Agomelatine in the tree shrew model of depression: Effects on stress-induced nocturnal hyperthermia and hormonal status

European Neuropsychopharmacology

Volumn 24, Issue 3, 2014, Pages 437-447

  Schmelting, Barthel ^a,c   Corbach Söhle, Silke ^a,d   Kohlhause, Susan ^a   Schlumbohm, Christina ^a   Flügge, Gabriele ^a,b   Fuchs, Eberhard ^a,b  

^a GERMAN PRIMATE CENTER   (Germany)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

^c UNIVERSITY OF LÜBECK   (Germany)

^d ETH ZURICH   (Switzerland)

Author keywords

Cortisol; Fluoxetine; Melatonin; Norepinephrine; S32006; Telemetry

Indexed keywords

ACETAMIDE DERIVATIVE; AGOMELATINE; ANTIDEPRESSANT AGENT; CENTRAL DEPRESSANT AGENT; FLUOXETINE; HYDROCORTISONE; INDOLE DERIVATIVE; MELATONIN; NORADRENALIN; PYRIDINE DERIVATIVE; S32006; SEROTONIN 2 ANTAGONIST;

ANIMAL; BODY TEMPERATURE; BODY WEIGHT; CIRCADIAN RHYTHM; DEPRESSIVE DISORDER; DRUG EFFECTS; DRUG THERAPY; FEVER; MALE; MENTAL STRESS; MOTOR ACTIVITY; PATHOPHYSIOLOGY; SCANDENTIA; URINE;

ACETAMIDES; ANIMALS; ANTIDEPRESSIVE AGENTS; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; BODY TEMPERATURE; BODY WEIGHT; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CIRCADIAN RHYTHM; DEPRESSIVE DISORDER; FEVER; FLUOXETINE; HYDROCORTISONE; INDOLES; MALE; MELATONIN; MOTOR ACTIVITY; NOREPINEPHRINE; PYRIDINES; SEROTONIN 5-HT2 RECEPTOR ANTAGONISTS; STRESS, PSYCHOLOGICAL; TUPAIIDAE;

EID: 84894346505     PISSN: 0924977X     EISSN: 18737862     Source Type: Journal    
DOI: 10.1016/j.euroneuro.2013.07.010     Document Type: Article

References (50)

