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Volumn 130, Issue 11, 2007, Pages 2858-2867

Thalamic metabolism and symptom onset in preclinical Huntington's disease

Author keywords

Brain metabolism; Positron emission tomography (PET); Preclinical Huntington's disease (p HD)

Indexed keywords

DOPAMINE 2 RECEPTOR; FLUORODEOXYGLUCOSE F 18; RACLOPRIDE C 11;

EID: 35648963039     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awm217     Document Type: Article
Times cited : (161)

References (67)
  • 1
    • 14044274123 scopus 로고    scopus 로고
    • Huntington's disease and related disorders
    • Anderson KE. Huntington's disease and related disorders. Psychiatr Clin North Am 2005; 28: 275-90.
    • (2005) Psychiatr Clin North Am , vol.28 , pp. 275-290
    • Anderson, K.E.1
  • 2
    • 0031594146 scopus 로고    scopus 로고
    • 11C]raclopride-PET studies of the Huntington's disease rate of progression: Relevance of the trinucleotide repeat length
    • Antonini A, Leenders KL, Eidelberg D. [11C]raclopride-PET studies of the Huntington's disease rate of progression: relevance of the trinucleotide repeat length. Ann Neurol 1998; 43: 253-5.
    • (1998) Ann Neurol , vol.43 , pp. 253-255
    • Antonini, A.1    Leenders, K.L.2    Eidelberg, D.3
  • 3
    • 12644252940 scopus 로고    scopus 로고
    • Striatal glucose metabolism and dopamine D2 receptor binding in asymptomatic gene carriers and patients with Huntington's disease
    • Antonini A, Leenders KL, Spiegel R, Meier D, Vontobel P, Weigell-Weber M, et al. Striatal glucose metabolism and dopamine D2 receptor binding in asymptomatic gene carriers and patients with Huntington's disease. Brain 1996; 119: 2085-95.
    • (1996) Brain , vol.119 , pp. 2085-2095
    • Antonini, A.1    Leenders, K.L.2    Spiegel, R.3    Meier, D.4    Vontobel, P.5    Weigell-Weber, M.6
  • 4
    • 85039781820 scopus 로고    scopus 로고
    • Army Individual Test Battery. Manual of Directions and Scoring. Washington, DC: War Department, Adjutant General's Office; 1944.
    • Army Individual Test Battery. Manual of Directions and Scoring. Washington, DC: War Department, Adjutant General's Office; 1944.
  • 5
    • 12544260182 scopus 로고    scopus 로고
    • Decreased striatal D2 receptor binding in non-manifesting carriers of the DYT1 dystonia mutation
    • Asanuma K, Ma Y, Okulski J, Dhawan V, Chaly T, Carbon M, et al. Decreased striatal D2 receptor binding in non-manifesting carriers of the DYT1 dystonia mutation. Neurology 2005; 64: 347-9.
    • (2005) Neurology , vol.64 , pp. 347-349
    • Asanuma, K.1    Ma, Y.2    Okulski, J.3    Dhawan, V.4    Chaly, T.5    Carbon, M.6
  • 6
    • 0030612119 scopus 로고    scopus 로고
    • Dopamine D1 and D2 receptor gene expression in the striatum in Huntington's disease
    • Augood SJ, Faull RL, Emson PC. Dopamine D1 and D2 receptor gene expression in the striatum in Huntington's disease. Ann Neurol 1997; 42: 215-21.
    • (1997) Ann Neurol , vol.42 , pp. 215-221
    • Augood, S.J.1    Faull, R.L.2    Emson, P.C.3
  • 8
    • 0034087487 scopus 로고    scopus 로고
    • Rate of caudate atrophy in presymptomatic and symptomatic stages of Huntington's disease
    • Aylward EH, Codori AM, Rosenblatt A, Sherr M, Brandt J, Stine OC, et al. Rate of caudate atrophy in presymptomatic and symptomatic stages of Huntington's disease. Mov Disord 2000; 15: 552-60.
