Tumor necrosis factor is elevated in progressive multiple sclerosis and causes excitotoxic neurodegeneration

Multiple Sclerosis Journal

Volumn 20, Issue 3, 2014, Pages 304-312

  Rossi, Silvia ^a,b   Motta, Caterina ^a,b   Studer, Valeria ^a,b   Barbieri, Francesca ^a,b   Buttari, Fabio ^a,b   Bergami, Alessandra ^c   Sancesario, Giulia ^d   Bernardini, Sergio ^d   De Angelis, Gottardo ^d   Martino, Gianvito ^c   Furlan, Roberto ^c   Centonze, Diego ^a,b  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b Fondazione Santa Lucia Centro Europeo per la Ricerca sul Cervello (CERC)   (Italy)

^c SAN RAFFAELE HOSPITAL   (Italy)

^d UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

B cells; cerebrospinal fluid; glutamate; inflammation; synaptic transmission; TNF

Indexed keywords

RITUXIMAB; TUMOR NECROSIS FACTOR ALPHA; GAMMA INTERFERON; INTERLEUKIN 1BETA; NEUROFILAMENT LIGHT; NEUROFILAMENT PROTEIN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; B LYMPHOCYTE; BRAIN SLICE; CELL SWELLING; CEREBROSPINAL FLUID; CHRONIC INFLAMMATION; CYTOKINE PRODUCTION; ELECTROPHYSIOLOGY; EXCITATORY POSTSYNAPTIC POTENTIAL; EXCITOTOXICITY; FEMALE; GRAY MATTER; HUMAN; IMMUNOPATHOGENESIS; MAJOR CLINICAL STUDY; MALE; MULTIPLE SCLEROSIS; NERVE DEGENERATION; SYNAPSE; SYNAPTIC TRANSMISSION; ANIMAL TISSUE; CEREBROSPINAL FLUID ANALYSIS; CONTROLLED STUDY; DISEASE DURATION; DISEASE EXACERBATION; IN VITRO STUDY; NERVE CELL LESION; NERVE CELL NECROSIS; NERVOUS SYSTEM INFLAMMATION; NEUROPROTECTION; NONHUMAN; SIGNAL TRANSDUCTION; SPONTANEOUS EXCITATORY POSTSYNAPTIC CURRENT;

B CELLS; CEREBROSPINAL FLUID; GLUTAMATE; INFLAMMATION; SYNAPTIC TRANSMISSION; TNF-Α;

ADULT; ANIMALS; BRAIN; EXCITATORY POSTSYNAPTIC POTENTIALS; FEMALE; HUMANS; INFLAMMATION; MALE; MICE; MIDDLE AGED; MULTIPLE SCLEROSIS; NERVE DEGENERATION; NEURONS; TUMOR NECROSIS FACTOR-ALPHA; YOUNG ADULT;

EID: 84895750295     PISSN: 13524585     EISSN: 14770970     Source Type: Journal    
DOI: 10.1177/1352458513498128     Document Type: Article

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