.G.J.-H., De Marinis F., Cobo M., Yang J.C.-H., Ragulin Y., Bondarenko I.N., et al. Afatinib monotherapy in patients with metastatic squamous cell carcinoma of the lung progressing after erlotinib/gefitinib (E/G) and chemotherapy: interim subset analysis from a phase III trial. J Clin Oncol 2012, 30. (abstr 7558).
-
(2012)
J Clin Oncol
, vol.30
-
-
Kim, F.G.J.-H.1
De Marinis, F.2
Cobo, M.3
Yang, J.C.-H.4
Ragulin, Y.5
Bondarenko, I.N.6
-
25
-
-
74949110711
-
Clinical definition of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer
-
Jackman D., Pao W., Riely G.J., Engelman J.A., Kris M.G., Janne P.A., et al. Clinical definition of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer. J Clin Oncol 2010, 28:357-360.
-
(2010)
J Clin Oncol
, vol.28
, pp. 357-360
-
-
Jackman, D.1
Pao, W.2
Riely, G.J.3
Engelman, J.A.4
Kris, M.G.5
Janne, P.A.6
-
26
-
-
83455167485
-
A phase II trial of afatinib (BIBW 2992) in patients (pts) with advanced non-small cell lung cancer previously treated with erlotinib (E) or gefitinib (G)
-
(abstr 7524)
-
Yamamoto N.N.K., Atagi S., Hida T., Goto K., Horai T., Inoue A., et al. A phase II trial of afatinib (BIBW 2992) in patients (pts) with advanced non-small cell lung cancer previously treated with erlotinib (E) or gefitinib (G). J Clin Oncol 2012, 29. (abstr 7524).
-
(2012)
J Clin Oncol
, vol.29
-
-
Yamamoto, N.N.K.1
Atagi, S.2
Hida, T.3
Goto, K.4
Horai, T.5
Inoue, A.6
-
27
-
-
84861976809
-
First-SIGNAL: first-line single-agent iressa versus gemcitabine and cisplatin trial in never-smokers with adenocarcinoma of the lung
-
Han J.Y., Park K., Kim S.W., Lee D.H., Kim H.Y., Kim H.T., et al. First-SIGNAL: first-line single-agent iressa versus gemcitabine and cisplatin trial in never-smokers with adenocarcinoma of the lung. J Clin Oncol 2012, 30:1122-1128.
-
(2012)
J Clin Oncol
, vol.30
, pp. 1122-1128
-
-
Han, J.Y.1
Park, K.2
Kim, S.W.3
Lee, D.H.4
Kim, H.Y.5
Kim, H.T.6
-
28
-
-
84871597401
-
Updated overall survival results from a randomized phase III trial comparing gefitinib with carboplatin-paclitaxel for chemo-naive non-small cell lung cancer with sensitive EGFR gene mutations (NEJ002)
-
Inoue A., Kobayashi K., Maemondo M., Sugawara S., Oizumi S., Isobe H., et al. Updated overall survival results from a randomized phase III trial comparing gefitinib with carboplatin-paclitaxel for chemo-naive non-small cell lung cancer with sensitive EGFR gene mutations (NEJ002). Ann Oncol 2013, 24:54-59.
-
(2013)
Ann Oncol
, vol.24
, pp. 54-59
-
-
Inoue, A.1
Kobayashi, K.2
Maemondo, M.3
Sugawara, S.4
Oizumi, S.5
Isobe, H.6
-
29
-
-
79960889662
-
Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study
-
Zhou C., Wu Y.L., Chen G., Feng J., Liu X.Q., Wang C., et al. Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study. Lancet Oncol 2011, 12:735-742.
-
(2011)
Lancet Oncol
, vol.12
, pp. 735-742
-
-
Zhou, C.1
Wu, Y.L.2
Chen, G.3
Feng, J.4
Liu, X.Q.5
Wang, C.6
-
30
-
-
84863892117
-
Randomized phase II trial of erlotinib alone or with carboplatin and paclitaxel in patients who were never or light former smokers with advanced lung adenocarcinoma: CALGB 30406 trial
-
Janne P.A., Wang X., Socinski M.A., Crawford J., Stinchcombe T.E., Gu L., et al. Randomized phase II trial of erlotinib alone or with carboplatin and paclitaxel in patients who were never or light former smokers with advanced lung adenocarcinoma: CALGB 30406 trial. J Clin Oncol 2012, 30:2063-2069.
