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Volumn 5 FEB, Issue , 2014, Pages

The role of iron in anthracycline cardiotoxicity

Author keywords

Anthracyclines; Doxorubicin; Heart; Iron; Reactive oxygen species

Indexed keywords

ANTHRACYCLINE DERIVATIVE; CD71 ANTIGEN; DOXORUBICIN; EPIRUBICIN; HFE PROTEIN; HYPOXIA INDUCIBLE FACTOR; IRON; IRON REGULATORY PROTEIN 1; IRON REGULATORY PROTEIN 2; METFORMIN; RAZOXANE; REACTIVE OXYGEN METABOLITE; TRANSFERRIN;

EID: 84895520569     PISSN: None     EISSN: 16639812     Source Type: Journal    
DOI: 10.3389/fphar.2014.00025     Document Type: Short Survey
Times cited : (129)

References (50)
  • 1
    • 84884980889 scopus 로고    scopus 로고
    • Genetic susceptibility to anthracycline-related congestive heart failure in survivors of haematopoietic cell transplantation
    • doi: 10.1111/bjh.12516
    • Armenian, S. H., Ding, Y., Mills, G., Sun, C., Venkataraman, K., Wong, F. L., et al. (2013). Genetic susceptibility to anthracycline-related congestive heart failure in survivors of haematopoietic cell transplantation. Br. J. Haematol. 163, 205-213. doi: 10.1111/bjh.12516.
    • (2013) Br. J. Haematol. , vol.163 , pp. 205-213
    • Armenian, S.H.1    Ding, Y.2    Mills, G.3    Sun, C.4    Venkataraman, K.5    Wong, F.L.6
  • 2
    • 77953810574 scopus 로고    scopus 로고
    • Cytosolic and mitochondrial ferritins in the regulation of cellular iron homeostasis and oxidative damage
    • doi: 10.1016/j.bbagen.2010.02.005
    • Arosio, P., and Levi, S. (2010). Cytosolic and mitochondrial ferritins in the regulation of cellular iron homeostasis and oxidative damage. Biochim. Biophys. Acta 1800, 783-792. doi: 10.1016/j.bbagen.2010.02.005.
    • (2010) Biochim. Biophys. Acta , vol.1800 , pp. 783-792
    • Arosio, P.1    Levi, S.2
  • 3
    • 84887976225 scopus 로고    scopus 로고
    • Ferritin heavy chain as main mediator of preventive effect of metformin against mitochondrial damage induced by doxorubicin in cardiomyocytes
    • doi: 10.1016/j.freeradbiomed.2013.11.003.
    • Asensio-López, M. C., Sanchez-Mas, J., Pascual-Figal, D. A., De Torre, C., Valdes, M., and Lax, A. (2013a). Ferritin heavy chain as main mediator of preventive effect of metformin against mitochondrial damage induced by doxorubicin in cardiomyocytes. Free Radic. Biol. Med. 67C, 19-29. doi: 10.1016/j.freeradbiomed.2013.11.003.
    • (2013) Free Radic. Biol. Med. , vol.67 C , pp. 19-29
    • Asensio-López, M.C.1    Sanchez-Mas, J.2    Pascual-Figal, D.A.3    De Torre, C.4    Valdes, M.5    Lax, A.6
  • 4
    • 84874658219 scopus 로고    scopus 로고
    • Involvement of ferritin heavy chain in the preventive effect of metformin against doxorubicin-induced cardiotoxicity
    • doi: 10.1016/j.freeradbiomed.2012.09.009
    • Asensio-López, M. C., Sánchez-Más, J., Pascual-Figal, D. A., Abenza, S., Pérez-Martínez, M. T., Valdés, M., et al. (2013b). Involvement of ferritin heavy chain in the preventive effect of metformin against doxorubicin-induced cardiotoxicity. Free Radic. Biol. Med. 57, 188-200. doi: 10.1016/j.freeradbiomed.2012.09.009.
    • (2013) Free Radic. Biol. Med. , vol.57 , pp. 188-200
    • Asensio-López, M.C.1    Sánchez-Más, J.2    Pascual-Figal, D.A.3    Abenza, S.4    Pérez-Martínez, M.T.5    Valdés, M.6
  • 6
    • 57349125695 scopus 로고    scopus 로고
    • Reactive oxygen species-independent apoptosis in doxorubicin-treated H9c2 cardiomyocytes: role for heme oxygenase-1 down-modulation
    • doi: 10.1016/j.cbi.2008.09.012
    • Bernuzzi, F., Recalcati, S., Alberghini, A., and Cairo, G. (2009). Reactive oxygen species-independent apoptosis in doxorubicin-treated H9c2 cardiomyocytes: role for heme oxygenase-1 down-modulation. Chem. Biol. Interact. 177, 12-20. doi: 10.1016/j.cbi.2008.09.012.
