The role of runt-related transcription factor 2 (Runx2) in the late stage of odontoblast differentiation and dentin formation

Biochemical and Biophysical Research Communications

Volumn 410, Issue 3, 2011, Pages 698-704

  Li, Shiting ^a   Kong, Hui ^a   Yao, Naihui ^b   Yu, Qing ^a   Wang, Ping ^a   Lin, Yuan ^a   Wang, Jing ^a   Kuang, Rong ^a   Zhao, Xiu ^a   Xu, Jie ^a   Zhu, Qinglin ^a   Ni, Longxing ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Cell differentiation; Dentinogenesis; Odontoblast; Osteoblast; Runx2

Indexed keywords

DENTIN MATRIX PROTEIN 1; TRANSCRIPTION FACTOR RUNX2;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DENTIN; MOUSE; NONHUMAN; ODONTOBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TOOTH DEVELOPMENT;

ANIMALS; CELL DIFFERENTIATION; CORE BINDING FACTOR ALPHA 1 SUBUNIT; DENTIN; DENTINOGENESIS; MICE; MICE, TRANSGENIC; MOLAR; ODONTOBLASTS;

MUS; MUS MUSCULUS;

EID: 79960031652     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.06.065     Document Type: Article

References (19)

1. Komori T. Regulation of bone development and extracellular matrix protein genes by RUNX2. Cell Tissue Res. 2010, 339:189-195.
2. D'Souza R.N., Aberg T., Gaikwad J., Cavender A., Owen M., Karsenty G., Thesleff I. Cbfa1 is required for epithelial-mesenchymal interactions regulating tooth development in mice. Development 1999, 126:2911-2920.
3. Aberg T., Wang X.P., Kim J.H., Yamashiro T., Bei M., Rice R., Ryoo H.M., Thesleff I. Runx2 mediates FGF signaling from epithelium to mesenchyme during tooth morphogenesis. Dev. Biol. 2004, 270:76-93.
4. Chen S., Rani S., Wu Y., Unterbrink A., Gu T.T., Gluhak-Heinrich J., Chuang H.H., Macdougall M. Differential regulation of dentin sialophosphoprotein expression by Runx2 during odontoblast cytodifferentiation. J. Biol. Chem. 2005, 280:29717-29727.
5. Bronckers A.L., Engelse M.A., Cavender A., Gaikwad J., D'Souza R.N. Cell-specific patterns of Cbfa1 mRNA and protein expression in postnatal murine dental tissues. Mech. Dev. 2001, 101:255-258.
6. Yamashiro T., Aberg T., Levanon D., Groner Y., Thesleff I. Expression of Runx1-2 and -3 during tooth palate and craniofacial bone development. Mech. Dev. 2002, 119(Suppl. 1):S107-S110.
7. Baba O., Qin C., Brunn J.C., Jones J.E., Wygant J.N., McIntyre B.W., Butler W.T. Detection of dentin sialoprotein in rat periodontium. Eur. J. Oral Sci. 2004, 112:163-170.
8. Feng J.Q., Ward L.M., Liu S., Lu Y., Xie Y., Yuan B., Yu X., Rauch F., Davis S.I., Zhang S., Rios H., Drezner M.K., Quarles L.D., Bonewald L.F., White K.E. Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism. Nat. Genet. 2006, 38:1310-1315.
9. Sreenath T., Thyagarajan T., Hall B., Longenecker G., D'Souza R., Hong S., Wright J.T., MacDougall M., Sauk J., Kulkarni A.B. Dentin sialophosphoprotein knockout mouse teeth display widened predentin zone and develop defective dentin mineralization similar to human dentinogenesis imperfecta type III. J. Biol. Chem. 2003, 278:24874-24880.
10. Begue-Kirn C., Krebsbach P.H., Bartlett J.D., Butler W.T. Dentin sialoprotein, dentin phosphoprotein, enamelysin and ameloblastin: tooth-specific molecules that are distinctively expressed during murine dental differentiation. Eur. J. Oral Sci. 1998, 106:963-970.
11. D'Souza R.N., Cavender A., Sunavala G., Alvarez J., Ohshima T., Kulkarni A.B., MacDougall M. Gene expression patterns of murine dentin matrix protein 1 (Dmp1) and dentin sialophosphoprotein (DSPP) suggest distinct developmental functions in vivo. J. Bone Miner. Res. 1997, 12:2040-2049.
12. Miyazaki T., Kanatani N., Rokutanda S., Yoshida C., Toyosawa S., Nakamura R., Takada S., Komori T. Inhibition of the terminal differentiation of odontoblasts and their transdifferentiation into osteoblasts in Runx2 transgenic mice. Arch. Histol. Cytol. 2008, 71:131-146.
13. Chen S., Rani S., Wu Y., Unterbrink A., Gu T.T., Gluhak-Heinrich J., Chuang H.H., MacDougall M. Differential regulation of dentin sialophosphoprotein expression by Runx2 during odontoblast cytodifferentiation. J. Biol. Chem. 2005, 280:29717.
14. Gaikwad J., Hoffmann M., Cavender A., Bronckers A., D'souza R. Molecular insights into the lineage-specific determination of odontoblasts: the role of Cbfa1. Adv. Dent. Res. 2001, 15:19.
15. Cajazeira Aguiar M., Arana Chavez V. Ultrastructural and immunocytochemical analyses of osteopontin in reactionary and reparative dentine formed after extrusion of upper rat incisors. J. Anat. 2007, 210:418-427.
16. Komori T. Regulation of osteoblast and odontoblast differentiation by RUNX2. J. Oral Biosci. 2010, 52:22-25.
17. Maruyama Z., Yoshida C., Furuichi T., Amizuka N., Ito M., Fukuyama R., Miyazaki T., Kitaura H., Nakamura K., Fujita T. Runx2 determines bone maturity and turnover rate in postnatal bone development and is involved in bone loss in estrogen deficiency. Dev. Dynam. 2007, 236:1876-1890.
18. Toyosawa S., Shintani S., Fujiwara T., Ooshima T., Sato A., Ijuhin N., Komori T. Dentin matrix protein 1 is predominantly expressed in chicken and rat osteocytes but not in osteoblasts. J. Bone Miner. Res. 2001, 16:2017-2026.
19. Haruyama N., Sreenath T.L., Suzuki S., Yao X., Wang Z., Wang Y., Honeycutt C., Iozzo R.V., Young M.F., Kulkarni A.B. Genetic evidence for key roles of decorin and biglycan in dentin mineralization. Matrix Biol. 2009, 28:129-136.