-
1
-
-
36849010167
-
Adaptive immunity maintains occult cancer in an equilibrium state
-
1:CAS:528:DC%2BD2sXhtl2gsbjL 18026089 10.1038/nature06309
-
Koebel CM, Vermi W, Swann JB, Zerafa N, Rodig SJ, Old LJ, et al. Adaptive immunity maintains occult cancer in an equilibrium state. Nature. 2007;450:903-7.
-
(2007)
Nature
, vol.450
, pp. 903-907
-
-
Koebel, C.M.1
Vermi, W.2
Swann, J.B.3
Zerafa, N.4
Rodig, S.J.5
Old, L.J.6
-
2
-
-
84867742083
-
Engineered T cells for anti-cancer therapy
-
1:CAS:528:DC%2BC38XhtVOlsLrP 3622551 22818942 10.1016/j.coi.2012.06.004
-
Turtle CJ, Hudecek M, Jensen MC, Riddell SR. Engineered T cells for anti-cancer therapy. Curr Opin Immunol. 2012;24:633-9.
-
(2012)
Curr Opin Immunol.
, vol.24
, pp. 633-639
-
-
Turtle, C.J.1
Hudecek, M.2
Jensen, M.C.3
Riddell, S.R.4
-
3
-
-
0037058993
-
Adoptive T cell therapy using antigen-specific CD8+ T cell clones for the treatment of patients with metastatic melanoma: In vivo persistence, migration, and antitumor effect of transferred T cells
-
1:CAS:528:DC%2BD38Xps1ensLk%3D 12427970 10.1073/pnas.242600099
-
Yee C, Thompson JA, Byrd D, Riddell SR, Roche P, Celis E, et al. Adoptive T cell therapy using antigen-specific CD8+ T cell clones for the treatment of patients with metastatic melanoma: in vivo persistence, migration, and antitumor effect of transferred T cells. Proc Natl Acad Sci USA. 2002;99:16168-73.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 16168-16173
-
-
Yee, C.1
Thompson, J.A.2
Byrd, D.3
Riddell, S.R.4
Roche, P.5
Celis, E.6
-
4
-
-
84863337726
-
Transferred melanoma-specific CD8+ T cells persist, mediate tumor regression, and acquire central memory phenotype
-
1:CAS:528:DC%2BC38XkvF2mtLg%3D 22393002 10.1073/pnas.1113748109
-
Chapuis AG, Thompson JA, Margolin KA, Rodmyre R, Lai IP, Dowdy K, et al. Transferred melanoma-specific CD8+ T cells persist, mediate tumor regression, and acquire central memory phenotype. Proc Natl Acad Sci USA. 2012;109:4592-7.
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. 4592-4597
-
-
Chapuis, A.G.1
Thompson, J.A.2
Margolin, K.A.3
Rodmyre, R.4
Lai, I.P.5
Dowdy, K.6
-
5
-
-
84875975917
-
Transferred WT1-reactive CD8+ T cells can mediate antileukemic activity and persist in post-transplant patients
-
Chapuis AG, Ragnarsson GB, Nguyen HN, Chaney CN, Pufnock JS, Schmitt TM, et al. Transferred WT1-reactive CD8+ T cells can mediate antileukemic activity and persist in post-transplant patients. Sci Transl Med. 2013;5:174ra27.
-
(2013)
Sci Transl Med.
, vol.5
-
-
Chapuis, A.G.1
Ragnarsson, G.B.2
Nguyen, H.N.3
Chaney, C.N.4
Pufnock, J.S.5
Schmitt, T.M.6
-
6
-
-
45549099784
-
Treatment of metastatic melanoma with autologous CD4+ T cells against NY-ESO-1
-
1:CAS:528:DC%2BD1cXns1ajtrw%3D 3277288 18565862 10.1056/NEJMoa0800251
-
Hunder NN, Wallen H, Cao J, Hendricks DW, Reilly JZ, Rodmyre R, et al. Treatment of metastatic melanoma with autologous CD4+ T cells against NY-ESO-1. N Engl J Med. 2008;358:2698-703.
-
(2008)
N Engl J Med
, vol.358
, pp. 2698-2703
-
-
Hunder, N.N.1
Wallen, H.2
Cao, J.3
Hendricks, D.W.4
Reilly, J.Z.5
Rodmyre, R.6
-
7
-
-
10344261422
-
Cutting edge: Persistence of transferred lymphocyte clonotypes correlates with cancer regression in patients receiving cell transfer therapy
-
1:CAS:528:DC%2BD2cXhtVCqur7N 2175171 15585832
-
Robbins PF, Dudley ME, Wunderlich J, El-Gamil M, Li YF, Zhou J, et al. Cutting edge: persistence of transferred lymphocyte clonotypes correlates with cancer regression in patients receiving cell transfer therapy. J Immunol. 2004;173:7125-30.
-
(2004)
J Immunol
, vol.173
, pp. 7125-7130
-
-
Robbins, P.F.1
Dudley, M.E.2
Wunderlich, J.3
El-Gamil, M.4
Li, Y.F.5
Zhou, J.6
-
8
-
-
84876005284
-
CD19-targeted T cells rapidly induce molecular remissions in adults with chemotherapy-refractory acute lymphoblastic leukemia
-
Brentjens RJ, Davila ML, Riviere I, Park J, Wang X, Cowell LG, et al. CD19-targeted T cells rapidly induce molecular remissions in adults with chemotherapy-refractory acute lymphoblastic leukemia. Sci Transl Med. 2013;5:177ra38.
-
(2013)
Sci Transl Med.
