Change in protein-ligand specificity through binding pocket grafting

Journal of Structural Biology

Volumn 185, Issue 2, 2014, Pages 186-192

  Scheib, Ulrike ^a   Shanmugaratnam, Sooruban ^a   Farías Rico, José Arcadio ^a   Höcker, Birte ^a  

^a MAX PLANCK INSTITUTE FOR DEVELOPMENTAL BIOLOGY   (Germany)

Author keywords

Periplasmic binding protein; Polyamine binding; Protein engineering; Putrescine; Rational design; Spermidine

Indexed keywords

PERIPLASMIC BINDING PROTEIN; POLYAMINE BINDING; PROTEIN ENGINEERING; PUTRESCINE; RATIONAL DESIGN; SPERMIDINE;

AMINO ACID SUBSTITUTION; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; LIGANDS; MEMBRANE TRANSPORT PROTEINS; MODELS, MOLECULAR; PERIPLASMIC BINDING PROTEINS; PROTEIN BINDING; PROTEIN ENGINEERING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PUTRESCINE; RECEPTORS, BIOGENIC AMINE; SPERMIDINE; THERMODYNAMICS;

EID: 84894910465     PISSN: 10478477     EISSN: 10958657     Source Type: Journal    
DOI: 10.1016/j.jsb.2013.06.002     Document Type: Article

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