Laser-structured bacterial nanocellulose hydrogels support ingrowth and differentiation of chondrocytes and show potential as cartilage implants

Acta Biomaterialia

Volumn 10, Issue 3, 2014, Pages 1341-1353

  Ahrem, Hannes ^a,f   Pretzel, David ^b,f   Endres, Michaela ^c   Conrad, Daniel ^d   Courseau, Julien ^e   Müller, Hartmut ^d   Jaeger, Raimund ^e   Kaps, Christian ^c   Klemm, Dieter O ^a   Kinne, Raimund W ^b  

^a Jenpolymer Materials Ltd and Co KG   (Germany)

^b Jena University Hospital   (Germany)

^c TRANSTISSUE TECHNOLOGIES GMBH   (Germany)

^d Günter Köhler Institut für Fügetechnik und Werkstoffprüfung GmbH   (Germany)

^e FRAUNHOFER INSTITUTE FOR MECHANICS OF MATERIALS IWM   (Germany)

^f FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Bacterial nanocellulose; Cartilage implant; Chondrocyte ingrowth differentiation; Laser structuring; Microbial cellulose

Indexed keywords

BIOCHEMISTRY; BIOCOMPATIBILITY; BODY FLUIDS; CHEMICAL MODIFICATION; COMPRESSIVE STRENGTH; DEIONIZED WATER; HYDROGELS; HYDROXYAPATITE; NANOCELLULOSE; NUTRIENTS; SCAFFOLDS (BIOLOGY); WASHING;

CARTILAGE IMPLANT; CHONDROCYTE INGROWTH/DIFFERENTIATION; CHONDROCYTES; HUMAN CHONDROCYTE; HYDROGEL SUPPORTS; IMPLANT MATERIALS; LASER PERFORATION; LASER STRUCTURING; MICROBIAL CELLULOSE; PLACEHOLDERS;

FOURIER TRANSFORM INFRARED SPECTROSCOPY;

AGGRECAN; CELLULOSE; COLLAGEN TYPE 1; COLLAGEN TYPE 2; COLLAGEN TYPE 9; NANOMATERIAL; SODIUM HYDROXIDE; HYDROGEL; NANOPARTICLE;

ANIMAL CELL; ARTICLE; BACTERIAL NANOCELLULOSE HYDROGEL; BIOCOMPATIBILITY; BIOSYNTHESIS; CARTILAGE CELL; CARTILAGE IMPLANT; CELL DEDIFFERENTIATION; CELL DIFFERENTIATION; CELL GROWTH; CELL ISOLATION; CELL STRUCTURE; CELL VIABILITY; CHEMICAL STRUCTURE; COMPRESSIVE STRENGTH; CONTROLLED STUDY; EXTRACELLULAR MATRIX; GLUCONACETOBACTER XYLINUS; HISTOLOGY; HOLSTEIN-FRIESIAN CATTLE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HYDROGEL; INFRARED SPECTROSCOPY; LASER; LASER MICROSCOPY; LOW LEVEL LASER THERAPY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; SCANNING ELECTRON MICROSCOPY; STEADY STATE; SURFACE PROPERTY; TISSUE ENGINEERING; TISSUE IMPLANT; X RAY PHOTOELECTRON SPECTROSCOPY; YOUNG MODULUS; AGED; ANIMAL; BOVINE; CARTILAGE; CELL PROLIFERATION; CELL SHAPE; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; MALE; METABOLISM; MIDDLE AGED; PHYSIOLOGY; PROSTHESES AND ORTHOSES; REAL TIME POLYMERASE CHAIN REACTION; ULTRASTRUCTURE;

BACTERIA (MICROORGANISMS); GLUCONACETOBACTER XYLINUS;

AGED; ANIMALS; CARTILAGE; CATTLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SHAPE; CELLULOSE; CHONDROCYTES; COMPRESSIVE STRENGTH; ELASTIC MODULUS; GLUCONACETOBACTER XYLINUS; HUMANS; HYDROGELS; LASERS; MALE; MIDDLE AGED; NANOPARTICLES; PHOTOELECTRON SPECTROSCOPY; PROSTHESES AND IMPLANTS; REAL-TIME POLYMERASE CHAIN REACTION; SODIUM HYDROXIDE; SPECTROSCOPY, FOURIER TRANSFORM INFRARED;

EID: 84895070057     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2013.12.004     Document Type: Article

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