, vol.5
-
-
Brentjens, R.J.1
Davila, M.L.2
Riviere, I.3
Park, J.4
Wang, X.5
Cowell, L.G.6
-
9
-
-
80051775476
-
T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced Leukemia
-
Kalos M, Levine BL, Porter DL, Katz S, Grupp SA, Bagg A, et al. T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced Leukemia. Sci Transl Med. 2011;3:95ra73.
-
(2011)
Sci Transl Med.
, vol.3
-
-
Kalos, M.1
Levine, B.L.2
Porter, D.L.3
Katz, S.4
Grupp, S.A.5
Bagg, A.6
-
10
-
-
70449117415
-
T cell receptor gene therapy for cancer
-
1:CAS:528:DC%2BD1MXhtlKitLvF 19702439 10.1089/hum.2009.146
-
Schmitt TM, Ragnarsson GB, Greenberg PD. T cell receptor gene therapy for cancer. Hum Gene Ther. 2009;20:1240-8.
-
(2009)
Hum Gene Ther
, vol.20
, pp. 1240-1248
-
-
Schmitt, T.M.1
Ragnarsson, G.B.2
Greenberg, P.D.3
-
11
-
-
79953104677
-
Genetically retargeting CD8+ lymphocyte subsets for cancer immunotherapy
-
1:CAS:528:DC%2BC3MXkt1Kitrc%3D 3130496 21237630 10.1016/j.coi.2010.12.012
-
Turtle CJ, Riddell SR. Genetically retargeting CD8+ lymphocyte subsets for cancer immunotherapy. Curr Opin Immunol. 2011;23:299-305.
-
(2011)
Curr Opin Immunol
, vol.23
, pp. 299-305
-
-
Turtle, C.J.1
Riddell, S.R.2
-
12
-
-
80455179612
-
Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias
-
1:CAS:528:DC%2BC3MXhsVOgsrjL 21849486 10.1182/blood-2011-04-348540
-
Brentjens RJ, Riviere I, Park JH, Davila ML, Wang X, Stefanski J, et al. Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias. Blood. 2011;118:4817-28.
-
(2011)
Blood.
, vol.118
, pp. 4817-4828
-
-
Brentjens, R.J.1
Riviere, I.2
Park, J.H.3
Davila, M.L.4
Wang, X.5
Stefanski, J.6
-
13
-
-
84862954607
-
Generation of CD19-chimeric antigen receptor modified CD8+ T cells derived from virus-specific central memory T cells
-
1:CAS:528:DC%2BC38XpvFGktQ%3D%3D 22031866 10.1182/blood-2011-07-366419
-
Terakura S, Yamamoto TN, Gardner RA, Turtle CJ, Jensen MC, Riddell SR. Generation of CD19-chimeric antigen receptor modified CD8+ T cells derived from virus-specific central memory T cells. Blood. 2012;119:72-82.
-
(2012)
Blood
, vol.119
, pp. 72-82
-
-
Terakura, S.1
Yamamoto, T.N.2
Gardner, R.A.3
Turtle, C.J.4
Jensen, M.C.5
Riddell, S.R.6
-
14
-
-
77950525914
-
A transposon and transposase system for human application
-
1:CAS:528:DC%2BC3cXhtVent7w%3D 20104209 10.1038/mt.2010.2
-
Hackett PB, Largaespada DA, Cooper LJ. A transposon and transposase system for human application. Mol Ther. 2010;18:674-83.
-
(2010)
Mol Ther
, vol.18
, pp. 674-683
-
-
Hackett, P.B.1
Largaespada, D.A.2
Cooper, L.J.3
-
15
-
-
84860333968
-
CD20-specific adoptive immunotherapy for lymphoma using a chimeric antigen receptor with both CD28 and 4-1BB domains: Pilot clinical trial results
-
1:CAS:528:DC%2BC38Xms1alt7w%3D 22308288 10.1182/blood-2011-10-387969
-
Till BG, Jensen MC, Wang J, Qian X, Gopal AK, Maloney DG, et al. CD20-specific adoptive immunotherapy for lymphoma using a chimeric antigen receptor with both CD28 and 4-1BB domains: pilot clinical trial results. Blood. 2012;119:3940-50.
-
(2012)
Blood
, vol.119
, pp. 3940-3950
-
-
Till, B.G.1
Jensen, M.C.2
Wang, J.3
Qian, X.4
Gopal, A.K.5
Maloney, D.G.6
-
16
-
-
67349189462
-
Adoptive immunotherapy using human peripheral blood lymphocytes transferred with RNA encoding Her-2/neu-specific chimeric immune receptor in ovarian cancer xenograft model
-
1:CAS:528:DC%2BD1MXpt1Kn 19096447 10.1038/cgt.2008.98
-
Yoon SH, Lee JM, Cho HI, Kim EK, Kim HS, Park MY, et al. Adoptive immunotherapy using human peripheral blood lymphocytes transferred with RNA encoding Her-2/neu-specific chimeric immune receptor in ovarian cancer xenograft model. Cancer Gene Ther. 2009;16:489-97.
-
(2009)
Cancer Gene Ther
, vol.16
, pp. 489-497
-
-
Yoon, S.H.1
Lee, J.M.2
Cho, H.I.3
Kim, E.K.4
Kim, H.S.5
Park, M.Y.6
-
17
-
-
33947217494
-
Facilitating matched pairing and expression of TCR chains introduced into human T cells
-
1:CAS:528:DC%2BD2sXnslygsrk%3D 17082316 10.1182/blood-2006-05-023069
-
Kuball J, Dossett ML, Wolfl M, Ho WY, Voss RH, Fowler C, et al. Facilitating matched pairing and expression of TCR chains introduced into human T cells. Blood. 2007;109:2331-8.
