Structure-activity relationships of the antimicrobial peptide gramicidin S and its analogs: Aqueous solubility, self-association, conformation, antimicrobial activity and interaction with model lipid membranes

Biochimica et Biophysica Acta - Biomembranes

Volumn 1838, Issue 5, 2014, Pages 1420-1429

  Abraham, Thomas ^a   Prenner, Elmar J ^a,d   Lewis, Ruthven N A H ^a   Mant, Colin T ^b   Keller, Sandro ^c   Hodges, Robert S ^b   McElhaney, Ronald N ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF COLORADO   (United States)

^c Rheinland Pfälzische Technische Universität Kaiserslautern Landau   (Germany)

^d UNIVERSITY OF CALGARY   (Canada)

Author keywords

Acholeplasma laidlawii B; Antimicrobial peptides; Gramicidin S (GS); Lipid model membranes; Peptide lipid interactions; Phospholipid bilayers

Indexed keywords

CHOLESTEROL; GRAMICIDIN DERIVATIVE; GRAMICIDIN S; PHOSPHOLIPID; UNCLASSIFIED DRUG; VALYLLYSYLLEUCINE DEXTRO TYROSYLPROLYLVALYLLYSYLLEUCINE DEXTRO TYROSYLPROLINE;

ACHOLEPLASMA LAIDLAWII; ANTIBACTERIAL ACTIVITY; AQUEOUS SOLUTION; ARTICLE; BETA SHEET; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG CONFORMATION; DRUG POTENCY; DRUG STRUCTURE; ENTHALPY; ENTROPY; HYDROPHOBICITY; LIPID MEMBRANE; MEMBRANE BINDING; NONHUMAN; PHOSPHOLIPID BILAYER; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ACHOLEPLASMA LAIDLAWII; BACTERIA (MICROORGANISMS);

ACHOLEPLASMA LAIDLAWII B; ANTIMICROBIAL PEPTIDES; GRAMICIDIN S (GS); LIPID MODEL MEMBRANES; PEPTIDE-LIPID INTERACTIONS; PHOSPHOLIPID BILAYERS;

ACHOLEPLASMA LAIDLAWII; ANTI-INFECTIVE AGENTS; CELL MEMBRANE; CHOLESTEROL; GRAMICIDIN; LIPID BILAYERS; MEMBRANE LIPIDS; MODELS, BIOLOGICAL; PEPTIDES; PHOSPHOLIPIDS; PROTEIN STRUCTURE, SECONDARY; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS; WATER;

EID: 84894539827     PISSN: 00052736     EISSN: 18792642     Source Type: Journal    
DOI: 10.1016/j.bbamem.2013.12.019     Document Type: Article

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