Abnormal synchrony of resting state networks in premanifest and symptomatic Huntington disease: The IMAGE-HD study

Journal of Psychiatry and Neuroscience

Volumn 39, Issue 2, 2014, Pages 87-96

  Poudel, Govinda R ^a,c   Egan, Gary F ^a,c   Churchyard, Andrew ^b   Chua, Phyllis ^a   Stout, Julie C ^a   Georgiou Karistianis, Nellie ^a  

^a MONASH UNIVERSITY   (Australia)

^b MONASH MEDICAL CENTRE   (Australia)

^c Life Sciences Computation Centre   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DEFAULT MODE NETWORK; DORSAL ATTENTION NETWORK; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HIPPOCAMPUS; HUMAN; HUNTINGTON CHOREA; INDEPENDENT COMPONENT ANALYSIS; MALE; MOTOR PERFORMANCE; PARIETAL CORTEX; PUTAMEN; RESTING STATE NETWORK; SENSORIMOTOR FUNCTION; UNIFIED HUNTINGTON DISEASE RATING SCALE; BRAIN; BRAIN MAPPING; COGNITION; COMPARATIVE STUDY; GENETICS; GENOTYPING TECHNIQUE; HETEROZYGOTE; MIDDLE AGED; MOTOR ACTIVITY; NERVE TRACT; NEUROPSYCHOLOGICAL TEST; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PHYSIOLOGY; PSYCHOLOGY; REGRESSION ANALYSIS; REST; SIGNAL PROCESSING;

HTT PROTEIN, HUMAN; NERVE PROTEIN;

ADULT; AGED; BRAIN; BRAIN MAPPING; COGNITION; FEMALE; GENOTYPING TECHNIQUES; HETEROZYGOTE; HUMANS; HUNTINGTON DISEASE; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MOTOR ACTIVITY; NERVE TISSUE PROTEINS; NEURAL PATHWAYS; NEUROPSYCHOLOGICAL TESTS; REGRESSION ANALYSIS; REST; SIGNAL PROCESSING, COMPUTER-ASSISTED;

EID: 84895450139     PISSN: 11804882     EISSN: 14882434     Source Type: Journal    
DOI: 10.1503/jpn.120226     Document Type: Article

References (67)

