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Volumn 126, Issue 2, 2013, Pages 115-126

Advances with the Chinese anthelminthic drug tribendimidine in clinical trials and laboratory investigations

Author keywords

Cestode; Chemotherapy; Clinical trials; In vitro studies; In vivo studies; Nematode; People's Republic of China; Pharmacokinetics; Soil transmitted helminthiases; Trematode; Tribendimidine

Indexed keywords

ALBENDAZOLE; ANTHELMINTIC AGENT; CHINESE DRUG; DRUG METABOLITE; NICOTINIC RECEPTOR; PRAZIQUANTEL; TRIBENDIMIDINE; UNCLASSIFIED DRUG;

EID: 84875500366     PISSN: 0001706X     EISSN: 18736254     Source Type: Journal    
DOI: 10.1016/j.actatropica.2013.01.009     Document Type: Review
Times cited : (66)

References (86)
  • 1
    • 0037899938 scopus 로고    scopus 로고
    • Efficacy of mebendazole and levamisole alone or in combination against intestinal nematode infections after repeated targeted mebendazole treatment in Zanzibar
    • Albonico M., Bickle Q., Ramsan M., Montresor A., Savioli L., Taylor M. Efficacy of mebendazole and levamisole alone or in combination against intestinal nematode infections after repeated targeted mebendazole treatment in Zanzibar. Bull. World Health Organ. 2003, 81:343-352.
    • (2003) Bull. World Health Organ. , vol.81 , pp. 343-352
    • Albonico, M.1    Bickle, Q.2    Ramsan, M.3    Montresor, A.4    Savioli, L.5    Taylor, M.6
  • 3
    • 70350569404 scopus 로고    scopus 로고
    • Heligmosomoides bakeri: a model for exploring the biology and genetics of resistance to chronic gastrointestinal nematode infections
    • Behnke J.M., Menge D.M., Noyes H. Heligmosomoides bakeri: a model for exploring the biology and genetics of resistance to chronic gastrointestinal nematode infections. Parasitology 2009, 136:1565-1580.
    • (2009) Parasitology , vol.136 , pp. 1565-1580
    • Behnke, J.M.1    Menge, D.M.2    Noyes, H.3
  • 7
    • 10444263729 scopus 로고    scopus 로고
    • Recent advances in the biology of Echinostoma species in the " revolutum" group
    • Fried B., Graczyk T.K. Recent advances in the biology of Echinostoma species in the " revolutum" group. Adv. Parasitol. 2004, 58:139-195.
    • (2004) Adv. Parasitol. , vol.58 , pp. 139-195
    • Fried, B.1    Graczyk, T.K.2
  • 8
    • 84857194723 scopus 로고    scopus 로고
    • Global burden of human food-borne trematodiasis: a systematic review and meta-analysis
    • Fürst T., Keiser J., Utzinger J. Global burden of human food-borne trematodiasis: a systematic review and meta-analysis. Lancet Infect. Dis. 2012, 12:210-221.
    • (2012) Lancet Infect. Dis. , vol.12 , pp. 210-221
    • Fürst, T.1    Keiser, J.2    Utzinger, J.3
  • 10
    • 0034110649 scopus 로고    scopus 로고
    • Drug resistance in human helminths: current situation and lessons from livestock
    • Geerts S., Gryseels B. Drug resistance in human helminths: current situation and lessons from livestock. Clin. Microbiol. Rev. 2000, 13:207-222.
    • (2000) Clin. Microbiol. Rev. , vol.13 , pp. 207-222
    • Geerts, S.1    Gryseels, B.2
  • 11
    • 79751500395 scopus 로고    scopus 로고
    • Ascaris lumbricoides: an overview of therapeutic targets
    • Hagel I., Giusti T. Ascaris lumbricoides: an overview of therapeutic targets. Infect. Disord. Drug Targets 2010, 10:349-367.
    • (2010) Infect. Disord. Drug Targets , vol.10 , pp. 349-367
    • Hagel, I.1    Giusti, T.2
  • 12
    • 0034439133 scopus 로고    scopus 로고
    • Albendazole: a review of anthelmintic efficacy and safety in humans
    • Horton J. Albendazole: a review of anthelmintic efficacy and safety in humans. Parasitology 2000, 121(Suppl.):S113-S132.
    • (2000) Parasitology , vol.121 , Issue.SUPPL.
    • Horton, J.1
  • 13
    • 0142227139 scopus 로고    scopus 로고
    • Human gastrointestinal helminth infections: are they now neglected diseases?
    • Horton J. Human gastrointestinal helminth infections: are they now neglected diseases?. Trends Parasitol. 2003, 19:527-531.
