-
1
-
-
84867681380
-
Structural basis for proton conduction and inhibition by the influenza M2 protein
-
M. Hong, and W. DeGrado Structural basis for proton conduction and inhibition by the influenza M2 protein Protein Sci. 21 2012 1620 1633
-
(2012)
Protein Sci.
, vol.21
, pp. 1620-1633
-
-
Hong, M.1
Degrado, W.2
-
2
-
-
25844438380
-
Incidence of adamantane resistance among influenza A (H3N2) viruses isolated worldwide from 1994 to 2005: A cause for concern
-
R. Bright, M. Medina, X. Xu, G. Perez-Oronoz, T. Wallis, X. Davis, L. Povinelli, N. Cox, and A. Klimov Incidence of adamantane resistance among influenza A (H3N2) viruses isolated worldwide from 1994 to 2005: a cause for concern Lancet 366 2005 1175 1181
-
(2005)
Lancet
, vol.366
, pp. 1175-1181
-
-
Bright, R.1
Medina, M.2
Xu, X.3
Perez-Oronoz, G.4
Wallis, T.5
Davis, X.6
Povinelli, L.7
Cox, N.8
Klimov, A.9
-
3
-
-
33644536465
-
Adamantane resistance among influenza A viruses isolated early during the 2005-2006 influenza season in the United States
-
R. Bright, D. Shay, B. Shu, N. Cox, and A. Klimov Adamantane resistance among influenza A viruses isolated early during the 2005-2006 influenza season in the United States JAMA 295 2006 891 894
-
(2006)
JAMA
, vol.295
, pp. 891-894
-
-
Bright, R.1
Shay, D.2
Shu, B.3
Cox, N.4
Klimov, A.5
-
4
-
-
67650018858
-
Identification of the functional core of the influenza A virus A/M2 proton-selective ion channel
-
C. Ma, A. Polishchuk, Y. Ohigashi, A. Stouffer, A. Schon, E. Magavern, X. Jing, J. Lear, E. Freire, R. Lamb, W. DeGrado, and L. Pinto Identification of the functional core of the influenza A virus A/M2 proton-selective ion channel Proc. Natl. Acad. Sci. U. S. A. 106 2009 12283 12288
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, pp. 12283-12288
-
-
Ma, C.1
Polishchuk, A.2
Ohigashi, Y.3
Stouffer, A.4
Schon, A.5
Magavern, E.6
Jing, X.7
Lear, J.8
Freire, E.9
Lamb, R.10
Degrado, W.11
Pinto, L.12
-
5
-
-
77956996035
-
Structure and mechanism of proton transport through the transmembrane tetrameric M2 protein bundle of the influenza A virus
-
R. Acharya, V. Carnevale, G. Fiorin, B. Levine, A. Polishchuk, V. Balannik, I. Samish, R. Lamb, L. Pinto, W. DeGrado, and M. Klein Structure and mechanism of proton transport through the transmembrane tetrameric M2 protein bundle of the influenza A virus Proc. Natl. Acad. Sci. U. S. A. 107 2010 15075 15080
-
(2010)
Proc. Natl. Acad. Sci. U. S. A.
, vol.107
, pp. 15075-15080
-
-
Acharya, R.1
Carnevale, V.2
Fiorin, G.3
Levine, B.4
Polishchuk, A.5
Balannik, V.6
Samish, I.7
Lamb, R.8
Pinto, L.9
Degrado, W.10
Klein, M.11
-
6
-
-
0028980598
-
Activation of the M2 ion channel of influenza virus: A role for the transmembrane domain histidine residue
-
C. Wang, R. Lamb, and L. Pinto Activation of the M2 ion channel of influenza virus: a role for the transmembrane domain histidine residue Biophys. J. 69 1995 1363 1371
-
(1995)
Biophys. J.