    • (2009) Chem. Biol. Interact. , vol.177 , pp. 12-20
    • Bernuzzi, F.1    Recalcati, S.2    Alberghini, A.3    Cairo, G.4
  • 7
    • 33845647342 scopus 로고    scopus 로고
    • Adriamycin-induced oxidative mitochondrial cardiotoxicity
    • doi: 10.1007/s10565-006-0140-y
    • Berthiaume, J. M., and Wallace, K. B. (2007). Adriamycin-induced oxidative mitochondrial cardiotoxicity. Cell Biol. Toxicol. 23, 15-25. doi: 10.1007/s10565-006-0140-y.
    • (2007) Cell Biol. Toxicol. , vol.23 , pp. 15-25
    • Berthiaume, J.M.1    Wallace, K.B.2
  • 8
    • 46049104446 scopus 로고    scopus 로고
    • Genetic polymorphisms in the carbonyl reductase 3 gene CBR3 and the NAD(P)H:quinone oxidoreductase 1 gene NQO1 in patients who developed anthracycline-related congestive heart failure after childhood cancer
    • doi: 10.1002/cncr.23534
    • Blanco, J. G., Leisenring, W. M., Gonzalez-Covarrubias, V. M., Kawashima, T. I., Davies, S. M., Relling, M. V., et al. (2008). Genetic polymorphisms in the carbonyl reductase 3 gene CBR3 and the NAD(P)H:quinone oxidoreductase 1 gene NQO1 in patients who developed anthracycline-related congestive heart failure after childhood cancer. Cancer 112, 2789-2795. doi: 10.1002/cncr.23534.
    • (2008) Cancer , vol.112 , pp. 2789-2795
    • Blanco, J.G.1    Leisenring, W.M.2    Gonzalez-Covarrubias, V.M.3    Kawashima, T.I.4    Davies, S.M.5    Relling, M.V.6
  • 9
    • 0034531651 scopus 로고    scopus 로고
    • Iron regulatory proteins in pathobiology
    • doi: 10.1042/0264-6021:3520241
    • Cairo, G., and Pietrangelo, A. (2000). Iron regulatory proteins in pathobiology. Biochem. J. 352(Pt 2), 241-250. doi: 10.1042/0264-6021:3520241.
    • (2000) Biochem. J. , vol.352 , Issue.PART 2 , pp. 241-250
    • Cairo, G.1    Pietrangelo, A.2
  • 10
    • 38449094356 scopus 로고    scopus 로고
    • Iron-regulatory proteins: molecular biology and pathophysiological implications
    • doi: 10.1017/S1462399407000531
    • Cairo, G., and Recalcati, S. (2007). Iron-regulatory proteins: molecular biology and pathophysiological implications. Expert Rev. Mol. Med. 9, 1-13. doi: 10.1017/S1462399407000531.
    • (2007) Expert Rev. Mol. Med. , vol.9 , pp. 1-13
    • Cairo, G.1    Recalcati, S.2
  • 11
    • 0037096190 scopus 로고    scopus 로고
    • The iron regulatory proteins: targets and modulators of free radical reactions and oxidative damage
    • doi: 10.1016/S0891-5849(02)00825-0
    • Cairo, G., Recalcati, S., Pietrangelo, A., and Minotti, G. (2002). The iron regulatory proteins: targets and modulators of free radical reactions and oxidative damage. Free Radic. Biol. Med. 32, 1237-1243. doi: 10.1016/S0891-5849(02)00825-0.
    • (2002) Free Radic. Biol. Med. , vol.32 , pp. 1237-1243
    • Cairo, G.1    Recalcati, S.2    Pietrangelo, A.3    Minotti, G.4
  • 12
    • 0028928738 scopus 로고
    • Induction of ferritin synthesis by oxidative stress. Transcriptional and post-transcriptional regulation by expansion of the 'free' iron pool
    • doi: 10.1074/jbc.270.2.700
    • Cairo, G., Tacchini, L., Pogliaghi, G., Anzon, E., Tomasi, A., and Bernelli-Zazzera, A. (1995). Induction of ferritin synthesis by oxidative stress. Transcriptional and post-transcriptional regulation by expansion of the "free" iron pool. J. Biol. Chem. 270, 700-703. doi: 10.1074/jbc.270.2.700.