    • (2003) Trends Parasitol. , vol.19 , pp. 527-531
    • Horton, J.1
  • 15
    • 77950401437 scopus 로고    scopus 로고
    • Bacillus thuringiensis Cry5B protein is highly efficacious as a single-dose therapy against an intestinal roundworm infection in mice
    • Hu Y., Georghiou S.B., Kelleher A.J., Aroian R.V. Bacillus thuringiensis Cry5B protein is highly efficacious as a single-dose therapy against an intestinal roundworm infection in mice. PLoS Negl. Trop. Dis. 2010, 4:e614.
    • (2010) PLoS Negl. Trop. Dis. , vol.4
    • Hu, Y.1    Georghiou, S.B.2    Kelleher, A.J.3    Aroian, R.V.4
  • 16
    • 70449511214 scopus 로고    scopus 로고
    • The new anthelmintic tribendimidine is an L-type (levamisole and pyrantel) nicotinic acetylcholine receptor agonist
    • Hu Y., Xiao S.H., Aroian R.V. The new anthelmintic tribendimidine is an L-type (levamisole and pyrantel) nicotinic acetylcholine receptor agonist. PLoS Negl. Trop. Dis. 2009, 3:e499.
    • (2009) PLoS Negl. Trop. Dis. , vol.3
    • Hu, Y.1    Xiao, S.H.2    Aroian, R.V.3
  • 17
    • 0015423525 scopus 로고
    • A simple device for quantitative stool thick-smear technique in schistosomiasis mansoni
    • Katz N., Chaves A., Pellegrino J. A simple device for quantitative stool thick-smear technique in schistosomiasis mansoni. Rev. Inst. Med. Trop. São Paulo 1972, 14:397-400.
    • (1972) Rev. Inst. Med. Trop. São Paulo , vol.14 , pp. 397-400
    • Katz, N.1    Chaves, A.2    Pellegrino, J.3
  • 18
    • 77949653928 scopus 로고    scopus 로고
    • In vitro and in vivo trematode models for chemotherapeutic studies
    • Keiser J. In vitro and in vivo trematode models for chemotherapeutic studies. Parasitology 2010, 137:589-603.
    • (2010) Parasitology , vol.137 , pp. 589-603
    • Keiser, J.1
  • 19
    • 35848955628 scopus 로고    scopus 로고
    • Artemisinins and synthetic trioxolanes in the treatment of helminth infections
    • Keiser J., Utzinger J. Artemisinins and synthetic trioxolanes in the treatment of helminth infections. Curr. Opin. Infect. Dis. 2007, 20:605-612.
    • (2007) Curr. Opin. Infect. Dis. , vol.20 , pp. 605-612
    • Keiser, J.1    Utzinger, J.2
  • 20
    • 42449084148 scopus 로고    scopus 로고
    • Efficacy of current drugs against soil-transmitted helminth infections: systematic review and meta-analysis
    • Keiser J., Utzinger J. Efficacy of current drugs against soil-transmitted helminth infections: systematic review and meta-analysis. JAMA 2008, 299:1937-1948.
    • (2008) JAMA , vol.299 , pp. 1937-1948
    • Keiser, J.1    Utzinger, J.2
  • 22
    • 77954582391 scopus 로고    scopus 로고
    • The drugs we have and the drugs we need against major helminth infections
    • Keiser J., Utzinger J. The drugs we have and the drugs we need against major helminth infections. Adv. Parasitol. 2010, 73:197-230.
    • (2010) Adv. Parasitol. , vol.73 , pp. 197-230
    • Keiser, J.1    Utzinger, J.2
  • 23
    • 77955317545 scopus 로고    scopus 로고
    • Effect of artemether, artesunate, OZ78, praziquantel, and tribendimidine alone or in combination chemotherapy on the tegument of Clonorchis sinensis
    • Keiser J., Vargas M. Effect of artemether, artesunate, OZ78, praziquantel, and tribendimidine alone or in combination chemotherapy on the tegument of Clonorchis sinensis. Parasitol. Int. 2010, 59:472-476.
    • (2010) Parasitol. Int. , vol.59 , pp. 472-476
    • Keiser, J.1    Vargas, M.2
  • 24
    • 84877289751 scopus 로고    scopus 로고
    • Activity of tribendimidine and praziquantel combination therapy against the liver fluke Opisthorchis viverrini in vitro
    • vivo. J. Helminthol. doi:10.1017/S0022149X12000387
    • Keiser, J., Adelfio, R., Vargas, M., Odermatt, P., Tesana, S., 2013. Activity of tribendimidine and praziquantel combination therapy against the liver fluke Opisthorchis viverrini in vitro and in vivo. J. Helminthol., doi:10.1017/S0022149X12000387.
    • (2013)
    • Keiser, J.1    Adelfio, R.2    Vargas, M.3    Odermatt, P.4    Tesana, S.5
  • 25
    • 39749087002 scopus 로고    scopus 로고
    • Opisthorchis viverrini: efficacy and tegumental alterations following administration of tribendimidine in vivo and in vitro
    • Keiser J., Utzinger J., Xiao S.H., Odermatt P., Tesana S. Opisthorchis viverrini: efficacy and tegumental alterations following administration of tribendimidine in vivo and in vitro. Parasitol. Res. 2008, 102:771-776.
