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Volumn 8, Issue 1, 2014, Pages

Simple, sensitive and rapid determination of linifanib (ABT-869), a novel tyrosine kinase inhibitor in rat plasma by UHPLC-MS/MS

Author keywords

ABT 869; Linifanib; Pharmacokinetics; Rat plasma; UHPLC MS MS

Indexed keywords


EID: 84894362245     PISSN: None     EISSN: 1752153X     Source Type: Journal    
DOI: 10.1186/1752-153X-8-13     Document Type: Article
Times cited : (7)

References (19)
  • 1
    • 0038476608 scopus 로고    scopus 로고
    • Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
    • 10.1172/JCI200317929, 154450, 12727920
    • Bergers G, Song S, Meyer-Morse N, Bergsland E, Hanahan D. Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. J Clin Invest 2003, 111(9):1287-1295. 10.1172/JCI200317929, 154450, 12727920.
    • (2003) J Clin Invest , vol.111 , Issue.9 , pp. 1287-1295
    • Bergers, G.1    Song, S.2    Meyer-Morse, N.3    Bergsland, E.4    Hanahan, D.5
  • 2
    • 1442290142 scopus 로고    scopus 로고
    • Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms
    • Erber R, Thurnher A, Katsen AD, Groth G, Kerger H, Hammes HP, Menger MD, Ullrich A, Vajkoczy P. Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms. FASEB J 2004, 18(2):338-340.
    • (2004) FASEB J , vol.18 , Issue.2 , pp. 338-340
    • Erber, R.1    Thurnher, A.2    Katsen, A.D.3    Groth, G.4    Kerger, H.5    Hammes, H.P.6    Menger, M.D.7    Ullrich, A.8    Vajkoczy, P.9
  • 3
    • 34147137124 scopus 로고    scopus 로고
    • Discovery of N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N'-(2-fluoro-5-methylphenyl)urea (ABT-869), a 3-aminoindazole-based orally active multitargeted receptor tyrosine kinase inhibitor
    • 10.1021/jm061280h, 17343372
    • Dai Y, Hartandi K, Ji Z, Ahmed AA, Albert DH, Bauch JL, Bouska JJ, Bousquet PF, Cunha GA, Glaser KB, et al. Discovery of N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N'-(2-fluoro-5-methylphenyl)urea (ABT-869), a 3-aminoindazole-based orally active multitargeted receptor tyrosine kinase inhibitor. J Med Chem 2007, 50(7):1584-1597. 10.1021/jm061280h, 17343372.
    • (2007) J Med Chem , vol.50 , Issue.7 , pp. 1584-1597
    • Dai, Y.1    Hartandi, K.2    Ji, Z.3    Ahmed, A.A.4    Albert, D.H.5    Bauch, J.L.6    Bouska, J.J.7    Bousquet, P.F.8    Cunha, G.A.9    Glaser, K.B.10
  • 5
    • 33646559845 scopus 로고    scopus 로고
    • Inhibition of phosphorylation of the colony-stimulating factor-1 receptor (c-Fms) tyrosine kinase in transfected cells by ABT-869 and other tyrosine kinase inhibitors
    • 10.1158/1535-7163.MCT-05-0359, 16648572
    • Guo J, Marcotte PA, McCall JO, Dai Y, Pease LJ, Michaelides MR, Davidsen SK, Glaser KB. Inhibition of phosphorylation of the colony-stimulating factor-1 receptor (c-Fms) tyrosine kinase in transfected cells by ABT-869 and other tyrosine kinase inhibitors. Mol Cancer Ther 2006, 5(4):1007-1013. 10.1158/1535-7163.MCT-05-0359, 16648572.
    • (2006) Mol Cancer Ther , vol.5 , Issue.4 , pp. 1007-1013
    • Guo, J.1    Marcotte, P.A.2    McCall, J.O.3    Dai, Y.4    Pease, L.J.5    Michaelides, M.R.6    Davidsen, S.K.7    Glaser, K.B.8
  • 7
    • 84984559340 scopus 로고    scopus 로고
    • Phase 2 trial of linifanib (ABT-869) in patients with unresectable or metastatic hepatocellular carcinoma
    • 10.1002/cncr.27758, 22833179