    • (1995) J. Biol. Chem. , vol.270 , pp. 700-703
    • Cairo, G.1    Tacchini, L.2    Pogliaghi, G.3    Anzon, E.4    Tomasi, A.5    Bernelli-Zazzera, A.6
  • 13
    • 57649243073 scopus 로고    scopus 로고
    • Mitochondrial ferritin limits oxidative damage regulating mitochondrial iron availability: hypothesis for a protective role in Friedreich ataxia
    • doi: 10.1093/hmg/ddn308
    • Campanella, A., Rovelli, E., Santambrogio, P., Cozzi, A., Taroni, F., and Levi, S. (2009). Mitochondrial ferritin limits oxidative damage regulating mitochondrial iron availability: hypothesis for a protective role in Friedreich ataxia. Hum. Mol. Genet. 18, 1-11. doi: 10.1093/hmg/ddn308.
    • (2009) Hum. Mol. Genet. , vol.18 , pp. 1-11
    • Campanella, A.1    Rovelli, E.2    Santambrogio, P.3    Cozzi, A.4    Taroni, F.5    Levi, S.6
  • 14
    • 57149098990 scopus 로고    scopus 로고
    • Interaction of anthracyclines with iron responsive element mRNAs
    • doi: 10.1093/nar/gkn774
    • Canzoneri, J. C., and Oyelere, A. K. (2008). Interaction of anthracyclines with iron responsive element mRNAs. Nucleic Acids Res. 36, 6825-6834. doi: 10.1093/nar/gkn774.
    • (2008) Nucleic Acids Res. , vol.36 , pp. 6825-6834
    • Canzoneri, J.C.1    Oyelere, A.K.2
  • 15
    • 84894765443 scopus 로고    scopus 로고
    • Doxorubicin-induced cardiotoxicity: from bioenergetic failure and cell death to cardiomyopathy
    • doi: 10.1002/med.21280
    • Carvalho, F. S., Burgeiro, A., Garcia, R., Moreno, A. J., Carvalho, R. A., and Oliveira, P. J. (2014). Doxorubicin-induced cardiotoxicity: from bioenergetic failure and cell death to cardiomyopathy. Med. Res. Rev. 34, 106-135. doi: 10.1002/med.21280.
    • (2014) Med. Res. Rev. , vol.34 , pp. 106-135
    • Carvalho, F.S.1    Burgeiro, A.2    Garcia, R.3    Moreno, A.J.4    Carvalho, R.A.5    Oliveira, P.J.6
  • 16
    • 84890376183 scopus 로고    scopus 로고
    • Protective effect of mitochondrial ferritin on cytosolic iron dysregulation induced by doxorubicin in HeLa cells
    • doi: 10.1007/s11033-013-2792-z
    • Cocco, E., Porrini, V., Derosas, M., Nardi, V., Biasiotto, G., Maccarinelli, F., et al. (2013). Protective effect of mitochondrial ferritin on cytosolic iron dysregulation induced by doxorubicin in HeLa cells. Mol. Biol. Rep. 40, 6757-6764. doi: 10.1007/s11033-013-2792-z.
    • (2013) Mol. Biol. Rep. , vol.40 , pp. 6757-6764
    • Cocco, E.1    Porrini, V.2    Derosas, M.3    Nardi, V.4    Biasiotto, G.5    Maccarinelli, F.6
  • 17
    • 33745601084 scopus 로고    scopus 로고
    • IRP1-independent alterations of cardiac iron metabolism in doxorubicin-treated mice
    • doi: 10.1007/s00109-006-0068-y
    • Corna, G., Galy, B., Hentze, M. W., and Cairo, G. (2006). IRP1-independent alterations of cardiac iron metabolism in doxorubicin-treated mice. J. Mol. Med. (Berl.) 84, 551-560. doi: 10.1007/s00109-006-0068-y.
    • (2006) J. Mol. Med. (Berl.) , vol.84 , pp. 551-560
    • Corna, G.1    Galy, B.2    Hentze, M.W.3    Cairo, G.4
  • 18
    • 1842690698 scopus 로고    scopus 로고
    • Doxorubicin paradoxically protects cardiomyocytes against iron-mediated toxicity: role of reactive oxygen species and ferritin
    • doi: 10.1074/jbc.M310106200
    • Corna, G., Santambrogio, P., Minotti, G., and Cairo, G. (2004). Doxorubicin paradoxically protects cardiomyocytes against iron-mediated toxicity: role of reactive oxygen species and ferritin. J. Biol. Chem. 279, 13738-13745. doi: 10.1074/jbc.M310106200.
