메뉴 건너뛰기




Volumn 31, Issue 27, 2013, Pages 3303-3306

Epidermal growth factor receptor inhibition in mutation-positive non-small-cell lung cancer: Is afatinib better or simply newer?

Author keywords

[No Author keywords available]

Indexed keywords

AFATINIB; CETUXIMAB; CISPLATIN; ERLOTINIB; GEFITINIB; GEMCITABINE; PEMETREXED; PLACEBO; PLATINUM; TAXANE DERIVATIVE;

EID: 84893080787     PISSN: 0732183X     EISSN: 15277755     Source Type: Journal    
DOI: 10.1200/JCO.2013.49.8782     Document Type: Review
Times cited : (59)

References (26)
  • 1
    • 84884736973 scopus 로고    scopus 로고
    • Phase iii study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with egfr mutations
    • Sequist LV, Yang JC-H, Yamamoto N, et al: Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations. J Clin Oncol 31:3327-3334, 2013.
    • (2013) J Clin Oncol , vol.31 , pp. 3327-3334
    • Sequist, L.V.1    Yang, J.C.-H.2    Yamamoto, N.3
  • 2
    • 69949162760 scopus 로고    scopus 로고
    • Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
    • Mok TS, Wu YL, Thongprasert S, et al: Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med 361:947-957, 2009.
    • (2009) N Engl J Med , vol.361 , pp. 947-957
    • Mok, T.S.1    Wu, Y.L.2    Thongprasert, S.3
  • 3
    • 84861976809 scopus 로고    scopus 로고
    • First-signal: First-line single-agent iressa versus gemcitabine and cisplatin trial in never-smokers with adenocarcinoma of the lung
    • Han JY, Park K, Kim SW, et al: First-SIGNAL: First-line single-agent Iressa versus gemcitabine and cisplatin trial in never-smokers with adenocarcinoma of the lung. J Clin Oncol 30:1122-1128, 2012.
    • (2012) J Clin Oncol , vol.30 , pp. 1122-1128
    • Han, J.Y.1    Park, K.2    Kim, S.W.3
  • 4
    • 75249087060 scopus 로고    scopus 로고
    • Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (wjtog3405): An open label, randomised phase 3 trial
    • Mitsudomi T, Morita S, Yatabe Y, et al: Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): An open label, randomised phase 3 trial. Lancet Oncol 11:121-128, 2010.
    • (2010) Lancet Oncol , vol.11 , pp. 121-128
    • Mitsudomi, T.1    Morita, S.2    Yatabe, Y.3
  • 5
    • 77953930730 scopus 로고    scopus 로고
    • Gefitinib or chemotherapy for non-small-cell lung cancer with mutated egfr
    • Maemondo M, Inoue A, Kobayashi K, et al: Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. N Engl J Med 362:2380-2388, 2010.
    • (2010) N Engl J Med , vol.362 , pp. 2380-2388
    • Maemondo, M.1    Inoue, A.2    Kobayashi, K.3
  • 6
    • 79960889662 scopus 로고    scopus 로고
    • Erlotinib versus chemotherapy as first-line treatment for patients with advanced egfr mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): A multicentre, open-label, randomised, phase 3 study
    • Zhou C, Wu YL, Chen G, et al: Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): A multicentre, open-label, randomised, phase 3 study. Lancet Oncol 12:735-742, 2011.
    • (2011) Lancet Oncol , vol.12 , pp. 735-742
    • Zhou, C.1    Wu, Y.L.2    Chen, G.3
  • 7
    • 84857502654 scopus 로고    scopus 로고
    • Erlotinib versus standard chemotherapy as first-line treatment for european patients with advanced egfr mutation-positive non-small-cell lung cancer (EURTAC): A multicentre, openlabel, randomised phase 3 trial