-
(2012)
J Clin Oncol
, vol.30
, pp. 2063-2069
-
-
Janne, P.A.1
Wang, X.2
Socinski, M.A.3
Crawford, J.4
Stinchcombe, T.E.5
Gu, L.6
-
31
-
-
84879887976
-
Impact of egfr mutation status on clinical benefit from bibw 2992 in patients (pts) with advanced Non-small cell lung cancer (NSCLC) progressing after chemotherapy (ctx) and erlotinib (E) or gefitinib (G) - a single center experience
-
abstr1339
-
Köhler J.K.W., Gauler T.C., Hoiczyk M., Theegarten D., Eberhardt W., Hense J., et al. Impact of egfr mutation status on clinical benefit from bibw 2992 in patients (pts) with advanced Non-small cell lung cancer (NSCLC) progressing after chemotherapy (ctx) and erlotinib (E) or gefitinib (G) - a single center experience. Ann Oncol 2012, 23(Suppl 9). abstr1339.
-
(2012)
Ann Oncol
, vol.23
, Issue.SUPPL. 9
-
-
Köhler, J.K.W.1
Gauler, T.C.2
Hoiczyk, M.3
Theegarten, D.4
Eberhardt, W.5
Hense, J.6
-
32
-
-
84879880779
-
Phase II trial of afatinib as a third-line treatment for Korean patients (pts) with wild-type epidermal growth factor receptor (wtEGFR) stage IIIB/IV lung adenocarcinoma
-
(abstr 1292P)
-
Ahn M.A.K.S., Cho B., Ahn J.S., Lee D.H., Sun J., Massey D., et al. Phase II trial of afatinib as a third-line treatment for Korean patients (pts) with wild-type epidermal growth factor receptor (wtEGFR) stage IIIB/IV lung adenocarcinoma. Ann Oncol 2012, 23(Suppl 9). (abstr 1292P).
-
(2012)
Ann Oncol
, vol.23
, Issue.SUPPL. 9
-
-
Ahn, M.A.K.S.1
Cho, B.2
Ahn, J.S.3
Lee, D.H.4
Sun, J.5
Massey, D.6
-
33
-
-
84879888935
-
Activity of afatinib in uncommon epidermal growth factor receptor (egfr) mutations in Lux-lung 3, a phase iii trial of afatinib or cisplatin/pemetrexed in egfr mutation-positive lung cancer
-
(abstr 1252P)
-
Yang J.C.M.S., Yamamoto N., O.' Byrne K.J., Hirsh V., Mok T.S.K., Massey D.V.Z., et al. Activity of afatinib in uncommon epidermal growth factor receptor (egfr) mutations in Lux-lung 3, a phase iii trial of afatinib or cisplatin/pemetrexed in egfr mutation-positive lung cancer. Ann Oncol 2012, 23(suppl 9). (abstr 1252P).
-
(2012)
Ann Oncol
, vol.23
, Issue.SUPPL. 9
-
-
Yang, J.C.M.S.1
Yamamoto, N.2
O.' Byrne, K.J.3
Hirsh, V.4
Mok, T.S.K.5
Massey, D.V.Z.6
-
34
-
-
80054964152
-
Comparison of clinical outcome of patients with non-small-cell lung cancer harbouring epidermal growth factor receptor exon 19 or exon 21 mutations
-
Won Y.W., Han J.Y., Lee G.K., Park S.Y., Lim K.Y., Yoon K.A., et al. Comparison of clinical outcome of patients with non-small-cell lung cancer harbouring epidermal growth factor receptor exon 19 or exon 21 mutations. J Clin Pathol 2011, 64:947-952.
-
(2011)
J Clin Pathol
, vol.64
, pp. 947-952
-
-
Won, Y.W.1
Han, J.Y.2
Lee, G.K.3
Park, S.Y.4
Lim, K.Y.5
Yoon, K.A.6
-
35
-
-
69949186250
-
Screening for epidermal growth factor receptor mutations in lung cancer
-
Rosell R., Moran T., Queralt C., Porta R., Cardenal F., Camps C., et al. Screening for epidermal growth factor receptor mutations in lung cancer. N Engl J Med 2009, 361:958-967.