    • (2008) Parasitol. Res. , vol.102 , pp. 771-776
    • Keiser, J.1    Utzinger, J.2    Xiao, S.H.3    Odermatt, P.4    Tesana, S.5
  • 27
    • 33847668824 scopus 로고    scopus 로고
    • Evaluation of the in vivo activity of tribendimidine against Schistosoma mansoni, Fasciola hepatica, Clonorchis sinensis, and Opisthorchis viverrini
    • Keiser J., Xiao S.H., Chollet J., Tanner M., Utzinger J. Evaluation of the in vivo activity of tribendimidine against Schistosoma mansoni, Fasciola hepatica, Clonorchis sinensis, and Opisthorchis viverrini. Antimicrob. Agents Chemother. 2007, 51:1096-1098.
    • (2007) Antimicrob. Agents Chemother. , vol.51 , pp. 1096-1098
    • Keiser, J.1    Xiao, S.H.2    Chollet, J.3    Tanner, M.4    Utzinger, J.5
  • 28
    • 70349147405 scopus 로고    scopus 로고
    • Combination chemotherapy against Clonorchis sinensis: experiments with artemether, artesunate, OZ78, praziquantel, and tribendimidine in a rat model
    • Keiser J., Xiao S.H., Smith T.A., Utzinger J. Combination chemotherapy against Clonorchis sinensis: experiments with artemether, artesunate, OZ78, praziquantel, and tribendimidine in a rat model. Antimicrob. Agents Chemother. 2009, 53:3770-3776.
    • (2009) Antimicrob. Agents Chemother. , vol.53 , pp. 3770-3776
    • Keiser, J.1    Xiao, S.H.2    Smith, T.A.3    Utzinger, J.4
  • 29
    • 33748925358 scopus 로고    scopus 로고
    • Effect of tribendimidine on adult Echinostoma caproni harbored in mice, including scanning electron microscopic observations
    • Keiser J., Xiao S.H., Utzinger J. Effect of tribendimidine on adult Echinostoma caproni harbored in mice, including scanning electron microscopic observations. J. Parasitol. 2006, 92:858-862.
    • (2006) J. Parasitol. , vol.92 , pp. 858-862
    • Keiser, J.1    Xiao, S.H.2    Utzinger, J.3
  • 33
    • 84861349404 scopus 로고    scopus 로고
    • In vivo efficacy of the anthelmintic tribendimidine against the cestode Hymenolepis microstoma in a controlled laboratory trial
    • Kulke D., Krücken J., Welz C., von Samson-Himmelstjerna G., Harder A. In vivo efficacy of the anthelmintic tribendimidine against the cestode Hymenolepis microstoma in a controlled laboratory trial. Acta Trop. 2012, 123:78-84.
    • (2012) Acta Trop. , vol.123 , pp. 78-84
    • Kulke, D.1    Krücken, J.2    Welz, C.3    von Samson-Himmelstjerna, G.4    Harder, A.5
  • 34
    • 84886949425 scopus 로고
    • Scanning electron microscopy on the surface of the tegument of Clonorchis sinensis treated with praziquantel
    • Li B.Z., Liu T.C., Deng L.J., Li Z.J., Zao L. Scanning electron microscopy on the surface of the tegument of Clonorchis sinensis treated with praziquantel. Acta Chin. Med. Univ. 1984, 13:56-58.
    • (1984) Acta Chin. Med. Univ. , vol.13 , pp. 56-58
    • Li, B.Z.1    Liu, T.C.2    Deng, L.J.3    Li, Z.J.4    Zao, L.5
  • 35
    • 40949098010 scopus 로고
    • Experimental chemotherapy of Clonorchis sinensis at different developing stages in rats with praziquantel
    • Li B.Z., Liu T.C., Yu X.H., Zhang D.Q., Wang X.C., Liu Y.Z. Experimental chemotherapy of Clonorchis sinensis at different developing stages in rats with praziquantel. Acta Pharmacol. Sin. 1984, 19:391-393.
    • (1984) Acta Pharmacol. Sin. , vol.19 , pp. 391-393
    • Li, B.Z.1    Liu, T.C.2    Yu, X.H.3    Zhang, D.Q.4    Wang, X.C.5    Liu, Y.Z.6
  • 36
    • 84862832911 scopus 로고    scopus 로고
    • Effect of oral administration of tribendimidine at different dosages against Trichinella spiralis encapsulated larvae in mice
    • Li R.H., Gao J.H., Wang S.F., Pei Y.J., Shen J.Y., Yan P.M., Yin G.R. Effect of oral administration of tribendimidine at different dosages against Trichinella spiralis encapsulated larvae in mice. Chin. J. Parasitol. Parasitic Dis. 2011, 29:117-121.