    • Rosell R, Carcereny E, Gervais R, et al: Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): A multicentre, openlabel, randomised phase 3 trial. Lancet Oncol 13:239-246, 2012.
    • (2012) Lancet Oncol , vol.13 , pp. 239-246
    • Rosell, R.1    Carcereny, E.2    Gervais, R.3
  • 8
    • 84884659258 scopus 로고    scopus 로고
    • Lux-lung 6: A randomized, open-label, phase iii study of afatinib (A) versus gemcitabine/cisplatin (GC) as first-line treatment for asian patients (pts) with egfr mutation-positive (EGFR M-) advanced adenocarcinoma of the lung
    • suppl; abstr 8016
    • Wu YL, Zhou C, Hu C-P, et al: LUX-Lung 6: A randomized, open-label, phase III study of afatinib (A) versus gemcitabine/cisplatin (GC) as first-line treatment for Asian patients (pts) with EGFR mutation-positive (EGFR M-) advanced adenocarcinoma of the lung. J Clin Oncol 31:490s, 2013 (suppl; abstr 8016).
    • (2013) J Clin Oncol , vol.31
    • Wu, Y.L.1    Zhou, C.2    Hu, C.-P.3
  • 9
    • 49049089802 scopus 로고    scopus 로고
    • Phase iii study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer
    • Scagliotti GV, Parikh P, von Pawel J, et al: Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer. J Clin Oncol 26:3543- 3551, 2008.
    • (2008) J Clin Oncol , vol.26 , pp. 3543-3551
    • Scagliotti, G.V.1    Parikh, P.2    Von Pawel, J.3
  • 10
    • 84857507055 scopus 로고    scopus 로고
    • Maintenance therapy with pemetrexed plus best supportive care versus placebo plus best supportive care after induction therapy with pemetrexed plus cisplatin for advanced nonsquamous non-small-cell lung cancer (PARAMOUNT): A double-blind, phase 3, randomised controlled trial
    • Paz-Ares L, de Marinis F, Dediu M, et al: Maintenance therapy with pemetrexed plus best supportive care versus placebo plus best supportive care after induction therapy with pemetrexed plus cisplatin for advanced nonsquamous non-small-cell lung cancer (PARAMOUNT): A double-blind, phase 3, randomised controlled trial. Lancet Oncol 13:247-255, 2012.
    • (2012) Lancet Oncol , vol.13 , pp. 247-255
    • Paz-Ares, L.1    De Marinis, F.2    Dediu, M.3
  • 11
    • 84884605223 scopus 로고    scopus 로고
    • Symptom control and quality of life in lux-lung 3: A phase iii study of afatinib or cisplatin/pemetrexed in patients with advanced lung adenocarcinoma with egfr mutations
    • Yang JC-H, Hirsh V, Schuler M, et al: Symptom control and quality of life in LUX-Lung 3: A phase III study of afatinib or cisplatin/pemetrexed in patients with advanced lung adenocarcinoma with EGFR mutations. J Clin Oncol 31:3342- 3350, 2013.
    • (2013) J Clin Oncol , vol.31 , pp. 3342-3350
    • Yang, J.C.-H.1    Hirsh, V.2    Schuler, M.3
  • 12
    • 84893090439 scopus 로고    scopus 로고
    • Response to erlotinib and prognosis for patients with de novo epidermal growth factor receptor (EGFR) T790m mutations
    • suppl; abstr 8018
    • Riely GJ, Yu HA, Arcila ME, et al: Response to erlotinib and prognosis for patients with de novo epidermal growth factor receptor (EGFR) T790M mutations. J Clin Oncol 31:490s, 2013 (suppl; abstr 8018).
    • (2013) J Clin Oncol , vol.31 , pp. 490
    • Riely, G.J.1    Yu, H.A.2    Arcila, M.E.3
  • 13
    • 84866756012 scopus 로고    scopus 로고
    • Overall survival (OS) results from optimal (CTONG0802), a phase iii trial of erlotinib (E) versus carboplatin plus gemcitabine (GC) as first-line treatment for chinese patients with egfr mutation-positive advanced non-small cell lung cancer (NSCLC)
