Chronic ketamine exposure induces permanent impairment of brain functions in adolescent cynomolgus monkeys

Addiction Biology

Volumn 19, Issue 2, 2014, Pages 185-194

  Sun, Lin ^a   Li, Qi ^b   Li, Qing ^a   Zhang, Yuzhe ^a   Liu, Dexiang ^a   Jiang, Hong ^a   Pan, Fang ^a   Yew, David T ^c,d  

^a SHANDONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

^c Prince of Wales Hospital   (Hong Kong)

^d CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

apoptosis; behavioral depression; cynomolgus monkeys; ketamine; prefrontal cortex

Indexed keywords

CASPASE 3; DNA NUCLEOTIDYLEXOTRANSFERASE; KETAMINE; PROTEIN BAX; PROTEIN BCL 2; AMINO ACID RECEPTOR BLOCKING AGENT; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BODY WEIGHT; BRAIN DISEASE; BRAIN FUNCTION; CELL DEATH; CONTROLLED STUDY; FUNCTIONAL DISEASE; LOCOMOTION; LONG TERM EXPOSURE; MACACA FASCICULARIS; MALE; MENTAL TASK; NEUROTOXICITY; NICK END LABELING; NONHUMAN; OUTCOME ASSESSMENT; PERMANENT BRAIN IMPAIRMENT; PREFRONTAL CORTEX; PRIORITY JOURNAL; ADDICTION; ADOLESCENT; ANALYSIS OF VARIANCE; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICALLY INDUCED; CHRONIC DISEASE; COGNITIVE DEFECT; DISEASE MODEL; DRUG EFFECTS; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MEMORY DISORDER; METABOLISM; MOTOR ACTIVITY; PATHOPHYSIOLOGY; PROCEDURES; RANDOMIZATION; WEIGHT GAIN; WESTERN BLOTTING; YOUNG ADULT;

ADOLESCENT; ANALYSIS OF VARIANCE; ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BEHAVIOR, ANIMAL; BLOTTING, WESTERN; CASPASE 3; CHRONIC DISEASE; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; EXCITATORY AMINO ACID ANTAGONISTS; HUMANS; IN SITU NICK-END LABELING; INJECTIONS, INTRAVENOUS; KETAMINE; MACACA FASCICULARIS; MALE; MEMORY DISORDERS; MOTOR ACTIVITY; PREFRONTAL CORTEX; PROTO-ONCOGENE PROTEINS C-BCL-2; RANDOM ALLOCATION; RECEPTORS, N-METHYL-D-ASPARTATE; SUBSTANCE-RELATED DISORDERS; WEIGHT GAIN; YOUNG ADULT;

EID: 84894432563     PISSN: 13556215     EISSN: 13691600     Source Type: Journal    
DOI: 10.1111/adb.12004     Document Type: Article

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