Dual-energy micro-CT functional imaging of primary lung cancer in mice using gold and iodine nanoparticle contrast agents: A validation study

PLoS ONE

Volumn 9, Issue 2, 2014, Pages

  Ashton, Jeffrey R ^a,c   Clark, Darin P ^a,c   Moding, Everett J ^a   Ghaghada, Ketan ^b   Kirsch, David G ^a   West, Jennifer L ^c   Badea, Cristian T ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b TEXAS CHILDREN S HOSPITAL   (United States)

^c Duke University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONTRAST MEDIUM; GOLD NANOPARTICLE; IODINE; IODINE NANOPARTICLE; NANOPARTICLE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL PERMEABILITY; BLOOD VOLUME; COMPUTER ASSISTED TOMOGRAPHY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG TISSUE LEVEL; DUAL ENERGY COMPUTED TOMOGRAPHY; FLAME PHOTOMETRY; HISTOLOGY; IN VIVO STUDY; KIDNEY; LIVER; LUNG CANCER; MOUSE; NEOPLASM; NONHUMAN; SINGLE ENERGY COMPUTED TOMOGRAPHY; SPLEEN; TISSUE CHARACTERIZATION; TUMOR BLOOD VOLUME; TUMOR VOLUME; VALIDATION STUDY;

ANIMALS; BLOOD VOLUME; CONTRAST MEDIA; GOLD; IODINE; LIPOSOMES; LUNG; LUNG NEOPLASMS; MICE; MICROVESSELS; NANOPARTICLES; REPRODUCIBILITY OF RESULTS; TUMOR BURDEN; TUMOR MARKERS, BIOLOGICAL; X-RAY MICROTOMOGRAPHY;

EID: 84895758037     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0088129     Document Type: Article

References (47)