-
(2007)
Blood
, vol.109
, pp. 2331-2338
-
-
Kuball, J.1
Dossett, M.L.2
Wolfl, M.3
Ho, W.Y.4
Voss, R.H.5
Fowler, C.6
-
18
-
-
0027471898
-
Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors
-
1:CAS:528:DyaK3sXitVCkurY%3D 8421711 10.1073/pnas.90.2.720
-
Eshhar Z, Waks T, Gross G, Schindler DG. Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors. Proc Natl Acad Sci USA. 1993;90:720-4.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 720-724
-
-
Eshhar, Z.1
Waks, T.2
Gross, G.3
Schindler, D.G.4
-
19
-
-
84877669593
-
The basic principles of chimeric antigen receptor design
-
1:CAS:528:DC%2BC3sXlvVCit7c%3D 23550147 10.1158/2159-8290.CD-12-0548
-
Sadelain M, Brentjens R, Riviere I. The basic principles of chimeric antigen receptor design. Cancer Discov. 2013;3:388-98.
-
(2013)
Cancer Discov
, vol.3
, pp. 388-398
-
-
Sadelain, M.1
Brentjens, R.2
Riviere, I.3
-
20
-
-
50549096284
-
Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cells
-
1:CAS:528:DC%2BD1cXhtFCrurjL 18509084 10.1182/blood-2007-12-128843
-
Till BG, Jensen MC, Wang J, Chen EY, Wood BL, Greisman HA, et al. Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cells. Blood. 2008;112:2261-71.
-
(2008)
Blood
, vol.112
, pp. 2261-2271
-
-
Till, B.G.1
Jensen, M.C.2
Wang, J.3
Chen, E.Y.4
Wood, B.L.5
Greisman, H.A.6
-
21
-
-
78649461928
-
The B-cell tumor-associated antigen ROR1 can be targeted with T cells modified to express a ROR1-specific chimeric antigen receptor
-
1:CAS:528:DC%2BC3cXhsFGgtbvO 20702778 10.1182/blood-2010-05-283309
-
Hudecek M, Schmitt TM, Baskar S, Lupo-Stanghellini MT, Nishida T, Yamamoto TN, et al. The B-cell tumor-associated antigen ROR1 can be targeted with T cells modified to express a ROR1-specific chimeric antigen receptor. Blood. 2010;116:4532-41.
-
(2010)
Blood
, vol.116
, pp. 4532-4541
-
-
Hudecek, M.1
Schmitt, T.M.2
Baskar, S.3
Lupo-Stanghellini, M.T.4
Nishida, T.5
Yamamoto, T.N.6
-
22
-
-
79955980426
-
In vitro and in vivo model of a novel immunotherapy approach for chronic lymphocytic leukemia by anti-CD23 chimeric antigen receptor
-
Giordano Attianese GM, Marin V, Hoyos V, Savoldo B, Pizzitola I, Tettamanti S, et al. In vitro and in vivo model of a novel immunotherapy approach for chronic lymphocytic leukemia by anti-CD23 chimeric antigen receptor. Blood. 2011;117:4736-4745.
-
(2011)
Blood
, vol.117
, pp. 4736-4745
-
-
Giordano Attianese, G.M.1
Marin, V.2
Hoyos, V.3
Savoldo, B.4
Pizzitola, I.5
Tettamanti, S.6
-
23
-
-
77956840374
-
Synergistic and persistent effect of T-cell immunotherapy with anti-CD19 or anti-CD38 chimeric receptor in conjunction with rituximab on B-cell non-Hodgkin lymphoma
-
1:CAS:528:DC%2BC3cXht12mtrrE 20678160 10.1111/j.1365-2141.2010.08297.x
-
Mihara K, Yanagihara K, Takigahira M, Kitanaka A, Imai C, Bhattacharyya J, et al. Synergistic and persistent effect of T-cell immunotherapy with anti-CD19 or anti-CD38 chimeric receptor in conjunction with rituximab on B-cell non-Hodgkin lymphoma. Br J Haematol. 2010;151:37-46.
-
(2010)
Br J Haematol
, vol.151
, pp. 37-46
-
-
Mihara, K.1
Yanagihara, K.2
Takigahira, M.3
Kitanaka, A.4
Imai, C.5
Bhattacharyya, J.6
-
24
-
-
33845256434
-
T lymphocytes redirected against the kappa light chain of human immunoglobulin efficiently kill mature B lymphocyte-derived malignant cells
-
1:CAS:528:DC%2BD28Xht1Kgs73F 16926291 10.1182/blood-2006-04-017061
-
Vera J, Savoldo B, Vigouroux S, Biagi E, Pule M, Rossig C, et al. T lymphocytes redirected against the kappa light chain of human immunoglobulin efficiently kill mature B lymphocyte-derived malignant cells. Blood. 2006;108:3890-7.
-
(2006)
Blood
, vol.108
, pp. 3890-3897
-
-
Vera, J.1
Savoldo, B.2
Vigouroux, S.3
Biagi, E.4
Pule, M.5
Rossig, C.6
-
25
-
-
84874027123
-
Anti-CD22-chimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemia
-
1:CAS:528:DC%2BC3sXjt1WhsLw%3D 23243285 10.1182/blood-2012-06-438002
-
Haso W, Lee DW, Shah NN, Stetler-Stevenson M, Yuan CM, Pastan IH, et al. Anti-CD22-chimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemia. Blood. 2013;121:1165-74.