    • (2011) Chin. J. Parasitol. Parasitic Dis. , vol.29 , pp. 117-121
    • Li, R.H.1    Gao, J.H.2    Wang, S.F.3    Pei, Y.J.4    Shen, J.Y.5    Yan, P.M.6    Yin, G.R.7
  • 40
    • 84861204266 scopus 로고    scopus 로고
    • The global limits and population at risk of soil-transmitted helminth infections in 2010
    • Pullan R.L., Brooker S.J. The global limits and population at risk of soil-transmitted helminth infections in 2010. Parasit Vectors 2012, 5:81.
    • (2012) Parasit Vectors , vol.5 , pp. 81
    • Pullan, R.L.1    Brooker, S.J.2
  • 41
    • 64949096679 scopus 로고
    • Light and electron microscopic studies on the effect of levo-praziquantel on Clonorchis sinensis in vivo
    • Quan M.X., Liu Y.H., Gong L., Wang X.G. Light and electron microscopic studies on the effect of levo-praziquantel on Clonorchis sinensis in vivo. Acta Chongqing Med. Univ. 1988, 13:6-8.
    • (1988) Acta Chongqing Med. Univ. , vol.13 , pp. 6-8
    • Quan, M.X.1    Liu, Y.H.2    Gong, L.3    Wang, X.G.4
  • 43
    • 0019191615 scopus 로고
    • Anthelmintic effect of amidantel (Bay d 8815) against Ancylostoma duodenale infection
    • Rim H.J., Joo K.H., Kim Y.Y., Lee J.S., Song S.D. Anthelmintic effect of amidantel (Bay d 8815) against Ancylostoma duodenale infection. Korean J. Parasitol. 1980, 18:24-36.
    • (1980) Korean J. Parasitol. , vol.18 , pp. 24-36
    • Rim, H.J.1    Joo, K.H.2    Kim, Y.Y.3    Lee, J.S.4    Song, S.D.5
  • 46
    • 78751701383 scopus 로고    scopus 로고
    • Efficacy and safety of mefloquine, artesunate, mefloquine-artesunate, tribendimidine, and praziquantel in patients with Opisthorchis viverrini: a randomised, exploratory, open-label, phase 2 trial
    • Soukhathammavong P., Odermatt P., Sayasone S., Vonghachack Y., Vounatsou P., Hatz C., Akkhavong K., Keiser J. Efficacy and safety of mefloquine, artesunate, mefloquine-artesunate, tribendimidine, and praziquantel in patients with Opisthorchis viverrini: a randomised, exploratory, open-label, phase 2 trial. Lancet Infect. Dis. 2011, 11:110-118.
    • (2011) Lancet Infect. Dis. , vol.11 , pp. 110-118
    • Soukhathammavong, P.1    Odermatt, P.2    Sayasone, S.3    Vonghachack, Y.4    Vounatsou, P.5    Hatz, C.6    Akkhavong, K.7    Keiser, J.8
  • 47
    • 78751702786 scopus 로고    scopus 로고
    • Tribendimidine: an alternative anthelmintic for liver flukes?
    • Sripa B., Hong S.T. Tribendimidine: an alternative anthelmintic for liver flukes?. Lancet Infect. Dis. 2011, 11:77-78.
    • (2011) Lancet Infect. Dis. , vol.11 , pp. 77-78
    • Sripa, B.1    Hong, S.T.2
  • 48
    • 80053205109 scopus 로고    scopus 로고
    • Efficacy of single-dose and triple-dose albendazole and mebendazole against soil-transmitted helminths and Taenia spp.: a randomized controlled trial
    • Steinmann P., Utzinger J., Du Z.W., Jiang J.Y., Chen J.X., Hattendorf J., Zhou H., Zhou X.N. Efficacy of single-dose and triple-dose albendazole and mebendazole against soil-transmitted helminths and Taenia spp.: a randomized controlled trial. PLoS One 2011, 6:e25003.
    • (2011) PLoS One , vol.6
    • Steinmann, P.1    Utzinger, J.2    Du, Z.W.3    Jiang, J.Y.4    Chen, J.X.5    Hattendorf, J.6    Zhou, H.7    Zhou, X.N.8
  • 49
    • 77954572990 scopus 로고    scopus 로고
    • Multiparasitism a neglected reality on global, regional and local scale
    • Steinmann P., Utzinger J., Du Z.W., Zhou X.N. Multiparasitism a neglected reality on global, regional and local scale. Adv. Parasitol. 2010, 73:21-50.
