메뉴 건너뛰기




Volumn 12, Issue 5, 2013, Pages 589-597

Afatinib prolongs survival compared with gefitinib in an epidermal growth factor receptor-driven lung cancer model

Author keywords

[No Author keywords available]

Indexed keywords

AFATINIB; BEVACIZUMAB; EPIDERMAL GROWTH FACTOR; GEFITINIB;

EID: 84877660788     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-12-0885     Document Type: Article
Times cited : (66)

References (33)
  • 1
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch TJ, Bell DW, Sordella R, Gurubhagavatula S, Okimoto RA, Brannigan BW, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 2004;350:2129-39.
    • (2004) N Engl J Med , vol.350 , pp. 2129-2139
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3    Gurubhagavatula, S.4    Okimoto, R.A.5    Brannigan, B.W.6
  • 2
    • 2342624080 scopus 로고    scopus 로고
    • EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
    • Paez JG, Janne PA, Lee JC, Tracy S, Greulich H, Gabriel S, et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 2004;304:1497-500.
    • (2004) Science , vol.304 , pp. 1497-1500
    • Paez, J.G.1    Janne, P.A.2    Lee, J.C.3    Tracy, S.4    Greulich, H.5    Gabriel, S.6
  • 3
    • 4444344330 scopus 로고    scopus 로고
    • EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib
    • Pao W, Miller V, Zakowski M, Doherty J, Politi K, Sarkaria I, et al. EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc Natl Acad Sci U S A 2004;101:13306-11.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 13306-13311
    • Pao, W.1    Miller, V.2    Zakowski, M.3    Doherty, J.4    Politi, K.5    Sarkaria, I.6
  • 4
    • 74549114727 scopus 로고    scopus 로고
    • Epidermal growth factor receptor in relation to tumor development: EGFR gene and cancer
    • Mitsudomi T, Yatabe Y. Epidermal growth factor receptor in relation to tumor development: EGFR gene and cancer. FEBS J 2010;277:301-8.
    • (2010) FEBS J , vol.277 , pp. 301-308
    • Mitsudomi, T.1    Yatabe, Y.2
  • 7
    • 79960889662 scopus 로고    scopus 로고
    • Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): A multicentre, open-label, randomised, phase 3 study
    • Zhou C, Wu YL, Chen G, Feng J, Liu XQ, Wang C, et al. Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study. Lancet Oncol 2011;12:735-42.
    • (2011) Lancet Oncol , vol.12 , pp. 735-742
    • Zhou, C.1    Wu, Y.L.2    Chen, G.3    Feng, J.4    Liu, X.Q.5    Wang, C.6
  • 8
    • 84857502654 scopus 로고    scopus 로고
    • Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-smallcell lung cancer (EURTAC): A multicentre, open-label, randomised phase 3 trial
    • Rosell R, Carcereny E, Gervais R, Vergnenegre A, Massuti B, Felip E, et al. Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-smallcell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial. Lancet Oncol 2012;13:239-46.
    • (2012) Lancet Oncol , vol.13 , pp. 239-246
    • Rosell, R.1    Carcereny, E.2    Gervais, R.3    Vergnenegre, A.4    Massuti, B.5    Felip, E.6
  • 9
    • 69949186250 scopus 로고    scopus 로고
    • Screening for epidermal growth factor receptor mutations in lung cancer
    • Rosell R, Moran T, Queralt C, Porta R, Cardenal F, Camps C, et al. Screening for epidermal growth factor receptor mutations in lung cancer. N Engl J Med 2009;361:958-67.
    • (2009) N Engl J Med , vol.361 , pp. 958-967
    • Rosell, R.1    Moran, T.2    Queralt, C.3    Porta, R.4    Cardenal, F.5    Camps, C.6
  • 10
    • 80054964152 scopus 로고    scopus 로고
    • Comparison of clinical outcome of patients with non-small-cell lung cancer harbouring epidermal growth factor receptor exon 19 or exon 21 mutations