    • (2000) Mov Disord , vol.15 , pp. 552-560
    • Aylward, E.H.1    Codori, A.M.2    Rosenblatt, A.3    Sherr, M.4    Brandt, J.5    Stine, O.C.6
  • 10
    • 85039780727 scopus 로고    scopus 로고
    • Biglan KM, Investigators P. Baseline characteristics of the prospective Huntington at risk observational study cohort. Ann Neurol 2004; 56: S24.
    • Biglan KM, Investigators P. Baseline characteristics of the prospective Huntington at risk observational study cohort. Ann Neurol 2004; 56: S24.
  • 11
    • 0028926373 scopus 로고
    • Calculating correlation coefficients with repeated observations: Part 1-Correlation within subjects
    • Bland JM, Altman DG. Calculating correlation coefficients with repeated observations: part 1-Correlation within subjects. Br Med J 1995; 310: 446.
    • (1995) Br Med J , vol.310 , pp. 446
    • Bland, J.M.1    Altman, D.G.2
  • 12
    • 29144468251 scopus 로고    scopus 로고
    • 3-Nitropropionic acid: A mitochondrial toxin to uncover physiopathological mechanisms underlying striatal degeneration in Huntington's disease
    • Brouillet E, Jacquard C, Bizat N, Blum D. 3-Nitropropionic acid: a mitochondrial toxin to uncover physiopathological mechanisms underlying striatal degeneration in Huntington's disease. J Neurochem 2005; 95: 1521-40.
    • (2005) J Neurochem , vol.95 , pp. 1521-1540
    • Brouillet, E.1    Jacquard, C.2    Bizat, N.3    Blum, D.4
  • 13
    • 0030919567 scopus 로고    scopus 로고
    • Oxidative damage and metabolic dysfunction in Huntington's disease: Selective vulnerability of the basal ganglia
    • Browne SE, Bowling AC, MacGarvey U, Baik MJ, Berger SC, Muqit MM, et al. Oxidative damage and metabolic dysfunction in Huntington's disease: selective vulnerability of the basal ganglia. Ann Neurol 1997; 41: 646-53.
    • (1997) Ann Neurol , vol.41 , pp. 646-653
    • Browne, S.E.1    Bowling, A.C.2    MacGarvey, U.3    Baik, M.J.4    Berger, S.C.5    Muqit, M.M.6
  • 15
    • 0028287162 scopus 로고
    • Automatic 3D intersubject registration of MR volumetric data in standardized Talairach space
    • Collins DL, Neelin P, Peters TM, Evans AC. Automatic 3D intersubject registration of MR volumetric data in standardized Talairach space. J Comput Assist Tomogr 1994; 18: 192-205.
    • (1994) J Comput Assist Tomogr , vol.18 , pp. 192-205
    • Collins, D.L.1    Neelin, P.2    Peters, T.M.3    Evans, A.C.4
  • 16
    • 0037150687 scopus 로고    scopus 로고
    • Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease
    • Dunah AW, Jeong H, Griffin A, Kim YM, Standaert DG, Hersch SM, et al. Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease. Science 2002; 296: 2238-43.
    • (2002) Science , vol.296 , pp. 2238-2243
    • Dunah, A.W.1    Jeong, H.2    Griffin, A.3    Kim, Y.M.4    Standaert, D.G.5    Hersch, S.M.6
  • 18
    • 0030861143 scopus 로고    scopus 로고
    • Metabolic correlates of pallidal neuronal activity in Parkinson's disease
    • Eidelberg D, Moeller JR, Kazumata K, Antonini A, Sterio D, Dhawan V, et al. Metabolic correlates of pallidal neuronal activity in Parkinson's disease. Brain 1997; 120: 1315-24.