    • (2010) Adv. Parasitol. , vol.73 , pp. 21-50
    • Steinmann, P.1    Utzinger, J.2    Du, Z.W.3    Zhou, X.N.4
  • 50
    • 56149097204 scopus 로고    scopus 로고
    • Tribendimidine and albendazole for treating soil-transmitted helminths, Strongyloides stercoralis and Taenia spp.: open label randomized trial
    • Steinmann P., Zhou X.N., Du Z.W., Jiang J.Y., Xiao S.H., Wu Z.X., Zhou H., Utzinger J. Tribendimidine and albendazole for treating soil-transmitted helminths, Strongyloides stercoralis and Taenia spp.: open label randomized trial. PLoS Negl. Trop. Dis. 2008, 2:e322.
    • (2008) PLoS Negl. Trop. Dis. , vol.2
    • Steinmann, P.1    Zhou, X.N.2    Du, Z.W.3    Jiang, J.Y.4    Xiao, S.H.5    Wu, Z.X.6    Zhou, H.7    Utzinger, J.8
  • 51
    • 84886948441 scopus 로고    scopus 로고
    • Efficacy of tribendimidine enteric coated tablet in treatment of children with roundworm, hookworm and whipworm infections
    • Tang L.N., Wang S.H., Chen Z.Y., Li A.M., Lin G.C., Xu L.N., Lu L.D. Efficacy of tribendimidine enteric coated tablet in treatment of children with roundworm, hookworm and whipworm infections. Chin. J. Zoonoses 2008, 24:681-682.
    • (2008) Chin. J. Zoonoses , vol.24 , pp. 681-682
    • Tang, L.N.1    Wang, S.H.2    Chen, Z.Y.3    Li, A.M.4    Lin, G.C.5    Xu, L.N.6    Lu, L.D.7
  • 52
    • 0023673408 scopus 로고
    • Scanning electron microscopic observation on the effects of pyquiton and albendazole on the tegument of Clonorchis sinensis
    • Tang Y.H., Xiao X.C., Liang X.H., Wang R., Wang M. Scanning electron microscopic observation on the effects of pyquiton and albendazole on the tegument of Clonorchis sinensis. Chin. J. Parasitol. Parasitic Dis. 1988, 6:123-125.
    • (1988) Chin. J. Parasitol. Parasitic Dis. , vol.6 , pp. 123-125
    • Tang, Y.H.1    Xiao, X.C.2    Liang, X.H.3    Wang, R.4    Wang, M.5
  • 53
    • 0018689091 scopus 로고
    • The efficacy of amidantel, a new anthelmintic on hookworms and ascarids in dogs
    • Thomas H. The efficacy of amidantel, a new anthelmintic on hookworms and ascarids in dogs. Tropenmed. Parasitol. 1979, 30:404-408.
    • (1979) Tropenmed. Parasitol. , vol.30 , pp. 404-408
    • Thomas, H.1
  • 55
    • 0022376713 scopus 로고
    • The effects of amidantel (BAY d 8815) and its deacylated derivative (BAY d 9216) on Caenorhabditis elegans
    • Tomlinson G., Albuquerque C.A., Woods R.A. The effects of amidantel (BAY d 8815) and its deacylated derivative (BAY d 9216) on Caenorhabditis elegans. Eur. J. Pharmacol. 1985, 113:255-262.
    • (1985) Eur. J. Pharmacol. , vol.113 , pp. 255-262
    • Tomlinson, G.1    Albuquerque, C.A.2    Woods, R.A.3
  • 56
    • 84857109108 scopus 로고    scopus 로고
    • In vitro and in vivo efficacy of tribendimidine and its metabolites alone and in combination against the hookworms Heligmosomoides bakeri and Ancylostoma ceylanicum
    • Tritten L., Nwosu U., Vargas M., Keiser J. In vitro and in vivo efficacy of tribendimidine and its metabolites alone and in combination against the hookworms Heligmosomoides bakeri and Ancylostoma ceylanicum. Acta Trop. 2012, 122:101-107.
    • (2012) Acta Trop. , vol.122 , pp. 101-107
    • Tritten, L.1    Nwosu, U.2    Vargas, M.3    Keiser, J.4
  • 57
    • 84861210652 scopus 로고    scopus 로고
    • A research and development agenda for the control and elimination of human helminthiases
    • Utzinger J. A research and development agenda for the control and elimination of human helminthiases. PLoS Negl. Trop. Dis. 2012, 6:e1646.
    • (2012) PLoS Negl. Trop. Dis. , vol.6
    • Utzinger, J.1
  • 61
    • 33749252978 scopus 로고    scopus 로고
    • World Health Organization, Geneva, Available at:, (accessed 15.10.12) WHO
    • WHO WHO Model List of Essential Medicines, 17th List (March 2011) 2011, World Health Organization, Geneva, Available at:, (accessed 15.10.12). http://whqlibdoc.who.int/hq/2011/a95053_eng.pdf.