1. Jemal A, Thun MJ, Ries LAG, Howe HL,Weir HK, et al. (2008) Annual Report to the Nation on the Status of Cancer, 1975-2005, Featuring Trends in Lung Cancer, Tobacco Use, and Tobacco Control. Journal of the National Cancer Institute 100: 1672-1694.
2. Markowitz SB, Miller A, Miller J, Manowitz A, Kieding S, et al. (2007) Ability of low-dose helical CT to distinguish between benign and malignant noncalcified lung nodules. Chest 131: 1028-1034. (Pubitemid 46608703)
3. Kramer BS, Berg CD, Aberle DR, Prorok PC (2011) Lung cancer screening with low-dose helical CT: results from the National Lung Screening Trial (NLST). J Med Screen 18: 109-111.
4. Hodnett PA, Ko JP (2012) Evaluation and management of indeterminate pulmonary nodules. Radiol Clin North Am 50: 895-914.
5. Goel S, Duda DG, Xu L, Munn LL, Boucher Y, et al. (2011) Normalization of the vasculature for treatment of cancer and other diseases. Physiol Rev 91: 1071-1121.
6. Meert AP, Paesmans M, Martin B, Delmotte P, Berghmans T, et al. (2002) The role of microvessel density on the survival of patients with lung cancer: a systematic review of the literature with meta-analysis. Br J Cancer 87: 694-701. (Pubitemid 35178743)
7. Tateishi U (2005) Vascular endothelial growth factor-related angiogenesis. Radiology 235: 1084; author reply 1084-1085.
8. Badea CT, Athreya KK, Espinosa G, Clark D, Ghafoori AP, et al. (2012) Computed tomography imaging of primary lung cancer in mice using a liposomal-iodinated contrast agent. PloS one 7: e34496.
9. Fornaro J, Leschka S, Hibbeln D, Butler A, Anderson N, et al. (2011) Dual- and multi-energy CT: approach to functional imaging. Insights Imaging 2: 149-159.
10. Schmid-Bindert G, Henzler T, Chu TQ, Meyer M, Nance JW, et al. (2012) Functional imaging of lung cancer using dual energy CT: how does iodine related attenuation correlate with standardized uptake value of 18FDG-PETCT? European radiology 22: 93-103.
11. Fink C, Henzler T, Chu TQ, Meyer M, Apfaltrer P, et al. (2011) Functional Imaging of Lung Cancer Using Dual Energy Ct: How Does Iodine Related Attenuation Correlate with Standardized Uptake Vlaue of 18fdg-Pet-Ct? Journal of Thoracic Oncology 6: S1139-S1139.
12. Ashton JR, Befera N, Clark D, Qi Y, Mao L, et al. (2013) Anatomical and functional imaging of myocardial infarction in mice using micro-CT and eXIA 160 contrast agent. Contrast Media & Molecular Imaging: In press.
13. Badea CT, Guo X, Clark D, Johnston SM, Marshall CD, et al. (2012) Dual-energy micro-CT of the rodent lung. American Journal of Physiology-Lung Cellular and Molecular Physiology 302: L1088-L1097.
14. Clark DP, Ghaghada K, Moding EJ, Kirsch DG, Badea CT (2013) In vivo characterization of tumor vasculature using iodine and gold nanoparticles and dual energy micro-CT. Physics in Medicine and Biology 58: 1683-1704.
15. Moding EJ, Clark DP, Qi Y, Li Y, Ma Y, et al. (2013) Dual-energy microcomputed tomography imaging of radiation-induced vascular changes in primary mouse sarcomas. Int J Radiat Oncol Biol Phys 85: 1353-1359.
16. Bourin M, Jolliet P, Ballereau F (1997) An overview of the clinical pharmacokinetics of x-ray contrast media. Clin Pharmacokinet 32: 180-193. (Pubitemid 27122519)
17. Maeda H (2001) The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting. Advances in enzyme regulation 41: 189-207.
18. Au JT, Craig G, Longo V, Zanzonico P, Mason M, et al. (2013) Gold nanoparticles provide bright long-lasting vascular contrast for CT imaging. AJR Am J Roentgenol 200: 1347-1351.
19. Danila D, Johnson E, Kee P (2013) CT imaging of myocardial scars with collagen-targeting gold nanoparticles. Nanomedicine.
20. Ghann WE, Aras O, Fleiter T, Daniel MC (2012) Syntheses and characterization of lisinopril-coated gold nanoparticles as highly stable targeted CT contrast agents in cardiovascular diseases. Langmuir 28: 10398-10408.
21. Badea C, Johnston S, Qi Y, Ghaghada K, Johnson G (2011) Dual-energy micro-CT imaging for differentiation of iodine-and gold-based nanoparticles. Proceedings of SPIE 7961: 79611X.
22. Hainfeld JF, O'Connor MJ, Dilmanian FA, Slatkin DN, Adams DJ, et al. (2011) Micro-CT enables microlocalisation and quantification of Her2-targeted gold nanoparticles within tumour regions. Br J Radiol 84: 526-533.
23. Cormode DP, Roessl E, Thran A, Skajaa T, Gordon RE, et al. (2010) Atherosclerotic Plaque Composition: Analysis with Multicolor CT and Targeted Gold Nanoparticles. Radiology 256: 774-782.
