β-catenin enhances odontoblastic differentiation of dental pulp cells through activation of Runx2

PLoS ONE

Volumn 9, Issue 2, 2014, Pages

  Han, Nana ^a   Zheng, Yong ^c   Li, Ran ^a   Li, Xianyu ^a   Zhou, Mi ^a   Niu, Yun ^a   Zhang, Qi ^a,b  

^a Wuhan University   (China)

^b TONGJI UNIVERSITY   (China)

^c WUHAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; LITHIUM CHLORIDE; TRANSCRIPTION FACTOR RUNX2;

ADOLESCENT; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CHROMATIN IMMUNOPRECIPITATION; COMPARATIVE STUDY; CONTROLLED STUDY; DENTIN; GENE INACTIVATION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MALE; NONHUMAN; ODONTOBLAST; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RAT; TOOTH DEVELOPMENT; TOOTH PULP; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; UPREGULATION;

ADOLESCENT; ANIMALS; BETA CATENIN; CELL DIFFERENTIATION; CORE BINDING FACTOR ALPHA 1 SUBUNIT; DENTAL PULP; DENTIN; GENE KNOCKDOWN TECHNIQUES; HUMANS; LITHIUM CHLORIDE; MALE; ODONTOBLASTS; RATS; RATS, WISTAR; TIME FACTORS; UP-REGULATION;

EID: 84895532455     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0088890     Document Type: Article

References (52)