    • (2011) WHO Model List of Essential Medicines, 17th List (March 2011)
  • 62
    • 79959775172 scopus 로고    scopus 로고
    • Soil-transmitted helminthiases: estimates of the number of children needing preventive chemotherapy and number treated, 2009 WHO
    • WHO Soil-transmitted helminthiases: estimates of the number of children needing preventive chemotherapy and number treated, 2009. Wkly Epidemiol. Rec. 2011, 86:257-267.
    • (2011) Wkly Epidemiol. Rec. , vol.86 , pp. 257-267
  • 64
    • 33847656847 scopus 로고    scopus 로고
    • Effect of a novel drug - enteric coated tribendimidine in the treatment of intestinal nematode infections
    • Wu Z.X., Fang Y.Y., Liu Y.S. Effect of a novel drug - enteric coated tribendimidine in the treatment of intestinal nematode infections. Chin. J. Parasitol. Parasitic Dis. 2006, 24:23-26.
    • (2006) Chin. J. Parasitol. Parasitic Dis. , vol.24 , pp. 23-26
    • Wu, Z.X.1    Fang, Y.Y.2    Liu, Y.S.3
  • 65
    • 33846441287 scopus 로고    scopus 로고
    • Tribendimidine - a new broad-spectrum drug against intestinal helminths
    • Xiao S.H., Wu H.M., Wang C. Tribendimidine - a new broad-spectrum drug against intestinal helminths. Chin. J. Parasitol. Parasitic Dis. 2004, 22:312-315.
    • (2004) Chin. J. Parasitol. Parasitic Dis. , vol.22 , pp. 312-315
    • Xiao, S.H.1    Wu, H.M.2    Wang, C.3
  • 66
    • 16244373381 scopus 로고    scopus 로고
    • Tribendimidine: a promising, safe and broad-spectrum anthelmintic agent from China
    • Xiao S.H., Wu H.M., Tanner M., Utzinger J., Wang C. Tribendimidine: a promising, safe and broad-spectrum anthelmintic agent from China. Acta Trop. 2005, 94:1-14.
    • (2005) Acta Trop. , vol.94 , pp. 1-14
    • Xiao, S.H.1    Wu, H.M.2    Tanner, M.3    Utzinger, J.4    Wang, C.5
  • 67
    • 38549143794 scopus 로고    scopus 로고
    • Clinical observation on 899 children infected with intestinal nematodes and treated with tribendimidine enteric coated tablets
    • Xiao S.H., Wu Z.X., Zhang J.H., Wang S.Q., Wang S.H., Qiu D.C., Wang C. Clinical observation on 899 children infected with intestinal nematodes and treated with tribendimidine enteric coated tablets. Chin. J. Parasitol. Parasitic Dis. 2007, 25:372-375.
    • (2007) Chin. J. Parasitol. Parasitic Dis. , vol.25 , pp. 372-375
    • Xiao, S.H.1    Wu, Z.X.2    Zhang, J.H.3    Wang, S.Q.4    Wang, S.H.5    Qiu, D.C.6    Wang, C.7
  • 68
    • 40949084307 scopus 로고    scopus 로고
    • Artemether, artesunate, praziquantel and tribendimidine administered singly at different dosages against Clonorchis sinensis: a comparative in vivo study
    • Xiao S.H., Xue J., Tanner M., Zhang Y.N., Keiser J., Utzinger J., Qiang H.Q. Artemether, artesunate, praziquantel and tribendimidine administered singly at different dosages against Clonorchis sinensis: a comparative in vivo study. Acta Trop. 2008, 106:54-59.
    • (2008) Acta Trop. , vol.106 , pp. 54-59
    • Xiao, S.H.1    Xue, J.2    Tanner, M.3    Zhang, Y.N.4    Keiser, J.5    Utzinger, J.6    Qiang, H.Q.7
  • 69
    • 67649985282 scopus 로고    scopus 로고
    • Effect of tribendimidine, artesunate, artemether and praziquantel, administered intragastrically at single, multiple or combined doses, to rats infected with Clonorchis sinensis
    • Xiao S.H., Xue J., Tanner M., Zhang Y.N., Keiser J., Utzinger J., Qiang H.Q., Liu X.Y. Effect of tribendimidine, artesunate, artemether and praziquantel, administered intragastrically at single, multiple or combined doses, to rats infected with Clonorchis sinensis. Chin. J. Parasitol. Parasitic Dis. 2008, 26:321-326.
    • (2008) Chin. J. Parasitol. Parasitic Dis. , vol.26 , pp. 321-326
    • Xiao, S.H.1    Xue, J.2    Tanner, M.3    Zhang, Y.N.4    Keiser, J.5    Utzinger, J.6    Qiang, H.Q.7    Liu, X.Y.8
  • 70
    • 79955929052 scopus 로고    scopus 로고
    • Comparative effect of mebendazole, albendazole, tribendimidine, and praziquantel in treatment of rats infected with Clonorchis sinensis
    • Xiao S.H., Xue J., Xu L.L., Zhang Y.N., Qiang H.Q. Comparative effect of mebendazole, albendazole, tribendimidine, and praziquantel in treatment of rats infected with Clonorchis sinensis. Parasitol. Res. 2011, 108:723-730.
