Comparison of hyperpolarized 3He and 129Xe MRI for the measurement of absolute ventilated lung volume in rats

Magnetic Resonance in Medicine

Volumn 71, Issue 3, 2014, Pages 1130-1136

  Fox, Matthew S ^a,b   Ouriadov, Alexei ^b   Santyr, Giles E ^a,b  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b ROBARTS RESEARCH INSTITUTE   (Canada)

Author keywords

apparent diffusion coefficient; helium 3, lung volume; xenon 129

Indexed keywords

BIOLOGICAL ORGANS; COMPUTERIZED TOMOGRAPHY; INERT GASES; NONINVASIVE MEDICAL PROCEDURES; RATS; RELAXATION TIME; RESPIRATORY SYSTEM;

APPARENT DIFFUSION COEFFICIENT; HYPERPOLARIZED; LUNG STRUCTURES; LUNG VOLUME; MEASUREMENTS OF; NON-INVASIVE ASSESSMENTS; PARTIAL VOLUMES; TRANSVERSE RELAXATION TIME;

SURFACE DIFFUSION;

HELIUM; UNCLASSIFIED DRUG; XENON; XENON 129; ISOTOPE; RADIOPHARMACEUTICAL AGENT;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DIFFUSION COEFFICIENT; LUNG COMPLIANCE; LUNG PARENCHYMA; LUNG VENTILATION; LUNG VOLUME; MICRO-COMPUTED TOMOGRAPHY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; RAT; RELAXATION TIME; TRACHEA; ANATOMY AND HISTOLOGY; ANIMAL; COMPARATIVE STUDY; DIAGNOSTIC USE; IMAGE ENHANCEMENT; INHALATIONAL DRUG ADMINISTRATION; LUNG; PROCEDURES; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; SPRAGUE DAWLEY RAT;

ADMINISTRATION, INHALATION; ANIMALS; HELIUM; IMAGE ENHANCEMENT; ISOTOPES; LUNG; LUNG VOLUME MEASUREMENTS; MAGNETIC RESONANCE IMAGING; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; XENON ISOTOPES;

EID: 84894488204     PISSN: 07403194     EISSN: 15222594     Source Type: Journal    
DOI: 10.1002/mrm.24746     Document Type: Article

References (28)