    • (1997) Brain , vol.120 , pp. 1315-1324
    • Eidelberg, D.1    Moeller, J.R.2    Kazumata, K.3    Antonini, A.4    Sterio, D.5    Dhawan, V.6
  • 19
    • 23844545908 scopus 로고    scopus 로고
    • Evidence from biomarkers and surrogate endpoints
    • Feigin A. Evidence from biomarkers and surrogate endpoints. Neuro Rx 2004; 1: 323-30.
    • (2004) Neuro Rx , vol.1 , pp. 323-330
    • Feigin, A.1
  • 20
    • 29944436350 scopus 로고    scopus 로고
    • Preclinical Huntington's disease: Compensatory brain responses during learning
    • Feigin A, Ghilardi MF, Huang C, Ma Y, Carbon M, Guttman M, et al. Preclinical Huntington's disease: compensatory brain responses during learning. Ann Neurol 2006; 59: 53-9.
    • (2006) Ann Neurol , vol.59 , pp. 53-59
    • Feigin, A.1    Ghilardi, M.F.2    Huang, C.3    Ma, Y.4    Carbon, M.5    Guttman, M.6
  • 22
  • 23
    • 0036312181 scopus 로고    scopus 로고
    • Recent advances in Huntington's disease: Implications for experimental therapeutics
    • Feigin A, Zgaljardic D. Recent advances in Huntington's disease: implications for experimental therapeutics. Curr Opin Neurol 2002; 15: 483-9.
    • (2002) Curr Opin Neurol , vol.15 , pp. 483-489
    • Feigin, A.1    Zgaljardic, D.2
  • 26
    • 0345465664 scopus 로고    scopus 로고
    • Nerve cell loss in the thalamic mediodorsal nucleus in Huntington's disease
    • Heinsen H, Rub U, Bauer M, Ulmar G, Bethke B, Schuler M, et al. Nerve cell loss in the thalamic mediodorsal nucleus in Huntington's disease. Acta Neuropathol 1999; 97: 613-22.
    • (1999) Acta Neuropathol , vol.97 , pp. 613-622
    • Heinsen, H.1    Rub, U.2    Bauer, M.3    Ulmar, G.4    Bethke, B.5    Schuler, M.6
  • 27
    • 13344278683 scopus 로고    scopus 로고
    • Nerve cell loss in the thalamic centromedian-parafascicular complex in patients with Huntington's disease
    • Heinsen H, Rub U, Gangnus D, Jungkunz G, Bauer M, Ulmar G, et al. Nerve cell loss in the thalamic centromedian-parafascicular complex in patients with Huntington's disease. Acta Neuropathol 1996; 91: 161-8.
    • (1996) Acta Neuropathol , vol.91 , pp. 161-168
    • Heinsen, H.1    Rub, U.2    Gangnus, D.3    Jungkunz, G.4    Bauer, M.5    Ulmar, G.6
  • 28
    • 85009332113 scopus 로고    scopus 로고
    • Unified Huntington's Disease Rating Scale: Reliability and consistency
    • Huntington Study Group
    • Huntington Study Group. Unified Huntington's Disease Rating Scale: reliability and consistency. Mov Disord 1996; 11: 136-42.
    • (1996) Mov Disord , vol.11 , pp. 136-142
  • 29
    • 26844550967 scopus 로고    scopus 로고
    • Effects of CAG repeat length, HTT protein length and protein context on cerebral metabolism measured using magnetic resonance spectroscopy in transgenic mouse models of Huntington's disease
    • Jenkins BG, Andreassen OA, Dedeoglu A, Leavitt B, Hayden M, Borchelt D, et al. Effects of CAG repeat length, HTT protein length and protein context on cerebral metabolism measured using magnetic resonance spectroscopy in transgenic mouse models of Huntington's disease. J Neurochem 2005; 95: 553-62.
