Dietary glutamine supplementation prevents jejunal atrophy in weaned pigs

Journal of Nutrition

Volumn 126, Issue 10, 1996, Pages 2578-2584

  Wu, Guoyao ^a   Meier, Sabina A ^a   Knabe, Darrell A ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

Author keywords

glutamine supplementation; intestinal morphology; pigs

Indexed keywords

ALANINE; ASPARTIC ACID; GLUTAMIC ACID; GLUTAMINE; TAURINE;

AMINO ACID BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ATROPHY; CONTROLLED STUDY; DIET SUPPLEMENTATION; INTESTINE INJURY; JEJUNUM; NONHUMAN; SWINE; WEANING;

ANIMALIA; GLYCINE MAX; SUS SCROFA; ZEA MAYS;

EID: 0029842804     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/126.10.2578     Document Type: Article

References (35)

1. Alverdy, A. M. (1990) Effects of glutamine-supplemented diets on immunology of the gut. J. Parenter. Enteral Nutr. 14: 109S-113S.
2. Ardawi, M. S. M. & Newsholme, E. A. (1983) Glutamine metabolism in lymphocytes of the rat. Biochem. J. 212: 835-842.
3. Borbolla, A. G. (1994) Utilization of Nutrients by the Small Intestine of the Developing Pig and Role of Corticosteroids in Post-weaning Lag in Pigs. Ph.D. Dissertation, Texas A&M University, College Station, Texas.
4. Buchman, A. L., Moukarzel, A. A., Bhuta, S., Belle, M., Ament, M. E., Eckhert, C. D., Hollander, D., Kopple, J. D. & Vijayaroghavan, S. R. (1995) Parenteral nutrition is associated with intestinal morphologic and functional changes in humans. J. Parenter. Enteral Nutr. 19: 453-460.
5. Burrin, D. G., Shulman, R. J., Storm, M. C. & Reeds, P. J. (1991) Glutamine or glutamic acid effects on intestinal growth and disaccharidase activity in infant piglets receiving total parenteral nutrition. J. Parenter. Enterai Nutr. 15: 262-266.
6. Dugan, M. E. R., Knabe, D. A. & Wu, G. (1994) Glutamine and glucose metabolism in intraepithelial lymphocytes from pre- and post-weaning pigs. Comp. Biochem. Physiol. 109B: 675-681.
7. Dunsford, B. R., Knabe, D. A. & Haensly, W. E. (1989) Effect of dietary soybean meal on the microscopic anatomy of the small intestine in the early-weaned pig. J. Anim. Sci. 67: 1855-1863.
8. Fox, A. D., De Paula, J. A. & Kripke, S. A. (1988) Glutamine-supplemented elemental diets reduce endotoxemia in a lethal model of enterocolitis. Surg. Forum 39: 46-51.
9. Furst, P., Albers, S. & Stehle, P. (1990) Glutamine-containing dipeptides in parenteral nutrition. J. Parenter. Enteral Nutr. 14: 118S-124S.
10. Hamilton, P. B. (1945) Glutamine: a major constituent of free α-amino acids in animal tissues and blood plasma. J. Biol. Chem. 158: 397-409.
11. Hampson, D. J. (1986) Attempts to modify changes in the piglet small intestine after weaning. Res. Vet. Sci. 40: 313-317.
12. Kenworthy, R. (1976) Observations on the effects of weaning in the young pig. Clinical and histopathological studies of intestinal function and morphology. Res. Vet. Sci. 21: 69-75.
13. Kenworthy, R., Stubbis, J. M. & Syme, G. (1967) Ultrastructure of small intestinal epithelium in weaned and unweaned pigs and pigs with post-weaning diarrhea. J. Pathol. Bacteriol. 93: 493-499.
14. Knabe, D. A., LaRue, D. C., Gregg, E. J., Martinez, G. M. & Tanksley, T. D., Jr. (1989) Apparent digestibility of nitrogen and amino acids in protein feedstuffs by growing pigs. J. Anim. Sci. 67: 441-458.
