Efficacy of Cyclooctadepsipeptides and Aminophenylamidines against Larval, Immature and Mature Adult Stages of a Parasitologically Characterized Trichurosis Model in Mice

PLoS Neglected Tropical Diseases

Volumn 8, Issue 2, 2014, Pages

  Kulke, Daniel ^a,b   Krücken, Jürgen ^a   Harder, Achim ^c   von Samson Himmelstjerna, Georg ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b BAYER PHARMA AG   (Germany)

^c HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDANTEL; AMINOPHENYLAMIDINE; ANTHELMINTIC AGENT; CLOTRIMAZOLE; CYCLOOCTADEPSIPEPTIDE; DEACYLATED AMIDANTEL; EMODEPSIDE; PF1022A; SISOMICIN; TRIBENDIMIDINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG EFFICACY; FEMALE; MALE; MOUSE; NONHUMAN; PARASITE IDENTIFICATION; SINGLE DRUG DOSE; TRICHURIASIS; TRICHURIS MURIS;

ANIMALS; ANTHELMINTICS; DEPSIPEPTIDES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; LARVA; MICE; MICE, INBRED C57BL; PHENYLENEDIAMINES; TRICHURIASIS; TRICHURIS;

EID: 84895741778     PISSN: 19352727     EISSN: 19352735     Source Type: Journal    
DOI: 10.1371/journal.pntd.0002698     Document Type: Article

References (50)

