Effects of creep feeding and supplemental glutamine or glutamine plus glutamate (Aminogut) on pre- and post-weaning growth performance and intestinal health of piglets

Journal of Animal Science and Biotechnology

Volumn 4, Issue 1, 2013, Pages

  Cabrera, Rafael A ^a,d   Usry, James L ^b,e   Arrellano, Consuelo ^a   Nogueira, Eduardo T ^c   Kutschenko, Marianne ^c   Moeser, Adam J ^a   Odle, Jack ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

^b Heartland Lysine Inc   (United States)

^c Ajinomoto do Brasil/Ajinomoto Animal Nutrition   (Brazil)

^d Huvepharma USA ^*  (United States)

^e Micronutrients   (United States)

Author keywords

Creep feeding; Glutamine; Growth performance; Intestinal health; SEM; Villi

Indexed keywords

EID: 84894465013     PISSN: 16749782     EISSN: 20491891     Source Type: Journal    
DOI: 10.1186/2049-1891-4-29     Document Type: Article

References (58)

1. Plunske JR, Hampson DJ, Williams IH. Factors influencing the structure and function of the small intestine in the weaned pig. A review. Livest Prod Sci 1997, 1997(51):215-236.
2. Kenworthy R, Crabb WE. The intestinal flora of young pigs with particular reference to early weaning, E, Coli and scours. J Comp Path 1963, 73:215-228.
3. Palmer NC, Hulland TK. Factors predisposing to the development of coliform gastroenteritis in weaned pigs. Can Vet J 1965, 6:310-316. 1696216, 5320517.
4. Cera KR, Mahan DC, Reinhart GA. Effect of weaning, week postweaning and diet composition on pancreatic and small intestinal luminal lipase response in young swine. J Anim Sci 1990, 68:384-391.
5. Newby TJ, Miller BG, Stokes CR, Bourne FJ. Hypersensitivity to dietary antigens as the predisposing factor in post-weaning diarrhea. Pig Vet Soc Proc 1983, 10:50.
6. Miller BG, Newby TJ, Stokes CR, Bourne FJ. Influence of diet on post-weaning malabsorption and diarrhea in the pig. Res Vet Sci 1984, 36:187.
7. Barnett KL, Kornegay ET, Risley CR, Lindemann MD, Schurig GG. Characterization of creep feed consumption and its subsequent effects on immune response, scouring index and performance of weanling pigs. J Anim Sci 1989, 67:2698-2708.
8. Klasing KC. Nutrition and the immune system. Br Poul Sci 2007, 48:525-537.
9. Li P, Yin YL, Li DF, Kim SW, Wu G. Amino acids and immune function. Br J Nutr 2007, 98:237-252. 10.1017/S000711450769936X, 17403271.
10. Wu G. Amino acids: metabolism, functions, and nutrition. Amino acids 2009, 37:1-17.
11. Wu G. Recent advances in swine amino acid nutrition. J Anim Sci Biotech 2010, 1:118-130.
12. Rhoads JM, Wu G. Glutamine, arginine, and leucine signaling in the intestine. Amino acids 2009, 37:111-122. 10.1007/s00726-008-0225-4, 19130170.
13. Schrock H, Goldstein L. Inter-organ relationships for glutamine metabolism in normal and acidotic rats. Am J Physiol 1981, 240:E519-E525.
14. Newsholme P. Why is L-glutamine metabolism important to cells of the immune system in health, post injury, surgery or infection?. J Nutr 2001, 131:2515S-2522S.
15. Nappert G, Zello GA, Naylor JM. Intestinal metabolism of glutamine and potential use of glutamine as a therapeutic agent in diarrheic calves. J Am Vet Med Assoc 1997, 211:547-553.
16. Van de Poll MC, Soeters PB, Deutz NE, Fearon KC, Dejong CH. Renal metabolism of amino acids: Its role in interogan amino acid exchange. Am J Clin Nutr 2004, 79:185-197.
17. Souba WW, Herskowitz K, Salloum RM, Chena MK, Augsten TR. Gut glutamine metabolism. J Parenter Enter Nutr 1990, 14(Suppl. 4):45S-50S.
18. Reeds PJ, Burrin DG, Stoll B, Jahoor F. Intestinal glutamate metabolism. J Nutr 2000, 130:978S-982S.
19. Wu G, Knabe DA, Flynn NE. Synthesis of citrulline from glutamine in pig enterocytes. Biochem J 1994, 299:115-121. 1138029, 8166628.
