Ibandronate and ventricular arrhythmia risk

Journal of Cardiovascular Electrophysiology

Volumn 25, Issue 3, 2014, Pages 299-306

  Bonilla, Ingrid M ^a   Vargas Pinto, Pedro ^b   Nishijima, Yoshinori ^a   Pedraza Toscano, Adriana ^b   Ho, Hsiang Ting ^b,c   Long III, Victor P ^a   Belevych, Andriy E ^b,c   Glynn, Patric ^b   Houmsse, Mahmoud ^b,c   Rhodes, Troy ^b,c   Weiss, Raul ^b,c   Hund, Thomas J ^b,d   Hamlin, Robert L ^b,c   Györke, Sandor ^b,d   Carnes, Cynthia A ^a,b,d  

^a College of Pharmacy ^*  (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

^d QTest Labs   (United States)

Author keywords

biophosphonates; calcium; ibandronate; ion channels; long QT; pharmacology; potassium; proarrhythmia; Torsade de Pointes

Indexed keywords

CALCIUM; IBANDRONIC ACID; POTASSIUM; BISPHOSPHONIC ACID DERIVATIVE; BONE DENSITY CONSERVATION AGENT;

ACTION POTENTIAL; ADULT; ANIMAL EXPERIMENT; ARTICLE; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CASE REPORT; DRUG WITHDRAWAL; ELECTROCARDIOGRAM; ELECTROPHYSIOLOGY; FAINTNESS; FEMALE; FOLLOW UP; HEART MUSCLE CELL; HUMAN; HYPOKALEMIA; IMPLANTABLE CARDIOVERTER DEFIBRILLATOR; IN VITRO STUDY; IN VIVO STUDY; MALE; MIDDLE AGED; NONHUMAN; POLYMORPHIC VENTRICULAR TACHYCARDIA; POTASSIUM CURRENT; PRIORITY JOURNAL; QT PROLONGATION; REPOLARIZATION; RISK FACTOR; SARCOPLASMIC RETICULUM; SINGLE DRUG DOSE; TELEMETRY; ANIMAL; CELL CULTURE; CHEMICALLY INDUCED; DOG; DRUG EFFECTS; PATHOPHYSIOLOGY; PHYSIOLOGY; VENTRICULAR FIBRILLATION;

ANIMALS; BONE DENSITY CONSERVATION AGENTS; CALCIUM SIGNALING; CELLS, CULTURED; DIPHOSPHONATES; DOGS; FEMALE; HUMANS; MALE; MIDDLE AGED; MYOCYTES, CARDIAC; VENTRICULAR FIBRILLATION;

EID: 84895559384     PISSN: 10453873     EISSN: 15408167     Source Type: Journal    
DOI: 10.1111/jce.12327     Document Type: Article

References (27)