, vol.69
, pp. 1363-1371
-
-
Wang, C.1
Lamb, R.2
Pinto, L.3
-
7
-
-
0037131381
-
The gate of the influenza virus M2 proton channel is formed by a single tryptophan residue
-
Y. Tang, F. Zaitseva, R. Lamb, and L. Pinto The gate of the influenza virus M2 proton channel is formed by a single tryptophan residue J. Biol. Chem. 277 2002 39880 39886
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 39880-39886
-
-
Tang, Y.1
Zaitseva, F.2
Lamb, R.3
Pinto, L.4
-
8
-
-
0030803839
-
The influenza A virus M2 channel: A molecular modeling and simulation study
-
M. Sansom, I. Kerr, G. Smith, and H. Son The influenza A virus M2 channel: a molecular modeling and simulation study Virology 233 1997 163 173
-
(1997)
Virology
, vol.233
, pp. 163-173
-
-
Sansom, M.1
Kerr, I.2
Smith, G.3
Son, H.4
-
9
-
-
0029816765
-
Selective proton permeability and pH regulation of the influenza virus M2 channel expressed in mouse erythroleukaemia cells
-
I. Chizhmakov, F. Geraghty, D. Ogden, A. Hayhurst, M. Antoniou, and A. Hay Selective proton permeability and pH regulation of the influenza virus M2 channel expressed in mouse erythroleukaemia cells J. Physiol. 494 1996 329 336
-
(1996)
J. Physiol.
, vol.494
, pp. 329-336
-
-
Chizhmakov, I.1
Geraghty, F.2
Ogden, D.3
Hayhurst, A.4
Antoniou, M.5
Hay, A.6
-
10
-
-
0030881872
-
A functionally defined model for the M2 proton channel of influenza A virus suggests a mechanism for its ion selectivity
-
L. Pinto, G. Dieckmann, C. Gandhi, C. Papworth, J. Braman, M. Shaughnessy, J. Lear, R. Lamb, and W. DeGrado A functionally defined model for the M2 proton channel of influenza A virus suggests a mechanism for its ion selectivity Proc. Natl. Acad. Sci. U. S. A. 94 1997 11301 11306
-
(1997)
Proc. Natl. Acad. Sci. U. S. A.
, vol.94
, pp. 11301-11306
-
-
Pinto, L.1
Dieckmann, G.2
Gandhi, C.3
Papworth, C.4
Braman, J.5
Shaughnessy, M.6
Lear, J.7
Lamb, R.8
Degrado, W.9
-
11
-
-
79951818142
-
A theory for the proton transport of the influenza virus M2 protein: Extensive test against conductance data
-
H. Zhou A theory for the proton transport of the influenza virus M2 protein: extensive test against conductance data Biophys. J. 100 2011 912 921
-
(2011)
Biophys. J.
, vol.100
, pp. 912-921
-
-
Zhou, H.1
-
12
-
-
78649500359
-
A pH-dependent conformational ensemble mediates proton transport through the influenza A/M2 protein
-
A. Polishchuk, J. Lear, C. Ma, R. Lamb, L. Pinto, and W. DeGrado A pH-dependent conformational ensemble mediates proton transport through the influenza A/M2 protein Biochemistry 49 2010 10061 10071
-
(2010)
Biochemistry
, vol.49
, pp. 10061-10071
-
-
Polishchuk, A.1
Lear, J.2
Ma, C.3
Lamb, R.4
Pinto, L.5
Degrado, W.6
-
13
-
-
84872875683
-
Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus
-
J. Wang, Y. Wu, C. Ma, G. Fiorin, J. Wang, L. Pinto, R. Lamb, M. Klein, and W. DeGrado Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus Proc. Natl. Acad. Sci. U. S. A. 110 2013 1315 1320
-
(2013)
Proc. Natl. Acad. Sci. U. S. A.
