Enteral glutamate is the preferential source for mucosal glutathione synthesis in fed piglets

American Journal of Physiology - Endocrinology and Metabolism

Volumn 273, Issue 2 36-2, 1997, Pages

  Reeds, Peter J ^b   Burrin, Douglas G ^c   Stoll, Barbara ^c   Jahoor, Farook ^c   Wykes, Linda ^a   Henry, Joseph ^c   Frazer, Margaret E ^c  

^a MCGILL UNIVERSITY   (Canada)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c NONE

Author keywords

Gut amine acid metabolism; Isotopomer analysis; Metabolic compartmentation; Stable isotope labeled amino acids

Indexed keywords

GLUTAMIC ACID; GLUTATHIONE;

AMINO ACID METABOLISM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; INTESTINE MUCOSA; MUCOSAL IMMUNITY; NONHUMAN; PRIORITY JOURNAL; SWINE;

EID: 0030832183     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1997.273.2.e408     Document Type: Article

References (16)

1. Aw, T. Y. Biliary glutathione promotes the mucosal metabolism of luminal peroxidized lipids by rat small intestine in vivo. J. Clin. Invest. 94: 1218-1225, 1994.
2. Aw, T. Y., and M. W. Williams. Intestinal absorption and lymphatic transport of peroxidized lipids in rats: effect of exogenous GSH. Am. J. Physiol 263 (Gastrointest. Liver Physiol. 26): G665-G672, 1992.
3. Battezzati, A., D. J. Brillon, and D. E. Matthews. Oxidation of glutamic acid by the splanchnic bed in humans. Am. J. Physiol. 269 (Endocrinol. Metab. 32): E269-E276, 1995.
4. Berthold, H. K., P. J. Reeds, and P. D. Klein. Isotopic evidence for the differential regulation of arginine and proline synthesis in man. Metabolism 44: 466-473, 1995.
5. Brauman, J. I. Least squares analysis and simplification of multi-isotope mass spectra. Anal. Chem. 38: 607-610, 1966.
6. Dahm, L. J., and D. P. Jones. Secretion of cysteine and glutathione from mucosa to lumen in rat small intestine. Am. J. Physiol. 267 (Gastrointest. Liver Physiol. 30): G292-G300, 1994.
7. Davis, T. A., D. G. Burrin, M. L. Fiorotto, and H. V. Nguyen. Protein synthesis in skeletal muscle and jejunum is more responsive to feeding in 7- than in 26-day-old pigs. Am. J. Physiol. 270 (Endocrinol. Metab. 33): E802-E809, 1996.
8. Davis, T. A., H. V. Nguyen, R. Garcia-Bravo, M. L. Fiorotto, E. M. Jackson, D. S. Lewis, D. R. Lee, and P. J. Reeds. The amino acid composition of human milk is not unique. J. Nutr. 124: 1126-1132, 1994.
9. 3]leucine. Am. J. Physiol. 267 (Gastrointest. Liver Physiol. 30): G1128-G1134, 1994.
10. Ebner, S., P. Schoknecht, P. Reeds, and D. Burrin. Growth and metabolism of gastrointestinal and skeletal muscle tissues in protein-malnourished neonatal pigs. Am. J. Physiol. 266 (Regulatory Integrative Comp. Physiol. 35): R1736-R1743, 1994.
11. Githens, P. Glutathione metabolism in the pancreas compared with that in the liver, kidney and small intestine. Int. J. Pancreatol. 8: 97-109, 1991.
12. Harward, T. R., D. Coe, W. W. Souba, N. Klingman, and J. M. Seeger. Glutamine preserves gut glutathione levels during intestinal ischemia/reperfusion. J. Surg. Res. 56: 351-355, 1994.
13. Helton, W. S., and R. Garcia. Oral prostaglandin E2 prevents gut atrophy during intravenous feeding but not bacterial translocation. Arch. Surg. 128: 178-183, 1993.
14. Iantomasi, T., P. Marraccini, F. Favilli, M. T. Vincenzini, P. Ferretti, and F. Tonelli. Glutathione metabolism in Crohn's disease. Biochem. Med. Metab. Biol. 53: 87-91, 1994.
15. Jahoor, F., L. J. Wykes, P. J. Reeds, J. E. Henry, M. P. del Rosario, and M. E. Frazer. Protein deficient pigs cannot maintain reduced glutathione homeostasis when subjected to the stress of inflammation. J. Nutr. 125: 1462-1472, 1995.
16. Kelly, F. J. Glutathione content of the small intestine: regulation and function. Br. J. Nutr. 69: 589-596, 1993.