1. Awasthi S, Bundy DA, Savioli L, (2003) Helminthic infections. BMJ 327: 431-433.
2. Lustigman S, Prichard RK, Gazzinelli A, Grant WN, Boatin BA, et al. (2012) A research agenda for helminth diseases of humans: the problem of helminthiases. PLoS Negl Trop Dis 6: e1582.
3. Knopp S, Steinmann P, Keiser J, Utzinger J, (2012) Nematode infections: soil-transmitted helminths and trichinella. Infect Dis Clin North Am 26: 341-358.
4. Hotez PJ, Fenwick A, Savioli L, Molyneux DH, (2009) Rescuing the bottom billion through control of neglected tropical diseases. Lancet 373: 1570-1575.
5. Pullan RL, Brooker SJ, (2012) The global limits and population at risk of soil-transmitted helminth infections in 2010. Parasit Vectors 5: 81.
6. Stephenson LS, Holland CV, Cooper ES, (2000) The public health significance of Trichuris trichiura. Parasitology 121 Suppl: S73-95.
7. World Health Organization (2011) WHO model list of essential medicines: 17th list, March 2011. Geneva: World Health Organization. 45 p. p.
8. Bethony J, Brooker S, Albonico M, Geiger SM, Loukas A, et al. (2006) Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm. Lancet 367: 1521-1532.
9. Prichard RK, Basanez MG, Boatin BA, McCarthy JS, Garcia HH, et al. (2012) A research agenda for helminth diseases of humans: intervention for control and elimination. PLoS Negl Trop Dis 6: e1549.
10. Keiser J, Utzinger J, (2010) The drugs we have and the drugs we need against major helminth infections. Adv Parasitol 73: 197-230.
11. Diawara A, Drake LJ, Suswillo RR, Kihara J, Bundy DA, et al. (2009) Assays to detect beta-tubulin codon 200 polymorphism in Trichuris trichiura and Ascaris lumbricoides. PLoS Negl Trop Dis 3: e397.
12. Traversa D, (2011) Are we paying too much attention to cardio-pulmonary nematodes and neglecting old-fashioned worms like Trichuris vulpis? Parasit Vectors 4: 32.
13. Arends J, Vercruysse J (2002) The use of macrocyclic lactones to control parasites of pigs. In: Vercruysse J, Rew RS, editors. Macrocyclic lactones in antiparasitic therapy. Wallingford, UK and New York, USA: CABI Publishing.
14. Keeling JE, (1961) Experimental trichuriasis. II. Anthelmintic screening against Trichuris muris in the albino mouse. J Parasitol 47: 647-651.
15. Anderson RC (2000) Nematode parasites of vertebrates: their development and transmission. Wallingford, Oxon, UK; New York, NY: CABI Pub. xx, 650 p. p.
16. Panesar TS, Croll NA, (1980) The location of parasites within their hosts: site selection by Trichuris muris in the laboratory mouse. Int J Parasitol 10: 261-273.
17. Wakelin D, (1967) Acquired immunity to Trichuris muris in the albino laboratory mouse. Parasitology 57: 515-524.
18. Johnston CE, Bradley JE, Behnke JM, Matthews KR, Else KJ, (2005) Isolates of Trichuris muris elicit different adaptive immune responses in their murine host. Parasite Immunol 27: 69-78.
19. Krücken J, Harder A, Jeschke P, Holden-Dye L, O'Connor V, et al. (2012) Anthelmintic cyclcooctadepsipeptides: complex in structure and mode of action. Trends Parasitol 28: 385-394.
20. Xiao SH, Utzinger J, Tanner M, Keiser J, Xue J, (2013) Advances with the Chinese anthelminthic drug tribendimidine in clinical trials and laboratory investigations. Acta Trop 126: 115-126.
21. Schimmel A, Altreuther G, Schroeder I, Charles S, Cruthers L, et al. (2009) Efficacy of emodepside plus praziquantel tablets (Profender tablets for dogs) against mature and immature adult Trichuris vulpis infections in dogs. Parasitol Res 105 Suppl 1: S17-22.
22. Mehlhorn H, Schmahl G, Frese M, Mevissen I, Harder A, et al. (2005) Effects of a combinations of emodepside and praziquantel on parasites of reptiles and rodents. Parasitol Res 97 Suppl 1: S65-69.
23. Schmahl G, Mehlhorn H, Harder A, Klimpel S, Krieger KJ, (2007) Efficacy of combination of emodepside plus praziquantel against larval and adult stages of nematodes (Trichuris muris, Angiostrongylus cantonensis) in rodents. Parasitol Res 101: 77-84.
24. Wollweber H, Niemers E, Flucke W, Andrews P, Schulz HP, et al. (1979) Amidantel, a potent anthelminthic from a new chemical class. Arzneimittelforschung 29: 31-32.
25. Steinmann P, Zhou XN, Du ZW, Jiang JY, Xiao SH, et al. (2008) Tribendimidine and albendazole for treating soil-transmitted helminths, Strongyloides stercoralis and Taenia spp.: open-label randomized trial. PLoS Negl Trop Dis 2: e322.
26. Xiao SH, Hui-Ming W, Tanner M, Utzinger J, Chong W, (2005) Tribendimidine: a promising, safe and broad-spectrum anthelmintic agent from China. Acta Trop 94: 1-14.