    • Won YW, Han JY, Lee GK, Park SY, Lim KY, Yoon KA, et al. Comparison of clinical outcome of patients with non-small-cell lung cancer harbouring epidermal growth factor receptor exon 19 or exon 21 mutations. J Clin Pathol 2011;64:947-52.
    • (2011) J Clin Pathol , vol.64 , pp. 947-952
    • Won, Y.W.1    Han, J.Y.2    Lee, G.K.3    Park, S.Y.4    Lim, K.Y.5    Yoon, K.A.6
  • 11
    • 33746789922 scopus 로고    scopus 로고
    • Prospective phase II study of gefitinib for chemotherapynaive patients with advanced non-small-cell lung cancer with epidermal growth factor receptor gene mutations
    • Inoue A, Suzuki T, Fukuhara T, Maemondo M, Kimura Y, Morikawa N, et al. Prospective phase II study of gefitinib for chemotherapynaive patients with advanced non-small-cell lung cancer with epidermal growth factor receptor gene mutations. J Clin Oncol 2006; 24:3340-6.
    • (2006) J Clin Oncol , vol.24 , pp. 3340-3346
    • Inoue, A.1    Suzuki, T.2    Fukuhara, T.3    Maemondo, M.4    Kimura, Y.5    Morikawa, N.6
  • 13
    • 18244371651 scopus 로고    scopus 로고
    • Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
    • Pao W, Miller VA, Politi KA, Riely GJ, Somwar R, Zakowski MF, et al. Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med 2005;2:e73.
    • (2005) PLoS Med , vol.2
    • Pao, W.1    Miller, V.A.2    Politi, K.A.3    Riely, G.J.4    Somwar, R.5    Zakowski, M.F.6
  • 14
    • 34548009812 scopus 로고    scopus 로고
    • Emergence of epidermal growth factor receptor T790M mutation during chronic exposure to gefitinib in a non small cell lung cancer cell line
    • Ogino A, Kitao H, Hirano S, Uchida A, Ishiai M, Kozuki T, et al. Emergence of epidermal growth factor receptor T790M mutation during chronic exposure to gefitinib in a non small cell lung cancer cell line. Cancer Res 2007;67:7807-14.
    • (2007) Cancer Res , vol.67 , pp. 7807-7814
    • Ogino, A.1    Kitao, H.2    Hirano, S.3    Uchida, A.4    Ishiai, M.5    Kozuki, T.6
  • 15
    • 58149333768 scopus 로고    scopus 로고
    • Acquired resistance to epidermal growth factor receptor kinase inhibitors associated with a novel T854A mutation in a patient with EGFRmutant lung adenocarcinoma
    • Bean J, Riely GJ, Balak M, Marks JL, Ladanyi M, Miller VA, et al. Acquired resistance to epidermal growth factor receptor kinase inhibitors associated with a novel T854A mutation in a patient with EGFRmutant lung adenocarcinoma. Clin Cancer Res 2008;14:7519-25.
    • (2008) Clin Cancer Res , vol.14 , pp. 7519-7525
    • Bean, J.1    Riely, G.J.2    Balak, M.3    Marks, J.L.4    Ladanyi, M.5    Miller, V.A.6
  • 16
    • 38049150665 scopus 로고    scopus 로고
    • MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib
    • Bean J, Brennan C, Shih JY, Riely G, Viale A, Wang L, et al. MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib. Proc Natl Acad Sci U S A 2007;104:20932-7.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 20932-20937
    • Bean, J.1    Brennan, C.2    Shih, J.Y.3    Riely, G.4    Viale, A.5    Wang, L.6
  • 17
    • 34249075147 scopus 로고    scopus 로고
    • MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
    • Engelman JA, Zejnullahu K, Mitsudomi T, Song Y, Hyland C, Park JO, et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science 2007;316:1039-43.
    • (2007) Science , vol.316 , pp. 1039-1043
    • Engelman, J.A.1    Zejnullahu, K.2    Mitsudomi, T.3    Song, Y.4    Hyland, C.5    Park, J.O.6
  • 18
    • 33947207989 scopus 로고    scopus 로고
    • Lung cancer cell lines harboring MET gene amplification are dependent on Met for growth and survival
    • Lutterbach B, Zeng Q, Davis LJ, Hatch H, Hang G, Kohl NE, et al. Lung cancer cell lines harboring MET gene amplification are dependent on Met for growth and survival. Cancer Res 2007;67:2081-8.
    • (2007) Cancer Res , vol.67 , pp. 2081-2088