-
(2013)
Blood
, vol.121
, pp. 1165-1174
-
-
Haso, W.1
Lee, D.W.2
Shah, N.N.3
Stetler-Stevenson, M.4
Yuan, C.M.5
Pastan, I.H.6
-
26
-
-
10844296758
-
Specific recognition and killing of glioblastoma multiforme by interleukin 13-zetakine redirected cytolytic T cells
-
1:CAS:528:DC%2BD2cXhtVOmsb7E 15604287 10.1158/0008-5472.CAN-04-0454
-
Kahlon KS, Brown C, Cooper LJ, Raubitschek A, Forman SJ, Jensen MC. Specific recognition and killing of glioblastoma multiforme by interleukin 13-zetakine redirected cytolytic T cells. Cancer Res. 2004;64:9160-6.
-
(2004)
Cancer Res
, vol.64
, pp. 9160-9166
-
-
Kahlon, K.S.1
Brown, C.2
Cooper, L.J.3
Raubitschek, A.4
Forman, S.J.5
Jensen, M.C.6
-
27
-
-
0036137615
-
Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCRzeta/CD28 receptor
-
1:CAS:528:DC%2BD38XislSktw%3D%3D 11753365 10.1038/nbt0102-70
-
Maher J, Brentjens RJ, Gunset G, Riviere I, Sadelain M. Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCRzeta/CD28 receptor. Nat Biotechnol. 2002;20:70-5.
-
(2002)
Nat Biotechnol
, vol.20
, pp. 70-75
-
-
Maher, J.1
Brentjens, R.J.2
Gunset, G.3
Riviere, I.4
Sadelain, M.5
-
28
-
-
79959914449
-
In vivo persistence, tumor localization, and antitumor activity of CAR-engineered T cells is enhanced by costimulatory signaling through CD137 (4-1BB)
-
1:CAS:528:DC%2BC3MXotlert74%3D 21546571 10.1158/0008-5472.CAN-11-0422
-
Song DG, Ye Q, Carpenito C, Poussin M, Wang LP, Ji C, et al. In vivo persistence, tumor localization, and antitumor activity of CAR-engineered T cells is enhanced by costimulatory signaling through CD137 (4-1BB). Cancer Res. 2011;71:4617-27.
-
(2011)
Cancer Res
, vol.71
, pp. 4617-4627
-
-
Song, D.G.1
Ye, Q.2
Carpenito, C.3
Poussin, M.4
Wang, L.P.5
Ji, C.6
-
29
-
-
84856071702
-
CD27 costimulation augments the survival and antitumor activity of redirected human T cells in vivo
-
1:CAS:528:DC%2BC38Xhs1KjtLk%3D 22117050 10.1182/blood-2011-03-344275
-
Song DG, Ye Q, Poussin M, Harms GM, Figini M, Powell DJJ. CD27 costimulation augments the survival and antitumor activity of redirected human T cells in vivo. Blood. 2012;119:696-706.
-
(2012)
Blood
, vol.119
, pp. 696-706
-
-
Song, D.G.1
Ye, Q.2
Poussin, M.3
Harms, G.M.4
Figini, M.5
Powell, D.J.J.6
-
30
-
-
0347994955
-
Activation of resting human primary T cells with chimeric receptors: Costimulation from CD28, inducible costimulator, CD134, and CD137 in series with signals from the TCR zeta chain
-
1:CAS:528:DC%2BD3sXpvFeht74%3D 14688315
-
Finney HM, Akbar AN, Lawson AD. Activation of resting human primary T cells with chimeric receptors: costimulation from CD28, inducible costimulator, CD134, and CD137 in series with signals from the TCR zeta chain. J Immunol. 2004;172:104-13.
-
(2004)
J Immunol
, vol.172
, pp. 104-113
-
-
Finney, H.M.1
Akbar, A.N.2
Lawson, A.D.3
-
31
-
-
44449162630
-
Retargeting of human T cells to tumor-associated MUC1: The evolution of a chimeric antigen receptor
-
1:CAS:528:DC%2BD1cXjsVKqt7Y%3D 18354214
-
Wilkie S, Picco G, Foster J, Davies DM, Julien S, Cooper L, et al. Retargeting of human T cells to tumor-associated MUC1: the evolution of a chimeric antigen receptor. J Immunol. 2008;180:4901-9.
-
(2008)
J Immunol
, vol.180
, pp. 4901-4909
-
-
Wilkie, S.1
Picco, G.2
Foster, J.3
Davies, D.M.4
Julien, S.5
Cooper, L.6
-
32
-
-
84855186143
-
Costimulation by chimeric antigen receptors revisited the T cell antitumor response benefits from combined CD28-OX40 signalling
-
1:CAS:528:DC%2BC3MXhtlKgur%2FO 22030616 10.1002/ijc.25960
-
Hombach AA, Abken H. Costimulation by chimeric antigen receptors revisited the T cell antitumor response benefits from combined CD28-OX40 signalling. Int J Cancer. 2011;129:2935-44.
-
(2011)
Int J Cancer
, vol.129
, pp. 2935-2944
-
-
Hombach, A.A.1
Abken, H.2
-
33
-
-
27744566329
-
A chimeric T cell antigen receptor that augments cytokine release and supports clonal expansion of primary human T cells
-
1:CAS:528:DC%2BD2MXhtFKmtLjK 15979412 10.1016/j.ymthe.2005.04.016
-
Pule MA, Straathof KC, Dotti G, Heslop HE, Rooney CM, Brenner MK. A chimeric T cell antigen receptor that augments cytokine release and supports clonal expansion of primary human T cells. Mol Ther. 2005;12:933-41.
