Caspase-3 modulates regenerative response after stroke

Stem Cells

Volumn 32, Issue 2, 2014, Pages 473-486

  Fan, Wenying ^a   Dai, Yiqin ^a   Xu, Haochen ^a   Zhu, Ximin ^a   Cai, Ping ^a   Wang, Lixiang ^a   Sun, Chungang ^a   Hu, Changlong ^a,b   Zheng, Ping ^a   Zhao, Bing Qiao ^a  

^a FUDAN UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

Author keywords

Caspase 3; Neurogenesis; Neuronal precursor cells; Stroke; Stroke recovery

Indexed keywords

CASPASE-3; NEUROGENESIS; NEURONAL PRECURSOR CELLS; STROKE; STROKE RECOVERY;

ANIMALS; BRAIN ISCHEMIA; CASPASE 3; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL- AND TISSUE-BASED THERAPY; CELLS, CULTURED; HUMANS; MICE; NERVE REGENERATION; NEURONS; RECOVERY OF FUNCTION; STEM CELLS; STROKE;

EID: 84894575779     PISSN: 10665099     EISSN: 15494918     Source Type: Journal    
DOI: 10.1002/stem.1503     Document Type: Article

References (61)

1. Lo EH. Degeneration and repair in central nervous system disease. Nat Med 2010; 16: 1205-1209.
2. Moskowitz MA, Lo EH, Iadecola C. The science of stroke: Mechanisms in search of treatments. Neuron 2010;67: 181-198.
3. Dobkin BH. Training and exercise to drive poststroke recovery. Nature clinical practice. Neurology 2008;4: 76-85.
4. Carmichael ST. Cellular and molecular mechanisms of neural repair after stroke: Making waves. Ann Neurol 2006;59: 735-742.
5. Hermann DM, Chopp M. Promoting brain remodelling and plasticity for stroke recovery: Therapeutic promise and potential pitfalls of clinical translation. Lancet Neurol 2012;11: 369-380.
6. Lindvall O, Kokaia Z. Stem cells in human neurodegenerative disorders-Time for clinical translation? J Clin Invest 2010; 120: 29-40.
7. Hyman BT, Yuan J. Apoptotic and nonapoptotic roles of caspases in neuronal physiology and pathophysiology. Nat Rev Neurosci 2012;13: 395-406.
8. McLaughlin B. The kinder side of killer proteases: Caspase activation contributes to neuroprotection and CNS remodeling. Apoptosis 2004;9: 111-121.
9. Li J, Yuan J. Caspases in apoptosis and beyond. Oncogene 2008;27: 6194-6206.
10. Nagata S, Nagase H, Kawane K et al. Degradation of chromosomal DNA during apoptosis. Cell Death Differ 2003;10: 108-116.
11. Israels LG, Israels ED. Apoptosis. Stem Cells 1999;17: 306-313.
12. Ma J, Endres M, Moskowitz MA. Synergistic effects of caspase inhibitors and MK-801 in brain injury after transient focal cerebral ischaemia in mice. Brit J Pharmacol 1998;124: 756-762.
13. Clark RS, Kochanek PM, Watkins SC et al. Caspase-3 mediated neuronal death after traumatic brain injury in rats. J Neurochem 2000; 74: 740-753.
14. Chen J, Nagayama T, Jin K et al. Induction of caspase-3-like protease may mediate delayed neuronal death in the hippocampus after transient cerebral ischemia. J Neurosci 1998;18: 4914-4928.
15. D'Amelio M, Cavallucci V, Cecconi F. Neuronal caspase-3 signaling: Not only cell death. Cell Death Differ 2010;17: 1104-1114.
16. Wagner DC, Riegelsberger UM, Michalk S et al. Cleaved caspase-3 expression after experimental stroke exhibits different phenotypes and is predominantly non-apoptotic. Brain Res 2011;1381: 237-242.
17. Ohab JJ, Fleming S, Blesch A et al. A neurovascular niche for neurogenesis after stroke. J Neurosci 2006;26: 13007-13016.
18. Taguchi A, Soma T, Tanaka H et al. Administration of CD341 cells after stroke enhances neurogenesis via angiogenesis in a mouse model. J Clin Invest 2004;114: 330-338.
19. Walter J, Keiner S, Witte OW et al. Enriched environment and spatial learning enhance hippocampal neurogenesis and salvages ischemic penumbra after focal cerebral ischemia. Neurobiol Dis 2006;22: 187-198.
20. Jin K, Xie L, Mao X et al. Effect of human neural precursor cell transplantation on endogenous neurogenesis after focal cerebral ischemia in the rat. Brain Res 2011; 1374: 56-62.