    • (2004) J. Biol. Chem. , vol.279 , pp. 13738-13745
    • Corna, G.1    Santambrogio, P.2    Minotti, G.3    Cairo, G.4
  • 19
    • 33745712227 scopus 로고    scopus 로고
    • Prevention of chronic anthracycline cardiotoxicity in the adult Fischer 344 rat by dexrazoxane and effects on iron metabolism
    • doi: 10.1007/s00280-006-0199-4
    • Cusack, B. J., Gambliel, H., Musser, B., Hadjokas, N., Shadle, S. E., Charlier, H., et al. (2006). Prevention of chronic anthracycline cardiotoxicity in the adult Fischer 344 rat by dexrazoxane and effects on iron metabolism. Cancer Chemother. Pharmacol. 58, 517-526. doi: 10.1007/s00280-006-0199-4.
    • (2006) Cancer Chemother. Pharmacol. , vol.58 , pp. 517-526
    • Cusack, B.J.1    Gambliel, H.2    Musser, B.3    Hadjokas, N.4    Shadle, S.E.5    Charlier, H.6
  • 20
    • 1842559586 scopus 로고    scopus 로고
    • The role of nitric oxide in anthracycline toxicity and prospects for pharmacologic prevention of cardiac damage
    • doi: 10.1096/fj.03-0724rev
    • Fogli, S., Nieri, P., and Breschi, M. C. (2004). The role of nitric oxide in anthracycline toxicity and prospects for pharmacologic prevention of cardiac damage. FASEB J. 18, 664-675. doi: 10.1096/fj.03-0724rev.
    • (2004) FASEB J. , vol.18 , pp. 664-675
    • Fogli, S.1    Nieri, P.2    Breschi, M.C.3
  • 22
    • 2042546096 scopus 로고    scopus 로고
    • Balancing acts: molecular control of mammalian iron metabolism
    • doi: 10.1016/S0092-8674(04)00343-5
    • Hentze, M. W., Muckenthaler, M. U., and Andrews, N. C. (2004). Balancing acts: molecular control of mammalian iron metabolism. Cell 117, 285-297. doi: 10.1016/S0092-8674(04)00343-5.
    • (2004) Cell , vol.117 , pp. 285-297
    • Hentze, M.W.1    Muckenthaler, M.U.2    Andrews, N.C.3
  • 23
    • 0027661677 scopus 로고
    • Anthracycline toxicity is potentiated by iron and inhibited by deferoxamine: studies in rat heart cells in culture
    • Hershko, C., Link, G., Tzahor, M., Kaltwasser, J. P., Athias, P., Grynberg, A., et al. (1993). Anthracycline toxicity is potentiated by iron and inhibited by deferoxamine: studies in rat heart cells in culture. J. Lab. Clin. Med. 122, 245-251.
    • (1993) J. Lab. Clin. Med. , vol.122 , pp. 245-251
    • Hershko, C.1    Link, G.2    Tzahor, M.3    Kaltwasser, J.P.4    Athias, P.5    Grynberg, A.6
  • 24
    • 84893845965 scopus 로고    scopus 로고
    • Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation
    • doi: 10.1172/JCI72931
    • Ichikawa, Y., Ghanefar, M., Bayeva, M., Wu, R., Khechaduri, A., Naga Prasad, S. V., et al. (2014). Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation. J. Clin. Invest. 124, 617-630. doi: 10.1172/JCI72931.
    • (2014) J. Clin. Invest. , vol.124 , pp. 617-630
    • Ichikawa, Y.1    Ghanefar, M.2    Bayeva, M.3    Wu, R.4    Khechaduri, A.5    Naga Prasad, S.V.6
  • 25
    • 0036784362 scopus 로고    scopus 로고
    • Unexpected anthracycline-mediated alterations in iron-regulatory protein-RNA-binding activity: the iron and copper complexes of anthracyclines decrease RNA-binding activity
    • doi: 10.1124/mol.62.4.888
    • Kwok, J. C., and Richardson, D. R. (2002). Unexpected anthracycline-mediated alterations in iron-regulatory protein-RNA-binding activity: the iron and copper complexes of anthracyclines decrease RNA-binding activity. Mol. Pharmacol. 62, 888-900. doi: 10.1124/mol.62.4.888.
