Inhibition of 12-lipoxygenase reduces platelet activation and prevents their mitogenic function

Platelets

Volumn 25, Issue 2, 2014, Pages 111-117

  Holm, Ann Charlotte B Svensson ^a   Grenegård, Magnus ^a,c   Öllinger, Karin ^a,b   Lindström, Eva G ^a  

^a LINKÖPING UNIVERSITY   (Sweden)

^b Operations and Specialty Surgery Center   (Sweden)

^c ÖREBRO UNIVERSITY   (Sweden)

Author keywords

12 lipoxygenase; Airway remodelling; Airway smooth muscle; Platelet induced proliferation

Indexed keywords

AIRWAY REMODELING; ARACHIDONATE 12-LIPOXYGENASE; BLOOD PLATELETS; CELL PROLIFERATION; CELLS, CULTURED; COCULTURE TECHNIQUES; ENZYME ACTIVATION; HUMANS; LIPOXYGENASE INHIBITORS; MYOCYTES, SMOOTH MUSCLE; PLATELET ACTIVATION; REACTIVE OXYGEN SPECIES;

EID: 84894448724     PISSN: 09537104     EISSN: 13691635     Source Type: Journal    
DOI: 10.3109/09537104.2013.783688     Document Type: Article

References (36)

1. Pitchford SC. Novel uses for anti-platelet agents as anti-inflammatory drugs. Br J Pharmacol 2007;152:987-1002
2. Pitchford SC, Momi S Giannini S Casali L, Spina D Page CP and Gresele P. Platelet P-selectin is required for pulmonary eosinophil and lymphocyte recruitment in a murine model of allergic inflammation. Blood 2005;105:2074-2081
3. Pitchford SC, Riffo-Vasquez Y Sousa A Momi S Gresele P Spina D and Page CP. Platelets are necessary for airway wall remodeling in a murine model of chronic allergic inflammation. Blood 2004;103: 639-647
4. Kornerup KN, and Page CP. The role of platelets in the pathophysiology of asthma. Platelets 2007;18:319-328
5. Halwani R, Al-Muhsen S, and Hamid Q. Airway remodeling in asthma. Curr Opin Pharmacol 2010;10:236-245
6. Svensson Holm AC, Bengtsson T Grenegard M and Lindstrom EG. Platelets stimulate airway smooth muscle cell proliferation through mechanisms involving 5-lipoxygenase and reactive oxygen species. Platelets 2008;19:528-536
7. Svensson Holm AC, Bengtsson T, Grenegard M, and Lindstrom EG. Platelet membranes induce airway smooth muscle cell proliferation. Platelets 2011;22:43-53
8. Berg C, Hammarstrom S, Herbertsson H, Lindstrom E, Svensson AC, Soderstrom M, Tengvall P, and Bengtsson T. Platelet-induced growth of human fibroblasts is associated with an increased expression of 5-lipoxygenase. Thromb Haemost 2006;96:652-659
9. Berg C, Trofast C, and Bengtsson T. Platelets induce reactive oxygen species-dependent growth of human skin fibroblasts. Eur J Cell Biol 2003;82:565-571
10. Svensson Holm A-C, Bengtsson T, Grenega;rd M, and Lindström E. Hyaluronic acid influence on platelet-induced airway smooth muscle cell proliferation. Exp Cell Res 2012; 632-640
11. Yoshimoto T and Takahashi Y. Arachidonate 12-lipoxygenases. Prostaglandins Other Lipid Mediat 2002;68-69:245-262
12. Hamberg M, and Samuelsson B. Prostaglandin endoperoxides: Novel transformations of arachidonic acid in human platelets. Proc Natl Acad Sci U S A 1974;71:3400-3404
13. Nugteren DH. Arachidonate lipoxygenase in blood platelets. Biochim Biophys Acta 1975;380:299-307
14. Heidt M, Furstenberger G, Vogel S, Marks F, and Krieg P. Diversity of mouse lipoxygenases: Identification of a subfamily of epidermal isozymes exhibiting a differentiation-dependent mRNA expression pattern. Lipids 2000;35:701-707
15. Nyby MD, Sasaki M, Ideguchi Y, Wynne HE, Hori MT, Berger ME, Golub MS, Brickman AS, and Tuck ML. Platelet lipoxygenase inhibitors attenuate thrombin-And thromboxane mimetic-induced intracellular calcium mobilization and platelet aggregation. J Pharmacol Exp Therap 1996;278:503-509
16. Sekiya F, Takagi J, Usui T, Kawajiri K, Kobayashi Y, Sato F, and Saito Y. 12S-Hydroxyeicosatetraenoic acid plays a central role in the regulation of platelet activation. Biochem Biophys Res Commun 1991;179:345-351
