Conditional ablation of the heparan sulfate-synthesizing enzyme Ext1 leads to dysregulation of bone morphogenic protein signaling and severe skeletal defects

Journal of Biological Chemistry

Volumn 285, Issue 25, 2010, Pages 19227-19234

  Matsumoto, Yoshihiro ^a   Matsumoto, Kazu ^a   Irie, Fumitoshi ^a   Fukushi, Jun Ichi ^a   Stallcup, William B ^a   Yamaguchi, Yu ^a  

^a BURNHAM INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENIC PROTEIN; CHONDROCYTES; CHONDROGENIC DIFFERENTIATION; GLYCOSYL TRANSFERASE; HEPARAN SULFATES; IMMUNOREACTIVITIES; INTEGRAL COMPONENTS; MICROMASS; MUTANT MICE; SIGNALING PATHWAYS; SKELETAL DEVELOPMENT; SKELETAL ELEMENTS; TRANSGENE;

BODY FLUIDS; BONE; CELL CULTURE; DEFECTS; PROTEINS;

SIGNALING;

BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 2; CRE RECOMBINASE; ENZYME; FIBRONECTIN; GLYCOSYLTRANSFERASE; HEPARAN SULFATE; PROTEIN EXT1; SMAD1 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DEVELOPMENT; CELL DIFFERENTIATION; CHONDROGENESIS; CONTROLLED STUDY; EMBRYO; IMMUNOREACTIVITY; LIMB BUD; LIMB MALFORMATION; MESENCHYME; MOUSE; NONHUMAN; PATHOGENESIS; PERICHONDRIUM; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SKELETON MALFORMATION; TRANSGENE;

ANIMALS; BONE AND BONES; BONE DISEASES; BONE MORPHOGENETIC PROTEINS; CHONDROCYTES; FIBRONECTINS; GLYCOSAMINOGLYCANS; HEPARITIN SULFATE; IMAGE PROCESSING, COMPUTER-ASSISTED; MESODERM; MICE; MODELS, BIOLOGICAL; MUTATION; N-ACETYLGLUCOSAMINYLTRANSFERASES; SIGNAL TRANSDUCTION;

MUS;

EID: 77953520690     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.105338     Document Type: Article

References (46)

