Expression of glutamate transporters GLT-1 and GLAST in different regions of rat brain during the course of experimental autoimmune encephalomyelitis

Neuroscience

Volumn 155, Issue 1, 2008, Pages 45-52

  Mitosek Szewczyk, K ^b   Sulkowski, G ^a   Stelmasiak, Z ^b   Struzynska L ^a  

^a MOSSAKOWSKI MEDICAL RESEARCH CENTRE   (Poland)

^b MEDICAL UNIVERSITY OF LUBLIN   (Poland)

Author keywords

EAE; excitatory amino acid transporters; glutamate excitotoxicity; multiple sclerosis

Indexed keywords

EXCITATORY AMINO ACID TRANSPORTER; MESSENGER RNA; VESICULAR GLUTAMATE TRANSPORTER 1;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CEREBELLUM; CONTROLLED STUDY; EXCITOTOXICITY; FEMALE; FOREBRAIN; GENE OVEREXPRESSION; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; UPREGULATION;

ANALYSIS OF VARIANCE; ANIMALS; CEREBELLUM; DISEASE MODELS, ANIMAL; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; EXCITATORY AMINO ACID TRANSPORTER 1; EXCITATORY AMINO ACID TRANSPORTER 2; FEMALE; FREUND'S ADJUVANT; GENE EXPRESSION REGULATION; PROSENCEPHALON; RATS; RATS, INBRED LEW; RNA, MESSENGER; TIME FACTORS;

EID: 47249091708     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2008.05.025     Document Type: Article

References (37)