    • (2002) Mol. Pharmacol. , vol.62 , pp. 888-900
    • Kwok, J.C.1    Richardson, D.R.2
  • 26
    • 0037379680 scopus 로고    scopus 로고
    • Anthracyclines induce accumulation of iron in ferritin in myocardial and neoplastic cells: inhibition of the ferritin iron mobilization pathway
    • doi: 10.1124/mol.63.4.849
    • Kwok, J. C., and Richardson, D. R. (2003). Anthracyclines induce accumulation of iron in ferritin in myocardial and neoplastic cells: inhibition of the ferritin iron mobilization pathway. Mol. Pharmacol. 63, 849-861. doi: 10.1124/mol.63.4.849.
    • (2003) Mol. Pharmacol. , vol.63 , pp. 849-861
    • Kwok, J.C.1    Richardson, D.R.2
  • 27
    • 1642576976 scopus 로고    scopus 로고
    • Examination of the mechanism(s) involved in doxorubicin-mediated iron accumulation in ferritin: studies using metabolic inhibitors, protein synthesis inhibitors, and lysosomotropic agents
    • doi: 10.1124/mol.65.1.181
    • Kwok, J. C., and Richardson, D. R. (2004). Examination of the mechanism(s) involved in doxorubicin-mediated iron accumulation in ferritin: studies using metabolic inhibitors, protein synthesis inhibitors, and lysosomotropic agents. Mol. Pharmacol. 65, 181-195. doi: 10.1124/mol.65.1.181.
    • (2004) Mol. Pharmacol. , vol.65 , pp. 181-195
    • Kwok, J.C.1    Richardson, D.R.2
  • 28
    • 0030091567 scopus 로고    scopus 로고
    • Role of iron in the potentiation of anthracycline cardiotoxicity: identification of heart cell mitochondria as a major site of iron-anthracycline interaction
    • doi: 10.1016/S0022-2143(96)90095-5
    • Link, G., Tirosh, R., Pinson, A., and Hershko, C. (1996). Role of iron in the potentiation of anthracycline cardiotoxicity: identification of heart cell mitochondria as a major site of iron-anthracycline interaction. J. Lab. Clin. Med. 127, 272-278. doi: 10.1016/S0022-2143(96)90095-5.
    • (1996) J. Lab. Clin. Med. , vol.127 , pp. 272-278
    • Link, G.1    Tirosh, R.2    Pinson, A.3    Hershko, C.4
  • 29
    • 84889608292 scopus 로고    scopus 로고
    • Treatment-related cardiotoxicity in survivors of childhood cancer
    • doi: 10.1038/nrclinonc.2013.195
    • Lipshultz, S. E., Cochran, T. R., Franco, V. I., and Miller, T. L. (2013a). Treatment-related cardiotoxicity in survivors of childhood cancer. Nat. Rev. Clin. Oncol. 10, 697-710. doi: 10.1038/nrclinonc.2013.195.
    • (2013) Nat. Rev. Clin. Oncol. , vol.10 , pp. 697-710
    • Lipshultz, S.E.1    Cochran, T.R.2    Franco, V.I.3    Miller, T.L.4
  • 30
    • 84884908105 scopus 로고    scopus 로고
    • Impact of hemochromatosis gene mutations on cardiac status in doxorubicin-treated survivors of childhood high-risk leukemia
    • doi: 10.1002/cncr.28256
    • Lipshultz, S. E., Lipsitz, S. R., Kutok, J. L., Miller, T. L., Colan, S. D., Neuberg, D. S., et al. (2013b). Impact of hemochromatosis gene mutations on cardiac status in doxorubicin-treated survivors of childhood high-risk leukemia. Cancer 119, 3555-3562. doi: 10.1002/cncr.28256.
    • (2013) Cancer , vol.119 , pp. 3555-3562
    • Lipshultz, S.E.1    Lipsitz, S.R.2    Kutok, J.L.3    Miller, T.L.4    Colan, S.D.5    Neuberg, D.S.6
  • 31
    • 75149193249 scopus 로고    scopus 로고
    • Anthracycline degradation in cardiomyocytes: a journey to oxidative survival
    • doi: 10.1021/tx9003424
    • Menna, P., Salvatorelli, E., and Minotti, G. (2010). Anthracycline degradation in cardiomyocytes: a journey to oxidative survival. Chem. Res. Toxicol. 23, 6-10. doi: 10.1021/tx9003424.
    • (2010) Chem. Res. Toxicol. , vol.23 , pp. 6-10
    • Menna, P.1    Salvatorelli, E.2    Minotti, G.3
  • 32
    • 0032965572 scopus 로고    scopus 로고
    • Role of iron in anthracycline cardiotoxicity: new tunes for an old song?