1. Kronenberg, H. M. (2003) Nature 423, 332-336
2. Olsen, B. R., Reginato, A. M., and Wang, W. (2000) Annu. Rev. Cell Dev. Biol. 16, 191-220
3. Colnot, C. (2005) J. Cell. Biochem. 95, 688-697
4. Bishop, J. R., Schuksz, M., and Esko, J. D. (2007) Nature 446, 1030-1037
5. Kreuger, J., Spillmann, D., Li, J. P., and Lindahl, U. (2006) J. Cell Biol. 174, 323-327
6. Duncan, G., McCormick, C., and Tufaro, F. (2001) J. Clin. Invest. 108, 511-516
7. Zak, B. M., Crawford, B. E., and Esko, J. D. (2002) Biochim. Biophys. Acta 1573, 346-355
8. Inatani, M., Irie, F., Plump, A. S., Tessier-Lavigne, M., and Yamaguchi, Y. (2003) Science 302, 1044-1046
9. Logan, M., Martin, J. F., Nagy, A., Lobe, C., Olson, E. N., and Tabin, C. J. (2002) Genesis 33, 77-80
10. Gritli-Linde, A., Lewis, P., McMahon, A. P., and Linde, A. (2001) Dev. Biol. 236, 364-386
11. Fukushi, J., Inatani, M., Yamaguchi, Y., and Stallcup, W. B. (2003) Dev. Dyn. 228, 143-148
12. Lefebvre, V., Garofalo, S., and de Crombrugghe, B. (1995) J. Cell Biol. 128, 239-245
13. Burke, A. C., Nelson, C. E., Morgan, B. A., and Tabin, C. (1995) Development 121, 333-346
14. Sun, X., Mariani, F. V., and Martin, G. R. (2002) Nature 418, 501-508
15. van der Hoeven, F., Sordino, P., Fraudeau, N., Izpisúa-Belmonte, J. C., and Duboule, D. (1996) Mech. Dev. 54, 9-21
16. Guy, R. K. (2000) Proc. Natl. Acad. Sci. U.S.A. 97, 7307-7312
17. James, C. G., Appleton, C. T., Ulici, V., Underhill, T. M., and Beier, F. (2005) Mol. Biol. Cell 16, 5316-5333
18. Fisher, M. C., Li, Y., Seghatoleslami, M. R., Dealy, C. N., and Kosher, R. A. (2006) Matrix Biol. 25, 27-39
19. Selever, J., Liu, W., Lu, M. F., Behringer, R. R., and Martin, J. F. (2004) Dev. Biol. 276, 268-279
20. Koziel, L., Kunath, M., Kelly, O. G., and Vortkamp, A. (2004) Dev. Cell 6, 801-813
21. St-Jacques, B., Hammerschmidt, M., and McMahon, A. P. (1999) Genes Dev. 13, 2072-2086
22. Brunet, L. J., McMahon, J. A., McMahon, A. P., and Harland, R. M. (1998) Science 280, 1455-1457
23. Pizette, S., and Niswander, L. (2000) Dev. Biol. 219, 237-249
24. Yoon, B. S., Ovchinnikov, D. A., Yoshii, I., Mishina, Y., Behringer, R. R., and Lyons, K. M. (2005) Proc. Natl. Acad. Sci. U.S.A. 102, 5062-5067
25. Ruppert, R., Hoffmann, E., and Sebald, W. (1996) Eur. J. Biochem. 237, 295-302
26. Ohkawara, B., Iemura, S., ten Dijke, P., and Ueno, N. (2002) Curr. Biol. 12, 205-209
27. Irie, A., Habuchi, H., Kimata, K., and Sanai, Y. (2003) Biochem. Biophys. Res. Commun. 308, 858-865
28. Stanford, W. L., Cohn, J. B., and Cordes, S. P. (2001) Nat. Rev. Genet. 2, 756-768
29. Hall, B. K., and Miyake, T. (2000) BioEssays 22, 138-147
30. Duprez, D., Bell, E. J., Richardson, M. K., Archer, C. W., Wolpert, L., Brickell, P. M., and Francis-West, P. H. (1996) Mech. Dev. 57, 145-157
31. Macias, D., Gañan, Y., Sampath, T. K., Piedra, M. E., Ros, M. A., and Hurle, J. M. (1997) Development 124, 1109-1117
32. Li, C., Xu, X., Nelson, D. K., Williams, T., Kuehn, M. R., and Deng, C. X. (2005) Development 132, 4755-4764
33. Verheyden, J. M., Lewandoski, M., Deng, C., Harfe, B. D., and Sun, X. (2005) Development 132, 4235-4245
34. Yu, K., Xu, J., Liu, Z., Sosic, D., Shao, J., Olson, E. N., Towler, D. A., and Ornitz, D. M. (2003) Development 130, 3063-3074
35. Hill, T. P., Später, D., Taketo, M. M., Birchmeier, W., and Hartmann, C. (2005) Dev. Cell 8, 727-738
36. Zelzer, E., Mamluk, R., Ferrara, N., Johnson, R. S., Schipani, E., and Olsen, B. R. (2004) Development 131, 2161-2171
37. Bandyopadhyay, A., Tsuji, K., Cox, K., Harfe, B. D., Rosen, V., and Tabin, C. J. (2006) PLoS Genet. 2, e216
38. Yayon, A., Klagsbrun, M., Esko, J. D., Leder, P., and Ornitz, D. M. (1991) Cell 64, 841-848
39. Matsumoto, Y., Irie, F., Inatani, M., Tessier-Lavigne, M., and Yamaguchi, Y. (2007) J. Neurosci. 27, 4342-4350
40. Paine-Saunders, S., Viviano, B. L., Economides, A. N., and Saunders, S. (2002) J. Biol. Chem. 277, 2089-2096
41. Laufer, E., Nelson, C. E., Johnson, R. L., Morgan, B. A., and Tabin, C. (1994) Cell 79, 993-1003
42. Hartmann, C., and Tabin, C. J. (2001) Cell 104, 341-351
43. Guo, X., Day, T. F., Jiang, X., Garrett-Beal, L., Topol, L., and Yang, Y. (2004) Genes Dev. 18, 2404-2417
44. Bradley, R. S., and Brown, A. M. (1990) EMBO J. 9, 1569-1575
45. Dhoot, G. K., Gustafsson, M. K., Ai, X., Sun, W., Standiford, D. M., and Emerson, C. P., Jr. (2001) Science 293, 1663-1666
46. Deirmengian, G. K., Hebela, N. M., O'Connell, M., Glaser, D. L., Shore, E. M., and Kaplan, F. S. (2008) J. Bone Joint Surg. Am. 90, 366-374