17. Setty BN, Werner MH, Hannun YA, and Stuart MJ. 15-Hydroxyeicosatetraenoic acid-mediated potentiation of thrombin-induced platelet functions occurs via enhanced production of phosphoinositide-derived second messengers-sn-1,2- diacylglycerol and inositol-1,4,5-Trisphosphate. Blood 1992;80:2765-2773
18. Preston IR, Hill NS, Warburton RR, and Fanburg BL. Role of 12-lipoxygenase in hypoxia-induced rat pulmonary artery smooth muscle cell proliferation. American J Physiol Lung Cell Mol Physiol 2006;290:L367-L374
19. Nieves D, and Moreno JJ. Enantioselective effect of 12(S)- hydroxyeicosatetraenoic acid on 3T6 fibroblast growth through ERK 1/2 and p38 MAPK pathways and cyclin D1 activation. Biochem Pharmacol 2008;76:654-661
20. Sauer H, Wartenberg M, and Hescheler J. Reactive oxygen species as intracellular messengers during cell growth and differentiation. Cell Physiol Biochem 2001;11:173-186
21. Chiarugi P, Pani G, Giannoni E, Taddei L, Colavitti R, Raugei G, Symons M, Borrello S, Galeotti T, and Ramponi G. Reactive oxygen species as essential mediators of cell adhesion: The oxidative inhibition of a FAK tyrosine phosphatase is required for cell adhesion. J Cell Biol 2003;161:933-944
22. Taddei ML, Parri M, Mello T, Catalano A, Levine AD, Raugei G, Ramponi G, and Chiarugi P. Integrin-mediated cell adhesion and spreading engage different sources of reactive oxygen species. Antioxidants Redox Signal 2007;9:469-481
23. Bokoch GM, and Knaus UG. NADPH oxidases: Not just for leukocytes anymore! Trends Biochem Sci 2003;28:502-508
24. Powell WS, and Rokach J. Biochemistry, biology and chemistry of the 5-lipoxygenase product 5-oxo-ETE. Prog Lipid Res 2005;44: 154-183
25. Woo CH, You HJ, Cho SH, Eom YW, Chun JS, Yoo YJ, and Kim JH. Leukotriene B(4) stimulates Rac-ERK cascade to generate reactive oxygen species that mediates chemotaxis. J Biol Chem 2002;277:8572-8578
26. Sumiya T, Fujimoto Y, Nishida H, Morikawa Y, Sakuma S, and Fujita T. Effects of reactive oxygen species on arachidonic acid metabolism in rabbit platelets. Free Radic Biol Med 1993;15: 101-104
27. Li J, Wang H, and Rosenberg PA. Vitamin K prevents oxidative cell death by inhibiting activation of 12-lipoxygenase in developing oligodendrocytes. J Neurosci Res 2009;87: 1997-2005
28. Campbell JH, and Campbell GR. Culture techniques and their applications to studies of vascular smooth muscle. Clin Sci (Lond) 1993;85:501-513
29. Cory AH, Owen TC, Barltrop JA, and Cory JG. Use of an aqueous soluble tetrazolium/formazan assay for cell growth assays in culture. Cancer Commun 1991;3:207-212
30. Wang H and Joseph JA. Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader. Free Radic Biol Med 1999;27:612-616
31. Coffey MJ, Jarvis GE, Gibbins JM, Coles B, Barrett NE, Wylie OR, and O'Donnell VB. Platelet 12-lipoxygenase activation via glycoprotein VI: Involvement of multiple signaling pathways in agonist control of H(P)ETE synthesis. Circ Res 2004;94:1598-1605
32. Kornerup K and Page C. The role of platelets in the pathophysiology of asthma. Platelets 2007;18:319-328
33. Pitchford S. Novel usees for anti-platelet agents as antiinflammatory drugs. Brit J Pharmacol 2007;152:987-1002
34. Yeung J, Apopa PL, Vesci J, Kenyon V, Rai G, Jadhav A, Simeonov A, Holman TR, Maloney DJ, Boutaud O, et al. Protein kinase C regulation of 12-lipoxygenase-mediated human platelet activation. Mol Pharmacol 2012;81:420-430
35. Morgan LT, Thomas CP, Kuhn H, and O'Donnell VB. Thrombinactivated human platelets acutely generate oxidized docosahexaenoic-Acid-containing phospholipids via 12-lipoxygenase. Biochem J 2010;431:141-148
36. Nardi MA, Gor Y, Feinmark SJ, Xu F and Karpatkin S. Platelet particle formation by anti GPIIIa49-66 Ab, Ca2 ionophore A23187, and phorbol myristate acetate is induced by reactive oxygen species and inhibited by dexamethasone blockade of platelet phospholipase A2, 12-lipoxygenase, and NADPH oxidase. Blood 2007;110:1989-1996