20. Stoll B, Burrin DG. Measuring splanchnic amino acid metabolism in vivo using stable isotopic tracers. J Anim Sci 2006, 84:E60-E72.
21. Wu G. Recent advances in swine amino acid nutrition. J Anim Sci Biotech 2010, 1:49-61.
22. Van der Hulst RRWJ, Van Kreel BK, Von Meyenfeldt MF, Brummer RK, Arends JW, Deutz NE, Soeters PB. Glutamine and the preservation of gut integrity. Lancet 1993, 431:1363-1365.
23. James LA, Lunn PG, Elia M. Glutamine metabolism in the gastrointestinal tract of the rat assessed by the relative activities of glutaminase and glutamine synthetase. Br J Nutr 1998, 79:365-372. 10.1079/BJN19980061, 9624228.
24. FASS Guide for the care and use of agricultural animals in agricultural research and teaching 1999, Savoy, IL: Fed. Anim. Sci. Soc, 1 rev, FASS.
25. Doerfler RE, Cain LD, Edens FW, Parkhurst CR, Qureshi MA, Havenstein GB. D-Xylose absorption as a measurement of malabsorption in poult enteritis and mortality syndrome. Poult Sci 2000, 79:656-660.
26. McDowell EM, Trump BF. Histological fixatives suitable for diagnostic light and electron microscopy. Arch Pathol Lab Med 1976, 100:405.
27. Goodwin MA, Latimer KS, Fletcher OJ. Quantification of intestinal D-xylose absorption in normal turkeys. Poult Sci 1984, 63:1742-1747. 10.3382/ps.0631742, 6483738.
28. Goodwin MA, Latimer LS, Nersessian BN. Quantification of intestinal D-xylose absorption in normal and reovirus-inoculated turkeys. Avian Dis 1984, 28:959-967. 10.2307/1590271, 6098256.
29. Eberts TJ, Sample RHB, Glick MR, Ellis GH. A simplified, colorimetric micro method for xylose in serum or urine, with phloroglucinol. Clin Chem 1979, 25:1440-1443.
30. Dahlqvist A. Assay of intestinal disaccharidases. Scand J Clin Lab Invest 1984, 44:169-172. 10.3109/00365518409161400, 6719024.
31. Windmueller HG, Spaeth AE. Metabolism of absorbed aspartate, asparagine and arginine by rat small intestine in vivo. Arch Biochem Biophys 1976, 175:670-676. 10.1016/0003-9861(76)90558-0, 958325.
32. Burrin DG, Reeds PJ. Alternative fuels in the gastrointestinal tract. Curr Opin Gastroenterol 1997, 13:165-170.
33. Windmueller HG, Spaeth AE. Intestinal metabolism of glutamine and glutamate from the lumen when compared to glutamine from the blood. Arch Biochem Biophys 1975, 171:662-672. 10.1016/0003-9861(75)90078-8, 1200644.
34. Reeds PJ, Burrin DG, Stoll B, Jahoor F, Wykes L, Henry J, Frazer ME. Enteral glutamate is the preferential source for mucosal glutathione synthesis in fed piglets. Am J Physiol 1997, 273:E408-E415.
35. Yin YL, Huang RL, Li TJ, Ruan Z, Xie MY, Deng ZY, Hou YQ, Wu G. Amino acid metabolism in the portal-drained viscera of young pigs: effects of dietary supplementation with chitosan and pea hull. Amino acids 2010, 39:1581-1587. 10.1007/s00726-010-0577-4, 20361217.
36. Boutry C, Bos C, Matsumoto H, Even P, Azzout-Marniche D, Tome D, Blachier F. Effects of monosodium glutamate supplementation on glutamine metabolism in rats. Front Biosci 2011, E3:279-290.
37. Wu G, Borbolla AG, Knabe DA. The uptake of glutamine and release of arginine, citrulline and proline by the small intestine of developing pigs. J Nutr 1994, 124:2437-2444.
38. Wu G, Ott TL, Knabe DA, Bazer FW. Amino acid composition of the fetal pig. J Nutr 1999, 129:1031-1038.
39. Kim SW, Wu G. Regulatory role of amino acids in mammary gland growth and milk synthesis. Amino acids 2009, 37:89-95. 10.1007/s00726-008-0151-5, 18683019.
40. Trottier NL, Shipley CF, Easter RA. Plasma amino acid uptake by the mammary gland of the lactating sow. J Anim Sci 1997, 75:1266-1278.
41. Haynes TE, Li P, Li X, Shimotori K, Sato H. L-Glutamine or L-alanyl-L-glutamine prevents oxidant or endotoxin-induced death of neonatal enterocytes. Amino Acids 2009, 37:131-142. 10.1007/s00726-009-0243-x, 19189199.