    • Minotti, G., Cairo, G., and Monti, E. (1999). Role of iron in anthracycline cardiotoxicity: new tunes for an old song? FASEB J. 13, 199-212.
    • (1999) FASEB J. , vol.13 , pp. 199-212
    • Minotti, G.1    Cairo, G.2    Monti, E.3
  • 33
    • 2642566088 scopus 로고    scopus 로고
    • Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity
    • doi: 10.1124/pr.56.2.6
    • Minotti, G., Menna, P., Salvatorelli, E., Cairo, G., and Gianni, L. (2004a). Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity. Pharmacol. Rev. 56, 185-229. doi: 10.1124/pr.56.2.6.
    • (2004) Pharmacol. Rev. , vol.56 , pp. 185-229
    • Minotti, G.1    Menna, P.2    Salvatorelli, E.3    Cairo, G.4    Gianni, L.5
  • 34
    • 1342283083 scopus 로고    scopus 로고
    • Doxorubicin cardiotoxicity and the control of iron metabolism: quinone-dependent and independent mechanisms
    • doi: 10.1016/S0076-6879(04)78025-8
    • Minotti, G., Recalcati, S., Menna, P., Salvatorelli, E., Corna, G., and Cairo, G. (2004b). Doxorubicin cardiotoxicity and the control of iron metabolism: quinone-dependent and independent mechanisms. Methods Enzymol. 378, 340-361. doi: 10.1016/S0076-6879(04)78025-8.
    • (2004) Methods Enzymol. , vol.378 , pp. 340-361
    • Minotti, G.1    Recalcati, S.2    Menna, P.3    Salvatorelli, E.4    Corna, G.5    Cairo, G.6
  • 35
    • 0031897342 scopus 로고    scopus 로고
    • The secondary alcohol metabolite of doxorubicin irreversibly inactivates aconitase/iron regulatory protein-1 in cytosolic fractions from human myocardium
    • Minotti, G., Recalcati, S., Mordente, A., Liberi, G., Calafiore, A. M., Mancuso, C., et al. (1998). The secondary alcohol metabolite of doxorubicin irreversibly inactivates aconitase/iron regulatory protein-1 in cytosolic fractions from human myocardium. FASEB J. 12, 541-552.
    • (1998) FASEB J. , vol.12 , pp. 541-552
    • Minotti, G.1    Recalcati, S.2    Mordente, A.3    Liberi, G.4    Calafiore, A.M.5    Mancuso, C.6
  • 36
    • 0035576817 scopus 로고    scopus 로고
    • Doxorubicin irreversibly inactivates iron regulatory proteins 1 and 2 in cardiomyocytes: evidence for distinct metabolic pathways and implications for iron-mediated cardiotoxicity of antitumor therapy
    • Minotti, G., Ronchi, R., Salvatorelli, E., Menna, P., and Cairo, G. (2001). Doxorubicin irreversibly inactivates iron regulatory proteins 1 and 2 in cardiomyocytes: evidence for distinct metabolic pathways and implications for iron-mediated cardiotoxicity of antitumor therapy. Cancer Res. 61, 8422-8428.
    • (2001) Cancer Res. , vol.61 , pp. 8422-8428
    • Minotti, G.1    Ronchi, R.2    Salvatorelli, E.3    Menna, P.4    Cairo, G.5
  • 37
    • 0141816698 scopus 로고    scopus 로고
    • Hfe deficiency increases susceptibility to cardiotoxicity and exacerbates changes in iron metabolism induced by doxorubicin
    • doi: 10.1182/blood-2003-03-0869
    • Miranda, C. J., Makui, H., Soares, R. J., Bilodeau, M., Mui, J., Vali, H., et al. (2003). Hfe deficiency increases susceptibility to cardiotoxicity and exacerbates changes in iron metabolism induced by doxorubicin. Blood 102, 2574-2580. doi: 10.1182/blood-2003-03-0869.
    • (2003) Blood , vol.102 , pp. 2574-2580
    • Miranda, C.J.1    Makui, H.2    Soares, R.J.3    Bilodeau, M.4    Mui, J.5    Vali, H.6
  • 38
    • 50949102412 scopus 로고    scopus 로고
    • Systemic iron homeostasis and the iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network
    • doi: 10.1146/annurev.nutr.28.061807.155521
    • Muckenthaler, M. U., Galy, B., and Hentze, M. W. (2008). Systemic iron homeostasis and the iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network. Annu. Rev. Nutr. 28, 197-213. doi: 10.1146/annurev.nutr.28.061807.155521.