    • (2011) Parasitol. Res. , vol.108 , pp. 723-730
    • Xiao, S.H.1    Xue, J.2    Xu, L.L.3    Zhang, Y.N.4    Qiang, H.Q.5
  • 71
    • 70350223985 scopus 로고    scopus 로고
    • The in vitro and in vivo effect of tribendimidine and its metabolites against Clonorchis sinensis
    • Xiao S.H., Xue J., Xu L.L., Zheng Q., Qiang H.Q., Zhang Y.N. The in vitro and in vivo effect of tribendimidine and its metabolites against Clonorchis sinensis. Parasitol. Res. 2009, 105:1497-1507.
    • (2009) Parasitol. Res. , vol.105 , pp. 1497-1507
    • Xiao, S.H.1    Xue, J.2    Xu, L.L.3    Zheng, Q.4    Qiang, H.Q.5    Zhang, Y.N.6
  • 72
    • 63849244947 scopus 로고    scopus 로고
    • Effect of single-dose oral artemether and tribendimidine on the tegument of adult Clonorchis sinensis in rats
    • Xiao S.H., Keiser J., Xue J., Tanner M., Morson G., Utzinger J. Effect of single-dose oral artemether and tribendimidine on the tegument of adult Clonorchis sinensis in rats. Parasitol. Res. 2009, 104:533-541.
    • (2009) Parasitol. Res. , vol.104 , pp. 533-541
    • Xiao, S.H.1    Keiser, J.2    Xue, J.3    Tanner, M.4    Morson, G.5    Utzinger, J.6
  • 73
    • 70350228330 scopus 로고    scopus 로고
    • Determination of urinary tribendimidine metabolite terephthalic acid by HPLC
    • Xu J., Yuan G.Y., Wei C.M., Wang B.J., Guo R.C. Determination of urinary tribendimidine metabolite terephthalic acid by HPLC. J. Shandong Univ.: Health Sci. 2008, 46:1016-1019.
    • (2008) J. Shandong Univ.: Health Sci. , vol.46 , pp. 1016-1019
    • Xu, J.1    Yuan, G.Y.2    Wei, C.M.3    Wang, B.J.4    Guo, R.C.5
  • 75
    • 27744553039 scopus 로고    scopus 로고
    • Necator americanus: optimization of the golden hamster model for testing anthelmintic drugs
    • Xue J., Qiang H.Q., Yao J.M., Fujiwara R., Zhan B., Hotez P., Xiao S.H. Necator americanus: optimization of the golden hamster model for testing anthelmintic drugs. Exp. Parasitol. 2005, 111:219-223.
    • (2005) Exp. Parasitol. , vol.111 , pp. 219-223
    • Xue, J.1    Qiang, H.Q.2    Yao, J.M.3    Fujiwara, R.4    Zhan, B.5    Hotez, P.6    Xiao, S.H.7
  • 76
    • 38549162092 scopus 로고    scopus 로고
    • Artemether and tribendimidine lack activity in experimental treatment of Paragonimus westermani in the dog
    • Xue J., Utzinger J., Zhang Y.N., Tanner M., Keiser J., Xiao S.H. Artemether and tribendimidine lack activity in experimental treatment of Paragonimus westermani in the dog. Parasitol. Res. 2008, 102:537-540.
    • (2008) Parasitol. Res. , vol.102 , pp. 537-540
    • Xue, J.1    Utzinger, J.2    Zhang, Y.N.3    Tanner, M.4    Keiser, J.5    Xiao, S.H.6
  • 77
    • 77957297535 scopus 로고    scopus 로고
    • Efficacy of tribendimidine and albendazole in treatment of mice infected with Trichinella spiralis
    • Xue J., Xiao S.H., Xu L.L., Zhang Y.N., Qiang H.Q. Efficacy of tribendimidine and albendazole in treatment of mice infected with Trichinella spiralis. Chin. J. Parasitol. Parasitic Dis. 2010, 28:8-11.
    • (2010) Chin. J. Parasitol. Parasitic Dis. , vol.28 , pp. 8-11
    • Xue, J.1    Xiao, S.H.2    Xu, L.L.3    Zhang, Y.N.4    Qiang, H.Q.5
  • 78
    • 79952062421 scopus 로고    scopus 로고
    • Treatment of rats infected with Clonorchis sinensis using clinical administration regimens of tribendimidine, praziquantel and artesunate
    • Xue J., Xu L.L., Qiang H.Q., Zhang Y.N., Xiao S.H. Treatment of rats infected with Clonorchis sinensis using clinical administration regimens of tribendimidine, praziquantel and artesunate. Chin. J. Parasitol. Parasitic Dis. 2010, 28:166-171.