1. Yu C, Abbott PV (2007) An overview of the dental pulp: its functions and responses to injury. Aust Dent J 52: S4-S16.
2. Sloan AJ, Smith AJ (2007) Stem cells and the dental pulp: potential roles in dentine regeneration and repair. Oral Dis 13: 151-157.
3. Cooper PR, Takahashi Y, Graham LW, Simon S, Imazato S, et al. (2010) Inflammation-regeneration interplay in the dentine-pulp complex. J Dent 38: 687-697.
4. Qin W, Yang F, Deng R, Li D, Song Z, et al. (2012) Smad 1/5 is involved in bone morphogenetic protein-2-induced odontoblastic differentiation in human dental pulp cells. J Endod 38: 66-71.
5. Smith AJ (2002) Pulpal responses to caries and dental repair. Caries Res 36: 223-232.
6. Tecles O, Laurent P, Zygouritsas S, Burger AS, Camps J, et al. (2005) Activation of human dental pulp progenitor/stem cells in response to odontoblast injury. Arch Oral Biol 50: 103-108. (Pubitemid 40252924)
7. Lee SK, Lee CY, Kook YA, Lee SK, Kim EC (2010) Mechanical stress promotes odontoblastic differentiation via the heme oxygenase-1 pathway in human dental pulp cell line. Life Sci 86: 107-114.
8. Lee YH, Kang YM, Heo MJ, Kim GE, Bhattarai G, et al. (2013) The survival role of peroxisome proliferator-activated receptor gamma induces odontoblast differentiation against oxidative stress in human dental pulp cells. J Endod 39: 236-241.
9. Grigoryan T, Wend P, Klaus A, Birchmeier W (2008) Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of beta-catenin in mice. Genes Dev 22: 2308-2341.
10. Lim X, Nusse R (2013) Wnt signaling in skin development, homeostasis, and disease. Cold Spring Harb Perspect Biol 5: in press.
11. Jarvinen E, Salazar-Ciudad I, Birchmeier W, Taketo MM, Jernvall J, et al. (2006) Continuous tooth generation in mouse is induced by activated epithelial Wnt/beta-catenin signaling. Proc Natl Acad Sci U S A 103: 18627-18632. (Pubitemid 44913461)
12. Chen J, Lan Y, Baek JA, Gao Y, Jiang R (2009) Wnt/beta-catenin signaling plays an essential role in activation of odontogenic mesenchyme during early tooth development. Dev Biol 334: 174-185.
13. Liu F, Millar SE (2010) Wnt/beta-catenin signaling in oral tissue development and disease. J Dent Res 89: 318-330.
14. Liu F, Chu EY, Watt B, Zhang Y, Gallant NM, et al. (2008) Wnt/beta-catenin signaling directs multiple stages of tooth morphogenesis. Dev Biol 313: 210-224. (Pubitemid 350298315)
15. Mitsiadis TA, Rahiotis C (2004) Parallels between tooth development and repair: conserved molecular mechanisms following carious and dental injury. J Dent Res 83: 896-902. (Pubitemid 41713824)
16. Ross SE, Hemati N, Longo KA, Bennett CN, Lucas PC, et al. (2000) Inhibition of adipogenesis by Wnt signaling. Science 289: 950-953. (Pubitemid 30659947)
17. Day TF, Guo X, Garrett-Beal L, Yang Y (2005) Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis. Dev Cell 8: 739-750. (Pubitemid 40585296)
18. Li J, Li J, Chen B (2012) Oct4 was a novel target of Wnt signaling pathway. Mol Cell Biochem 362: 233-240.
19. Lickert H, Domon C, Huls G, Wehrle C, Duluc I, et al. (2000) Wnt/(beta)-catenin signaling regulates the expression of the homeobox gene Cdx1 in embryonic intestine. Development 127: 3805-3813.
20. Ordonez-Moran P, Irmisch A, Barbachano A, Chicote I, Tenbaum S, et al. (2013) SPROUTY2 is a beta-catenin and FOXO3a target gene indicative of poor prognosis in colon cancer. Oncogene: in press.
21. Li S, Kong H, Yao N, Yu Q, Wang P, et al. (2011) The role of runt-related transcription factor 2 (Runx2) in the late stage of odontoblast differentiation and dentin formation. Biochem Biophys Res Commun 410: 698-704.
22. Chen S, Rani S, Wu Y, Unterbrink A, Gu TT, et al. (2005) Differential regulation of dentin sialophosphoprotein expression by Runx2 during odontoblast cytodifferentiation. J Biol Chem 280: 29717-29727. (Pubitemid 41177049)
23. Komori T (2010) Regulation of bone development and extracellular matrix protein genes by RUNX2. Cell Tissue Res 339: 189-195.
24. Chen S, Gu TT, Sreenath T, Kulkarni AB, Karsenty G, et al. (2002) Spatial expression of Cbfa1/Runx2 isoforms in teeth and characterization of binding sites in the DSPP gene. Connect Tissue Res 43: 338-344. (Pubitemid 34777944)
25. Zhang Q, Wang X, Chen Z, Liu G, Chen Z (2007) Semi-quantitative RT-PCR analysis of LIM mineralization protein 1 and its associated molecules in cultured human dental pulp cells. Arch Oral Biol 52: 720-726. (Pubitemid 46908796)
26. Liu H, Li W, Shi S, Habelitz S, Gao C, et al. (2005) MEPE is downregulated as dental pulp stem cells differentiate. Arch Oral Biol 50: 923-928. (Pubitemid 41393049)
27. Lee SI, Kim DS, Lee HJ, Cha HJ, Kim EC (2013) The role of thymosin beta 4 on odontogenic differentiation in human dental pulp cells. PLoS One 8: e61960.