    • (2008) Annu. Rev. Nutr. , vol.28 , pp. 197-213
    • Muckenthaler, M.U.1    Galy, B.2    Hentze, M.W.3
  • 39
    • 84860523994 scopus 로고    scopus 로고
    • Doxorubicin-induced cardiomyopathy: from molecular mechanisms to therapeutic strategies
    • doi: 10.1016/j.yjmcc.2012.03.006
    • Octavia, Y., Tocchetti, C. G., Gabrielson, K. L., Janssens, S., Crijns, H. J., and Moens, A. L. (2012). Doxorubicin-induced cardiomyopathy: from molecular mechanisms to therapeutic strategies. J. Mol. Cell Cardiol. 52, 1213-1225. doi: 10.1016/j.yjmcc.2012.03.006.
    • (2012) J. Mol. Cell Cardiol. , vol.52 , pp. 1213-1225
    • Octavia, Y.1    Tocchetti, C.G.2    Gabrielson, K.L.3    Janssens, S.4    Crijns, H.J.5    Moens, A.L.6
  • 40
    • 34250787016 scopus 로고    scopus 로고
    • Potentiation of doxorubicin cardiotoxicity by iron loading in a rodent model
    • doi: 10.1016/j.jacc.2007.02.060
    • Panjrath, G. S., Patel, V., Valdiviezo, C. I., Narula, N., Narula, J., and Jain, D. (2007). Potentiation of doxorubicin cardiotoxicity by iron loading in a rodent model. J. Am. Coll. Cardiol. 49, 2457-2464. doi: 10.1016/j.jacc.2007.02.060.
    • (2007) J. Am. Coll. Cardiol. , vol.49 , pp. 2457-2464
    • Panjrath, G.S.1    Patel, V.2    Valdiviezo, C.I.3    Narula, N.4    Narula, J.5    Jain, D.6
  • 41
    • 77954271890 scopus 로고    scopus 로고
    • Iron regulatory proteins: from molecular mechanisms to drug development
    • doi: 10.1089/ars.2009.2983
    • Recalcati, S., Minotti, G., and Cairo, G. (2010). Iron regulatory proteins: from molecular mechanisms to drug development. Antioxid. Redox. Signal. 13, 1593-1616. doi: 10.1089/ars.2009.2983.
    • (2010) Antioxid. Redox. Signal. , vol.13 , pp. 1593-1616
    • Recalcati, S.1    Minotti, G.2    Cairo, G.3
  • 42
    • 33746361251 scopus 로고    scopus 로고
    • The role of iron regulatory proteins in mammalian iron homeostasis and disease
    • doi: 10.1038/nchembio807
    • Rouault, T. A. (2006). The role of iron regulatory proteins in mammalian iron homeostasis and disease. Nat. Chem. Biol. 2, 406-414. doi: 10.1038/nchembio807.
    • (2006) Nat. Chem. Biol. , vol.2 , pp. 406-414
    • Rouault, T.A.1
  • 43
    • 10744224134 scopus 로고    scopus 로고
    • Chronic cardiotoxicity of anticancer anthracyclines in the rat: role of secondary metabolites and reduced toxicity by a novel anthracycline with impaired metabolite formation and reactivity
    • doi: 10.1038/sj.bjp.0705270
    • Sacco, G., Giampietro, R., Salvatorelli, E., Menna, P., Bertani, N., Graiani, G., et al. (2003). Chronic cardiotoxicity of anticancer anthracyclines in the rat: role of secondary metabolites and reduced toxicity by a novel anthracycline with impaired metabolite formation and reactivity. Br. J. Pharmacol. 139, 641-651. doi: 10.1038/sj.bjp.0705270.
    • (2003) Br. J. Pharmacol. , vol.139 , pp. 641-651
    • Sacco, G.1    Giampietro, R.2    Salvatorelli, E.3    Menna, P.4    Bertani, N.5    Graiani, G.6
  • 44
    • 33744959330 scopus 로고    scopus 로고
    • Defective one-or two-electron reduction of the anticancer anthracycline epirubicin in human heart. Relative importance of vesicular sequestration and impaired efficiency of electron addition
    • doi: 10.1074/jbc.M508343200
    • Salvatorelli, E., Guarnieri, S., Menna, P., Liberi, G., Calafiore, A. M., Mariggiò, M. A., et al. (2006). Defective one-or two-electron reduction of the anticancer anthracycline epirubicin in human heart. Relative importance of vesicular sequestration and impaired efficiency of electron addition. J. Biol. Chem. 281, 10990-11001. doi: 10.1074/jbc.M508343200.