1. Huntington's Disease Collaborative Research Group. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 1993; 72: 971-83.
2. Folstein SE, Leigh RJ, Parhad IM, et al. The diagnosis of Huntington's disease. Neurology 1986; 36: 1279-83.
3. Stout JC, Paulsen JS, Queller S, et al. Neurocognitive signs in prodromal Huntington disease. Neuropsychology 2011; 25: 1-14.
4. Stout JC, Jones R, Labuschagne I, et al. Evaluation of longitudinal 12 and 24 month cognitive outcomes in premanifest and early Huntington's disease. J Neurol Neurosurg Psychiatry 2012; 83: 687-94.
5. Douaud G, Gaura V, Ribeiro MJ, et al. Distribution of grey matter atrophy in Huntington's disease patients: a combined ROI-based and voxel-based morphometric study. Neuroimage 2006; 32: 1562-75.
6. Fennema-Notestine C, Archibald SL, Jacobson MW, et al. In vivo evi dence of cerebellar atrophy and cerebral white matter loss in Huntington disease. Neurology 2004; 63: 989-95.
7. Georgiou-Karistianis N, Scahill R, Tabrizi SJ, et al. Magnetic reson-ance imaging in Huntington's disease and recommendations for its potential use in clinical trials. Neurosci Biobehav Rev. In press.
8. Wolf RC, Vasic N, Schonfeldt-Lecuona C, et al. Dorsolateral prefrontal cortex dysfunction in presymptomatic Huntington's disease: evidence from event-related fMRI. Brain 2007; 130: 2845-57.
9. Georgiou-Karistianis N. A peek inside the Huntington's brain: Will functional imaging take us one step closer in solving the puzzle? Exp Neurol 2009; 220: 5-8.
10. Seibert TM, Majid DSA, Aron AR, et al. Stability of resting fMRI interregional correlations analyzed in subject-native space: a oneyear longitudinal study in healthy adults and premanifest Huntington's disease. Neuroimage 2012; 59: 2452-63.
11. Smith SM, Fox PT, Miller KL, et al. Correspondence of the brain's functional architecture during activation and rest. Proc Natl Acad Sci U S A 2009; 106: 13040-5.
12. Filippini N, MacIntosh BJ, Hough MG, et al. Distinct patterns of brain activity in young carriers of the APOE-epsilon4 allele. Proc Natl Acad Sci U S A 2009; 106: 7209-14.
13. Helmich RC, Derikx LC, Bakker M, et al. Spatial remapping of cortico-striatal connectivity in Parkinson's disease. Cereb Cortex 2010; 20: 1175-86.
14. Unschuld PG, Joel SE, Liu X, et al. Impaired cortico-striatal functional connectivity in prodromal Huntington's disease. Neurosci Lett 2012; 514: 204-9.
15. Feigin A, Tang C, Ma Y, et al. Thalamic metabolism and symptom onset in preclinical Huntington's disease. Brain 2007; 130: 2858-67.
16. Beckmann CF, Mackay CE, Filippini N, et al. Group comparison of resting-state fMRI data using multi-subject ICA and dualregression. Neuroimage 2009; 47 (Suppl 1): S148.
17. Roosendaal SD, Schoonheim MM, Hulst HE, et al. Resting state networks change in clinically isolated syndrome. Brain 2010; 133: 1612-21.
18. Wolf RC, Grön G, Sambataro F, et al. Brain activation and functional connectivity in premanifest Huntington's disease during states of intrinsic and phasic alertness. Hum Brain Mapp 2012; 33: 2161-73.
19. Thiruvady DR, Georgiou-Karistianis N, Egan GF, et al. Functional connectivity of the prefrontal cortex in Huntington's disease. J Neurol Neurosurg Psychiatry 2007; 78: 127-33.
20. Wolf RC, Sambataro F, Vasic N, et al. Altered frontostriatal coupling in pre-manifest Huntington's disease: effects of increasing cognitive load. Eur J Neurol 2008; 15: 1180-90.
21. Wolf RC, Sambataro F, Vasic N, et al. Aberrant connectivity of lateral prefrontal networks in presymptomatic Huntington's disease. Exp Neurol 2008; 213: 137-44.
22. Wolf RC, Sambataro F, Vasic N, et al. Default-mode network changes in preclinical Huntington's disease. Exp Neurol 2012; 237: 191-8.
23. Feigin A, Leenders KL, Moeller JR, et al. Metabolic network abnormalities in early Huntington's disease: an [(18) F]FDG PET study. J Nucl Med 2001; 42: 1591-5.
24. Weir DW, Sturrock A, Leavitt BR. Development of biomarkers for Huntington's disease. Lancet Neurol 2011; 10: 573-90.
25. Georgiou-Karistianis N, Gray MA, Domínguez D JF, et al. Automated differentiation of pre-diagnosis Huntington's disease from healthy control individuals based on quadratic discriminant analysis of the basal ganglia: The IMAGE-HD study. Neurobiol Dis 2013; 51: 82-92.
26. Gray MA, Egan GF, Ando A, et al. Prefrontal activity in Huntington's disease reflects cognitive and neuropsychiatric disturbances: the IMAGE-HD study. Exp Neurol 2013; 239: 218-28.
27. Oldfield RC. The assessment and analysis of handedness: the Edinburgh Inventory. Neuropsychologia 1971; 9: 97-113.
28. Weissman-Fogel I, Moayedi M, Taylor KS, et al. Cognitive and default-mode resting state networks: Do male and female brains "rest" differently? Hum Brain Mapp 2010; 31: 1713-26.
29. Tabrizi SJ, Langbehn DR, Leavitt BR, et al. Biological and clinical manifestations of Huntington's disease in the longitudinal TRACKHD study: cross-sectional analysis of baseline data. Lancet Neurol 2009; 8: 791-801.
30. Langbehn DR, Brinkman RR, Falush D, et al. A new model for prediction of the age of onset and penetrance for Huntington's disease based on CAG length. Clin Genet 2004; 65: 267-77.
31. Penney JB Jr, Vonsattel JP, MacDonald ME, et al. CAG repeat number governs the development rate of pathology in Huntington's disease. Ann Neurol 1997; 41: 689-92.
32. Tabrizi SJ, Scahill RI, Durr A, et al. Biological and clinical changes in premanifest and early stage Huntington's disease in the TRACK-HD study: the 12-month longitudinal analysis. Lancet Neurol 2011; 10: 31-42.