    • Lutterbach, B.1    Zeng, Q.2    Davis, L.J.3    Hatch, H.4    Hang, G.5    Kohl, N.E.6
  • 19
    • 49149118719 scopus 로고    scopus 로고
    • BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models
    • Li D, Ambrogio L, Shimamura T, Kubo S, Takahashi M, Chirieac LR, et al. BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models. Oncogene 2008;27:4702-11.
    • (2008) Oncogene , vol.27 , pp. 4702-4711
    • Li, D.1    Ambrogio, L.2    Shimamura, T.3    Kubo, S.4    Takahashi, M.5    Chirieac, L.R.6
  • 20
    • 79957936388 scopus 로고    scopus 로고
    • How genetically engineered mouse tumor models provide insights into human cancers
    • Politi K, Pao W. How genetically engineered mouse tumor models provide insights into human cancers. J Clin Oncol 2011;29:2273-81.
    • (2011) J Clin Oncol , vol.29 , pp. 2273-2281
    • Politi, K.1    Pao, W.2
  • 21
    • 58849132314 scopus 로고    scopus 로고
    • HER2-YVMA drives rapid development of adenosquamous lung tumors in mice that are sensitive to BIBW2992 and rapamycin combination therapy
    • Perera SA, Li D, Shimamura T, Raso MG, Ji H, Chen L, et al. HER2-YVMA drives rapid development of adenosquamous lung tumors in mice that are sensitive to BIBW2992 and rapamycin combination therapy. Proc Natl Acad Sci U S A 2009;106:474-9.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 474-479
    • Perera, S.A.1    Li, D.2    Shimamura, T.3    Raso, M.G.4    Ji, H.5    Chen, L.6
  • 22
    • 70349684791 scopus 로고    scopus 로고
    • Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer
    • Regales L, Gong Y, Shen R, de Stanchina E, Vivanco I, Goel A, et al. Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer. J Clin Invest 2009;119:3000-10.
    • (2009) J Clin Invest , vol.119 , pp. 3000-3010
    • Regales, L.1    Gong, Y.2    Shen, R.3    De Stanchina, E.4    Vivanco, I.5    Goel, A.6
  • 23
    • 77953394930 scopus 로고    scopus 로고
    • Enhanced anticancer effect of the combination of BIBW2992 and thymidylate synthase-targeted agents in non-small cell lung cancer with the T790M mutation of epidermal growth factor receptor
    • Takezawa K, Okamoto I, Tanizaki J, Kuwata K, Yamaguchi H, Fukuoka M, et al. Enhanced anticancer effect of the combination of BIBW2992 and thymidylate synthase-targeted agents in non-small cell lung cancer with the T790M mutation of epidermal growth factor receptor. Mol Cancer Ther 2010;9:1647-56.
    • (2010) Mol Cancer Ther , vol.9 , pp. 1647-1656
    • Takezawa, K.1    Okamoto, I.2    Tanizaki, J.3    Kuwata, K.4    Yamaguchi, H.5    Fukuoka, M.6
  • 24
    • 76249108622 scopus 로고    scopus 로고
    • Chemogenomic profiling provides insights into the limited activity of irreversible EGFR inhibitors in tumor cells expressing the T790M EGFR resistance mutation
    • Sos ML, Rode HB, Heynck S, Peifer M, Fischer F, Kluter S, et al. Chemogenomic profiling provides insights into the limited activity of irreversible EGFR inhibitors in tumor cells expressing the T790M EGFR resistance mutation. Cancer Res 2010;70:868-74.
    • (2010) Cancer Res , vol.70 , pp. 868-874
    • Sos, M.L.1    Rode, H.B.2    Heynck, S.3    Peifer, M.4    Fischer, F.5    Kluter, S.6
  • 25
    • 67449138855 scopus 로고    scopus 로고
    • Effects of vandetanib on lung adenocarcinoma cells harboring epidermal growth factor receptor T790M mutation in vivo
    • Ichihara E, Ohashi K, Takigawa N, Osawa M, Ogino A, Tanimoto M, et al. Effects of vandetanib on lung adenocarcinoma cells harboring epidermal growth factor receptor T790M mutation in vivo. Cancer Res 2009;69:5091-8.
    • (2009) Cancer Res , vol.69 , pp. 5091-5098
    • Ichihara, E.1    Ohashi, K.2    Takigawa, N.3    Osawa, M.4    Ogino, A.5    Tanimoto, M.6
  • 26
    • 2642570481 scopus 로고    scopus 로고