-
(2005)
Mol Ther
, vol.12
, pp. 933-941
-
-
Pule, M.A.1
Straathof, K.C.2
Dotti, G.3
Heslop, H.E.4
Rooney, C.M.5
Brenner, M.K.6
-
34
-
-
33845294816
-
CD28 costimulation provided through a CD19-specific chimeric antigen receptor enhances in vivo persistence and antitumor efficacy of adoptively transferred T cells
-
1:CAS:528:DC%2BD2sXivVyqt70%3D 17108138 10.1158/0008-5472.CAN-06-0160
-
Kowolik CM, Topp MS, Gonzalez S, Pfeiffer T, Olivares S, Gonzalez N, et al. CD28 costimulation provided through a CD19-specific chimeric antigen receptor enhances in vivo persistence and antitumor efficacy of adoptively transferred T cells. Cancer Res. 2006;66:10995-1004.
-
(2006)
Cancer Res
, vol.66
, pp. 10995-11004
-
-
Kowolik, C.M.1
Topp, M.S.2
Gonzalez, S.3
Pfeiffer, T.4
Olivares, S.5
Gonzalez, N.6
-
35
-
-
79955517235
-
CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients
-
1:CAS:528:DC%2BC3MXlvFKnt7o%3D 3083795 21540550 10.1172/JCI46110
-
Savoldo B, Ramos CA, Liu E, Mims MP, Keating MJ, Carrum G, et al. CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients. J Clin Invest. 2011;121:1822-6.
-
(2011)
J Clin Invest
, vol.121
, pp. 1822-1826
-
-
Savoldo, B.1
Ramos, C.A.2
Liu, E.3
Mims, M.P.4
Keating, M.J.5
Carrum, G.6
-
36
-
-
62549097817
-
Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains
-
1:CAS:528:DC%2BD1MXivF2jsbw%3D 19211796 10.1073/pnas.0813101106
-
Carpenito C, Milone MC, Hassan R, Simonet JC, Lakhal M, Suhoski MM, et al. Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains. Proc Natl Acad Sci USA. 2009;106:3360-5.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 3360-3365
-
-
Carpenito, C.1
Milone, M.C.2
Hassan, R.3
Simonet, J.C.4
Lakhal, M.5
Suhoski, M.M.6
-
37
-
-
76349087378
-
Chimeric antigen receptors combining 4-1BB and CD28 signaling domains augment PI3kinase/AKT/Bcl-XL activation and CD8+ T cell-mediated tumor eradication
-
1:CAS:528:DC%2BD1MXhtFGrsb7P 19773745 10.1038/mt.2009.210
-
Zhong XS, Matsushita M, Plotkin J, Riviere I, Sadelain M. Chimeric antigen receptors combining 4-1BB and CD28 signaling domains augment PI3kinase/AKT/Bcl-XL activation and CD8+ T cell-mediated tumor eradication. Mol Ther. 2010;18:413-20.
-
(2010)
Mol Ther
, vol.18
, pp. 413-420
-
-
Zhong, X.S.1
Matsushita, M.2
Plotkin, J.3
Riviere, I.4
Sadelain, M.5
-
38
-
-
84879480191
-
Receptor affinity and extracellular domain modifications affect tumor recognition by ROR1-specific chimeric antigen receptor T cells
-
1:CAS:528:DC%2BC3sXpsVyns78%3D 3804130 23620405 10.1158/1078-0432.CCR-13- 0330
-
Hudecek M, Lupo-Stanghellini MT, Kosasih PL, Sommermeyer D, Jensen MC, Rader C, et al. Receptor affinity and extracellular domain modifications affect tumor recognition by ROR1-specific chimeric antigen receptor T cells. Clin Cancer Res. 2013;19:3153-64.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 3153-3164
-
-
Hudecek, M.1
Lupo-Stanghellini, M.T.2
Kosasih, P.L.3
Sommermeyer, D.4
Jensen, M.C.5
Rader, C.6
-
39
-
-
45549093089
-
Antigen sensitivity of CD22-specific chimeric TCR is modulated by target epitope distance from the cell membrane
-
1:CAS:528:DC%2BD1cXltlCrs7s%3D 2585549 18453625
-
James SE, Greenberg PD, Jensen MC, Lin Y, Wang J, Till BG, et al. Antigen sensitivity of CD22-specific chimeric TCR is modulated by target epitope distance from the cell membrane. J Immunol. 2008;180:7028-38.
-
(2008)
J Immunol
, vol.180
, pp. 7028-7038
-
-
James, S.E.1
Greenberg, P.D.2
Jensen, M.C.3
Lin, Y.4
Wang, J.5
Till, B.G.6
-
40
-
-
77952753137
-
Mathematical modeling of chimeric TCR triggering predicts the magnitude of target lysis and its impairment by TCR downmodulation
-
1:CAS:528:DC%2BC3cXkt1Wqt70%3D 2896691 20220093 10.4049/jimmunol.0903701
-
James SE, Greenberg PD, Jensen MC, Lin Y, Wang J, Budde LE, et al. Mathematical modeling of chimeric TCR triggering predicts the magnitude of target lysis and its impairment by TCR downmodulation. J Immunol. 2010;184:4284-94.
-
(2010)
J Immunol
, vol.184
, pp. 4284-4294
-
-
James, S.E.1
Greenberg, P.D.2
Jensen, M.C.3
Lin, Y.4
Wang, J.5
Budde, L.E.6
-
41
-
-
84875469804
-
Adoptive immunotherapy with redirected T cells produces CCR7- cells that are trapped in the periphery and benefit from combined CD28-OX40 costimulation
-
1:CAS:528:DC%2BC3sXktleltbk%3D 23350854 10.1089/hum.2012.247
-
Hombach AA, Chmielewski M, Rappl G, Abken H. Adoptive immunotherapy with redirected T cells produces CCR7- cells that are trapped in the periphery and benefit from combined CD28-OX40 costimulation. Hum Gene Ther. 2013;24:259-69.
