Thrombin-activated human platelets acutely generate oxidized docosahexaenoic-acid-containing phospholipids via 12-lipoxygenase

Biochemical Journal

Volumn 431, Issue 1, 2010, Pages 141-148

  Morgan, Lloyd T ^a   Thomas, Christopher P ^a   Kühn, Hartmut ^b   O'Donnell, Valerie B ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b HUMBOLDT UNIVERSITY   (Germany)

Author keywords

Docosahexanoic acid; Lipoxygenase; Mass spectrometry; Phospholipid; Platelet; Thrombin

Indexed keywords

ACIDS; CALCIUM; ESTERS; ISOMERS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PHOSPHOLIPIDS;

ACTIVATED PLATELETS; ARACHIDONATE; DOCOSAHEXAENOIC ACID; DOCOSAHEXANOIC ACID; LIPOXYGENASES; OXIDIZED PHOSPHOLIPIDS; POSITIONAL ISOMERS; TANDEM MS; THROMBIN;

PLATELETS;

ARACHIDONATE 12 LIPOXYGENASE; DOCOSAHEXAENOIC ACID; HYDROXYDOCOSAHEXAENOIC ACID; PHOSPHATIDYLETHANOLAMINE; PHOSPHOLIPID; THROMBIN; UNCLASSIFIED DRUG; RECOMBINANT PROTEIN;

ARTICLE; ESTERIFICATION; HUMAN; HUMAN CELL; ISOMER; LIPID OXIDATION; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN STRUCTURE; REVERSED PHASE LIQUID CHROMATOGRAPHY; TANDEM MASS SPECTROMETRY; THROMBOCYTE ACTIVATION; CHEMISTRY; ENZYMOLOGY; GENETICS; MASS SPECTROMETRY; METABOLISM; OXIDATION REDUCTION REACTION; THROMBOCYTE;

ARACHIDONATE 12-LIPOXYGENASE; BLOOD PLATELETS; DOCOSAHEXAENOIC ACIDS; HUMANS; MASS SPECTROMETRY; OXIDATION-REDUCTION; PHOSPHATIDYLETHANOLAMINES; PHOSPHOLIPIDS; RECOMBINANT PROTEINS; THROMBIN;

EID: 77956621962     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20100415     Document Type: Article

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