, vol.110
, pp. 1315-1320
-
-
Wang, J.1
Wu, Y.2
Ma, C.3
Fiorin, G.4
Wang, J.5
Pinto, L.6
Lamb, R.7
Klein, M.8
Degrado, W.9
-
14
-
-
38749151911
-
Structural basis for the function and inhibition of an influenza virus proton channel
-
A. Stouffer, R. Acharya, D. Salom, A. Levine, L. Di Constanzo, C. Soto, V. Tereshko, V. Nanda, S. Stayrook, and W. DeGrado Structural basis for the function and inhibition of an influenza virus proton channel Nature 451 2008 596 599
-
(2008)
Nature
, vol.451
, pp. 596-599
-
-
Stouffer, A.1
Acharya, R.2
Salom, D.3
Levine, A.4
Di Constanzo, L.5
Soto, C.6
Tereshko, V.7
Nanda, V.8
Stayrook, S.9
Degrado, W.10
-
15
-
-
38749106195
-
Structure and mechanism of the M2 proton channel of influenza A virus
-
J. Schnell, and J. Chou Structure and mechanism of the M2 proton channel of influenza A virus Nature 451 2008 591 595
-
(2008)
Nature
, vol.451
, pp. 591-595
-
-
Schnell, J.1
Chou, J.2
-
16
-
-
59049103481
-
Molecular dynamics calculations suggest a conduction mechanism for the M2 proton channel from influenza A virus
-
E. Khurana, M. Dal Peraro, R. DeVane, S. Vemparala, W. DeGrado, and M. Klein Molecular dynamics calculations suggest a conduction mechanism for the M2 proton channel from influenza A virus Proc. Natl. Acad. Sci. U. S. A. 106 2009 1069 1074
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, pp. 1069-1074
-
-
Khurana, E.1
Dal Peraro, M.2
Devane, R.3
Vemparala, S.4
Degrado, W.5
Klein, M.6
-
17
-
-
84857711312
-
NMR detection of pH-dependent histidine-water proton exchange reveals the conduction mechanism of a transmembrane proton channel
-
F. Hu, K. Schmidt-Rohr, and M. Hong NMR detection of pH-dependent histidine-water proton exchange reveals the conduction mechanism of a transmembrane proton channel J. Am. Chem. Soc. 134 2012 3703 3713
-
(2012)
J. Am. Chem. Soc.
, vol.134
, pp. 3703-3713
-
-
Hu, F.1
Schmidt-Rohr, K.2
Hong, M.3
-
18
-
-
77958156306
-
Insight into the mechanism of the influenza A proton channel from a structure in a lipid bilayer
-
M. Sharma, M. Yi, H. Dong, H. Qin, E. Peterson, D. Busath, H. Zhou, and T. Cross Insight into the mechanism of the influenza A proton channel from a structure in a lipid bilayer Science 330 2010 509 512
-
(2010)
Science
, vol.330
, pp. 509-512
-
-
Sharma, M.1
Yi, M.2
Dong, H.3
Qin, H.4
Peterson, E.5
Busath, D.6
Zhou, H.7
Cross, T.8
-
19
-
-
77958162674
-
Mechanism of proton conduction and gating in influenza M2 proton channels from solid-state NMR
-
F. Hu, W. Luo, and M. Hong Mechanism of proton conduction and gating in influenza M2 proton channels from solid-state NMR Science 330 2010 505 508
-
(2010)
Science
, vol.330
, pp. 505-508
-
-
Hu, F.1
Luo, W.2
Hong, M.3
-
20
-
-
77957269747
-
Proton and cation transport activity of the M2 proton channel from influenza A virus
-
T. Leiding, J. Wang, J. Martinsson, W. DeGrado, and S. Arskold Proton and cation transport activity of the M2 proton channel from influenza A virus Proc. Natl. Acad. Sci. U. S. A. 107 2010 15409 15414
-
(2010)
Proc. Natl. Acad. Sci. U. S. A.