33. Nelson HE, Willison J, Owen AM. National Adult Reading Test, 2nd Edition. Int J Geriatr Psychiatry 1992; 7: 533.
34. Smith A. Symbol digit modality test (SDMT): manual (revised). Los Angeles (CA): Psychological Services; 1982.
35. Stroop JR. Studies of interference in serial verbal reactions. J Exp Psychol 1935; 18: 643-62.
36. Watson D, Wu KD. Development and validation of the Schedule of Compulsions, Obsessions, and Pathological Impulses (SCOPI). Assessment 2005; 12: 50-65.
37. Grace J, Mallory PF. Frontal systems behavior scale: professional manual. Lutz (FL): Psychological Assessment Resources; 2001.
38. Zigmond AS, Snaith RP. The Hospital Anxiety and Depression Scale. Acta Psychiatr Scand 1983; 67: 361-70.
39. Beck AT, Steer RA, Brown GK. Manual for the Beck Depression Inventory-II. San Antonio (TX): Psychological Corporation; 1996.
40. Bylsma FW, Moberg PJ, Doty RL, et al. Odor identification in Huntington's disease patients and asymptomatic gene carriers. J Neuropsychiatry Clin Neurosci 1997; 9: 598-600.
41. Doty RL, Shaman P, Kimmelman CP, et al. University of Pennsylvania Smell Identification Test: a rapid quantitative olfactory function test for the clinic. Laryngoscope 1984; 94: 176-8.
42. Ashburner J, Friston KJ. Unified segmentation. Neuroimage 2005; 26: 839-51.
43. Smith SM, Nichols TE. Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference. Neuroimage 2009; 44: 83-98.
44. Rowe KC, Paulsen JS, Langbehn DR, et al. Self-paced timing detects and tracks change in prodromal Huntington disease. Neuropsychology 2010; 24: 435-42.
45. Hart E, Middelkoop H, Jurgens CK, et al. Seven-year clinical followup of premanifest carriers of Huntington's disease. PLoS Curr 2011; 3: RRN1288.
46. Hinton SC, Paulsen JS, Hoffmann RG, et al. Motor timing variability increases in preclinical Huntington's disease patients as estimated onset of motor symptoms approaches. J Int Neuropsychol Soc 2007; 13: 539-43.
47. Rosas HD, Salat DH, Lee SY, et al. Cerebral cortex and the clinical expression of Huntington's disease: complexity and heterogeneity. Brain 2008; 131: 1057-68.
48. Bartenstein P, Weindl A, Spiegel S, et al. Central motor processing in Huntington's disease. A PET study. Brain 1997; 120: 1553-67.
49. Gavazzi C, Nave RD, Petralli R, et al. Combining functional and structural brain magnetic resonance imaging in Huntington disease. J Comput Assist Tomogr 2007; 31: 574-80.
50. Klöppel S, Draganski B, Siebner HR, et al. Functional compensation of motor function in pre-symptomatic Huntington's disease. Brain 2009; 132: 1624-32.
51. Bechtel N, Scahill RI, Rosas HD, et al. Tapping linked to function and structure in premanifest and symptomatic Huntington disease. Neurology 2010; 75: 2150-60.
52. D'Esposito M, Deouell LY, Gazzaley A. Alterations in the BOLD fMRI signal with ageing and disease: a challenge for neuroim-aging. Nat Rev Neurosci 2003; 4: 863-72.
53. Desimone R, Duncan J. Neural mechanisms of selective visual attention. Annu Rev Neurosci 1995; 18: 193-222.
54. Mangun GR. Neural mechanisms of visual selective attention. Psychophysiology 1995; 32: 4-18.
55. Clark VP, Lai S, Deckel AW. Altered functional MRI responses in Huntington's disease. Neuroreport 2002; 13: 703-6.
56. Georgiou-Karistianis N, Sritharan A, Farrow M, et al. Increased cortical recruitment in Huntington's disease using a Simon task. Neuropsychologia 2007; 45: 1791-800.
57. Wolf RC, Vasic N, Schonfeldt-Lecuona C, et al. Cortical dysfunction in patients with Huntington's disease during working memory performance. Hum Brain Mapp 2009; 30: 327-39.
58. Paulsen JS, Langbehn DR, Stout JC, et al. Detection of Huntington's disease decades before diagnosis: the Predict-HD study. J Neurol Neurosurg Psychiatry 2008; 79: 874-80.
59. Bohanna I, Georgiou-Karistianis N, Egan GF. Connectivity-based segmentation of the striatum in Huntington's disease: vulnerability of motor pathways. Neurobiol Dis 2011; 42: 475-81.
60. Roos RA, Pruyt JF, de Vries J, et al. Neuronal distribution in the putamen in Huntington's disease. J Neurol Neurosurg Psychiatry 1985; 48: 422-5.
61. Bohanna I, Georgiou-Karistianis N, Sritharan A, et al. Diffusion tensor imaging in Huntington's disease reveals distinct patterns of white matter degeneration associated with motor and cognitive deficits. Brain Imaging Behav 2011; 5: 171-80.
62. Ligot N, Krystkowiak P, Simonin C, et al. External globus pallidus stimulation modulates brain connectivity in Huntington's disease. J Cereb Blood Flow Metab 2011; 31: 41-6.
63. Wolf RC, Gron G, Sambataro F, et al. Magnetic resonance perfusion imaging of resting-state cerebral blood flow in preclinical Huntington's disease. J Cereb Blood Flow Metab 2011; 31: 1908-18.
64. Shmueli K, van Gelderen P, de Zwart JA, et al. Low-frequency fluctuations in the cardiac rate as a source of variance in the resting-state fMRI BOLD signal. Neuroimage 2007; 38: 306-20.
65. Di Martino A, Scheres A, Margulies DS, et al. Functional connectivity of human striatum: a resting state FMRI study. Cereb Cortex 2008; 18: 2735-47.
66. Fingelkurts AA, Fingelkurts AA, Kahkonen S. Functional connectivity in the brain-Is it an elusive concept? Neurosci Biobehav Rev 2005; 28: 827-36.
67. Power JD, Barnes KA, Snyder AZ, et al. Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion. Neuroimage 2012; 59: 2142-54.