24. Zheng J, Allen C, Serra S, Vines D, Charron M, et al. (2010) Liposome contrast agent for CT-based detection and localization of neoplastic and inflammatory lesions in rabbits: validation with FDG-PET and histology. Contrast Media Mol Imaging 5: 147-154.
25. Mukundan Jr S, Ghaghada KB, Badea CT, Kao CY, Hedlund LW, et al. (2006) A liposomal nanoscale contrast agent for preclinical CT in mice. American Journal of Roentgenology 186: 300.
26. Frens G (1973) Controlled Nucleation for Regulation of Particle-Size in Monodisperse Gold Suspensions. Nature-Physical Science 241: 20-22.
27. Haiss W, Thanh NT, Aveyard J, Fernig DG (2007) Determination of size and concentration of gold nanoparticles from UV-vis spectra. Anal Chem 79: 4215-4221. (Pubitemid 46903175)
28. Kirsch DG, Grimm J, Guimaraes AR, Wojtkiewicz GR, Perez BA, et al. (2010) Imaging primary lung cancers in mice to study radiation biology. International journal of radiation oncology, biology, physics 76: 973-977.
29. Jackson EL, Olive KP, Tuveson DA, Bronson R, Crowley D, et al. (2005) The differential effects of mutant p53 alleles on advanced murine lung cancer. Cancer research 65: 10280-10288. (Pubitemid 41743720)
30. Johnson L, Mercer K, Greenbaum D, Bronson RT, Crowley D, et al. (2001) Somatic activation of the K-ras oncogene causes early onset lung cancer in mice. Nature 410: 1111-1116. (Pubitemid 32391044)
31. Badea CT, Johnston S, Johnson B, Lin M, Hedlund LW, et al. (2008) A dual micro-CT system for small animal imaging. Proceedings of SPIE 6913: 691342.
32. Badea C, Hedlund LW, Johnson GA (2004) Micro-CT with respiratory and cardiac gating. Medical Physics 31: 3324-3329. (Pubitemid 40064984)
33. Feldkamp LA, Davis LC, Kress JW (1984) Practical cone-beam algorithm. J Opt Soc Am 1: 612-619.
34. Avants BB, Tustison NJ, Song G, Cook PA, Klein A, et al. (2011) A reproducible evaluation of ANTs similarity metric performance in brain image registration. NeuroImage 54: 2033-2044.
35. Hermosillo G, Chefd'Hotel C, Faugeras O (2002) Variational methods for multimodal image matching. International Journal of Computer Vision 50: 329-343.
36. Clark D, Johnson GA, Badea CT (2012) Denoising of 4D Cardiac Micro-CT Data Using Median-Centric Bilateral Filtration. Medical Imaging 2012: Image Processing 8314.
37. Badea CT, Johnston SM, Qi Y, Ghaghada K, Johnson GA (2011) Dual energy micro-CT imaging for differentiation of iodine and gold-based nanoparticles. Medical Imaging 2011: Physics of Medical Imaging 7961.
38. Perrault SD, Walkey C, Jennings T, Fischer HC, Chan WC (2009) Mediating tumor targeting efficiency of nanoparticles through design. Nano Lett 9: 1909-1915.
39. Toy R, Hayden E, Camann A, Berman Z, Vicente P, et al. (2013) Multimodal in vivo imaging exposes the voyage of nanoparticles in tumor microcirculation. ACS Nano 7: 3118-3129.
40. Karathanasis E, Suryanarayanan S, Balusu SR, McNeeley K, Sechopoulos I, et al. (2009) Imaging Nanoprobe for Prediction of Outcome of Nanoparticle Chemotherapy by Using Mammography. Radiology 250: 398-406.
41. Song L, Ho VH, Chen C, Yang Z, Liu D, et al. (2013) Efficient, pH-triggered drug delivery using a pH-responsive DNA-conjugated gold nanoparticle. Adv Healthc Mater 2: 275-280.
42. Kim D, Jeong YY, Jon S (2010) A drug-loaded aptamer-gold nanoparticle bioconjugate for combined CT imaging and therapy of prostate cancer. ACS Nano 4: 3689-3696.
43. Duncan B, Kim C, Rotello VM (2010) Gold nanoparticle platforms as drug and biomacromolecule delivery systems. J Control Release 148: 122-127.
44. Kennedy LC, Bickford LR, Lewinski NA, Coughlin AJ, Hu Y, et al. (2011) A new era for cancer treatment: gold-nanoparticle-mediated thermal therapies. Small 7: 169-183.
45. Hainfeld JF, Dilmanian FA, Zhong Z, Slatkin DN, Kalef-Ezra JA, et al. (2010) Gold nanoparticles enhance the radiation therapy of a murine squamous cell carcinoma. Phys Med Biol 55: 3045-3059.
46. Rygh CB, Qin S, Seo JW, Mahakian LM, Zhang H, et al. (2011) Longitudinal investigation of permeability and distribution of macromolecules in mouse malignant transformation using PET. Clinical cancer research : an official journal of the American Association for Cancer Research 17: 550-559.
47. Karathanasis E, Chan L, Karumbaiah L, McNeeley K, D'Orsi CJ, et al. (2009) Tumor vascular permeability to a nanoprobe correlates to tumor-specific expression levels of angiogenic markers. PLoS One 4: e5843.