1. World Health Organization. World Health Statistics 2008. Geneva, Switzerland: World Health Organization; 2008.
2. Yablonskiy DA, Sukstanskii AL, Leawoods JC, Gierada DS, Bretthorst GL, Lefrak SS, Cooper JD, Conradi MS,. Quantitative in vivo assessment of lung microstructure at the alveolar level with hyperpolarized 3He diffusion MRI. Proc Natl Acad Sci USA 2002; 99: 3111-3116.
3. Kirby M, Svenningsen S, Owrangi A, et al. Hyperpolarized 3He and 129Xe MR imaging in healthy volunteers and patients with chronic obstructive pulmonary disease. Radiology 2012; 265: 600-610.
4. Akhavan Sharif MR, Lam WW, Ouriadov AV, Holdsworth DW, Santyr GE,. Comparison of hyperpolarized (3)He MRI rat lung volume measurement with micro-computed tomography. NMR Biomed 2010; 23: 359-367.
5. Black RD, Middleton HL, Cates GD, Cofer GP, Driehuys B, Happer W, Hedlund LW, Johnson GA, Shattuck MD, Swartz JC,. In vivo He-3 MR images of guinea pig lungs. Radiology 1996; 199: 867-870.
6. Boudreau M, Xu X, Santyr GE,. Measurement of (129) Xe gas apparent diffusion coefficient anisotropy in an elastase-instilled rat model of emphysema. Magn Reson Med 2013; 69: 211-220.
7. Chen XJ, Hedlund LW, Moller HE, Chawla MS, Maronpot RR, Johnson GA,. Detection of emphysema in rat lungs by using magnetic resonance measurements of 3He diffusion. Proc Natl Acad Sci U S A 2000; 97: 11478-11481.
8. Couch MJ, Ouriadov A, Santyr GE,. Regional ventilation mapping of the rat lung using hyperpolarized (129) Xe magnetic resonance imaging. Magn Reson Med 2012; 68: 1623-1631.
9. Deninger AJ, Mansson S, Petersson JS, Pettersson G, Magnusson P, Svensson J, Fridlund B, Hansson G, Erjefeldt I, Wollmer P, Golman K,. Quantitative measurement of regional lung ventilation using 3He MRI. Magn Reson Med 2002; 48: 223-232.
10. Driehuys B, Hedlund LW,. Imaging techniques for small animal models of pulmonary disease: MR microscopy. Toxicol Pathol 2007; 35: 49-58.
11. Imai H, Kimura A, Iguchi S, Hori Y, Masuda S, Fujiwara H,. Noninvasive Detection of Pulmonary Tissue Distruction in a Mouse Model of Emphysema Using Hyperpolarized 129Xe MRS Under Spontaneous Respiration. Magn Reson Med 2010; 64: 929-938.
12. Ishii M, Emami K, Xin Y, et al. Regional function-structure relationships in lungs of an elastase murine model of emphysema. J Appl Physiol 2012; 112: 135-148.
13. Ward ER, Hedlund LW, Kurylo WC, Wheeler CT, Cofer GP, Dewhirst MW, Marks LB, Vujaskovic Z,. Proton and hyperpolarized helium magnetic resonance imaging of radiation-induced lung injury in rats. Int J Radiat Oncol Biol Phys 2004; 58: 1562-1569.
14. Xu X, Boudreau M, Ouriadov A, Santyr GE,. Mapping of (3) He apparent diffusion coefficient anisotropy at sub-millisecond diffusion times in an elastase-instilled rat model of emphysema. Magn Reson Med 2012; 67: 1146-1153.
15. Woodhouse N, Wild JM, Paley MN, Fichele S, Said Z, Swift AJ, van Beek EJ,. Combined helium-3/proton magnetic resonance imaging measurement of ventilated lung volumes in smokers compared to never-smokers. J Magn Reson Imaging 2005; 21: 365-369.
16. Cleveland ZI, Cofer GP, Metz G, et al. Hyperpolarized Xe MR imaging of alveolar gas uptake in humans. PLoS One 2010; 5: e12192.
17. Driehuys B, Cofer GP, Pollaro J, Mackel JB, Hedlund LW, Johnson GA,. Imaging alveolar-capillary gas transfer using hyperpolarized 129Xe MRI. Proc Natl Acad Sci U S A 2006; 103: 18278-18283.
18. Mugler JP, 3rd, Altes TA, Ruset IC, Dregely IM, Mata JF, Miller GW, Ketel S, Ketel J, Hersman FW, Ruppert K,. Simultaneous magnetic resonance imaging of ventilation distribution and gas uptake in the human lung using hyperpolarized xenon-129. Proc Natl Acad Sci U S A 2010; 107: 21707-21712.
19. Mansson S, Wolber J, Driehuys B, Wollmer P, Golman K,. Characterization of diffusing capacity and perfusion of the rat lung in a lipopolysaccaride disease model using hyperpolarized 129Xe. Magn Reson Med 2003; 50: 1170-1179.
20. Zhou X, Sun Y, Mazzanti M, Henninger N, Mansour J, Fisher M, Albert M,. MRI of stroke using hyperpolarized 129Xe. NMR Biomed 2011; 24: 170-175.
21. Driehuys B, Cates GD, Miron E, Sauer K, Walter DK, Happer W,. High volume production of laser-polarized 129Xe. Applied Physics Letters 1996; 69: 1668-1670.
22. Hersman FW, Ruset IC, Ketel S, et al. Large production system for hyperpolarized 129Xe for human lung imaging studies. Acad Radiol 2008; 15: 683-692.
23. Kaushik SS, Cleveland ZI, Cofer GP, et al. Diffusion-weighted hyperpolarized (129)Xe MRI in healthy volunteers and subjects with chronic obstructive pulmonary disease. Magn Reson Med 2011; 65: 1155-1165.
24. Dominguez-Viquera W, P-RJ, Fox, MS, et al. Variable field strength system for hyperpolarized noble gas mr imaging of rodent lungs. Magn Reson Eng 2008; 33B: 124-137.
25. Santyr GE, Lam WW, Ouriadov A,. Rapid and efficient mapping of regional ventilation in the rat lung using hyperpolarized 3He with Flip Angle Variation for Offset of RF and Relaxation (FAVOR). Magn Reson Med 2008; 59: 1304-1310.
26. Foster-Gareau P, Heyn C, Alejski A, Rutt BK,. Imaging single mammalian cells with a 1.5 T clinical MRI scanner. Magn Reson Med 2003; 49: 968-971.
27. Ouriadov AV, Lam WW, Santyr GE,. Rapid 3-D mapping of hyperpolarized 3He spin-lattice relaxation times using variable flip angle gradient echo imaging with application to alveolar oxygen partial pressure measurement in rat lungs. MAGMA 2009; 22: 309-318.
28. Lai YL, Hildebrandt J,. Respiratory mechanics in the anesthetized rat. J Appl Physiol 1978; 45: 255-260