15. Krebs, H. (1980) Glutamine metabolism in the animal body. In: Glutamine: Metabolism, Enzymology, and Regulation (Mora, J. & Palacios, E., eds.), pp. 319-329. Academic Press, New York, NY.
16. Lacey, J. M. & Wilmore, D. W. (1990) Is glutamine a conditionally essential amino acid? Nutr. Rev. 48: 297-309.
17. Li, J., Langkamp-Henken, B., Suzuki, K. & Stahlgren, L. H. (1994) Glutamine prevents parenteral nutrition-induced increases in intestinal permeability. J. Parenter. Enterai Nutr. 18: 303-307.
18. Lipkin, M. (1985) Growth and development of gastrointestinal cells. Annu. Rev. Physiol. 47: 175-197.
19. Mertz, E. T., Beeson, W. M. & Jackson, H. D. (1952) Classification of essential amino acids for weanling pigs. Arch. Biochem. Biophys. 38: 121-128.
20. Miller, B. G., James, P. S., Smith, M. W. & Bourne, F. J. (1986) Effects of weaning on the capacity of pig intestinal villi to digest and absorb nutrients. J. Agri. Sci. 107: 579-585.
21. Rana, S. K. & Sanders, T.A.B. (1986) Taurine concentrations in the diet, plasma, urine and breast milk of vegans compared with omnivores. Br. J. Nutr. 56: 17-27.
22. Reeds, P. J., Burrin, D. G., Davis, T. A. & Fiorotto, M. L. (1993) Postnatal growth of gut and muscle: competitors or collaborators. Proc. Nutr. Soc. 52: 57-67.
23. SAS Institute Inc. (1990) SAS User's Guide: Statistics. SAS Institute, Cary, NC.
24. Schroder, J., Wardelmann, E., Winkler, W., Fandrich, F., Schweizer, E. & Schroeder, P. (1995) Glutamine dipeptide-supplemented parenteral nutrition reverses gut atrophy, disaccharidase enzyme activity, and absorption in rats. J. Parenter. Enteral Nutr. 19: 502-506.
25. Souba, W. W., Klimberg, V. S., Hautamaki, R. D., Mendenhall, W. H., Bova, F. C., Howard, R. J., Bland, K. I. & Copeland, E. M. (1990a) Oral glutamine reduces bacterial translocation following abdominal radiation. J. Surg. Res. 48: 1-5.
26. Souba, W. W., Klimberg, V. S., Plumley, D. A., Salloum, R. M., Flynn, T. C., Bland, K. I. & Copeland, E. M. (1990b) The role of glutamine in maintaining a healthy gut and supporting the metabolic response to injury and infection. J. Surg. Res. 48: 383-391.
27. Sturman, J. A. (1993) Taurine in development. Physiol. Rev. 73: 119-147.
28. Tamada, H., Nezu, R., Imamura, I., Matsuo, Y., Takagi, Y., Kamata, S. & Okada, A. (1992) The dipeptide alanyl-glutamine prevents intestinal mucosal atrophy in parenterally fed rats. J. Parenter. Enteral Nutr. 16: 110-116.
29. Visek, W. J. (1984) An update of concepts of essential amino acids. Annu. Rev. Nutr. 4: 137-155.
30. Windmueller, H. G. & Spaeth, A. E. (1980) Respiratory fuels and nitrogen metabolism in vivo in small intestine of fed rats. J. Biol. Chem. 255: 107-112.
31. Wu, G. (1996) Effects of concanavalin A and phorbol myristate acetate on glutamine metabolism and proliferation of porcine intraepithelial lymphocytes. Comp. Biochem. Physiol. 114A: 363-368.
32. Wu, G., Borbolla, A. G. & Knabe, D. A. (1994) The uptake of glutamine and release of arginine, citrulline and proline by the small intestine of developing pigs. J. Nutr. 124: 2437-2444.
33. Wu, G. & Knabe, D. A. (1994) Free and protein-bound amino acids in sow's colostrum and milk. J. Nutr. 124: 415-424.
34. Wu, G. & Knabe, D. A. (1995) Arginine synthesis in enterocytes of neonatal pigs. Am. J. Physiol. 269: R621-R629.
35. Wu, G., Knabe, D. A., Yan, W., & Flynn, N. E. (1995) Glutamine and glucose metabolism in enterocytes of the neonatal pig. Am. J. Physiol. 268: R334-R342.