    • (2010) Chin. J. Parasitol. Parasitic Dis. , vol.28 , pp. 166-171
    • Xue, J.1    Xu, L.L.2    Qiang, H.Q.3    Zhang, Y.N.4    Xiao, S.H.5
  • 79
    • 77952516739 scopus 로고    scopus 로고
    • The effect of tribendimidine and its metabolites against Necator americanus in golden hamsters and Nippostrongylus braziliensis in rats
    • Xue J., Xiao S.H., Xu L.L., Qiang H.Q. The effect of tribendimidine and its metabolites against Necator americanus in golden hamsters and Nippostrongylus braziliensis in rats. Parasitol. Res. 2010, 106:775-781.
    • (2010) Parasitol. Res. , vol.106 , pp. 775-781
    • Xue, J.1    Xiao, S.H.2    Xu, L.L.3    Qiang, H.Q.4
  • 80
    • 77957311640 scopus 로고    scopus 로고
    • Therapeutic effect of tribendimidine, artesunate and praziquantel administered to hamsters infected with Clonorchis sinensis
    • Xue J., Xu L.L., Qiang H.Q., Zhang Y.N., Xiao S.H. Therapeutic effect of tribendimidine, artesunate and praziquantel administered to hamsters infected with Clonorchis sinensis. Chin. J. Parasitol. Parasitic Dis. 2009, 27:215-218.
    • (2009) Chin. J. Parasitol. Parasitic Dis. , vol.27 , pp. 215-218
    • Xue, J.1    Xu, L.L.2    Qiang, H.Q.3    Zhang, Y.N.4    Xiao, S.H.5
  • 81
    • 84875553397 scopus 로고
    • Synthesis of tribendimidine and its substituted analogues as new anthelmintic agents
    • Chinese Academy of Preventive Medicine
    • Yao R.H., Chen Y.Q. Synthesis of tribendimidine and its substituted analogues as new anthelmintic agents. Annual Report of Institute of Parasitic Diseases 1986, Chinese Academy of Preventive Medicine, pp. 199-202.
    • (1986) Annual Report of Institute of Parasitic Diseases , pp. 199-202
    • Yao, R.H.1    Chen, Y.Q.2
  • 82
    • 46149092171 scopus 로고    scopus 로고
    • LC-MS determination of P-(1-dimethylamino ethylimino) aniline: a metabolite of tribendimidine in human plasma
    • Yuan G.Y., Wang B.J., Wei C.M., Zhong R., Guo R.C. LC-MS determination of P-(1-dimethylamino ethylimino) aniline: a metabolite of tribendimidine in human plasma. Chromatographia 2008, 68:139-142.
    • (2008) Chromatographia , vol.68 , pp. 139-142
    • Yuan, G.Y.1    Wang, B.J.2    Wei, C.M.3    Zhong, R.4    Guo, R.C.5
  • 84
    • 78751702491 scopus 로고    scopus 로고
    • Metabolism and disposition of tribendimidine and its metabolites in healthy Chinese volunteers
    • Yuan G.Y., Xu J., Qu T., Wang B.J., Zhang R., Wei C.M., Guo R.C. Metabolism and disposition of tribendimidine and its metabolites in healthy Chinese volunteers. Drugs R&D 2010, 10:83-90.
    • (2010) Drugs R&D , vol.10 , pp. 83-90
    • Yuan, G.Y.1    Xu, J.2    Qu, T.3    Wang, B.J.4    Zhang, R.5    Wei, C.M.6    Guo, R.C.7
  • 85
    • 56149106023 scopus 로고    scopus 로고
    • Tribendimidine enteric coated tablet in treatment of 1,292 cases with intestinal nematode infection - a phase IV clinical trial
    • Zhang J.H., Xiao S.H., Wu Z.X., Qiu D.C., Wang S.H., Wang S.Q., Wang C. Tribendimidine enteric coated tablet in treatment of 1,292 cases with intestinal nematode infection - a phase IV clinical trial. Chin. J. Parasitol. Parasitic Dis. 2008, 26:6-9.
    • (2008) Chin. J. Parasitol. Parasitic Dis. , vol.26 , pp. 6-9
    • Zhang, J.H.1    Xiao, S.H.2    Wu, Z.X.3    Qiu, D.C.4    Wang, S.H.5    Wang, S.Q.6    Wang, C.7
  • 86
    • 84886953560 scopus 로고    scopus 로고
    • Therapeutic effect of tribendimidine in treatment of Enterobius vermicularis infection
    • Zhou X.Y., Lin L., Zang Y.Y. Therapeutic effect of tribendimidine in treatment of Enterobius vermicularis infection. Chin. J. Schistosomiasis Control 2008, 20:226.
    • (2008) Chin. J. Schistosomiasis Control , vol.20 , pp. 226
    • Zhou, X.Y.1    Lin, L.2    Zang, Y.Y.3


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