    • Sensitivity to gefitinib (Iressa, ZD1839) in non-small cell lung cancer cell lines correlates with dependence on the epidermal growth factor (EGF) receptor/extracellular signal-regulated kinase 1/2 and EGF receptor/Akt pathway for proliferation
    • Ono M, Hirata A, Kometani T, Miyagawa M, Ueda S, Kinoshita H, et al. Sensitivity to gefitinib (Iressa, ZD1839) in non-small cell lung cancer cell lines correlates with dependence on the epidermal growth factor (EGF) receptor/extracellular signal-regulated kinase 1/2 and EGF receptor/Akt pathway for proliferation. Mol Cancer Ther 2004;3: 465-72.
    • (2004) Mol Cancer Ther , vol.3 , pp. 465-472
    • Ono, M.1    Hirata, A.2    Kometani, T.3    Miyagawa, M.4    Ueda, S.5    Kinoshita, H.6
  • 27
    • 4143066760 scopus 로고    scopus 로고
    • Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways
    • Sordella R, Bell DW, Haber DA, Settleman J. Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways. Science 2004;305:1163-7.
    • (2004) Science , vol.305 , pp. 1163-1167
    • Sordella, R.1    Bell, D.W.2    Haber, D.A.3    Settleman, J.4
  • 28
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
    • Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983;65:55-63.
    • (1983) J Immunol Methods , vol.65 , pp. 55-63
    • Mosmann, T.1
  • 29
    • 50149108795 scopus 로고    scopus 로고
    • Induction of lung adenocarcinoma in transgenic mice expressing activated EGFR driven by the SP-C promoter
    • Ohashi K, Rai K, Fujiwara Y, Osawa M, Hirano S, Takata K, et al. Induction of lung adenocarcinoma in transgenic mice expressing activated EGFR driven by the SP-C promoter. Cancer Sci 2008;99: 1747-53.
    • (2008) Cancer Sci , vol.99 , pp. 1747-1753
    • Ohashi, K.1    Rai, K.2    Fujiwara, Y.3    Osawa, M.4    Hirano, S.5    Takata, K.6
  • 30
    • 70149105488 scopus 로고    scopus 로고
    • Chemopreventive effects of gefitinib on nonsmoking-related lung tumorigenesis in activating epidermal growth factor receptor transgenic mice
    • Ohashi K, Takigawa N, Osawa M, Ichihara E, Takeda H, Kubo T, et al. Chemopreventive effects of gefitinib on nonsmoking-related lung tumorigenesis in activating epidermal growth factor receptor transgenic mice. Cancer Res 2009;69:7088-95.
    • (2009) Cancer Res , vol.69 , pp. 7088-7095
    • Ohashi, K.1    Takigawa, N.2    Osawa, M.3    Ichihara, E.4    Takeda, H.5    Kubo, T.6
  • 32
    • 84862785051 scopus 로고    scopus 로고
    • Afatinib versus placebo for patients with advanced, metastatic non-small-cell lung cancer after failure of erlotinib, gefitinib, or both, and one or two lines of chemotherapy (LUX-Lung 1): A phase 2b/3 randomised trial
    • Miller VA, Hirsh V, Cadranel J, Chen YM, Park K, Kim SW, et al. Afatinib versus placebo for patients with advanced, metastatic non-small-cell lung cancer after failure of erlotinib, gefitinib, or both, and one or two lines of chemotherapy (LUX-Lung 1): a phase 2b/3 randomised trial. Lancet Oncol 2012;13:528-38.
    • (2012) Lancet Oncol , vol.13 , pp. 528-538
    • Miller, V.A.1    Hirsh, V.2    Cadranel, J.3    Chen, Y.M.4    Park, K.5    Kim, S.W.6
  • 33
    • 80052441453 scopus 로고    scopus 로고
    • Activity and tolerability of afatinib (BIBW 2992) and cetuximab in NSCLC patients with acquired resistance to erlotinib or gefitinib
    • (abstr 7525)
    • Janjigian YY, Groen HJ, Horn L, Smit EF, Fu Y, Wang F, et al. Activity and tolerability of afatinib (BIBW 2992) and cetuximab in NSCLC patients with acquired resistance to erlotinib or gefitinib. J Clin Oncol 29: 2011 (suppl; abstr 7525).
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Janjigian, Y.Y.1    Groen, H.J.2    Horn, L.3    Smit, E.F.4    Fu, Y.5    Wang, F.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.