Aldehyde dehydrogenase variation enhances effect of pesticides associated with Parkinson disease

Neurology

Volumn 82, Issue 5, 2014, Pages 419-426

  Fitzmaurice, Arthur G ^a,b   Rhodes, Shannon L ^c   Cockburn, Myles ^d   Ritz, Beate ^a,b,c   Bronstein, Jeff M ^a,b,e  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^e VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE DEHYDROGENASE ISOENZYME 2; BENOMYL; CAPTAN; CARBON DISULFIDE; DICARBOXYMIDE; DIELDRIN; DITHIOCARBAMIC ACID; FOLPET; IMIDAZOLE; IMIDAZOLE DERIVATIVE; MANCOZEB; MANEB; ORGANOCHLORINE DERIVATIVE; PESTICIDE; THIOPHOSGENE; THIRAM; TRIFLUMIZOLE; UNCLASSIFIED DRUG; ZINEB; ZIRAM;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; EXPOSURE VARIABLE; FEMALE; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; NONHUMAN; OCCUPATIONAL EXPOSURE; PARKINSON DISEASE; POPULATION BASED CASE CONTROL STUDY; PRIORITY JOURNAL; RAT; SINGLE NUCLEOTIDE POLYMORPHISM; TELEPHONE INTERVIEW; WORKPLACE;

ALDEHYDE DEHYDROGENASE; ANIMALS; ANIMALS, NEWBORN; CASE-CONTROL STUDIES; ENVIRONMENTAL EXPOSURE; GENETIC VARIATION; HUMANS; NEURONS; PARKINSON DISEASE; PESTICIDES; POPULATION SURVEILLANCE; RATS;

EID: 84895724811     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/WNL.0000000000000083     Document Type: Article

References (40)