    • (2005) J Neurochem , vol.95 , pp. 553-562
    • Jenkins, B.G.1    Andreassen, O.A.2    Dedeoglu, A.3    Leavitt, B.4    Hayden, M.5    Borchelt, D.6
  • 30
    • 18844422479 scopus 로고    scopus 로고
    • Thalamic atrophy in Huntington's disease co-varies with cognitive performance: A morphometric MRI analysis
    • Kassubek J, Juengling FD, Ecker D, Landwehrmeyer GB. Thalamic atrophy in Huntington's disease co-varies with cognitive performance: a morphometric MRI analysis. Cereb Cortex 2005; 15: 846-53.
    • (2005) Cereb Cortex , vol.15 , pp. 846-853
    • Kassubek, J.1    Juengling, F.D.2    Ecker, D.3    Landwehrmeyer, G.B.4
  • 34
    • 0031044805 scopus 로고    scopus 로고
    • Energy metabolism defects in Huntington's disease and effects of coenzyme Q10
    • Koroshetz WJ, Jenkins BG, Rosen BR, Beal MF. Energy metabolism defects in Huntington's disease and effects of coenzyme Q10. Ann Neurol 1997; 41: 160-5.
    • (1997) Ann Neurol , vol.41 , pp. 160-165
    • Koroshetz, W.J.1    Jenkins, B.G.2    Rosen, B.R.3    Beal, M.F.4
  • 36
    • 1842477303 scopus 로고    scopus 로고
    • A new model for prediction of the age of onset and penetrance for Huntington's disease based on CAG length
    • Langbehn DR, Brinkman RR, Falush D, Paulsen JS, Hayden MR. A new model for prediction of the age of onset and penetrance for Huntington's disease based on CAG length. Clin Genet 2004; 65: 267-77.
    • (2004) Clin Genet , vol.65 , pp. 267-277
    • Langbehn, D.R.1    Brinkman, R.R.2    Falush, D.3    Paulsen, J.S.4    Hayden, M.R.5
  • 37
    • 0033914747 scopus 로고    scopus 로고
    • Abnormal in vivo skeletal muscle energy metabolism in Huntington's disease and dentatorubropallidoluysian atrophy
    • Lodi R, Schapira AH, Manners D, Styles P, Wood NW, Taylor DJ, et al. Abnormal in vivo skeletal muscle energy metabolism in Huntington's disease and dentatorubropallidoluysian atrophy. Ann Neurol 2000; 48: 72-6.
    • (2000) Ann Neurol , vol.48 , pp. 72-76
    • Lodi, R.1    Schapira, A.H.2    Manners, D.3    Styles, P.4    Wood, N.W.5    Taylor, D.J.6
  • 38
    • 0033729522 scopus 로고    scopus 로고
    • Graphical analysis of PET data applied to reversible and irreversible tracers
    • Logan J. Graphical analysis of PET data applied to reversible and irreversible tracers. Nucl Med Biol 2000; 27: 661-70.
    • (2000) Nucl Med Biol , vol.27 , pp. 661-670
    • Logan, J.1
  • 39
    • 34447105713 scopus 로고    scopus 로고
    • Implementation of atrophy correction in metabolic mapping studies of presymptomatic Huntington's disease
    • Ma Y, Feigin A, Okulski J, Dhawan V, Chaly T, Eidelberg D. Implementation of atrophy correction in metabolic mapping studies of presymptomatic Huntington's disease. J Cereb Blood Flow Metab 2003; 23: S629.
    • (2003) J Cereb Blood Flow Metab , vol.23
    • Ma, Y.1    Feigin, A.2    Okulski, J.3    Dhawan, V.4    Chaly, T.5    Eidelberg, D.6
  • 40
    • 33847188067 scopus 로고    scopus 로고
    • Abnormal metabolic network activity in Parkinson's disease: Test-retest reproducibility
    • Ma Y, Tang C, Spetsieris P, Dhawan V, Eidelberg D. Abnormal metabolic network activity in Parkinson's disease: test-retest reproducibility. J Cereb Blood Flow Metab 2007; 27: 597-605.