21. Brint S, Jacewicz M, Kiessling M et al. Focal brain ischemia in the rat: Methods for reproducible neocortical infarction using tandem occlusion of the distal middle cerebral and ipsilateral common carotid arteries. J Cereb Blood Flow Metab 1988;8: 474-485.
22. Braeuninger S, Kleinschnitz C. Rodent models of focal cerebral ischemia: Procedural pitfalls and translational problems. Exp Transl Stroke Med 2009;1: 8.
23. Sun H, Le T, Chang TT et al. AAV-mediated netrin-1 overexpression increases periinfarct blood vessel density and improves motor function recovery after experimental stroke. Neurobiol Dis 2011;44: 73-83.
24. Liauw J, Hoang S, Choi M et al. Thrombospondins 1 and 2 are necessary for synaptic plasticity and functional recovery after stroke. J Cereb Blood Flow Metab 2008;28: 1722-1732.
25. Zhao BQ, Wang S, Kim HY et al. Role of matrix metalloproteinases in delayed cortical responses after stroke. Nat Med 2006;12: 441-445.
26. Lee SR, Kim HY, Rogowska J et al. Involvement of matrix metalloproteinase in neuroblast cell migration from the subventricular zone after stroke. J Neurosci 2006;26: 3491-3495.
27. Miura M, Chen XD, Allen MR et al. A crucial role of caspase-3 in osteogenic differentiation of bone marrow stromal stem cells. J Clin Invest 2004;114: 1704-1713.
28. Abrahamson EE, Ikonomovic MD, Ciallella JR et al. Caspase inhibition therapy abolishes brain trauma-induced increases in Abeta peptide: Implications for clinical outcome. Exp Neurol 2006;197: 437-450.
29. Shen J, Ishii Y, Xu G et al. PDGFR-b as a positive regulator of tissue repair in a mouse model of focal cerebral ischemia. J Cereb Blood Flow Metab 2012;32: 353-367.
30. Ohlsson AL, Johansson BB. Environment influences functional outcome of cerebral infarction in rats. Stroke 1995;26: 644-649.
31. Sun F, Wang X, Mao X et al. Ablation of neurogenesis attenuates recovery of motor function after focal cerebral ischemia in middle-aged mice. Plos One 2012;7: e46326.
32. Zhao BQ, Ikeda Y, Ihara H et al. Essential role of endogenous tissue plasminogen activator through matrix metalloproteinase 9 induction and expression on heparinproduced cerebral hemorrhage after cerebral ischemia in mice. Blood 2004;103: 2610-2616.
33. Zhao BQ, Chauhan AK, Canault M et al. von Willebrand factor-cleaving protease ADAMTS13 reduces ischemic brain injury in experimental stroke. Blood 2009;114: 3329-3334.
34. Mackey ME, Wu Y, Hu R et al. Cell death suggestive of apoptosis after spinal cord ischemia in rabbits. Stroke 1997;28: 2012-2017.
35. Chen J, Zacharek A, Li A et al. Atorvastatin promotes presenilin-1 expression and Notch1 activity and increases neural progenitor cell proliferation after stroke. Stroke 2008;39: 220-226.
36. Wang L, Fan W, Cai P et al. Recombinant ADAMTS13 reduces tissue plasminogen activator-induced hemorrhage after stroke in mice. Ann Neurol 2013;73: 189-198.
37. Clarkson AN, Huang BS, Macisaac SE et al. Reducing excessive GABA-mediated tonic inhibition promotes functional recovery after stroke. Nature 2010;468: 305-309.
38. Dijkhuizen RM, Singhal AB, Mandeville JB et al. Correlation between brain reorganization, ischemic damage, and neurologic status after transient focal cerebral ischemia in rats: A functional magnetic resonance imaging study. J Neurosci 2003;23: 510-517.
39. Dempsey RJ, Sailor KA, Bowen KK et al. Stroke-induced progenitor cell proliferation in adult spontaneously hypertensive rat brain: Effect of exogenous IGF-1 and GDNF. J Neurochem 2003;87: 586-597.
40. Zhang R, Zhang Z,Wang L et al. Activated neural stem cells contribute to stroke-induced neurogenesis and neuroblast migration toward the infarct boundary in adult rats. J Cereb Blood Flow Metab 2004;24: 441-448.