27. Xiao SH, Wu ZX, Zhang JH, Wang SQ, Wang SH, et al. (2007) Clinical observation on 899 children infected with intestinal nematodes and treated with tribendimidine enteric coated tablets. Chin J Parasit Dis 25: 372-375.
28. Hu Y, Xiao SH, Aroian RV, (2009) The new anthelmintic tribendimidine is an L-type (levamisole and pyrantel) nicotinic acetylcholine receptor agonist. PLoS Negl Trop Dis 3: e499.
29. Miltsch SM, Krucken J, Demeler J, Ramunke S, Harder A, et al. (2013) Interactions of anthelmintic drugs in Caenorhabditis elegans neuro-muscular ion channel mutants. Parasitol Int 62: 591-8.
30. Welz C, Kruger N, Schniederjans M, Miltsch SM, Krucken J, et al. (2011) SLO-1-channels of parasitic nematodes reconstitute locomotor behaviour and emodepside sensitivity in Caenorhabditis elegans slo-1 loss of function mutants. PLoS Pathog 7: e1001330.
31. Guest M, Bull K, Walker RJ, Amliwala K, O'Connor V, et al. (2007) The calcium-activated potassium channel, SLO-1, is required for the action of the novel cyclo-octadepsipeptide anthelmintic, emodepside, in Caenorhabditis elegans. Int J Parasitol 37: 1577-1588.
32. Saeger B, Schmitt-Wrede HP, Dehnhardt M, Benten WP, Krucken J, et al. (2001) Latrophilin-like receptor from the parasitic nematode Haemonchus contortus as target for the anthelmintic depsipeptide PF1022A. FASEB J 15: 1332-1334.
33. Chen W, Terada M, Cheng JT, (1996) Characterization of subtypes of gamma-aminobutyric acid receptors in an Ascaris muscle preparation by binding assay and binding of PF1022A, a new anthelmintic, on the receptors. Parasitol Res 82: 97-101.
34. Miltsch SM, Krucken J, Demeler J, Janssen IJ, Kruger N, et al. (2012) Decreased emodepside sensitivity in unc-49 gamma-aminobutyric acid (GABA)-receptor-deficient Caenorhabditis elegans. Int J Parasitol 42: 761-770.
35. Stoll NR, (1923) Investigations on the control of hookworm disease. XV. An effective method of counting hookworm eggs in feces. Am J Epidemiol 3: 59-70.
36. Panesar TS, (1989) The moulting pattern in Trichuris muris (Nematoda: Trichuroidea). Can J Zool 67: 2340-2343.
37. Pike EH, (1969) Egg output of Trichuris muris (Schrank, 1788). J Parasitol 55: 1046-1049.
38. Motulsky H, Christopoulos A (2004) Fitting models to biological data using linear and nonlinear regression: a practical guide to curve fitting. Oxford; New York: Oxford University Press. 351 p. p.
39. Suputtamongkol Y, Premasathian N, Bhumimuang K, Waywa D, Nilganuwong S, et al. (2011) Efficacy and safety of single and double doses of ivermectin versus 7-day high dose albendazole for chronic strongyloidiasis. PLoS Negl Trop Dis 5: e1044.
40. Shoop WL, Eary CH, Michael BF, Haines HW, Seward RL, (1991) Anthelmintic activity of paraherquamide in dogs. Vet Parasitol 40: 339-341.
41. Tritten L, Silbereisen A, Keiser J, (2011) In vitro and in vivo efficacy of Monepantel (AAD 1566) against laboratory models of human intestinal nematode infections. PLoS Negl Trop Dis 5: e1457.
42. Little PR, Hodge A, Maeder SJ, Wirtherle NC, Nicholas DR, et al. (2011) Efficacy of a combined oral formulation of derquantel-abamectin against the adult and larval stages of nematodes in sheep, including anthelmintic-resistant strains. Vet Parasitol 181: 180-193.
43. Sutherland I, Scott I (2010) Gastrointestinal nematodes of sheep and cattle- biology and control. Oxford, United Kingdom, Ames, Iowa, United States of America: Blackwell Publishing.
44. Wu ZX, Fang YY, Liu YS, (2006) Effect of a novel drug - enteric coated tribendimidine in the treatment of intestinal nematode infections. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 24: 23-26.
45. Yuan G, Xu J, Qu T, Wang B, Zhang R, et al. (2010) Metabolism and disposition of tribendimidine and its metabolites in healthy Chinese volunteers. Drugs R D 10: 83-90.
46. Petry G, Altreuther G, Wolken S, Swart P, Kok DJ, (2013) Efficacy of emodepside plus toltrazuril oral suspension for dogs (Procox(R), Bayer) against Trichuris vulpis in naturally infected dogs. Parasitol Res 112 Suppl 1: 133-138.
47. Olliaro P, Seiler J, Kuesel A, Horton J, Clark JN, et al. (2011) Potential drug development candidates for human soil-transmitted helminthiases. PLoS Negl Trop Dis 5: e1138.
48. Nwosu U, Vargas M, Harder A, Keiser J, (2011) Efficacy of the cyclooctadepsipeptide PF1022A against Heligmosomoides bakeri in vitro and in vivo. Parasitology 138: 1193-1201.
49. von Samson-Himmelstjerna G, Harder A, Schnieder T, Kalbe J, Mencke N, (2000) In vivo activities of the new anthelmintic depsipeptide PF 1022A. Parasitol Res 86: 194-199.
50. Epe C, Kaminsky R, (2013) New advancement in anthelmintic drugs in veterinary medicine. Trends Parasitol 29: 129-134.