C-Src kinase inhibition reduces arrhythmia inducibility and connexin43 dysregulation after myocardial infarction

Journal of the American College of Cardiology

Volumn 63, Issue 9, 2014, Pages 928-934

  Rutledge, Cody A ^a,b   Ng, Fu Siong ^c   Sulkin, Matthew S ^c   Greener, Ian D ^b   Sergeyenko, Artem M ^b   Liu, Hong ^b   Gemel, Joanna ^d   Beyer, Eric C ^d   Sovari, Ali A ^b   Efimov, Igor R ^c   Dudley, Samuel C ^b  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b BROWN UNIVERSITY   (United States)

^c WASHINGTON UNIVERSITY IN ST LOUIS   (United States)

^d UNIVERSITY OF CHICAGO   (United States)

Author keywords

connexin43; gap junctions; myocardial infarction; Src; sudden death

Indexed keywords

C SRC KINASE; CONNEXIN 43; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG; 4 AMINO 7 PHENYLPYRAZOL[3,4 D]PYRIMIDINE; 4 AMINO 7 TERT BUTYL 5 (4 METHYLPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; SARACATINIB; SODIUM CHANNEL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOVASCULAR RISK; CONTROLLED STUDY; DOWN REGULATION; ECHOCARDIOGRAPHY; ELECTROCARDIOGRAPHY MONITORING; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; HEART ARRHYTHMIA; HEART INFARCTION; HEART INFARCTION SIZE; HEART LEFT VENTRICLE FUNCTION; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RISK REDUCTION; TELEMETRY; UPREGULATION; DRUG MECHANISM; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE ENDDIASTOLIC VOLUME; HEART LEFT VENTRICLE ENDSYSTOLIC VOLUME; HEART MUSCLE POTENTIAL; HEART VENTRICLE ARRHYTHMIA; PROTEIN LOCALIZATION;

CONNEXIN43; GAP JUNCTIONS; MYOCARDIAL INFARCTION; SRC; SUDDEN DEATH;

ANIMALS; ARRHYTHMIAS, CARDIAC; BENZODIOXOLES; CONNEXIN 43; DEATH, SUDDEN; ECHOCARDIOGRAPHY; ENZYME INHIBITORS; GAP JUNCTIONS; GENE EXPRESSION REGULATION; MALE; MICE; MICE, INBRED C57BL; MYOCARDIAL INFARCTION; PROTEIN PHOSPHATASE 1; QUINAZOLINES; REACTIVE OXYGEN SPECIES; SRC-FAMILY KINASES;

EID: 84895559564     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2013.10.081     Document Type: Article

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