1. Casartelli A, Lanzoni A, Comelli R, Crivellente F, Defazio R, Dorigatti R, Fasdelli N, Faustinelli I, Pagliarusco S, Tontodonati M, Cristofori P,: A novel and integrated approach for the identification and characterization of drug-induced cardiac toxicity in the dog. Toxicol Pathol 2011; 39: 361-371.
2. Bowes J, Brown AJ, Hamon J, Jarolimek W, Sridhar A, Waldron G, Whitebread S,: Reducing safety-related drug attrition: The use of in vitro pharmacological profiling. Nat Rev Drug Discov 2012; 11: 909-922.
3. Guo L, Dong Z, Guthrie H,: Validation of a guinea pig Langendorff heart model for assessing potential cardiovascular liability of drug candidates. J Pharmacol Toxicol Methods 2009; 60: 130-151.
4. Thomsen MB, Oros A, Schoenmakers M, van Opstal JM, Maas JN, Beekman JD, Vos MA,: Proarrhythmic electrical remodelling is associated with increased beat-to-beat variability of repolarisation. Cardiovasc Res 2007; 73: 521-530.
5. Varkevisser R, Wijers SC, van der Heyden MA, Beekman JD, Meine M, Vos MA,: Beat-to-beat variability of repolarization as a new biomarker for proarrhythmia in vivo. Heart Rhythm 2012; 9: 1718-1726.
6. Wier WG, Hess P,: Excitation-contraction coupling in cardiac Purkinje fibers. Effects of cardiotonic steroids on the intracellular [Ca2+] transient, membrane potential, and contraction. J Gen Physiol 1984; 83: 395-415.
7. Ho HT, Stevens SC, Terentyeva R, Carnes CA, Terentyev D, Gyorke S,: Arrhythmogenic adverse effects of cardiac glycosides are mediated by redox modification of ryanodine receptors. J Physiol 2011; 589 (Pt 19): 4697-4708.
8. Zipes DP, Camm AJ, Borggrefe M, Buxton AE, Chaitman B, Fromer M, Gregoratos G, Klein G, Moss AJ, Myerburg RJ, Priori SG, Quinones MA, Roden DM, Silka MJ, Tracy C, Smith SC, Jr, Jacobs AK, Adams CD, Antman EM, Anderson JL, Hunt SA, Halperin JL, Nishimura R, Ornato JP, Page RL, Riegel B, Blanc JJ, Budaj A, Dean V, Deckers JW, Despres C, Dickstein K, Lekakis J, McGregor K, Metra M, Morais J, Osterspey A, Tamargo JL, Zamorano JL,: ACC/AHA/ESC 2006 Guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: A report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines (writing committee to develop Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death): Developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society. Circulation 2006; 114: e385-e484.
9. Sridhar A, Nishijima Y, Terentyev D, Terentyeva R, Uelmen R, Kukielka M, Bonilla IM, Robertson GA, Gyorke S, Billman GE, Carnes CA,: Repolarization abnormalities and afterdepolarizations in a canine model of sudden cardiac death. Am J Physiol Regul Integr Comp Physiol 2008; 295: R1463-R1472.
10. Sridhar A, da Cunha DN, Lacombe VA, Zhou Q, Fox JJ, Hamlin RL, Carnes CA,: The plateau outward current in canine ventricle, sensitive to 4-aminopyridine, is a constitutive contributor to ventricular repolarization. Br J Pharmacol 2007; 152: 870-879.
11. Bonilla IM, Belevych A, Sridhar A, Nishijima Y, Ho HT, He Q, Kukielka M, Terentyev D, Terentyeva R, Liu B, Long VP, Gyorke S, Carnes CA, Billman GE,: Endurance exercise training normalizes repolarization and calcium handling abnormalities preventing ventricular fibrillation in a model of sudden cardiac death. J Appl Physiol 2012; 113: 1772-1783.
12. Barrett J, Worth E, Bauss F, Epstein S,: Ibandronate: A clinical pharmacological and pharmacokinetic update. J Clin Pharmacol 2004; 44: 951-965.
13. Kimmel DB,: Mechanism of action, pharmacokinetic and pharmacodynamic profile, and clinical applications of nitrogen-containing bisphosphonates. J Dent Res 2007; 86: 1022-1033.
14. Grandi E, Pasqualini FS, Bers DM,: A novel computational model of the human ventricular action potential and Ca transient. J Mol Cell Cardiol 2010; 48: 112-121.
15. Romero L, Pueyo E, Fink M, Rodriguez B,: Impact of ionic current variability on human ventricular cellular electrophysiology. Am J Physiol Heart Circ Physiol 2009; 297: H1436-H1445.
16. Salari SP, Abdollahi M, Larijani B,: Current, new and future treatments of osteoporosis. Rheumatol Int 2011; 31: 289-300.
17. Salari P, Abdollahi M,: Long term bisphosphonate use in osteoporotic patients; A step forward, two steps back. J Pharm Pharm Sci 2012; 15: 305-317.
18. John CA,: Review of the cardiovascular safety of zoledronic acid and other bisphosphonates for the treatment of osteoporosis. Clin Ther 2010; 32: 426-436.
19. Friedrichs GS, Patmore L, Bass A,: Non-clinical evaluation of ventricular repolarization (ICH S7B): Results of an interim survey of international pharmaceutical companies. J Pharmacol Toxicol Methods 2005; 52: 6-11.
20. Dumotier BM, Georgieva AV,: Preclinical cardio-safety assessment of torsadogenic risk and alternative methods to animal experimentation: The inseparable twins. Cell Biol Toxicol 2007; 23: 293-302.
21. January CT, Moscucci A,: Cellular mechanisms of early afterdepolarizations. Ann N Y Acad Sci 1992; 644: 23-32.
22. Spencer CI, Sham JS,: Effects of Na+/Ca2 +exchange induced by SR Ca2+ release on action potentials and afterdepolarizations in guinea pig ventricular myocytes. Am J Physiol Heart Circ Physiol 2003; 285: H2552-H2562.
23. Huffaker R, Lamp ST, Weiss JN, Kogan B,: Intracellular calcium cycling, early afterdepolarizations, and reentry in simulated long QT syndrome. Heart Rhythm 2004; 1: 441-448.
24. Gyorke S, Carnes C,: Dysregulated sarcoplasmic reticulum calcium release: Potential pharmacological target in cardiac disease. Pharmacol Ther 2008; 119: 340-354.
25. Cerrone M, Colombi B, Santoro M, di Barletta MR, Scelsi M, Villani L, Napolitano C, Priori SG,: Bidirectional ventricular tachycardia and fibrillation elicited in a knock-in mouse model carrier of a mutation in the cardiac ryanodine receptor. Circ Res 2005; 96: e77-e82.
26. Radwanski PB, Belevych AE, Brunello L, Carnes CA, Gyorke S,: Store-dependent deactivation: Cooling the chain-reaction of myocardial calcium signaling. J Mol Cell Cardiol 2013; 58: 77-83.
27. Cheng H, Lederer WJ, Cannell MB,: Calcium sparks: Elementary events underlying excitation-contraction coupling in heart muscle. Science 1993; 262: 740-744.