-
(2013)
Hum Gene Ther
, vol.24
, pp. 259-269
-
-
Hombach, A.A.1
Chmielewski, M.2
Rappl, G.3
Abken, H.4
-
42
-
-
36849021712
-
T cell-encoded CD80 and 4-1BBL induce auto- and transcostimulation, resulting in potent tumor rejection
-
1:CAS:528:DC%2BD2sXhtl2gs7nJ 18026115 10.1038/nm1676
-
Stephan MT, Ponomarev V, Brentjens RJ, Chang AH, Dobrenkov KV, Heller G, et al. T cell-encoded CD80 and 4-1BBL induce auto- and transcostimulation, resulting in potent tumor rejection. Nat Med. 2007;13:1440-9.
-
(2007)
Nat Med
, vol.13
, pp. 1440-1449
-
-
Stephan, M.T.1
Ponomarev, V.2
Brentjens, R.J.3
Chang, A.H.4
Dobrenkov, K.V.5
Heller, G.6
-
43
-
-
77951746241
-
IL-7 and IL-21 are superior to IL-2 and IL-15 in promoting human T cell-mediated rejection of systemic lymphoma in immunodeficient mice
-
1:CAS:528:DC%2BC3cXmtFylur4%3D 20190192 10.1182/blood-2009-09-241398
-
Markley JC, Sadelain M. IL-7 and IL-21 are superior to IL-2 and IL-15 in promoting human T cell-mediated rejection of systemic lymphoma in immunodeficient mice. Blood. 2010;115:3508-19.
-
(2010)
Blood
, vol.115
, pp. 3508-3519
-
-
Markley, J.C.1
Sadelain, M.2
-
44
-
-
34250023777
-
Cytokine-independent growth and clonal expansion of a primary human CD8+ T-cell clone following retroviral transduction with the IL-15 gene
-
1:CAS:528:DC%2BD2sXmslOrsrs%3D 17353346 10.1182/blood-2006-06-029173
-
Hsu C, Jones SA, Cohen CJ, Zheng Z, Kerstann K, Zhou J, et al. Cytokine-independent growth and clonal expansion of a primary human CD8+ T-cell clone following retroviral transduction with the IL-15 gene. Blood. 2007;109:5168-77.
-
(2007)
Blood
, vol.109
, pp. 5168-5177
-
-
Hsu, C.1
Jones, S.A.2
Cohen, C.J.3
Zheng, Z.4
Kerstann, K.5
Zhou, J.6
-
45
-
-
79954573204
-
In vivo inhibition of human CD19-targeted effector T cells by natural T regulatory cells in a xenotransplant murine model of B cell malignancy
-
1:CAS:528:DC%2BC3MXkslWjsrc%3D 3094720 21487038 10.1158/0008-5472.CAN-10- 0552
-
Lee JC, Hayman E, Pegram HJ, Santos E, Heller G, Sadelain M, et al. In vivo inhibition of human CD19-targeted effector T cells by natural T regulatory cells in a xenotransplant murine model of B cell malignancy. Cancer Res. 2011;71:2871-81.
-
(2011)
Cancer Res
, vol.71
, pp. 2871-2881
-
-
Lee, J.C.1
Hayman, E.2
Pegram, H.J.3
Santos, E.4
Heller, G.5
Sadelain, M.6
-
46
-
-
84892165951
-
Interleukin-7 mediates selective expansion of tumor-redirected cytotoxic T lymphocytes without enhancement of regulatory T-cell inhibition
-
Perna SK, Pagliara D, Mahendravada A, Liu H, Brenner MK, Savoldo B, et al. Interleukin-7 mediates selective expansion of tumor-redirected cytotoxic T lymphocytes without enhancement of regulatory T-cell inhibition. Clin Cancer Res. 2013.
-
(2013)
Clin Cancer Res.
-
-
Perna, S.K.1
Pagliara, D.2
Mahendravada, A.3
Liu, H.4
Brenner, M.K.5
Savoldo, B.6
-
47
-
-
67349169780
-
Genome-wide analysis of histone methylation reveals chromatin state-based regulation of gene transcription and function of memory CD8+ T cells
-
Araki Y, Wang Z, Zang C, Wood Iii WH, Schones D, Cui K, et al. Genome-wide analysis of histone methylation reveals chromatin state-based regulation of gene transcription and function of memory CD8+ T cells. Immunity. 2009;30:912-25.
-
(2009)
Immunity
, vol.30
, pp. 912-925
-
-
Araki, Y.1
Wang, Z.2
Zang, C.3
Wood III, W.H.4
Schones, D.5
Cui, K.6
-
48
-
-
84858797295
-
The molecular basis of the memory T cell response: Differential gene expression and its epigenetic regulation
-
1:CAS:528:DC%2BC38XktVars78%3D 22421787 10.1038/nri3173
-
Weng NP, Araki Y, Subedi K. The molecular basis of the memory T cell response: differential gene expression and its epigenetic regulation. Nat Rev Immunol. 2012;12:306-15.
-
(2012)
Nat Rev Immunol
, vol.12
, pp. 306-315
-
-
Weng, N.P.1
Araki, Y.2
Subedi, K.3
-
49
-
-
70449474686
-
A distinct subset of self-renewing human memory CD8 + T cells survives cytotoxic chemotherapy
-
1:CAS:528:DC%2BD1MXhsFylsbjF 2789980 19879163 10.1016/j.immuni.2009.09. 015
-
Turtle CJ, Swanson HM, Fujii N, Estey EH, Riddell SR. A distinct subset of self-renewing human memory CD8 + T cells survives cytotoxic chemotherapy. Immunity. 2009;31:834-44.