28. Gaur T, Lengner CJ, Hovhannisyan H, Bhat RA, Bodine PV, et al. (2005) Canonical WNT signaling promotes osteogenesis by directly stimulating Runx2 gene expression. J Biol Chem 280: 33132-33140. (Pubitemid 41397109)
29. Li X, Zhou M, Wang X, Li R, Han N, et al. (2012) Quantitative determination of high-temperature requirement protein A1 and its possible associated molecules during induced reparative dentin formation. J Endod 38: 814-820.
30. Lin H, Liu H, Sun Q, Yuan G, Zhang L, et al. (2013) KLF4 promoted odontoblastic differentiation of mouse dental papilla cells via regulation of DMP1. J Cell Physiol 228: 2076-2085.
31. Salins P, Shawesh S, He Y, Dibrov A, Kashour T, et al. (2007) Lovastatin protects human neurons against Abeta-induced toxicity and causes activation of beta-catenin-TCF/LEF signaling. Neurosci Lett 412: 211-216. (Pubitemid 46109146)
32. Chau WK, Ip CK, Mak AS, Lai HC, Wong AS (2013) c-Kit mediates chemoresistance and tumor-initiating capacity of ovarian cancer cells through activation of Wnt/beta-catenin-ATP-binding cassette G2 signaling. Oncogene 32: 2767-2781.
33. Dull T, Zufferey R, Kelly M, Mandel RJ, Nguyen M, et al. (1998) A third-generation lentivirus vector with a conditional packaging system. J Virol 72: 8463-8471. (Pubitemid 28471781)
34. Piek E, Sleumer LS, van Someren EP, Heuver L, de Haan JR, et al. (2010) Osteo-transcriptomics of human mesenchymal stem cells: accelerated gene expression and osteoblast differentiation induced by vitamin D reveals c-MYC as an enhancer of BMP2-induced osteogenesis. Bone 46: 613-627.
35. Cohen P, Goedert M (2004) GSK3 inhibitors: development and therapeutic potential. Nat Rev Drug Discov 3: 479-487. (Pubitemid 38807530)
36. Heo JS, Lee SY, Lee JC (2010) Wnt/beta-catenin signaling enhances osteoblastogenic differentiation from human periodontal ligament fibroblasts. Mol Cells 30: 449-454.
37. Wang J, Liu B, Gu S, Liang J (2012) Effects of Wnt/beta-catenin signalling on proliferation and differentiation of apical papilla stem cells. Cell Prolif 45: 121-131.
38. Wei Y, Chen YH, Li LY, Lang J, Yeh SP, et al. (2011) CDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cells. Nat Cell Biol 13: 87-94.
39. Oguntebi BR, Heaven T, Clark AE, Pink FE (1995) Quantitative assessment of dentin bridge formation following pulp-capping in miniature swine. J Endod 21: 79-82.
40. Sarkar NK, Caicedo R, Ritwik P, Moiseyeva R, Kawashima I (2005) Physicochemical basis of the biologic properties of mineral trioxide aggregate. J Endod 31: 97-100. (Pubitemid 40222786)
41. Faraco IJ, Holland R (2001) Response of the pulp of dogs to capping with mineral trioxide aggregate or a calcium hydroxide cement. Dent Traumatol 17: 163-166.
42. Parirokh M, Asgary S, Eghbal MJ, Kakoei S, Samiee M (2011) A comparative study of using a combination of calcium chloride and mineral trioxide aggregate as the pulp-capping agent on dogs' teeth. J Endod 37: 786-788.
43. Huang GT, Shagramanova K, Chan SW (2006) Formation of odontoblast-like cells from cultured human dental pulp cells on dentin in vitro. J Endod 32: 1066-1073. (Pubitemid 44573413)
44. Lee SY, Min KS, Choi GW, Park JH, Park SH, et al. (2012) Effects of simvastain and enamel matrix derivative on Portland cement with bismuth oxide-induced growth and odontoblastic differentiation in human dental pulp cells. J Endod 38: 405-410.
45. Yoshioka S, Takahashi Y, Abe M, Michikami I, Imazato S, et al. (2013) Activation of the Wnt/beta-catenin pathway and tissue inhibitor of metalloprotease 1 during tertiary dentinogenesis. J Biochem 153: 43-50.
46. Scheller EL, Chang J, Wang CY (2008) Wnt/beta-catenin inhibits dental pulp stem cell differentiation. J Dent Res 87: 126-130.
47. Silkstone D, Hong H, Alman BA (2008) Beta-catenin in the race to fracture repair: in it to Wnt. Nat Clin Pract Rheumatol 4: 413-419.
48. Chen Y, Whetstone HC, Lin AC, Nadesan P, Wei Q, et al. (2007) Beta-catenin signaling plays a disparate role in different phases of fracture repair: implications for therapy to improve bone healing. PLoS Med 4: e249.
49. Li Y, Lu Y, Maciejewska I, Galler KM, Cavender A, et al. (2011) TWIST1 promotes the odontoblast-like differentiation of dental stem cells. Adv Dent Res 23: 280-284.
50. Wei X, Ling J, Wu L, Liu L, Xiao Y (2007) Expression of mineralization markers in dental pulp cells. J Endod 33: 703-708.
51. Miyabayashi T, Teo JL, Yamamoto M, McMillan M, Nguyen C, et al. (2007) Wnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency. Proc Natl Acad Sci U S A 104: 5668-5673. (Pubitemid 47175738)
52. Miki T, Yasuda SY, Kahn M (2011) Wnt/beta-catenin signaling in embryonic stem cell self-renewal and somatic cell reprogramming. Stem Cell Rev 7: 836-846.