Multiple hereditary exostoses (MHE): Elucidating the pathogenesis of a rare skeletal disorder through interdisciplinary research

Connective Tissue Research

Volumn 55, Issue 2, 2014, Pages 80-88

  Jones, Kevin B ^a   Pacifici, Maurizio ^b   Hilton, Matthew J ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

Cartilage; Ext1; Ext2; Heparan sulfate; Multiple hereditary exostoses; Osteochondromas; Perichondrium

Indexed keywords

2 HYDROXYGLUTARIC ACID; ADENYLATE CYCLASE; BONE MORPHOGENETIC PROTEIN; CATHEPSIN K; COLLAGEN TYPE 2; EXT 1 PROTEIN; EXT 2 PROTEIN; FIBROBLAST GROWTH FACTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; HEPARAN SULFATE; HISTONE DEACETYLASE 4; HYPOXIA INDUCIBLE FACTOR; MICRORNA; PARATHYROID HORMONE RELATED PROTEIN; PROTEIN; PROTEIN TYROSINE PHOSPHATASE SHP 2; PROTEOGLYCAN; TRANSCRIPTION FACTOR RUNX2; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN RECEPTOR;

ALLELE; ANGIOGENESIS; APOPTOSIS; ARTICLE; ARTICULAR CARTILAGE; BLOOD; BONE DEVELOPMENT; BONE GROWTH; BONE MASS; BONE MATURATION; CARTILAGE; CARTILAGE CELL; CARTILAGE INJURY; CARTILAGE MATRIX; CELL DIFFERENTIATION; CELL FATE; CELL GROWTH; CELL LINEAGE; CELL PROLIFERATION; CELL SURFACE; CELL TRANSFORMATION; CHIMERA; CHONDROGENESIS; CHONDROSARCOMA; CROSS FERTILIZATION; EMBRYO DEVELOPMENT; EMBRYONIC STEM CELL; ENCHONDROMA; ENDOPLASMIC RETICULUM STRESS; ENDOTHELIUM CELL; EXPLANT; EYE DEVELOPMENT; FIBROBLAST; FIBROSARCOMA; GENE DELETION; GENE EXPRESSION; GENE PRODUCT; GENETIC MODEL; GENETICS; GENOTYPE PHENOTYPE CORRELATION; GRADUATE STUDENT; GROWTH PLATE; GROWTH RETARDATION; HAPLOINSUFFICIENCY; HEREDITARY MULTIPLE EXOSTOSIS; HETEROZYGOSITY; HETEROZYGOSITY LOSS; HOMEOSTASIS; HOMOZYGOSITY; HUMAN; HYPERTROPHY; INTERDISCIPLINARY RESEARCH; LETHALITY; LIMB; LIMB BUD; LIMB DEFECT; LONG BONE; LOSS OF FUNCTION MUTATION; LYMPHOCYTE; MALIGNANT TRANSFORMATION; MESENCHYMAL STEM CELL; MESENCHYME; MODIFIER GENE; MOSAICISM; NONHUMAN; ORTHOPEDIC SURGEON; OSSIFICATION; OSTEOARTHRITIS; OSTEOBLAST; OSTEOCHONDROMA; OSTEOCLASTOGENESIS; OSTEOPHYTE; PATHOGENESIS; PATIENT ADVOCACY; PERICHONDRIUM; PHENOTYPE; PROMOTER REGION; RANGE OF MOTION; SINGLE NUCLEOTIDE POLYMORPHISM; SKELETON MALFORMATION; SOMATIC MUTATION; STEM CELL; TARGET CELL; TUMOR SPHEROID; VASCULARIZATION;

ANIMALS; BIOMEDICAL RESEARCH; BONE NEOPLASMS; CHONDROSARCOMA; CONGRESSES AS TOPIC; EXOSTOSES, MULTIPLE HEREDITARY; GROWTH DISORDERS; HUMANS; N-ACETYLGLUCOSAMINYLTRANSFERASES; NEOPLASM PROTEINS; PHILADELPHIA;

EID: 84895509658     PISSN: 03008207     EISSN: 16078438     Source Type: Journal    
DOI: 10.3109/03008207.2013.867957     Document Type: Article

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