, vol.107
, pp. 15409-15414
-
-
Leiding, T.1
Wang, J.2
Martinsson, J.3
Degrado, W.4
Arskold, S.5
-
21
-
-
78650288665
-
Functional reconstitution of influenza A M2(22-62)
-
E. Peterson, T. Ryser, S. Funk, D. Inouye, M. Sharma, H. Qin, T. Cross, and D. Busath Functional reconstitution of influenza A M2(22-62) Biochim. Biophys. Acta 1808 2011 516 521
-
(2011)
Biochim. Biophys. Acta
, vol.1808
, pp. 516-521
-
-
Peterson, E.1
Ryser, T.2
Funk, S.3
Inouye, D.4
Sharma, M.5
Qin, H.6
Cross, T.7
Busath, D.8
-
22
-
-
0035085645
-
Definitive assignment of proton selectivity and attoampere unitary current to the M2 ion channel protein of influenza A virus
-
T. Lin, and C. Schroeder Definitive assignment of proton selectivity and attoampere unitary current to the M2 ion channel protein of influenza A virus J. Virol. 75 2001 3647 3656
-
(2001)
J. Virol.
, vol.75
, pp. 3647-3656
-
-
Lin, T.1
Schroeder, C.2
-
23
-
-
33646494326
-
Histidines, heart of the hydrogen ion channel from influenza A virus: Toward an understanding of conductance and proton selectivity
-
J. Hu, R. Fu, K. Nishimura, L. Zhang, H.-X. Zhou, D. Busath, V. Vijayvergiya, and T. Cross Histidines, heart of the hydrogen ion channel from influenza A virus: toward an understanding of conductance and proton selectivity Proc. Natl. Acad. Sci. U. S. A. 103 2006 6865 6870
-
(2006)
Proc. Natl. Acad. Sci. U. S. A.
, vol.103
, pp. 6865-6870
-
-
Hu, J.1
Fu, R.2
Nishimura, K.3
Zhang, L.4
Zhou, H.-X.5
Busath, D.6
Vijayvergiya, V.7
Cross, T.8
-
24
-
-
84878779397
-
Ab initio calculations and validation of the pH-dependent structures of the His37-Trp41 quartet, the heart of acid activation and proton conductance in the M2 protein of Influenza A virus
-
H. Dong, M. Yi, T. Cross, and H. Zhou Ab initio calculations and validation of the pH-dependent structures of the His37-Trp41 quartet, the heart of acid activation and proton conductance in the M2 protein of Influenza A virus Chem. Sci. 4 2013 2776 2787
-
(2013)
Chem. Sci.
, vol.4
, pp. 2776-2787
-
-
Dong, H.1
Yi, M.2
Cross, T.3
Zhou, H.4
-
25
-
-
84866359064
-
Hydrogen-bonding partner of the proton-conducting histidine in the influenza M2 proton channel revealed from 1H chemical shifts
-
M. Hong, K. Fritzsching, and J. Williams Hydrogen-bonding partner of the proton-conducting histidine in the influenza M2 proton channel revealed from 1H chemical shifts J. Am. Chem. Soc. 134 2012 14753 14755
-
(2012)
J. Am. Chem. Soc.
, vol.134
, pp. 14753-14755
-
-
Hong, M.1
Fritzsching, K.2
Williams, J.3
-
26
-
-
84884547099
-
Exploring histidine conformations in the M2 channel lumen of the influenza A virus at neutral pH via molecular simulations
-
H. Dong, G. Fiorin, W. DeGrado, and M. Klein Exploring histidine conformations in the M2 channel lumen of the influenza A virus at neutral pH via molecular simulations J. Phys. Chem. Lett. 4 2013 3067 3071
-
(2013)
J. Phys. Chem. Lett.
, vol.4
, pp. 3067-3071
-
-
Dong, H.1
Fiorin, G.2
Degrado, W.3
Klein, M.4
-
27
-
-
20444385829
-
Chemical rescue of histidine selectivity filter mutants of the M2 ion channel of influenza A virus
-
P. Venkataraman, R. Lamb, and L. Pinto Chemical rescue of histidine selectivity filter mutants of the M2 ion channel of influenza A virus J. Biol. Chem. 280 2005 21463 21472
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 21463-21472
-
-
Venkataraman, P.1
Lamb, R.2
Pinto, L.3
-
28
-
-
0345598917
-
Use of thiol-disulfide equilibria to measure the energetics of assembly of transmembrane helices in phospholipid bilayers
-
L. Cristian, J. Lear, and W. DeGrado Use of thiol-disulfide equilibria to measure the energetics of assembly of transmembrane helices in phospholipid bilayers Proc. Natl. Acad. Sci. U. S. A. 100 2003 14772 14777
-
(2003)
Proc. Natl. Acad. Sci. U. S. A.
