Gold nanoparticles provide bright long-lasting vascular contrast for CT imaging

American Journal of Roentgenology

Volumn 200, Issue 6, 2013, Pages 1347-1351

  Au, Joyce T ^a   Craig, Gary ^b   Longo, Valerie ^a   Zanzonico, Pat ^a   Mason, Michael ^b   Fong, Yuman ^a   Allen, Peter J ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b University of Maine   (United States)

Author keywords

Gold; Imaging; Interventional procedure; Nanotechnology; Vascular surgery

Indexed keywords

CONTINUOUS ERYTHROPOIESIS RECEPTOR ACTIVATOR; GOLD NANOPARTICLE; IODINATED CONTRAST MEDIUM; CONTRAST MEDIUM; GADOLINIUM; GOLD; METAL NANOPARTICLE;

ABDOMINAL AORTA; ANIMAL EXPERIMENT; ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DRUG COATING; DRUG SYNTHESIS; FEASIBILITY STUDY; IMAGE ANALYSIS; IMAGE QUALITY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RENAL ARTERY; ANIMAL; CHEMISTRY; HALF LIFE TIME;

ANIMALS; CONTRAST MEDIA; GADOLINIUM; GOLD; HALF-LIFE; METAL NANOPARTICLES; MICE; TOMOGRAPHY, X-RAY COMPUTED;

MLCS; MLOWN;

EID: 84880954823     PISSN: 0361803X     EISSN: 15463141     Source Type: Journal    
DOI: 10.2214/AJR.12.8933     Document Type: Article

References (22)

1. Mettler FA Jr, Thomadsen BR, Bhargavan M, et al. Medical radiation exposure in the U.S. in 2006: preliminary results. Health Phys 2008; 95:502-507
2. McCullough PA. Acute kidney injury with iodinated contrast. Crit Care Med 2008; 36(suppl 4):S204-S211
3. McCullough PA, Adam A, Becker CR, et al. Epidemiology and prognostic implications of contrastinduced nephropathy. Am J Cardiol 2006; 98(suppl 1):5-13
4. Solomon R, Dauerman HL. Contrast-induced acute kidney injury. Circulation 2010; 122:2451-2455
5. Boisselier E, Astruc D. Gold nanoparticles in nanomedicine: preparations, imaging, diagnostics, therapies and toxicity. Chem Soc Rev 2009; 38:1759-1782
6. Aydogan B, Li J, Rajh T, et al. AuNP-DG: deoxyglucose-labeled gold nanoparticles as X-ray computed tomography contrast agents for cancer imaging. Mol Imaging Biol 2010; 12:463-467
7. Cormode DP, Roessl E, Thran A, et al. Atherosclerotic plaque composition: analysis with multicolor CT and targeted gold nanoparticles. Radiology 2010; 256:774-782
8. Eck W, Craig G, Sigdel A, et al. PEGylated gold nanoparticles conjugated to monoclonal F19 antibodies as targeted labeling agents for human pancreatic carcinoma tissue. ACS Nano 2008; 2:2263-2272
9. Eck W, Nicholson AI, Zentgraf H, Semmler W, Bartling S. Anti-CD4-targeted gold nanoparticles induce specific contrast enhancement of peripheral lymph nodes in X-ray computed tomography of live mice. Nano Lett 2010; 10:2318-2322
10. Hainfeld JF, O'Connor MJ, Dilmanian FA, Slatkin DN, Adams DJ, Smilowitz HM. Micro-CT enables microlocalisation and quantification of Her2-targeted gold nanoparticles within tumour regions. Br J Radiol 2011; 84:526-533
11. Kim D, Jeong YY, Jon S. A drug-loaded aptamergold nanoparticle bioconjugate for combined CT imaging and therapy of prostate cancer. ACS Nano 2010; 4:3689-3696
12. Visaria RK, Griffin RJ, Williams BW, et al. Enhancement of tumor thermal therapy using gold nanoparticle-assisted tumor necrosis factor-alpha delivery. Mol Cancer Ther 2006; 5:1014-1020
13. Libutti SK, Paciotti GF, Byrnes AA, et al. Phase I and pharmacokinetic studies of CYT-6091, a novel PEGylated colloidal gold-rhTNF nanomedicine. Clin Cancer Res 2010; 16:6139-6149
14. Jana NR, Gearheart L, Murphy CJ. Evidence for seed-mediated nucleation in the chemical reduction of gold salts to gold nanoparticles. Chem Mater 2001; 13:2313-2322
15. Radwan SH, Azzazy HM. Gold nanoparticles for molecular diagnostics. Expert Rev Mol Diagn 2009; 9:511-524
16. Sperling RA, Rivera Gil P, Zhang F, Zanella M, Parak WJ. Biological applications of gold nanoparticles. Chem Soc Rev 2008; 37:1896-1908
17. Hainfeld JF, Slatkin DN, Focella TM, Smilowitz HM. Gold nanoparticles: a new X-ray contrast agent. Br J Radiol 2006; 79:248-253
18. Kim D, Park S, Lee JH, Jeong YY, Jon S. Antibiofouling polymer-coated gold nanoparticles as a contrast agent for in vivo X-ray computed tomography imaging. J Am Chem Soc 2007; 129:7661-7665
19. Cai QY, Kim SH, Choi KS, et al. Colloidal gold nanoparticles as a blood-pool contrast agent for X-ray computed tomography in mice. Invest Radiol 2007; 42:797-806
20. Lu W, Huang Q, Ku G, et al. Photoacoustic imaging of living mouse brain vasculature using hollow gold nanospheres. Biomaterials 2010; 31:2617-2626
21. Craig GA, Allen PJ, Mason MD. Synthesis, characterization, and functionalization of gold nanoparticles for cancer imaging. Methods Mol Biol 2010; 624:177-193
22. Boote E, Fent G, Kattumuri V, et al. Gold nanoparticle contrast in a phantom and juvenile swine: models for molecular imaging of human organs using x-ray computed tomography. Acad Radiol 2010; 17:410-417