Effects of imidazoline I 2 receptor ligands on acute nociception in rats

NeuroReport

Volumn 23, Issue 2, 2012, Pages 73-77

  Sampson, Cristal ^a   Zhang, Yanan ^b   Bello, Fabio Del ^c   Li, Jun Xu ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b RTI INTERNATIONAL   (United States)

^c UNIVERSITY OF CAMERINO   (Italy)

Author keywords

antinociception; imidazoline I 2 receptor; locomotion; pain; rats

Indexed keywords

2 (2 BENZOFURANYL) 2 IMIDAZOLINE HYDROCHLORIDE; 2 (2 IMIDAZOLIN 2 YL)QUINOLINE; [5 (2 METHYL PHENOXY METHYL) 1, 3 OXAZOLIN 2 YL]AMINE; AGMATINE; ANALGESIC AGENT; DIPHENYZOLINE; HOT WATER; IDAZOXAN; IMIDAZOLINE I2 RECEPTOR; PHENYZOLINE; S 22687; UNCLASSIFIED DRUG; IMIDAZOLINE RECEPTOR; IMIDAZOLINE RECEPTOR 2; LIGAND; NARCOTIC ANALGESIC AGENT;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANTINOCICEPTION; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFICACY; LOCOMOTION; MALE; MOTOR DYSFUNCTION; NOCICEPTION; NONHUMAN; PAIN; PRIORITY JOURNAL; RAT; WATER TEMPERATURE; WITHDRAWAL REFLEX; ANIMAL; DRUG POTENTIATION; SPRAGUE DAWLEY RAT;

ANALGESICS; ANALGESICS, OPIOID; ANIMALS; IMIDAZOLINE RECEPTORS; LIGANDS; MALE; PAIN; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84855356434     PISSN: 09594965     EISSN: 1473558X     Source Type: Journal    
DOI: 10.1097/WNR.0b013e32834e7db3     Document Type: Article

References (22)

1. Hoy D, March L, Brooks P, Woolf A, Blyth F, Vos T, et al. Measuring the global burden of low back pain. Best Pract Res Clin Rheumatol 2010; 24: 155-165.
2. Deandrea S, Montanari M, Moja L, Apolone G. Prevalence of undertreatment in cancer pain. A review of published literature. Ann Oncol 2008; 19: 1985-1991.
3. 2 receptors: target for new analgesics? Eur J Pharmacol 2011; 658:49-56.
4. Ferrari F, Fiorentino S, Mennuni L, Garofalo P, Letari O, Mandelli S, et al. Analgesic efficacy of CR4056, a novel imidazoline-2 receptor ligand, in rat models of inflammatory and neuropathic pain. J Pain Res 2011; 4: 111-125.
5. Fairbanks CA, Schreiber KL, Brewer KL, Yu CG, Stone LS, Kitto KF, et al. Agmatine reverses pain induced by inflammation, neuropathy, and spinal cord injury. Proc Natl Acad Sci USA 2000; 97:10584-10589.
6. Courteix C, Privat AM, Pelissier T, Hernandez A, Eschalier A, Fialip J. Agmatine induces antihyperalgesic effects in diabetic rats and a superadditive interaction with R(-)-3-(2-carboxypiperazine-4-yl)-propyl-1-phosphonic acid, a N-methyl-D-aspartate-receptor antagonist. J Pharmacol Exp Ther 2007; 322:1237-1245. (Pubitemid 47295777)
7. Keynan O, Mirovsky Y, Dekel S, Gilad VH, Gilad GM. Safety and efficacy of dietary agmatine sulfate in lumbar disc-associated radiculopathy. An open-label, dose-escalating study followed by a randomized, double-blind, placebo-controlled trial. Pain Med 2010; 11:356-368.
8. Sanchez-Blazquez P, Boronat MA, Olmos G, Garcia-Sevilla JA, Garzon J. Activation of I(2)-imidazoline receptors enhances supraspinal morphine analgesia in mice: a model to detect agonist and antagonist activities at these receptors. Br J Pharmacol 2000; 130:146-152. (Pubitemid 30248438)
9. Yesilyurt O, Uzbay IT. Agmatine potentiates the analgesic effect of morphine by an alpha(2)-adrenoceptor-mediated mechanism in mice. Neuropsychopharmacology 2001; 25:98-103. (Pubitemid 32493826)
10. Gentili F, Cardinaletti C, Carrieri A, Ghelfi F, Mattioli L, Perfumi M, et al. Involvement of I2-imidazoline binding sites in positive and negative morphine analgesia modulatory effects. Eur J Pharmacol 2006; 553: 73-81. (Pubitemid 44779586)
11. Thorn DA, Zhang Y, Peng BW, Winter JC, Li JX. Effects of imidazoline I2 receptor ligands on morphine-and tramadol-induced antinociception in rats. Eur J Pharmacol 2011; 670: 435-440.
12. Li JX, Koek W, Rice KC, France CP. Effects of direct-and indirect-acting serotonin receptor agonists on the antinociceptive and discriminative stimulus effects of morphine in rhesus monkeys. Neuropsychopharmacology 2011; 36:940-949.
13. Pigini M, Bousquet P, Carotti A, Dontenwill M, Giannella M, Moriconi R, et al. Imidazoline receptors: qualitative structure-activity relationships and discovery of tracizoline and benazoline. Two ligands with high affinity and unprecedented selectivity. Bioorg Med Chem 1997; 5:833-841. (Pubitemid 27246662)
14. Ishihara M, Togo H. Direct oxidative conversion of aldehydes and alcohols to 2-imidazolines and 2-oxazolines using molecular iodine. Tetrahedron 2007; 63:1474-1480. (Pubitemid 44969407)
15. Aricioglu F, Korcegez E, Bozkurt A, Ozyalcin S. Effect of agmatine on acute and mononeuropathic pain. Ann N Y Acad Sci 2003; 1009:106-115. (Pubitemid 38265094)
16. Aggarwal S, Shavalian B, Kim E, Rawls SM. Agmatine enhances cannabinoid action in the hot-plate assay of thermal nociception. Pharmacol Biochem Behav 2009; 93:426-432.
17. Li J, Li X, Pei G, Qin BY. Analgesic effect of agmatine and its enhancement on morphine analgesia in mice and rats. Zhongguo Yao Li Xue Bao 1999; 20:81-85. (Pubitemid 29042469)
18. Fischer BD. Preclinical assessment of drug combinations for the treatment of pain: isobolographic and dose-addition analysis of the opioidergic system. CNS Neurol Disord Drug Targets 2011; 10:529-535.
19. Li JX, Zhang Y, Winter JC. Morphine-induced antinociception in the rat: supra-additive interactions with imidazoline I2 receptor ligands. Eur J Pharmacol 2011; 669:59-65.
20. 2-imidazoline binding sites. Neurochem Int 1997; 30:47-53. (Pubitemid 27032543)
21. Hudson AL, Tyacke RJ, Lalies MD, Davies N, Finn DP, Marti O, et al. Novel ligands for the investigation of imidazoline receptors and their binding proteins. Ann N Y Acad Sci 2003; 1009:302-308. (Pubitemid 38265124)
22. Barrot M, Rettori MC, Guardiola-Lemaitre B, Jarry C, Le Moal M, Piazza PV. Interactions between imidazoline binding sites and dopamine levels in the rat nucleus accumbens. Eur J Neurosci 2000; 12:4547-4551. (Pubitemid 32037863)