-
(2009)
Immunity
, vol.31
, pp. 834-844
-
-
Turtle, C.J.1
Swanson, H.M.2
Fujii, N.3
Estey, E.H.4
Riddell, S.R.5
-
50
-
-
80053997259
-
A human memory T cell subset with stem cell-like properties
-
1:CAS:528:DC%2BC3MXhtFyls7bJ 3192229 21926977 10.1038/nm.2446
-
Gattinoni L, Lugli E, Ji Y, Pos Z, Paulos CM, Quigley MF, et al. A human memory T cell subset with stem cell-like properties. Nat Med. 2011;17:1290-7.
-
(2011)
Nat Med
, vol.17
, pp. 1290-1297
-
-
Gattinoni, L.1
Lugli, E.2
Ji, Y.3
Pos, Z.4
Paulos, C.M.5
Quigley, M.F.6
-
51
-
-
0033554726
-
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
-
1:CAS:528:DyaK1MXntVWntrw%3D 10537110 10.1038/44385
-
Sallusto F, Lenig D, Forster R, Lipp M, Lanzavecchia A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature. 1999;401:708-12.
-
(1999)
Nature
, vol.401
, pp. 708-712
-
-
Sallusto, F.1
Lenig, D.2
Forster, R.3
Lipp, M.4
Lanzavecchia, A.5
-
52
-
-
38149117105
-
Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates
-
1:CAS:528:DC%2BD1cXksFOktA%3D%3D 2104476 18060041 10.1172/JCI32103
-
Berger C, Jensen MC, Lansdorp PM, Gough M, Elliott C, Riddell SR. Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates. J Clin Invest. 2008;118:294-305.
-
(2008)
J Clin Invest
, vol.118
, pp. 294-305
-
-
Berger, C.1
Jensen, M.C.2
Lansdorp, P.M.3
Gough, M.4
Elliott, C.5
Riddell, S.R.6
-
53
-
-
78751689288
-
Human effector CD8+ T cells derived from naive rather than memory subsets possess superior traits for adoptive immunotherapy
-
1:CAS:528:DC%2BC3MXhslKksrc%3D 20971955 10.1182/blood-2010-05-286286
-
Hinrichs CS, Borman ZA, Gattinoni L, Yu Z, Burns WR, Huang J, et al. Human effector CD8+ T cells derived from naive rather than memory subsets possess superior traits for adoptive immunotherapy. Blood. 2011;117:808-14.
-
(2011)
Blood
, vol.117
, pp. 808-814
-
-
Hinrichs, C.S.1
Borman, Z.A.2
Gattinoni, L.3
Yu, Z.4
Burns, W.R.5
Huang, J.6
-
54
-
-
84887821770
-
Infusion of donor-derived CD19-redirected virus-specific T cells for B-cell malignancies relapsed after allogeneic stem cell transplant: A phase 1 study
-
1:CAS:528:DC%2BC3sXhslejurnN 24030379 10.1182/blood-2013-06-506741
-
Cruz CR, Micklethwaite KP, Savoldo B, Ramos CA, Lam S, Ku S, et al. Infusion of donor-derived CD19-redirected virus-specific T cells for B-cell malignancies relapsed after allogeneic stem cell transplant: a phase 1 study. Blood. 2013;122:2965-73.
-
(2013)
Blood
, vol.122
, pp. 2965-2973
-
-
Cruz, C.R.1
Micklethwaite, K.P.2
Savoldo, B.3
Ramos, C.A.4
Lam, S.5
Ku, S.6
-
55
-
-
80051720194
-
Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia
-
1:CAS:528:DC%2BC3MXhtV2lu7nP 3387277 21830940 10.1056/NEJMoa1103849
-
Porter DL, Levine BL, Kalos M, Bagg A, June CH. Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia. N Engl J Med. 2011;365:725-33.
-
(2011)
N Engl J Med
, vol.365
, pp. 725-733
-
-
Porter, D.L.1
Levine, B.L.2
Kalos, M.3
Bagg, A.4
June, C.H.5
-
56
-
-
78549278144
-
Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19
-
1:CAS:528:DC%2BC3cXhsFCiu7fK 20668228 10.1182/blood-2010-04-281931
-
Kochenderfer JN, Wilson WH, Janik JE, Dudley ME, Stetler-Stevenson M, Feldman SA, et al. Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19. Blood. 2010;116:4099-102.
-
(2010)
Blood
, vol.116
, pp. 4099-4102
-
-
Kochenderfer, J.N.1
Wilson, W.H.2
Janik, J.E.3
Dudley, M.E.4
Stetler-Stevenson, M.5
Feldman, S.A.6
-
57
-
-
84863337890
-
B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells
-
1:CAS:528:DC%2BC38XkvFalt7o%3D 22160384 10.1182/blood-2011-10-384388
-
Kochenderfer JN, Dudley ME, Feldman SA, Wilson WH, Spaner DE, Maric I, et al. B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells. Blood. 2012;119:2709-20.