, vol.100
, pp. 14772-14777
-
-
Cristian, L.1
Lear, J.2
Degrado, W.3
-
29
-
-
0041914460
-
Determination of membrane protein stability via thermodynamic coupling of folding to thiol-disulfide interchange
-
L. Cristian, J. Lear, and W. DeGrado Determination of membrane protein stability via thermodynamic coupling of folding to thiol-disulfide interchange Protein Sci. 12 2003 1732 1740
-
(2003)
Protein Sci.
, vol.12
, pp. 1732-1740
-
-
Cristian, L.1
Lear, J.2
Degrado, W.3
-
30
-
-
0022556749
-
Determination of the net proton-hydroxide ion permeability across vesicular lipid bilayers and membrane proteins by optical probes
-
N. Dencher, P. Burghaus, and S. Grzesiek Determination of the net proton-hydroxide ion permeability across vesicular lipid bilayers and membrane proteins by optical probes Methods Enzymol. 127 1986 746 760
-
(1986)
Methods Enzymol.
, vol.127
, pp. 746-760
-
-
Dencher, N.1
Burghaus, P.2
Grzesiek, S.3
-
31
-
-
0034708477
-
Mechanism for proton conduction of the M2 ion channel of influenza A virus
-
J. Mould, H.-C. Li, C. Dudlack, J. Lear, A. Pekosz, R. Lamb, and L. Pinto Mechanism for proton conduction of the M2 ion channel of influenza A virus J. Biol. Chem. 275 2000 8592 8599
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 8592-8599
-
-
Mould, J.1
Li, H.-C.2
Dudlack, C.3
Lear, J.4
Pekosz, A.5
Lamb, R.6
Pinto, L.7
-
32
-
-
0034700255
-
PH-dependent tetramerization and amantadine binding of the transmembrane helix of M2 from the influenza A virus
-
D. Salom, B. Hill, J. Lear, and W. DeGrado pH-dependent tetramerization and amantadine binding of the transmembrane helix of M2 from the influenza A virus Biochemistry 39 2000 14160 14170
-
(2000)
Biochemistry
, vol.39
, pp. 14160-14170
-
-
Salom, D.1
Hill, B.2
Lear, J.3
Degrado, W.4
-
34
-
-
84867026687
-
Design and synthesis of pinanamine derivatives as anti-influenza A M2 ion channel inhibitors
-
X. Zhao, Y. Jie, M. Rosenberg, J. Wan, S. Zeng, W. Cui, Y. Xiao, Z. Li, Z. Tu, M. Casarotto, and W. Hu Design and synthesis of pinanamine derivatives as anti-influenza A M2 ion channel inhibitors Antiviral Res. 96 2012 91 99
-
(2012)
Antiviral Res.
, vol.96
, pp. 91-99
-
-
Zhao, X.1
Jie, Y.2
Rosenberg, M.3
Wan, J.4
Zeng, S.5
Cui, W.6
Xiao, Y.7
Li, Z.8
Tu, Z.9
Casarotto, M.10
Hu, W.11
-
35
-
-
84884576955
-
Role of the viral hemagglutinin in the anti-influenza virus activity of newly synthesized polycyclic amine compounds
-
E. Torres, M. Duque, E. Vanderlinden, C. Ma, L. Pinto, P. Camps, M. Froeyen, S. Vazquez, and L. Naesens Role of the viral hemagglutinin in the anti-influenza virus activity of newly synthesized polycyclic amine compounds Antiviral Res. 99 2013 281 291
-
(2013)
Antiviral Res.
, vol.99
, pp. 281-291
-
-
Torres, E.1
Duque, M.2
Vanderlinden, E.3
Ma, C.4
Pinto, L.5
Camps, P.6
Froeyen, M.7
Vazquez, S.8
Naesens, L.9
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