41. Le DA,Wu Y, Huang Z et al. Caspase activation and neuroprotection in caspase-3-deficient mice after in vivo cerebral ischemia and in vitro oxygen glucose deprivation. Proc Natl Acad Sci USA 2002;99: 15188-15193.
42. Rosell A, Agin V, Rahman M et al. Distal occlusion of the middle cerebral artery in mice: Are we ready to assess long-term functional outcome? Transl Stroke Res 2013;4: 297-307.
43. Janzen V, Fleming HE, Riedt T et al. Hematopoietic stem cell responsiveness to exogenous signals is limited by caspase-3. Cell Stem Cell 2008;2: 584-594.
44. Li Z, Jo J, Jia JM et al. Caspase-3 activation via mitochondria is required for longterm depression and AMPA receptor internalization. Cell 2010;141: 859-871.
45. Knoblach SM, Alroy DA, Nikolaeva M et al. Caspase inhibitor z-DEVD-fmk attenuates calpain and necrotic cell death in vitro and after traumatic brain injury. J Cereb Blood Flow Metab 2004;24: 1119-1132.
46. Li M, Ona VO, Chen M et al. Functional role and therapeutic implications of neuronal caspase-1 and 23 in a mouse model of traumatic spinal cord injury. Neuroscience 2000; 99: 333-342.
47. Zhou C, Yamaguchi M, Kusaka G et al. Caspase inhibitors prevent endothelial apo-ptosis and cerebral vasospasm in dog model of experimental subarachnoid hemorrhage. J Cereb Blood Flow Metab 2004;24: 419-431.
48. Kennedy NJ, Kataoka T, Tschopp J et al. Caspase activation is required for T cell proliferation. J Exp Med 1999;190: 1891-1896.
49. Zermati Y, Garrido C, Amsellem S et al. Caspase activation is required for terminal erythroid differentiation. J Exp Med 2001;193: 247-254.
50. Yan XX, Najbauer J, Woo CC et al. Expression of active caspase-3 in mitotic and postmitotic cells of the rat forebrain. J Comp Neurol 2001;433: 4-22.
51. Bravarenko NI, Onufriev MV, Stepanichev MY et al. Caspase-like activity is essential for long-term synaptic plasticity in the terrestrial snail Helix. Eur J Neurosci 2006;23: 129-140.
52. Yuan J. Divergence from a dedicated cellular suicide mechanism: Exploring the evolution of cell death. Mol Cell 2006;23: 1-12.
53. Gilman CP, Mattson MP. Do apoptotic mechanisms regulate synaptic plasticity and growth-cone motility? Neuromol Med 2002; 2: 197-214.
54. Pinan-Lucarre B, Gabel CV, Reina CP et al. The core apoptotic executioner proteins CED-3 and CED-4 promote initiation of neuronal regeneration in Caenorhabditis elegans. PLoS Biol 2012;10: e1001331.
55. D'Amelio M, Cavallucci V, Middei S et al. Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease. Nat Neurosci 2011;14: 69-76.
56. Campbell PA, Rudnicki MA. Oct4 interaction with Hmgb2 regulates Akt signaling and pluripotency. Stem Cells 2013;31: 1107-1120.
57. Bachelder RE, Ribick MJ, Marchetti A et al. p53 inhibits alpha 6 beta 4 integrin survival signaling by promoting the caspase 3-dependent cleavage of AKT/PKB. J Cell Biol 1999;147: 1063-1072.
58. Widmann C, Gibson S, Johnson GL. Caspase-dependent cleavage of signaling proteins during apoptosis. A turn-off mechanism for anti-apoptotic signals. J Biol Chem 1998; 273: 7141-7147.
59. Chen J, Zhang ZG, Li Y et al. Statins induce angiogenesis, neurogenesis, and synaptogenesis after stroke. Ann Neurol 2003; 53: 743-751.
60. Shioda N, Han F, Morioka M et al. Bis(1-oxy-2-pyridinethiolato) oxovanadium(IV) enhances neurogenesis via phosphatidylinositol 3-kinase/Akt and extracellular signal regulated kinase activation in the hippocampal subgranular zone after mouse focal cerebral ischemia. Neuroscience 2008;155: 876-887.
61. Gregorian C, Nakashima J, Le Belle J et al. Pten deletion in adult neural stem/progenitor cells enhances constitutive neurogenesis. J Neurosci 2009;29: 1874-1886.