1. Avery D.H., Shah S.H., Eder D.N., Wildschiodtz G. Nocturnal sweating and temperature in depression. Acta Psychiatry Scand. 1999, 100:295-301.
2. Brown G.W. Life events and affective disorder: replications and limitations. Psychosom. Med. 1993, 55:248-259.
3. Chenu F., El Mansari M., Blier P. Electrophysiological effects of repeated administration of agomelatine on the dopamine, norepinephrine, and serotonin systems in the rat brain. Neuropsychopharmacology 2013, 38:275-284.
4. Conboy L., Tanrikut C., Zoladz P.R., Campbell A.M., Park C.R., Gabriel C., Mocaer E., Sandi C., Diamond D.M. The antidepressant agomelatine blocks the adverse effects of stress on memory and enables spatial learning to rapidly increase neural cell adhesion molecule (NCAM) expression in the hippocampus of rats. Int. J. Neuropsychopharmacol. 2009, 12:329-341.
5. Czéh B., Michaelis T., Watanabe T., Frahm J., de Biurrun G., van Kampen M., Bartolomucci A., Fuchs E. Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine. Proc. Nat. Acad. Sci. U.S.A 2001, 98:12796-12801.
6. Czéh B., Simon M., Schmelting B., Hiemke C., Fuchs E. Astroglial plasticity in the hippocampus is affected by chronic psychosocial stress and concomitant fluoxetine treatment. Neuropsychopharmacology 2006, 31:1616-1626.
7. Dagyte G., Crescente I., Postema F., Seguin L., Gabriel C., Mocaer E., Boer J.A., Koolhaas J.M. Agomelatine reverses the decrease in hippocampal cell survival induced by chronic mild stress. Behav. Brain Res. 2011, 218:121-128.
8. de Bodinat C., Guardiola-Lemaitre B., Mocaer E., Renard P., Munoz C., Millan M.J. Agomelatine, the first melatonergic antidepressant: discovery, characterization and development. Nat. Rev. Drug Discovery 2010, 9:628-642.
9. Dekeyne A., Mannoury la Cour C., Gobert A., Brocco M., Lejeune F., Serres F., Sharp T., Daszuta A., Soumier A., Papp M., Rivet J.M., Flik G., Cremers T.I., Muller O., Lavielle G., Millan M.J. S32006, a novel 5-HT2C receptor antagonist displaying broad-based antidepressant and anxiolytic properties in rodent models. Psychopharmacology (Berl) 2008, 199:549-568.
10. Descamps A., Rousset C., Millan M.J., Spedding M., Delagrange P., Cespuglio R. Influence of the novel antidepressant and melatonin agonist/serotonin2C receptor antagonist, agomelatine, on the rat sleep-wake cycle architecture. Psychopharmacology (Berl) 2009, 205:93-106.
11. Fuchs E., Corbach-Söhle S. Tree shrews. The UFAW Handbook on the Care and Management of Laboratory Animals and other Research Animals 2010, 262-275. Wiley-Blackwell, Chichester. R. Hubrecht, J. Kirkwood (Eds.).
12. Fuchs E., Czéh B., Flugge G. Examining novel concepts of the pathophysiology of depression in the chronic psychosocial stress paradigm in tree shrews. Behav. Pharmacol. 2004, 15:315-325.
13. Fuchs E., Flugge G. Social stress in tree shrews: effects on physiology, brain function, and behavior of subordinate individuals. Pharmacol. Biochem. Behav. 2002, 73:247-258.
14. Fuchs E., Johren O., Flugge G. Psychosocial conflict in the tree shrew: effects on sympathoadrenal activity and blood pressure. Psychoneuroendocrinology 1993, 18:557-565.
15. Fuchs E., Schumacher M. Psychosocial stress affects pineal function in the tree shrew (Tupaia belangeri). Physiol. Behav. 1990, 47:713-717.
16. Hayashida S., Oka T., Mera T., Tsuji S. Repeated social defeat stress induces chronic hyperthermia in rats. Physiol. Behav. 2010, 101:124-131.
17. Heisler L.K., Pronchuk N., Nonogaki K., Zhou L., Raber J., Tung L., Yeo G.S., O'Rahilly S., Colmers W.F., Elmquist J.K., Tecott L.H. Serotonin activates the hypothalamic-pituitary-adrenal axis via serotonin 2C receptor stimulation. J. Neurosci. 2007, 27:6956-6964.
18. Hickie I.B., Rogers N.L. Novel melatonin-based therapies: potential advances in the treatment of major depression. Lancet 2011, 378:621-631.
19. Kendler K.S., Karkowski L.M., Prescott C.A. Causal relationship between stressful life events and the onset of major depression. Am. J. Psychiatry 1999, 156:837-841.
