Noninvasive detection of pulmonary tissue destruction in a mouse model of emphysema using hyperpolarized 129Xe MRS under spontaneous respiration

Magnetic Resonance in Medicine

Volumn 64, Issue 4, 2010, Pages 929-938

  Imai, Hirohiko ^a,b   Kimura, Atsuomi ^b   Iguchi, Satoshi ^b   Hori, Yuki ^b   Masuda, Shoko ^b   Fujiwara, Hideaki ^b  

^a OSAKA UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

CSSR; Emphysema; Lung function; Lung structure; Spontaneous respiration

Indexed keywords

BIOLOGICAL ORGANS; BIOMARKERS; CHEMICAL SHIFT; MAGNETIC RESONANCE SPECTROSCOPY;

CSSR; EMPHYSEMA; LUNG FUNCTION; LUNG STRUCTURES; SPONTANEOUS RESPIRATION;

MAMMALS;

UNCLASSIFIED DRUG; XENON; XENON 129;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIAGNOSTIC VALUE; LUNG EMPHYSEMA; LUNG INJURY; MALE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; TISSUE INJURY;

EID: 77957306550     PISSN: 07403194     EISSN: 15222594     Source Type: Journal    
DOI: 10.1002/mrm.22437     Document Type: Article

References (46)

1. Möller HE, Chen XJ, Saam B, Hagspiel KD, Johnson GA, Altes TA, de Lange EE, Kauczor HU. MRI of the lungs using hyperpolarized noble gases. Magn Reson Med 2002;47:1029-1051.
2. Fain SB, Korosec FR, Holmes JH, O'Halloran R, Sorkness RL, Grist TM. Functional lung imaging using hyperpolarized gas MRI. J Magn Reson Imaging 2007;25:910-923.
3. Patz S, Hersman W, Muradian I, Hrovat MI, Ruset IC, Ketel S, Jacobson F, Topulos GP, Hatabu H, Butler JP. Hyperpolarized 129Xe MRI: a viable functional lung imaging modality? Eur J Radiol 2007;64:335-344.
4. Beckmann N, Kneuer R, Gremlich HU, Karmouty-Quintana H, Blé FX, Müller M. In vivo mouse imaging and spectroscopy in drug discovery. NMR Biomed 2007;20:154-185.
5. 3He MRI in mouse models of asthma. Magn Reson Med 2007;58:893-900.
6. Beckmann N, Cannet C, Karmouty-Quintana H, Tigani B, Zurbruegg S, Blé FX, Crémillieux Y, Trifilieff A. Lung MRI for experimental drug research. Eur J Radiol 2007;64:381-396.
7. 129Xe as a novel probe agent of lung functions in MRI and MRS: experimental results with mice at 9.4 T. Int Cong Ser 2004;1265:124-130.
8. 129Xe in the chest of mouse-effect of contrast agents on the MRS. Int Cong Ser 2004;1265:177-180.
9. 3He: image acquisition and T1 estimation under spontaneous respiration. Magn Reson Med Sci 2006;5:57-64.
10. 129Xe dynamics observed in mouse lungs under spontaneous respiration for the separate determination of lung functional parameters and relaxation time. Magn Reson Med Sci 2006;5:119-128.
11. 3He ventilation imaging under spontaneous breathing conditions: a non-invasive protocol for small-animal lung function imaging. NMR Biomed 2007;20:104-112.
12. 129Xe MRI of the mouse lung at a low xenon concentration using a continuous flow type hyperpolarizing system. J Magn Reson Imaging 2008;27:777-784.
13. 129Xe phase-selective imaging of mouse lung at 9.4T using a continuous-flow hyperpolarizing system. Magn Reson Med Sci 2008;7:65-72.
14. 129Xe dynamic study in mouse lung under spontaneous respiration: application to murine tumor B16BL6 melanoma. Eur J Radiol 2010;73:196-205.
15. 3He lung ventilation spiral MR imaging. Invest Radiol 2009;44:185-191.
16. 129Xe MRI of mouse lung at low xenon concentration using a continuous flow-type hyperpolarizing system: feasibility for quantitative measurement of regional ventilation. Magn Reson Med Sci 2009;8:73-79.
17. Barnes PJ. COPD: is there light at the end of the tunnel? Curr Opin Pharmacol 2004;4:263-272.
18. Mata J. Hyperpolarized gas MRI to evaluate emphysema. Saarbrücken: VDM Verlag Dr. Müller Aktiengesellschaft & Co. KG; 2008, p 140.