42. Yi GF, Carroll JA, Allee GL, Gaines AM, Kendall DC, Usry J, Toride Y, Izuru S. Effect of glutamine and spray-dried plasma on growth performance, small intestine morphology, and immune responses of Escherichia coli K88+-challenged weaned pigs. J Anim Sci 2005, 83:634-643.
43. Jiang ZY, Sun LH, Lin YC, Ma XY, Zheng CT, Zhou GL, Chen F, Zou ST. Effects of dietary glycyl-glutamine on growth performance, small intestinal integrity, and immune responses of weaning piglets challenged with lipopolysaccharide. J Anim Sci 2009, 87:4050-4056. 10.2527/jas.2008-1120, 19717785.
44. Wu G. Functional amino acids in growth, reproduction and health. Adv Nutr 2010, 1:31-37. 10.3945/an.110.1008, 3042786, 22043449.
45. Wu G, Meier SA, Knabe DA. Dietary glutamine supplementation prevents jejunal atrophy in waned pigs. J Nutr 1996, 126:2578-2584.
46. Wang JJ, Chen X, Li P, Li XL, Zhou HJ, Wang FL, Li DF, Yin YL, Wu G. Gene expression is altered in piglet small intestine by weaning and dietary glutamine supplementation. J Nutr 2008, 138:1025-1032.
47. Liu T, Peng J, Xiong Y, Zhou S, Cheng X. Effects of dietary glutamine and glutamate supplementation on small intestine structure, active absorption and DNA, RNA concentrations in skeletal muscle tissue of weaned piglets during d 28 to 42 d of age. Asian-Aust J Anim Sci 2001, 15:238-242.
48. Mansoori B, Nodeh H, Modirsanei M, Rahbari S, Aparnak P. D-xylose absorption test: A tool for the assessment of the effect of anticoccidials on the intestinal absorptive capacity of broilers during experimental coccidiosis. Anim Feed Sci Technol 2009, 148:301-308.
49. You-Sheng L, Jie-Shou L, Ninj L, Zhi-Wei J, Yun-Zhao Z, Nan-Yun L, Fang-Nan L. Evaluation of various solutions for small bowel graft preservation. World J Gastr 1998, 4:140-143.
50. Chang RW, David PJ, Oh J-T, Andreoli S, Kim HB, Fauza D, Jaksic T. Serial transverse enteroplasty enhances intestinal function in a model of short bowel syndrome. Ann Surg 2006, 243:223-228. 10.1097/01.sla.0000197704.76166.07, 1448911, 16432355.
51. Nasrallah SM, Iber FL. Mannitol absorption and metabolism in man. Am J Med Sci 1969, 258:80-88. 10.1097/00000441-196908000-00003, 4979740.
52. Cox MA, Lewis KO, Cooper BT. Measurement of small intestinal permeability markers, lactulose and mannitol in serum. Dig Dis Sci 1999, 44:402-406. 10.1023/A:1026679123148, 10063930.
53. Andre C, Andre F, Colin L, Cavagna S. Measurement of intestinal permeability to mannitol and lactulose as a means of diagnosing food allergy and evaluating therapeutic effectiveness of disodium cromoglycate. Ann Allergy 1987, 59:127-130.
54. Kidder DE, Manners MJ. Carbohydrases in the small intestine mucosa of sow-reared and 3-wk weaned pigs. Proc Nutr Soc 1978, 37:51A.
55. Skrzypek T, Valverde JL, Skrzypek H, Wolinski J, Kazimierczak W, Szymanczyk S, Pawlowska M, Zabielski R. Light and scanning electron microscopy evaluation of the postnatal small intestinal mucosa development in pigs. J Physiol Pharmacol 2005, 56:71-87.
56. Blikslager A, Hunt E, Guerrant R, Rhoads M, Argenzio A. Glutamine transporter in crypts compensates for loss of villus absorption in bovine cryptosporidiosis. Am J Physiol Gastrointest Liver Physiol 2001, 281:G645-G653.
57. Xi P, Jiang Z, Dai Z, Li X, Yao K, Zheng C, Lin Y, Wang J, Wu G. Regulation of protein turnover by L-glutamine in porcine intestinal epithelial cells. J Nutr Biochem 2012, 23:1012-1017. 10.1016/j.jnutbio.2011.05.009, 22000664.
58. Manso HE, Filho HC, de Carvalho LE, Kutschenko M, Nogueira ET, Watford M. Glutamine and glutamate supplementation raise milk glutamine concentrations in lactating gilts. J Anim Sci Biotech 2012, 3:2.