    • (2006) J. Biol. Chem. , vol.281 , pp. 10990-11001
    • Salvatorelli, E.1    Guarnieri, S.2    Menna, P.3    Liberi, G.4    Calafiore, A.M.5    Mariggiò, M.A.6
  • 45
    • 66949171305 scopus 로고    scopus 로고
    • Anthracycline-induced cardiotoxicity: overview of studies examining the roles of oxidative stress and free cellular iron
    • Simůnek, T., Stérba, M., Popelová, O., Adamcová, M., Hrdina, R., and Gersl, V. (2009). Anthracycline-induced cardiotoxicity: overview of studies examining the roles of oxidative stress and free cellular iron. Pharmacol. Rep. 61, 154-171.
    • (2009) Pharmacol. Rep. , vol.61 , pp. 154-171
    • Simůnek, T.1    Stérba, M.2    Popelová, O.3    Adamcová, M.4    Hrdina, R.5    Gersl, V.6
  • 46
    • 79954501357 scopus 로고    scopus 로고
    • Role of hypoxia-inducible factors in the dexrazoxane-mediated protection of cardiomyocytes from doxorubicin-induced toxicity
    • doi: 10.1111/j.1476-5381.2011.01208.x
    • Spagnuolo, R. D., Recalcati, S., Tacchini, L., and Cairo, G. (2011). Role of hypoxia-inducible factors in the dexrazoxane-mediated protection of cardiomyocytes from doxorubicin-induced toxicity. Br. J. Pharmacol. 163, 299-312. doi: 10.1111/j.1476-5381.2011.01208.x.
    • (2011) Br. J. Pharmacol. , vol.163 , pp. 299-312
    • Spagnuolo, R.D.1    Recalcati, S.2    Tacchini, L.3    Cairo, G.4
  • 47
    • 84873836880 scopus 로고    scopus 로고
    • Oxidative stress, redox signaling, and metal chelation in anthracycline cardiotoxicity and pharmacological cardioprotection
    • doi: 10.1089/ars.2012.4795
    • Stěrba, M., Popelová, O., Vávrová, A., Jirkovský, E., Kovaříková, P., Geršl, V., et al. (2013). Oxidative stress, redox signaling, and metal chelation in anthracycline cardiotoxicity and pharmacological cardioprotection. Antioxid. Redox. Signal. 18, 899-929. doi: 10.1089/ars.2012.4795.
    • (2013) Antioxid. Redox. Signal. , vol.18 , pp. 899-929
    • Stěrba, M.1    Popelová, O.2    Vávrová, A.3    Jirkovský, E.4    Kovaříková, P.5    Geršl, V.6
  • 48
    • 0022904805 scopus 로고
    • Reductive release of iron from ferritin by cation free radicals of paraquat and other bipyridyls
    • Thomas, C. E., and Aust, S. D. (1986). Reductive release of iron from ferritin by cation free radicals of paraquat and other bipyridyls. J. Biol. Chem. 261, 13064-13070.
    • (1986) J. Biol. Chem. , vol.261 , pp. 13064-13070
    • Thomas, C.E.1    Aust, S.D.2
  • 49
    • 23044447053 scopus 로고    scopus 로고
    • Molecular pharmacology of the interaction of anthracyclines with iron
    • Xu, X., Persson, H. L., and Richardson, D. R. (2005). Molecular pharmacology of the interaction of anthracyclines with iron. Mol. Pharmacol. 68, 261-271.
    • (2005) Mol. Pharmacol. , vol.68 , pp. 261-271
    • Xu, X.1    Persson, H.L.2    Richardson, D.R.3
  • 50
    • 84869209094 scopus 로고    scopus 로고
    • Identification of the molecular basis of doxorubicin-induced cardiotoxicity
    • doi: 10.1038/nm.2919
    • Zhang, S., Liu, X., Bawa-Khalfe, T., Lu, L. S., Lyu, Y. L., Liu, L. F., et al. (2012). Identification of the molecular basis of doxorubicin-induced cardiotoxicity. Nat. Med. 18, 1639-1642. doi: 10.1038/nm.2919.
    • (2012) Nat. Med. , vol.18 , pp. 1639-1642
    • Zhang, S.1    Liu, X.2    Bawa-Khalfe, T.3    Lu, L.S.4    Lyu, Y.L.5    Liu, L.F.6


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