1. Braak H, Del Tredici K, Rub U, de Vos RA, Jansen Steur EN, Braak E. Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol Aging 2003;24:197-211.
2. Nalls MA, Plagnol V, Hernandez DG, et al. Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. Lancet 2011;377:641-649.
3. Priyadarshi A, Khuder SA, Schaub EA, Priyadarshi SS. Environmental risk factors and Parkinson's disease: a metaanalysis. Environ Res 2001;86:122-127.
4. Kamel F, Tanner C, Umbach D, et al. Pesticide exposure and self-reported Parkinson's disease in the agricultural health study. Am J Epidemiol 2007;165:364-374.
5. Wang A, Costello S, Cockburn M, Zhang X, Bronstein J, Ritz B. Parkinson's disease risk from ambient exposure to pesticides. Eur J Epidemiol 2011;26:547-555.
6. Pezzoli G, Cereda E. Exposure to pesticides or solvents and risk of Parkinson disease. Neurology 2013;80:2035-2041.
7. Elbaz A, Levecque C, Clavel J, et al. CYP2D6 polymorphism, pesticide exposure, and Parkinson's disease. Ann Neurol 2004;55:430-434.
8. Hancock DB, Martin ER, Vance JM, Scott WK. Nitric oxide synthase genes and their interactions with environmental factors in Parkinson's disease. Neurogenetics 2008;9:249-262.
9. Ritz BR, Manthripragada AD, Costello S, et al. Dopamine transporter genetic variants and pesticides in Parkinson's disease. Environ Health Perspect 2009;117:964-969.
10. Manthripragada AD, Costello S, Cockburn MG, Bronstein JM, Ritz B. Paraoxonase 1, agricultural organophosphate exposure, and Parkinson disease. Epidemiology 2010;21:87-94.
11. Fitzmaurice AG, Rhodes SL, Lulla A, et al. Aldehyde dehydrogenase inhibition as a pathogenic mechanism in Parkinson disease. Proc Natl Acad Sci USA 2013;110:636-641.
12. Kataria HR, Grover RK. Effect of benomyl and thiophanate-methyl on metabolic activities of Rhizoctonia solani Kuhn. Ann Microbiol 1976;127A:297-306.
13. LaMondia JA, Douglas SM. Sensitivity of Botrytis cinerea from Connecticut greenhouses to benzimidazole and dicarboximide fungicides. Plant Dis 1997;81:729-732.
14. Hutchinson CM, McGiffen ME Jr, Sims JJ, Becker JO. Fumigant combinations for Cyperus esculentum L control. Pest Manag Sci 2004;60:369-374.
15. Potocnik I, Vukojevic J, Stajic M, et al. In vitro toxicity of selected fungicides from the groups of benzimidazoles and demethylation inhibitors to Cladobotryum dendroides and Agaricus bisporus. J Environ Sci Health B 2009;44:365-370.
16. Deepak SA, Basavaraju P, Chaluvaraju G, Shetty NP, Oros G, Shekar Shetty H. Developmental stage response of pearl millet downy mildew (Sclerospora graminicola) to fungicides. Appl Ecol Environ Res 2006;4:125-149.
17. Prom LK. Laboratory, greenhouse, and field assessment of fourteen fungicides for activity against Claviceps africana, causal agent of sorghum ergot. Plant Dis 2003;87 252-258.
18. Kang GA, Bronstein JM, Masterman DL, Redelings M, Crum JA, Ritz B. Clinical characteristics in early Parkinson's disease in a central California population-based study. Mov Disord 2005;20:1133-1142.
19. Bordelon YM, Hays RD, Vassar SD, Diaz N, Bronstein J, Vickrey BG. Medication responsiveness of motor symptoms in a population-based study of Parkinson disease. Parkinsons Dis 2011;2011:967839.
20. Ritz B, Rhodes SL, Bordelon Y, Bronstein J. Alpha-synuclein genetic variants predict faster motor symptom progression in idiopathic Parkinson disease. PLoS One 2012;7:e36199.
21. Vassar SD, Bordelon YM, Hays RD, et al. Confirmatory factor analysis of the motor unified Parkinson's disease rating scale. Parkinsons Dis 2012;2012:719167.
22. Hughes AJ, Ben-Shlomo Y, Daniel SE, Lees AJ. What features improve the accuracy of clinical diagnosis in Parkinson's disease: a clinicopathologic study. 1992. Neurology 2001;57(suppl 3):S34-S38.
23. Goldberg DW, Wilson JP, Knoblock CA, Ritz B, Cockburn MG. An effective and efficient approach for manually improving geocoded data. Int J Health Geogr 2008;7: 1-20.
24. Rull RP, Ritz B. Historical pesticide exposure in California using pesticide use reports and land-use surveys: an assessment of misclassification error and bias. Environ Health Perspect 2003;111:1582-1589.
25. Daly MJ, Rioux JD, Schaffner SF, Hudson TJ, Lander ES. High-resolution haplotype structure in the human genome. Nat Genet 2001;29:229-232.
26. Wall JD, Pritchard JK. Assessing the performance of the haplotype block model of linkage disequilibrium. Am J Hum Genet 2003;73:502-515.
27. Crawford DC, Nickerson DA. Definition and clinical importance of haplotypes. Annu Rev Med 2005;56:303-320.
28. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005;21:263-265.
29. Takeuchi F, Isono M, Nabika T, et al. Confirmation of ALDH2 as a major locus of drinking behavior and of its variants regulating multiple metabolic phenotypes in a Japanese population. Circ J 2011;75:911-918.
30. Seltman H, Roeder K, Devlin B. Evolutionary-based association analysis using haplotype data. Genet Epidemiol 2003; 25:48-58.
31. Narayan S, Liew Z, Paul K, et al. Household organophosphorus pesticide use and Parkinson's disease. Int J Epidemiol 2013;42:1476-1485.
32. Liew Z, Wang A, Bronstein J, Ritz B. Job exposure matrix (JEM) derived estimates of lifetime occupational pesticide exposure and the risk of Parkinson's disease. Arch Environ Occup Health 2013 March 23. Available at: http://www. tandfonline.com/doi/full/10.1080/19338244.2013.778808#. UrIrPSiv1To. Accessed March 18, 2013
33. Vance JM, Ali S, Bradley WG, Singer C, Di Monte DA. Gene-environment interactions in Parkinson's disease and other forms of parkinsonism. Neurotoxicology 2010;31:598-602.
34. Mitchell DY, Petersen DR. Inhibition of rat hepatic mitochondrial aldehyde dehydrogenase-mediated acetaldehyde oxidation by trans-4-hydroxy-2- nonenal. Hepatology 1991;13:728-734.
35. Doorn JA, Hurley TD, Petersen DR. Inhibition of human mitochondrial aldehyde dehydrogenase by 4-hydroxynon-2-enal and 4-oxonon-2-enal. Chem Res Toxicol 2006;19: 102-110.
36. Staub RE, Quistad GB, Casida JE. Mechanism for benomyl action as a mitochondrial aldehyde dehydrogenase inhibitor in mice. Chem Res Toxicol 1998;11:535-543.
37. Staub RE, Sparks SE, Quistad GB, Casida JE. S-methylation as a bioactivation mechanism for mono-and dithiocarbamate pesticides as aldehyde dehydrogenase inhibitors. Chem Res Toxicol 1995;8:1063-1069.
38. Valentine WM, Amarnath V, Amarnath K, Rimmele F, Graham DG. Carbon disulfide mediated protein crosslinking by N,N-diethyldithiocarbamate. Chem Res Toxicol 1995;8:96-102.
39. Sparks SE, Quistad GB, Li W, Casida JE. Chloropicrin dechlorination in relation to toxic action. J Biochem Mol Toxicol 2000;14:26-32.
40. Prabhudesai S, Sinha S, Attar A, et al. A novel "molecular tweezer" inhibitor of alpha-synuclein neurotoxicity in vitro and in vivo. Neurotherapeutics 2012;9:464-476.