19. Butler JP, Mair RW, Hoffmann D, Hrovat MI, Rogers RA, Topulos GP, Walsworth RL, Patz S. Measuring surface-area to volume ratios in soft porous materials using laser-polarized xenon interphase exchange nuclear magnetic resonance. J Phys Condens Matter 2002;14:L297-304.
20. 129Xe. Magn Reson Med 2003;50:1170-1179.
21. 129Xe MRI and dynamic spectroscopy in a single breath-hold. Magn Reson Med 2006;56:255-264.
22. 129Xe MRI. Proc Natl Acad Sci U|S|A 2006;103:18278-18283.
23. 129Xe. In: Proceedings of the 16th Annual Meeting of ISMRM, Toronto, Ontario, Canada, 2008. p 2678.
24. 129Xe gas: preliminary human results. Magn Reson Med 1997;37:809-815.
25. 129Xe resonances in living rats. J Magn Reson B 1996;111:300-304.
26. 129Xe magnetization in vivo. Magn Reson Med 1999;42:1137-1145.
27. Ruppert K, Brookeman JR, Hagspiel KD, Mugler JP III. Probing lung function with xenon polarization transfer constant (XTC). Magn Reson Med 2000;44:349-357.
28. 129Xe nuclear magnetic resonance. Magn Reson Med 2004;51:676-687.
29. 129Xe. Magn Reson Med 1996;36:183-191.
30. Chang Y, Mata JF, Cai J, Altes T, Brookeman JR, Hagspiel KD, Mugler JP III, Ruppert K. Detection of a new pulmonary gasexchange component for hyperpolarized xenon-129. In: Proceedings of the 16th Annual Meetings of ISMRM, Toronto, Ontario, Canada, 2008. p 201.
31. 129Xe. In: The 16th Annual Meeting of ISMRM, Toronto, Ontario, Canada, 2008. p 2678.
32. Ito S, Ingenito EP, Arold SP, Parameswaran H, Tgavalekos NT, Lutchen KR, Suki B. Tissue heterogeneity in the mouse lung: effects of elastase treatment. J Appl Physiol 2004;97:204-212.
33. Ohno Y, Hatabu H, Murase K, Higashino T, Kawamitsu H, Watanabe H, Takeneka D, Fujii M, Sugimura K. Quantitative assessment of regional pulmonary perfusion in the entire lung using three-dimensional ultrafast dynamic contrast-enhanced magnetic resonance imaging: preliminary experience in 40 subjects. J Magn Reson Imaging 2004;20:353-365.
34. Ladefoged J, Andersen AM. Solubility of xenon-133 at 37°C in water, saline, olive oil, liquid paraffin, solutions of albumin, and blood. Phys Med Biol 1967;12:353-358.
35. Altman PL, Dittmer DS. Respiration and circulation. Bethesda, MD: Federation of American Societies for Experimental Biology; 1971, p 930.
36. Champion HC, Villnave DJ, Tower A, Kadowitz PJ, Hyman AL. A novel right-heart catheterization technique for in vivo measurement of vascular responses in lungs of intact mice. Am J Physiol Heart Circ Physiol 2000;278:H8-H15.
37. Walker TG, Happer W. Spin-exchange optical pumping of noble-gas nuclei. Rev Mod Phys 1997;69:629-642.
38. 129Xe gas on a simple system working under atmospheric pressure. J Magn Reson 2003;160:26-32.
39. Parameswaran H, Majumdar A, Ito S, Alencar AM, Suki B. Quantitative characterization of air space enlargement in emphysema. J Appl Physiol 2006;100:186-193.
40. Ashour K, Shan L, Lee JH, Schlicher W, Wada K, Wada E, Sunday ME. Bombesin inhibits alveolarization and promotes pulmonary fibrosis in newborn mice. Am J Respir Crit Care Med 2006;173:1377-1385.
41. Cambell H, Tomkeieff SI. Calculation of internal surface area. Nature 1952;170:117.
42. 3He MRI study. J Appl Physiol 2008;104:773-786.
43. Valentine R, Rucker RB, Chrisp CE, Fisher GL. Morphological and biochemical features of elastase-induced emphysema in strain A/J mice. Toxicol Appl Pharmacol 1983;68:451-461.
44. 129Xe gas: development of a simple continuous flow mode hyperpolarizing system working at pressures as low as 0.15 atm. Concept Magn Reson B 2008;33B:192-200.
45. Ruppert K, Chang V, Altes TA, Dregely IM, Ketel S, Ruset IC, Mata JF, Hersman FW, Mugler III JP. Compartment-selective XTC MRI at 1.5T and 3T. In: Proceedings of the 17th Annual Meeting of ISMRM, Honolulu, HI, 2009. p 9.
46. 129Xe MR. In: Proceedings of the 17th Annual Meeting of ISMRM, Honolulu, HI, 2009. p 4384.