    • suppl; abstr 7520
    • Zhou C, Wu YL, Liu X, et al: Overall survival (OS) results from OPTIMAL (CTONG0802), a phase III trial of erlotinib (E) versus carboplatin plus gemcitabine (GC) as first-line treatment for Chinese patients with EGFR mutation-positive advanced non-small cell lung cancer (NSCLC). J Clin Oncol 30:485s, 2012 (suppl; abstr 7520).
    • (2012) J Clin Oncol , vol.30 , pp. 485
    • Zhou, C.1    Wu, Y.L.2    Liu, X.3
  • 14
    • 84875912476 scopus 로고    scopus 로고
    • Updated overall survival results of wjtog 3405, a randomized phase iii trial comparing gefitinib (G) with cisplatin plus docetaxel (CD) as the first-line treatment for patients with non-small cell lung cancer harboring mutations of the epidermal growth factor receptor (EGFR)
    • suppl; abstr 7521
    • Mitsudomi T, Morita S, Yatabe Y, et al: Updated overall survival results of WJTOG 3405, a randomized phase III trial comparing gefitinib (G) with cisplatin plus docetaxel (CD) as the first-line treatment for patients with non-small cell lung cancer harboring mutations of the epidermal growth factor receptor (EGFR). J Clin Oncol 30:485s, 2012 (suppl; abstr 7521).
    • (2012) J Clin Oncol , vol.30
    • Mitsudomi, T.1    Morita, S.2    Yatabe, Y.3
  • 15
    • 77953541527 scopus 로고    scopus 로고
    • Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: A multicentre, randomised, placebo-controlled phase 3 study
    • Cappuzzo F, Ciuleanu T, Stelmakh L, et al: Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: A multicentre, randomised, placebo-controlled phase 3 study. Lancet Oncol 11:521-529, 2010.
    • (2010) Lancet Oncol , vol.11 , pp. 521-529
    • Cappuzzo, F.1    Ciuleanu, T.2    Stelmakh, L.3
  • 16
    • 69949186250 scopus 로고    scopus 로고
    • Screening for epidermal growth factor receptor mutations in lung cancer
    • Rosell R, Moran T, Queralt C, et al: Screening for epidermal growth factor receptor mutations in lung cancer. N Engl J Med 361:958-967, 2009.
    • (2009) N Engl J Med , vol.361 , pp. 958-967
    • Rosell, R.1    Moran, T.2    Queralt, C.3
  • 17
    • 49149118719 scopus 로고    scopus 로고
    • Bibw2992, an irreversible egfr/her2 inhibitor highly effective in preclinical lung cancer models
    • Li D, Ambrogio L, Shimamura T, et al: BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models. Oncogene 27:4702-4711, 2008.
    • (2008) Oncogene , vol.27 , pp. 4702-4711
    • Li, D.1    Ambrogio, L.2    Shimamura, T.3
  • 18
    • 84867621201 scopus 로고    scopus 로고
    • Target binding properties and cellular activity of afatinib (bibw 2992), an irreversible erbb family blocker
    • Solca F, Dahl G, Zoephel A, et al: Target binding properties and cellular activity of afatinib (BIBW 2992), an irreversible ErbB family blocker. J Pharmacol Exp Ther 343:342-350, 2012.
    • (2012) J Pharmacol Exp Ther , vol.343 , pp. 342-350
    • Solca, F.1    Dahl, G.2    Zoephel, A.3
  • 19
    • 84884618137 scopus 로고    scopus 로고
    • Lux-lung 4: A phase ii trial of afatinib in patients with advanced non-small-cell lung cancer who progressed during prior treatment with erlotinib, gefitinib, or both
    • Katakami N, Atagi S, Goto K, et al: LUX-Lung 4: A phase II trial of afatinib in patients with advanced non-small-cell lung cancer who progressed during prior treatment with erlotinib, gefitinib, or both. J Clin Oncol 31:3335-3341, 2013.