1. Auger C., and Attwell D. Fast removal of synaptic glutamate by postsynaptic transporters. Neuron 28 (2000) 547-558
2. Ayers M.M., Hazelwood L.J., Catmull D.V., Wang D., McKormack Q., Bernard C., and Orian J.M. Early glial responses in murine models of multiple sclerosis. Neurochem Int 45 (2004) 409-419
3. Chomczyński P., and Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162 (1987) 156-159
4. Danbolt N.C. Glutamate uptake. Prog Neurobiol 65 (2001) 1-105
5. De Stefano N., Narayanan S., Francis G.S., Arnaoutelis R., Tartaglia M.C., Antel J.P., Matthews P.M., and Arnold D.L. Evidence of axonal damage in the early stages of multiple sclerosis and its relevance to disability. Arch Neurol 58 (2001) 65-70
6. Gegelashvili G., Robinson M.B., Trotti D., and Rauen T. Regulation of glutamate transporters in health and disease. Prog Brain Res 132 (2001) 267-286
7. Gonzales M.I., Susarla B., and Robinson M.B. Evidence that protein kinase Cα interacts with and regulates the glial glutamate transporter GLT-1. J Neurochem 94 (2005) 1180-1188
8. Groom A.J., Smith T., and Turski L. Multiple sclerosis and glutamate. Ann N Y Acad Sci 993 (2003) 229-275
9. Huang Y.H., and Bergles D.E. Glutamate transporters bring competition to the synapse. Curr Opin Neurobiol 14 (2004) 346-352
10. Kerschensteiner M., Stadelmann C., Buddeberg B.S., Merkler D., Bareyre F.M., Anthony D.C., Linington C., Bruck W., and Schwab M.E. Animal model-targeting experimental autoimmune encephalomyelitis lesions to a predetermined axonal tract system allows for refined behavioral testing in an animal model of multiple sclerosis. Am J Pathol 164 (2004) 1455-1469
11. Lee J.M., Zipfel G.J., and Choi D.W. The changing landscape of ischaemic brain injury mechanisms. Nature 399 (1999) 7-14
12. Lipton S.A., and Rosenberg P.A. Excitatory amino acid as a final common pathway for neurologic disorders. N Engl J Med 330 (1994) 613-622
13. Lowry O.W., Rosenbrough N.J., Farr A.L., and Randal R.J. Protein measurement with Folin phenol reagent. J Biol Chem 193 (1951) 265-275
14. Maragakis N.J., and Rothstein J.D. Glutamate transporters in neurologic diseases. Arch Neurol 58 (2001) 365-370
15. Matute C., Alberdi E., Domercq M., Peréz-Cerdá F., Peréz-Samartin A., and Sánchez-Gómez M.V. The link between excitotoxic oligodendroglial death and demyelinating diseases. Trends Neurosci 24 (2001) 224-230
16. +-dependent glutamate transport activity. Neurochem Int 37 (2000) 147-162
17. Ohgoh M., Hanada T., Smith T., Hashimoto T., Ueno M., Yamanishi Y., Watanabe M., and Nishizawa Y. Altered expression of glutamate transporters in experimental autoimmune encephalomyelitis. J Neuroimmunol 125 (2002) 170-178
18. Onuki M., Ayers M.M., Bernard C.C., and Orian J.M. Axonal degeneration is an early pathological feature in autoimmune-mediated demyelination in mice. Microsc Res Tech 52 (2001) 731-739
19. Pines G., Danbolt N.C., Bjorras M., Zhang Y., Bendahan A., Eide L., Koepsell H., Storm-Mathisen J., Seeberg E., and Kanner B.I. Cloning and expression of a rat brain L-glutamate transporter. Nature 360 (1992) 464-467
20. Pitt D., Nagelmeier I.E., Wilson H.C., and Raine C.S. Glutamate uptake by oligodendrocytes: Implications for excitotoxicity in multiple sclerosis. Neurology 61 (2003) 1113-1120
21. Pitt D., Werner P., and Raine C.S. Glutamate excitotoxicity in a model of multiple sclerosis. Nat Med 6 (2000) 67-70
22. Robinson M.B. The family of sodium-dependent glutamate transporters: a focus on the GLT-1/EAAT2 subtypes. Neurochem Int 33 (1999) 479-491
23. Rothstein J.D., Martin L., Levey A.I., Dykes-Hoberg M., Jin L., Wu D., Nash N., and Kuncl R.W. Localization of neuronal and glial glutamate transporters. Neuron 13 (1994) 713-725
24. Rothstein J.D., Dykes-Hoberg M., Pardo C.A., Bristol L.A., Jin L., Kuncl R.W., Kanai Y., Hediger M.A., Wang Y., Schielke J.P., and Welty D.F. Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate. Neuron 16 (1996) 675-686
25. Sims K.D., Straff D.J., and Robinson M.B. Platelet-derived growth factor rapidly increases activity and cell surface expression of the EAAC1 subtype of glutamate transporter trough activation of phosphatidylinositol 3-kinase. J Biol Chem 274 (2000) 5228-5327
26. Smith T., Groom A., Zhu B., and Turski L. Autoimmune encephalomyelitis ameliorated by AMPA antagonists. Nat Med 6 (2000) 62-66
27. Srinivasan R., Sailasuta N., Hurd R., Nelson S., and Pelletier D. Evidence of elevated glutamate in multiple sclerosis using magnetic resonance spectroscopy at 3 T. Brain 128 (2005) 1016-1025
28. Storck T., Schulte S., Hofmann K., and Stoffel W. Structure, expression, and functional analysis of a Na-dependent glutamate/aspartate transporter from rat brain. Proc Natl Acad Sci U S A 89 (1992) 10955-10959
29. Stover J.F., Pleines U.E., Morganti-Kossmann M.C., Kossmann T., Lowitzsch K., and Kempski O.S. Neurotransmitters in cerebrospinal fluid reflect pathological activity. Eur J Clin Invest 27 (1997) 1038-1043
30. Stys P.C. White matter injury mechanisms. Curr Mol Med 4 (2004) 113-130
31. Takahashi J.L., Giuliani F., Power C., Imai Y., and Yong V.W. Interleukin-1beta promotes oligodendrocytes death through glutamate excitotoxicity. Ann Neurol 53 (2003) 588-595
32. Tanaka K., Watase K., Manabe T., Yamada K., Watanabe M., Takahashi K., Iwama H., Nishikawa T., Ichihara N., Kikuchi T., Okuyama S., Kavashima K., Hori S., Takimoto M., and Wada K. Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1. Science 276 (1997) 1699-1702
33. Trapp B.D., Peterson J., Ranshoff R.M., Rudick R., Mork S., and Bo L. Axonal transection in the lesion of multiple sclerosis. N Engl J Med 338 (1998) 278-285
34. Tsumoda I., and Fujinami R.S. Two models for multiple sclerosis: experimental allergic encephalomyelitis and Theiler's murine encephalomyelitis virus. J Neuropathol Exp Neurol 55 (1996) 673-686
35. Vallejo-Illarramendi A., Domercq M., Pérez-Cerdá F., Ravid R., and Matute C. Increased expression and function of glutamate transporters in multiple sclerosis. Neurobiol Dis 21 (2006) 154-164
36. Volterra A., and Stainhäuser C. Glial modulation of synaptic transmission in the hippocampus. Glia 47 (2004) 249-257
37. Wang D., Ayers M., Catmull D.V., Hazelwood L., Bernard C., and Orian J.M. Astrocyte-associated axonal damage in pre-onset stages of experimental autoimmune encephalomyelitis. Glia 51 (2005) 235-240