    • Toh HC, Chen PJ, Carr BI, Knox JJ, Gill S, Ansell P, McKeegan EM, Dowell B, Pedersen M, Qin Q, et al. Phase 2 trial of linifanib (ABT-869) in patients with unresectable or metastatic hepatocellular carcinoma. Cancer 2013, 119(2):380-387. 10.1002/cncr.27758, 22833179.
    • (2013) Cancer , vol.119 , Issue.2 , pp. 380-387
    • Toh, H.C.1    Chen, P.J.2    Carr, B.I.3    Knox, J.J.4    Gill, S.5    Ansell, P.6    McKeegan, E.M.7    Dowell, B.8    Pedersen, M.9    Qin, Q.10
  • 9
    • 84888001200 scopus 로고    scopus 로고
    • Exposure-response (safety) analysis to identify linifanib dose for a phase III study in patients with hepatocellular carcinoma
    • 10.1016/j.clinthera.2013.09.002, 24094464
    • Chiu YL, Carlson DM, Pradhan RS, Ricker JL. Exposure-response (safety) analysis to identify linifanib dose for a phase III study in patients with hepatocellular carcinoma. Clin Ther 2013, 35(11):1770-1777. 10.1016/j.clinthera.2013.09.002, 24094464.
    • (2013) Clin Ther , vol.35 , Issue.11 , pp. 1770-1777
    • Chiu, Y.L.1    Carlson, D.M.2    Pradhan, R.S.3    Ricker, J.L.4
  • 10
    • 84863796413 scopus 로고    scopus 로고
    • An open-label, phase 1 study evaluating safety, tolerability, and pharmacokinetics of linifanib (ABT-869) in Japanese patients with solid tumors
    • 10.1007/s00280-012-1846-6, 3362725, 22382879
    • Asahina H, Tamura Y, Nokihara H, Yamamoto N, Seki Y, Shibata T, Goto Y, Tanioka M, Yamada Y, Coates A, et al. An open-label, phase 1 study evaluating safety, tolerability, and pharmacokinetics of linifanib (ABT-869) in Japanese patients with solid tumors. Cancer Chemother Pharmacol 2012, 69(6):1477-1486. 10.1007/s00280-012-1846-6, 3362725, 22382879.
    • (2012) Cancer Chemother Pharmacol , vol.69 , Issue.6 , pp. 1477-1486
    • Asahina, H.1    Tamura, Y.2    Nokihara, H.3    Yamamoto, N.4    Seki, Y.5    Shibata, T.6    Goto, Y.7    Tanioka, M.8    Yamada, Y.9    Coates, A.10
  • 11
    • 70350464165 scopus 로고    scopus 로고
    • Phase I and biomarker study of ABT-869, a multiple receptor tyrosine kinase inhibitor, in patients with refractory solid malignancies
    • 10.1200/JCO.2008.21.7125, 19720910
    • Wong CI, Koh TS, Soo R, Hartono S, Thng CH, McKeegan E, Yong WP, Chen CS, Lee SC, Wong J, et al. Phase I and biomarker study of ABT-869, a multiple receptor tyrosine kinase inhibitor, in patients with refractory solid malignancies. J Clin Oncol 2009, 27(28):4718-4726. 10.1200/JCO.2008.21.7125, 19720910.
    • (2009) J Clin Oncol , vol.27 , Issue.28 , pp. 4718-4726
    • Wong, C.I.1    Koh, T.S.2    Soo, R.3    Hartono, S.4    Thng, C.H.5    McKeegan, E.6    Yong, W.P.7    Chen, C.S.8    Lee, S.C.9    Wong, J.10
  • 12
    • 33750013392 scopus 로고    scopus 로고
    • A high-throughput, fully automated liquid/liquid extraction liquid chromatography/mass spectrometry method for the quantitation of a new investigational drug ABT-869 and its metabolite A-849529 in human plasma samples
    • 10.1002/rcm.2703, 16969771
    • Rodila RC, Kim JC, Ji QC, El-Shourbagy TA. A high-throughput, fully automated liquid/liquid extraction liquid chromatography/mass spectrometry method for the quantitation of a new investigational drug ABT-869 and its metabolite A-849529 in human plasma samples. Rapid Commun Mass Spectrom 2006, 20(20):3067-3075. 10.1002/rcm.2703, 16969771.
    • (2006) Rapid Commun Mass Spectrom , vol.20 , Issue.20 , pp. 3067-3075
    • Rodila, R.C.1    Kim, J.C.2    Ji, Q.C.3    El-Shourbagy, T.A.4
  • 13
    • 57849137291 scopus 로고    scopus 로고