    • (2013) J Clin Oncol , vol.31 , pp. 3335-3341
    • Katakami, N.1    Atagi, S.2    Goto, K.3
  • 20
    • 84862785051 scopus 로고    scopus 로고
    • Afatinib versus placebo for patients with advanced, metastatic non-small-cell lung cancer after failure of erlotinib, gefitinib, or both, and one or two lines of chemotherapy (LUX-Lung 1): A phase 2b/3 randomised trial
    • Miller VA, Hirsh V, Cadranel J, et al: Afatinib versus placebo for patients with advanced, metastatic non-small-cell lung cancer after failure of erlotinib, gefitinib, or both, and one or two lines of chemotherapy (LUX-Lung 1): A phase 2b/3 randomised trial. Lancet Oncol 13:528-538, 2012.
    • (2012) Lancet Oncol , vol.13 , pp. 528-538
    • Miller, V.A.1    Hirsh, V.2    Cadranel, J.3
  • 21
    • 74949110711 scopus 로고    scopus 로고
    • Clinical definition of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer
    • Jackman D, Pao W, Riely GJ, et al: Clinical definition of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer. J Clin Oncol 28:357-360, 2010.
    • (2010) J Clin Oncol , vol.28 , pp. 357-360
    • Jackman, D.1    Pao, W.2    Riely, G.J.3
  • 22
    • 33750302365 scopus 로고    scopus 로고
    • Analysis of epidermal growth factor receptor gene mutation in patients with non-small cell lung cancer and acquired resistance to gefitinib
    • DOI 10.1158/1078-0432.CCR-06-0714
    • Kosaka T, Yatabe Y, Endoh H, et al: Analysis of epidermal growth factor receptor gene mutation in patients with non-small cell lung cancer and acquired resistance to gefitinib. Clin Cancer Res 12:5764-5769, 2006. (Pubitemid 44629607)
    • (2006) Clinical Cancer Research , vol.12 , Issue.19 , pp. 5764-5769
    • Kosaka, T.1    Yatabe, Y.2    Endoh, H.3    Yoshida, K.4    Hida, T.5    Tsuboi, M.6    Tada, H.7    Kuwano, H.8    Mitsudomi, T.9
  • 24
    • 84870813984 scopus 로고    scopus 로고
    • Activity and tolerability of combined egfr targeting with afatinib (BIBW 2992) and cetuximab in T790m- NSCLC patients
    • Amsterdam, the Netherlands, July 3-7, (abstr O19.07
    • Horn L, Groen H, Smit E, et al: Activity and tolerability of combined EGFR targeting with afatinib (BIBW 2992) and cetuximab in T790M- NSCLC patients. 14th World Conference on Lung Cancer, Amsterdam, the Netherlands, July 3-7, 2011 (abstr O19.07).
    • (2011) 14th World Conference on Lung Cancer
    • Horn, L.1    Groen, H.2    Smit, E.3
  • 25
    • 80052441453 scopus 로고    scopus 로고
    • Activity and tolerability of afatinib (bibw 2992) and cetuximab in nsclc patients with acquired resistance to erlotinib or gefitinib
    • suppl; abstr 7525
    • Janjigian Y, Groen HJ, Horn L: Activity and tolerability of afatinib (BIBW 2992) and cetuximab in NSCLC patients with acquired resistance to erlotinib or gefitinib. J Clin Oncol 29:482s, 2011 (suppl; abstr 7525).
    • (2011) J Clin Oncol , vol.29
    • Janjigian, Y.1    Groen, H.J.2    Horn, L.3
  • 26
    • 79957449411 scopus 로고    scopus 로고
    • National Comprehensive Cancer Network, Fort Washington, v. 2.2013, PA
    • National Comprehensive Cancer Network: NCCN guidelines: Non-small cell lung cancer, v. 2.2013. National Comprehensive Cancer Network, Fort Washington, PA, 2013. http://www.nccn.org/professionals/physician-gls/f-guidelines.asp.
    • (2013) NCCN Guidelines: Non-small Cell Lung Cancer


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.