    • (2007) J Cereb Blood Flow Metab , vol.27 , pp. 597-605
    • Ma, Y.1    Tang, C.2    Spetsieris, P.3    Dhawan, V.4    Eidelberg, D.5
  • 43
    • 0032868781 scopus 로고    scopus 로고
    • Reproducibility of regional metabolic covariance patterns: Comparison of four populations
    • Moeller JR, Nakamura T, Mentis MJ, Dhawan V, Spetsieres P, Antonini A, et al. Reproducibility of regional metabolic covariance patterns: comparison of four populations. J Nucl Med 1999; 40: 1264-9.
    • (1999) J Nucl Med , vol.40 , pp. 1264-1269
    • Moeller, J.R.1    Nakamura, T.2    Mentis, M.J.3    Dhawan, V.4    Spetsieres, P.5    Antonini, A.6
  • 44
    • 85039794931 scopus 로고    scopus 로고
    • Nelson HE. The National Adult Reading Test (NART): test manual. Windsor, Berks, UK: NFER-Nelson; 1982.
    • Nelson HE. The National Adult Reading Test (NART): test manual. Windsor, Berks, UK: NFER-Nelson; 1982.
  • 47
    • 0037408213 scopus 로고    scopus 로고
    • Progressive striatal and cortical dopamine receptor dysfunction in Huntington's disease: A PET study
    • Pavese N, Andrews TC, Brooks DJ, Ho AK, Rosser AE, Barker RA, et al. Progressive striatal and cortical dopamine receptor dysfunction in Huntington's disease: a PET study. Brain 2003; 126: 1127-35.
    • (2003) Brain , vol.126 , pp. 1127-1135
    • Pavese, N.1    Andrews, T.C.2    Brooks, D.J.3    Ho, A.K.4    Rosser, A.E.5    Barker, R.A.6
  • 48
    • 33745637954 scopus 로고    scopus 로고
    • Microglial activation correlates with severity in Huntington disease: A clinical and PET study
    • Pavese N, Gerhard A, Tai YF, Ho AK, Turkheimer F, Barker RA, et al. Microglial activation correlates with severity in Huntington disease: a clinical and PET study. Neurology 2006; 66: 1638-43.
    • (2006) Neurology , vol.66 , pp. 1638-1643
    • Pavese, N.1    Gerhard, A.2    Tai, Y.F.3    Ho, A.K.4    Turkheimer, F.5    Barker, R.A.6
  • 50
    • 23844514798 scopus 로고    scopus 로고
    • Using advances in neuroimaging to detect, understand, and monitor disease progression in Huntington's disease
    • Rosas HD, Feigin AS, Hersch SM. Using advances in neuroimaging to detect, understand, and monitor disease progression in Huntington's disease. Neuro Rx 2004; 1: 263-72.
    • (2004) Neuro Rx , vol.1 , pp. 263-272
    • Rosas, H.D.1    Feigin, A.S.2    Hersch, S.M.3
  • 51
    • 0037066115 scopus 로고    scopus 로고
    • Regional and progressive thinning of the cortical ribbon in Huntington's disease
    • Rosas HD, Liu AK, Hersch S, Glessner M, Ferrante RJ, Salat DH, et al. Regional and progressive thinning of the cortical ribbon in Huntington's disease. Neurology 2002; 58: 695-701.
    • (2002) Neurology , vol.58 , pp. 695-701
    • Rosas, H.D.1    Liu, A.K.2    Hersch, S.3    Glessner, M.4    Ferrante, R.J.5    Salat, D.H.6
  • 52
    • 85039798421 scopus 로고    scopus 로고
    • Clinical and radiographic features among presymptomatic individuals carrying an expanded CAG repeat in the Huntington's disease gene: Analysis of baseline characteristics of the PREDICT-HD Cohort
    • Ross CA, Aylward EH, Stout JC, Biglan KM, Hayden MR, Shoulson I, et al. Clinical and radiographic features among presymptomatic individuals carrying an expanded CAG repeat in the Huntington's disease gene: analysis of baseline characteristics of the PREDICT-HD Cohort. Neurology 2004; 62: A357.