    • Simultaneous determination of a hydrophobic drug candidate and its metabolite in human plasma with salting-out assisted liquid/liquid extraction using a mass spectrometry friendly salt
    • 10.1016/j.jpba.2008.09.002, 18926659
    • Wu H, Zhang J, Norem K, El-Shourbagy TA. Simultaneous determination of a hydrophobic drug candidate and its metabolite in human plasma with salting-out assisted liquid/liquid extraction using a mass spectrometry friendly salt. J Pharm Biomed Anal 2008, 48(4):1243-1248. 10.1016/j.jpba.2008.09.002, 18926659.
    • (2008) J Pharm Biomed Anal , vol.48 , Issue.4 , pp. 1243-1248
    • Wu, H.1    Zhang, J.2    Norem, K.3    El-Shourbagy, T.A.4
  • 14
    • 84863641625 scopus 로고    scopus 로고
    • UPLC: a preeminent technique in pharmaceutical analysis
    • Kumar A, Saini G, Nair A, Sharma R. UPLC: a preeminent technique in pharmaceutical analysis. Acta Pol Pharm 2012, 69(3):371-380.
    • (2012) Acta Pol Pharm , vol.69 , Issue.3 , pp. 371-380
    • Kumar, A.1    Saini, G.2    Nair, A.3    Sharma, R.4
  • 15
    • 39749129773 scopus 로고    scopus 로고
    • A novel 'peak parking' strategy for ultra-performance liquid chromatography/tandem mass spectrometric detection for enhanced performance of bioanalytical assays
    • 10.1002/rcm.3389, 18215007
    • Li F, Maguigad J, Pelzer M, Jiang X, Ji QC. A novel 'peak parking' strategy for ultra-performance liquid chromatography/tandem mass spectrometric detection for enhanced performance of bioanalytical assays. Rapid Commun Mass Spectrom 2008, 22(4):486-494. 10.1002/rcm.3389, 18215007.
    • (2008) Rapid Commun Mass Spectrom , vol.22 , Issue.4 , pp. 486-494
    • Li, F.1    Maguigad, J.2    Pelzer, M.3    Jiang, X.4    Ji, Q.C.5
  • 16
    • 30144444985 scopus 로고    scopus 로고
    • Advantages of application of UPLC in pharmaceutical analysis
    • 10.1016/j.talanta.2005.06.035, 18970409
    • Novakova L, Matysova L, Solich P. Advantages of application of UPLC in pharmaceutical analysis. Talanta 2006, 68(3):908-918. 10.1016/j.talanta.2005.06.035, 18970409.
    • (2006) Talanta , vol.68 , Issue.3 , pp. 908-918
    • Novakova, L.1    Matysova, L.2    Solich, P.3
  • 17
    • 0037621007 scopus 로고    scopus 로고
    • Guidance for industry on bioanalytical method validation
    • Rockville, MD: Department of Health and Human Services, US Food and Drug Administration, Center for Drug Evaluation and Research (CDER)
    • US Food and Drug Administration, Center for Drug Evaluation and Research (CDER) Guidance for industry on bioanalytical method validation. 2001, Rockville, MD: Department of Health and Human Services, [http://www.fda.gov/downloads/Drugs/Guidances/ucm070107.pdf], US Food and Drug Administration, Center for Drug Evaluation and Research (CDER).
    • (2001)
  • 18
    • 81055146012 scopus 로고    scopus 로고
    • Guideline on bioanalytical method validation, 2011
    • European Medicines Agency
    • European Medicines Agency Guideline on bioanalytical method validation, 2011. [http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2011/08/WC500109686.pdf], European Medicines Agency.
  • 19
    • 0014147006 scopus 로고
    • Composition of phospholipids and of phospholipid fatty acids of human plasma
    • Phillips GB, Dodge JT. Composition of phospholipids and of phospholipid fatty acids of human plasma. J Lipid Res 1967, 8(6):676-681.
    • (1967) J Lipid Res , vol.8 , Issue.6 , pp. 676-681
    • Phillips, G.B.1    Dodge, J.T.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.