-
(2012)
Blood
, vol.119
, pp. 2709-2720
-
-
Kochenderfer, J.N.1
Dudley, M.E.2
Feldman, S.A.3
Wilson, W.H.4
Spaner, D.E.5
Maric, I.6
-
58
-
-
77955510549
-
Antitransgene rejection responses contribute to attenuated persistence of adoptively transferred CD20/CD19-specific chimeric antigen receptor redirected T cells in humans
-
1:CAS:528:DC%2BC3cXpvVOhtr4%3D 3383803 20304086 10.1016/j.bbmt.2010.03. 014
-
Jensen MC, Popplewell L, Cooper LJ, DiGiusto D, Kalos M, Ostberg JR, et al. Antitransgene rejection responses contribute to attenuated persistence of adoptively transferred CD20/CD19-specific chimeric antigen receptor redirected T cells in humans. Biol Blood Marrow Transplant. 2010;16:1245-56.
-
(2010)
Biol Blood Marrow Transplant
, vol.16
, pp. 1245-1256
-
-
Jensen, M.C.1
Popplewell, L.2
Cooper, L.J.3
Digiusto, D.4
Kalos, M.5
Ostberg, J.R.6
-
59
-
-
84876325876
-
Chimeric antigen receptor-modified T cells for acute lymphoid leukemia
-
1:CAS:528:DC%2BC3sXmsFKgtLo%3D 23527958 10.1056/NEJMoa1215134
-
Grupp SA, Kalos M, Barrett D, Aplenc R, Porter DL, Rheingold SR, et al. Chimeric antigen receptor-modified T cells for acute lymphoid leukemia. N Engl J Med. 2013;368:1509-18.
-
(2013)
N Engl J Med
, vol.368
, pp. 1509-1518
-
-
Grupp, S.A.1
Kalos, M.2
Barrett, D.3
Aplenc, R.4
Porter, D.L.5
Rheingold, S.R.6
-
60
-
-
84890827981
-
Donor-derived CD19-targeted T cells cause regression of malignancy persisting after allogeneic hematopoietic stem cell transplantation
-
[Epub ahead of print]
-
Kochenderfer JN, Dudley ME, Carpenter RO, Kassim SH, Rose JJ, Telford WG, et al. Donor-derived CD19-targeted T cells cause regression of malignancy persisting after allogeneic hematopoietic stem cell transplantation. Blood. 2013 [Epub ahead of print].
-
(2013)
Blood
-
-
Kochenderfer, J.N.1
Dudley, M.E.2
Carpenter, R.O.3
Kassim, S.H.4
Rose, J.J.5
Telford, W.G.6
-
61
-
-
77958000233
-
Allogeneic virus-specific T cells with HLA alloreactivity do not produce GVHD in human subjects
-
1:CAS:528:DC%2BC3cXhsFGgtbnN 20709906 10.1182/blood-2010-06-289991
-
Melenhorst JJ, Leen AM, Bollard CM, Quigley MF, Price DA, Rooney CM, et al. Allogeneic virus-specific T cells with HLA alloreactivity do not produce GVHD in human subjects. Blood. 2010;116:4700-2.
-
(2010)
Blood
, vol.116
, pp. 4700-4702
-
-
Melenhorst, J.J.1
Leen, A.M.2
Bollard, C.M.3
Quigley, M.F.4
Price, D.A.5
Rooney, C.M.6
-
62
-
-
84880733312
-
Adoptive T cell transfer for cancer immunotherapy in the era of synthetic biology
-
1:CAS:528:DC%2BC3sXhtFOhs7vK 23890063 10.1016/j.immuni.2013.07.002
-
Kalos M, June CH. Adoptive T cell transfer for cancer immunotherapy in the era of synthetic biology. Immunity. 2013;39:49-60.
-
(2013)
Immunity
, vol.39
, pp. 49-60
-
-
Kalos, M.1
June, C.H.2
-
63
-
-
33644750264
-
Analysis of transgene-specific immune responses that limit the in vivo persistence of adoptively transferred HSV-TK-modified donor T cells after allogeneic hematopoietic cell transplantation
-
1:CAS:528:DC%2BD28XisFOjtL0%3D 16282341 10.1182/blood-2005-08-3503
-
Berger C, Flowers ME, Warren EH, Riddell SR. Analysis of transgene-specific immune responses that limit the in vivo persistence of adoptively transferred HSV-TK-modified donor T cells after allogeneic hematopoietic cell transplantation. Blood. 2006;107:2294-302.
-
(2006)
Blood
, vol.107
, pp. 2294-2302
-
-
Berger, C.1
Flowers, M.E.2
Warren, E.H.3
Riddell, S.R.4
-
64
-
-
80455162464
-
Inducible apoptosis as a safety switch for adoptive cell therapy
-
3236370 22047558 10.1056/NEJMoa1106152
-
Di Stasi SK, Tey A, Dotti G, Fujita Y, Kennedy-Nasser A, Martinez C, et al. Inducible apoptosis as a safety switch for adoptive cell therapy. N Engl J Med. 2011;365:1673-83.
-
(2011)
N Engl J Med
, vol.365
, pp. 1673-1683
-
-
Di Stasi, S.K.1
Tey, A.2
Dotti, G.3
Fujita, Y.4
Kennedy-Nasser, A.5
Martinez, C.6
-
65
-
-
80051589534
-
A transgene-encoded cell surface polypeptide for selection, in vivo tracking, and ablation of engineered cells
-
1:CAS:528:DC%2BC3MXhtVCnurjN 21653320 10.1182/blood-2011-02-337360
-
Wang X, Chang WC, Wong CW, Colcher D, Sherman M, Ostberg JR, et al. A transgene-encoded cell surface polypeptide for selection, in vivo tracking, and ablation of engineered cells. Blood. 2011;118:1255-63.
-
(2011)
Blood
, vol.118
, pp. 1255-1263
-
-
Wang, X.1
Chang, W.C.2
Wong, C.W.3
Colcher, D.4
Sherman, M.5
Ostberg, J.R.6
|