    • (2004) Neurology , vol.62
    • Ross, C.A.1    Aylward, E.H.2    Stout, J.C.3    Biglan, K.M.4    Hayden, M.R.5    Shoulson, I.6
  • 53
    • 22844440902 scopus 로고    scopus 로고
    • Mitochondrial impairment in patients and asymptomatic mutation carriers of Huntington's disease
    • Saft C, Zange J, Andrich J, Muller K, Lindenberg K, Landwehrmeyer B, et al. Mitochondrial impairment in patients and asymptomatic mutation carriers of Huntington's disease. Mov Disord 2005; 20: 674-9.
    • (2005) Mov Disord , vol.20 , pp. 674-679
    • Saft, C.1    Zange, J.2    Andrich, J.3    Muller, K.4    Lindenberg, K.5    Landwehrmeyer, B.6
  • 57
    • 0032251946 scopus 로고    scopus 로고
    • Using SAS PROC MIXED to fit multilevel models, hierarchical models, and individual growth models
    • Singer JD. Using SAS PROC MIXED to fit multilevel models, hierarchical models, and individual growth models. J Edu Behav Stat 1998; 25: 323-55.
    • (1998) J Edu Behav Stat , vol.25 , pp. 323-355
    • Singer, J.D.1
  • 60
    • 4344658072 scopus 로고    scopus 로고
    • The thalamostriatal system: A highly specific network of the basal ganglia circuitry
    • Smith Y, Raju DV, Pare JF, Sidibe M. The thalamostriatal system: a highly specific network of the basal ganglia circuitry. Trends Neurosci 2004; 27: 520-7.
    • (2004) Trends Neurosci , vol.27 , pp. 520-527
    • Smith, Y.1    Raju, D.V.2    Pare, J.F.3    Sidibe, M.4
  • 64
    • 0027161814 scopus 로고
    • Noninvasive quantitative fluorodeoxyglucose PET studies with an estimated input function derived from a population-based arterial blood curve
    • Takikawa S, Dhawan V, Spetsieris P, Robeson W, Chaly T, Dahl R, et al. Noninvasive quantitative fluorodeoxyglucose PET studies with an estimated input function derived from a population-based arterial blood curve. Radiology 1993; 188: 131-6.
    • (1993) Radiology , vol.188 , pp. 131-136
    • Takikawa, S.1    Dhawan, V.2    Spetsieris, P.3    Robeson, W.4    Chaly, T.5    Dahl, R.6
  • 65
    • 0036894150 scopus 로고    scopus 로고
    • Tros?t M, Carbon M, Edwards C, Raymond D, Mentis M, Moeller JR, et al. Primary dystonia: is abnormal functional brain architecture linked to genotype? Ann Neurol 2002; 52: 853-6.
    • Tros?t M, Carbon M, Edwards C, Raymond D, Mentis M, Moeller JR, et al. Primary dystonia: is abnormal functional brain architecture linked to genotype? Ann Neurol 2002; 52: 853-6.
  • 66
    • 33645085291 scopus 로고    scopus 로고
    • Huntington disease patients and transgenic mice have similar pro-catabolic serum metabolite profiles
    • Underwood BR, Broadhurst D, Dunn WB, Ellis DI, Michell AW, Vacher C, et al. Huntington disease patients and transgenic mice have similar pro-catabolic serum metabolite profiles. Brain 2006; 129: 877-86.
    • (2006) Brain , vol.129 , pp. 877-886
    • Underwood, B.R.1    Broadhurst, D.2    Dunn, W.B.3    Ellis, D.I.4    Michell, A.W.5    Vacher, C.6


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