-
(2009)
N Engl J Med
, vol.361
, pp. 958-967
-
-
Rosell, R.1
Moran, T.2
Queralt, C.3
Porta, R.4
Cardenal, F.5
Camps, C.6
-
36
-
-
45749120442
-
Specific EGFR mutations predict treatment outcome of stage IIIB/IV patients with chemotherapy-naive non-small-cell lung cancer receiving first-line gefitinib monotherapy
-
Yang C.H., Yu C.J., Shih J.Y., Chang Y.C., Hu F.C., Tsai M.C., et al. Specific EGFR mutations predict treatment outcome of stage IIIB/IV patients with chemotherapy-naive non-small-cell lung cancer receiving first-line gefitinib monotherapy. J Clin Oncol 2008, 26:2745-2753.
-
(2008)
J Clin Oncol
, vol.26
, pp. 2745-2753
-
-
Yang, C.H.1
Yu, C.J.2
Shih, J.Y.3
Chang, Y.C.4
Hu, F.C.5
Tsai, M.C.6
-
37
-
-
77954584507
-
Neratinib, an irreversible pan-ErbB receptor tyrosine kinase inhibitor: results of a phase II trial in patients with advanced non-small-cell lung cancer
-
Sequist L.V., Besse B., Lynch T.J., Miller V.A., Wong K.K., Gitlitz B., et al. Neratinib, an irreversible pan-ErbB receptor tyrosine kinase inhibitor: results of a phase II trial in patients with advanced non-small-cell lung cancer. J Clin Oncol 2010, 28:3076-3083.
-
(2010)
J Clin Oncol
, vol.28
, pp. 3076-3083
-
-
Sequist, L.V.1
Besse, B.2
Lynch, T.J.3
Miller, V.A.4
Wong, K.K.5
Gitlitz, B.6
-
38
-
-
84859418112
-
The EGFR T790M mutation in acquired resistance to an irreversible second-generation EGFR inhibitor
-
Kim Y., Ko J., Cui Z., Abolhoda A., Ahn J.S., Ou S.H., et al. The EGFR T790M mutation in acquired resistance to an irreversible second-generation EGFR inhibitor. Mol Cancer Ther 2012, 11:784-791.
-
(2012)
Mol Cancer Ther
, vol.11
, pp. 784-791
-
-
Kim, Y.1
Ko, J.2
Cui, Z.3
Abolhoda, A.4
Ahn, J.S.5
Ou, S.H.6
-
39
-
-
77951643141
-
Amplification of EGFR T790M causes resistance to an irreversible EGFR inhibitor
-
Ercan D., Zejnullahu K., Yonesaka K., Xiao Y., Capelletti M., Rogers A., et al. Amplification of EGFR T790M causes resistance to an irreversible EGFR inhibitor. Oncogene 2010, 29:2346-2356.
-
(2010)
Oncogene
, vol.29
, pp. 2346-2356
-
-
Ercan, D.1
Zejnullahu, K.2
Yonesaka, K.3
Xiao, Y.4
Capelletti, M.5
Rogers, A.6
-
40
-
-
34249075147
-
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
-
Engelman J.A., Zejnullahu K., Mitsudomi T., Song Y., Hyland C., Park J.O., et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science 2007, 316:1039-1043.
-
(2007)
Science
, vol.316
, pp. 1039-1043
-
-
Engelman, J.A.1
Zejnullahu, K.2
Mitsudomi, T.3
Song, Y.4
Hyland, C.5
Park, J.O.6
-
41
-
-
38049150665
-
MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib
-
Bean J., Brennan C., Shih J.Y., Riely G., Viale A., Wang L., et al. MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib. Proc Natl Acad Sci U S A 2007, 104:20932-20937.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 20932-20937
-
-
Bean, J.1
Brennan, C.2
Shih, J.Y.3
Riely, G.4
Viale, A.5
Wang, L.6
-
42
-
-
0036141447
-
Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling
-
Chakravarti A., Loeffler J.S., Dyson N.J. Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling. Cancer Res 2002, 62:200-207.
-
(2002)
Cancer Res
, vol.62
, pp. 200-207
-
-
Chakravarti, A.1
Loeffler, J.S.2
Dyson, N.J.3
-
43
-
-
5144229336
-
Combined epidermal growth factor receptor targeting with the tyrosine kinase inhibitor gefitinib (ZD1839) and the monoclonal antibody cetuximab (IMC-C225): superiority over single-agent receptor targeting
-
Matar P., Rojo F., Cassia R., Moreno-Bueno G., Di Cosimo S., Tabernero J., et al. Combined epidermal growth factor receptor targeting with the tyrosine kinase inhibitor gefitinib (ZD1839) and the monoclonal antibody cetuximab (IMC-C225): superiority over single-agent receptor targeting. Clin Cancer Res 2004, 10:6487-6501.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 6487-6501
-
-
Matar, P.1
Rojo, F.2
Cassia, R.3
Moreno-Bueno, G.4
Di Cosimo, S.5
Tabernero, J.6
-
44
-
-
3442891161
-
Dual-agent molecular targeting of the epidermal growth factor receptor (EGFR): combining anti-EGFR antibody with tyrosine kinase inhibitor
-
Huang S., Armstrong E.A., Benavente S., Chinnaiyan P., Harari P.M. Dual-agent molecular targeting of the epidermal growth factor receptor (EGFR): combining anti-EGFR antibody with tyrosine kinase inhibitor. Cancer Res 2004, 64:5355-5362.
-
(2004)
Cancer Res
, vol.64
, pp. 5355-5362
-
-
Huang, S.1
Armstrong, E.A.2
Benavente, S.3
Chinnaiyan, P.4
Harari, P.M.5
-
45
-
-
79954586068
-
Phase I/II trial of cetuximab and erlotinib in patients with lung adenocarcinoma and acquired resistance to erlotinib
-
Janjigian Y.Y., Azzoli C.G., Krug L.M., Pereira L.K., Rizvi N.A., Pietanza M.C., et al. Phase I/II trial of cetuximab and erlotinib in patients with lung adenocarcinoma and acquired resistance to erlotinib. Clin Cancer Res 2011, 17:2521-2527.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 2521-2527
-
-
Janjigian, Y.Y.1
Azzoli, C.G.2
Krug, L.M.3
Pereira, L.K.4
Rizvi, N.A.5
Pietanza, M.C.6
-
46
-
-
70349684791
-
Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer
-
Regales L.G.Y., Shen R., de Stanchina E., Vivanco I., Goel A., Koutcher J.A., et al. Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer. J Clin Invest 2009, 119:3000-3010.
-
(2009)
J Clin Invest
, vol.119
, pp. 3000-3010
-
-
Regales, L.G.Y.1
Shen, R.2
de Stanchina, E.3
Vivanco, I.4
Goel, A.5
Koutcher, J.A.6
-
47
-
-
80052441453
-
Activity and tolerability of afatinib (BIBW 2992) and cetuximab in NSCLC patients with acquired resistance to erlotinib or gefitinib
-
(abstr 7525)
-
Janjigian Y.Y.H.J.G., Horn L., Smit E.F., Fu Y., Wang F., Shahidi M., et al. Activity and tolerability of afatinib (BIBW 2992) and cetuximab in NSCLC patients with acquired resistance to erlotinib or gefitinib. J Clin Oncol 2012, 29. (abstr 7525).
-
(2012)
J Clin Oncol
, vol.29
-
-
Janjigian, Y.Y.H.J.G.1
Horn, L.2
Smit, E.F.3
Fu, Y.4
Wang, F.5
Shahidi, M.6
-
48
-
-
77953394930
-
Enhanced anticancer effect of the combination of BIBW2992 and thymidylate synthase-targeted agents in non-small cell lung cancer with the T790M mutation of epidermal growth factor receptor
-
Takezawa K., Okamoto I., Tanizaki J., Kuwata K., Yamaguchi H., Fukuoka M., et al. Enhanced anticancer effect of the combination of BIBW2992 and thymidylate synthase-targeted agents in non-small cell lung cancer with the T790M mutation of epidermal growth factor receptor. Mol Cancer Ther 2010, 9:1647-1656.
-
(2010)
Mol Cancer Ther
, vol.9
, pp. 1647-1656
-
-
Takezawa, K.1
Okamoto, I.2
Tanizaki, J.3
Kuwata, K.4
Yamaguchi, H.5
Fukuoka, M.6
-
49
-
-
84879881139
-
Once-daily oral afatinib (A) combined with pemetrexed (P) in patients (pts) with advanced solid tumors: a phase I dose escalation trial
-
(abstr e13011)
-
Quincy C.R.S., Hotte S.J., Deng Q., Gyorffy S., Chand V.K., Hirte H.W. Once-daily oral afatinib (A) combined with pemetrexed (P) in patients (pts) with advanced solid tumors: a phase I dose escalation trial. J Clin Oncol 2012, 30. (abstr e13011).
-
(2012)
J Clin Oncol
, vol.30
-
-
Quincy, C.R.S.1
Hotte, S.J.2
Deng, Q.3
Gyorffy, S.4
Chand, V.K.5
Hirte, H.W.6
|