20. Kohlhause S., Hoffmann K., Schlumbohm C., Fuchs E., Flugge G. Nocturnal hyperthermia induced by social stress in male tree shrews: relation to low testosterone and effects of age. Physiol. Behav. 2011, 104:786-795.
21. Koolhaas J.M., Bartolomucci A., Buwalda B., de Boer S.F., Flugge G., Korte S.M., Meerlo P., Murison R., Olivier B., Palanza P., Richter-Levin G., Sgoifo A., Steimer T., Stiedl O., van Dijk G., Wohr M., Fuchs E. Stress revisited: a critical evaluation of the stress concept. Neurosci. Biobehav. Rev. 2011, 35:1291-1301.
22. Koresh O., Kozlovsky N., Kaplan Z., Zohar J., Matar M.A., Cohen H. The long-term abnormalities in circadian expression of Period 1 and Period 2 genes in response to stress is normalized by agomelatine administered immediately after exposure. Eur. Neuropsychopharmacol 2012, 22:205-221.
23. Kozicz T., Bordewin L.A., Czéh B., Fuchs E., Roubos E.W. Chronic psychosocial stress affects corticotropin-releasing factor in the paraventricular nucleus and central extended amygdala as well as urocortin 1 in the non-preganglionic Edinger-Westphal nucleus of the tree shrew. Psychoneuroendocrinology 2008, 33:741-754.
24. Kramer M., Hiemke C., Fuchs E. Chronic psychosocial stress and antidepressant treatment in tree shrews: time-dependent behavioral and endocrine effects. Neurosci. Biobehav. Rev. 1999, 23:937-947.
25. Kurre J., Fuchs E. Measuring the spontaneous activity of tree shrews (Tupaia belangeri) with passive infrared detectors. Z. Versuchstierkd 1988, 31:105-110.
26. Ladurelle N., Gabriel C., Viggiano A., Mocaer E., Baulieu E.E., Bianchi M. Agomelatine (S20098) modulates the expression of cytoskeletal microtubular proteins, synaptic markers and BDNF in the rat hippocampus, amygdala and PFC. Psychopharmacology (Berl) 2012, 221:493-509.
27. Legros C., Chalivoix S., Gabriel C., Mocaer E., Delagrange P., Fuchs E., Malpaux B. First evidence of melatonin receptors distribution in the suprachiasmatic nucleus of tree shrew brain. Neuro Endocrinol. Lett 2007, 28:267-273.
28. Leproult R., Van Onderbergen A., L'Hermite-Baleriaux M., Van Cauter E., Copinschi G. Phase-shifts of 24-h rhythms of hormonal release and body temperature following early evening administration of the melatonin agonist agomelatine in healthy older men. Clin. Endocrinol. (Oxf) 2005, 63:298-304.
29. Mairesse J., Silletti V., Laloux C., Zuena A.R., Giovine A., Consolazione M., van Camp G., Malagodi M., Gaetani S., Cianci S., Catalani A., Mennuni G., Mazzetta A., van Reeth O., Gabriel C., Mocaer E., Nicoletti F., Morley-Fletcher S., Maccari S. Chronic agomelatine treatment corrects the abnormalities in the circadian rhythm of motor activity and sleep/wake cycle induced by prenatal restraint stress in adult rats. Int. J. Neuropsychopharmacol. 2013, 16:323-338.
30. Meerlo P., De Boer S.F., Koolhaas J.M., Daan S., Van den Hoofdakker R.H. Changes in daily rhythms of body temperature and activity after a single social defeat in rats. Physiol. Behav. 1996, 59:735-739.
31. Meinrath M., D'Amato M.R. Interrelationships among heart rate, activity, and body temperature in the rat. Physiol. Behav. 1979, 22:491-498.
32. Moffitt J.A., Johnson A.K. Short-term fluoxetine treatment enhances baroreflex control of sympathetic nervous system activity after hindlimb unloading. Am. J. Physiol. Regul. Integr. Comp. Physiol 2004, 286:R584-R590.
33. Morley-Fletcher S., Mairesse J., Soumier A., Banasr M., Fagioli F., Gabriel C., Mocaer E., Daszuta A., McEwen B., Nicoletti F., Maccari S. Chronic agomelatine treatment corrects behavioral, cellular, and biochemical abnormalities induced by prenatal stress in rats. Psychopharmacology (Berl) 2011, 217:301-313.
34. Oka T., Oka K., Hori T. Mechanisms and mediators of psychological stress-induced rise in core temperature. Psychosom. Med. 2001, 63:476-486.
35. Pariante C.M., Lightman S.L. The HPA axis in major depression: classical theories and new developments. Trends Neurosci. 2008, 31:464-468.
36. Racagni G., Riva M.A., Molteni R., Musazzi L., Calabrese F., Popoli M., Tardito D. Mode of action of agomelatine: synergy between melatonergic and 5-HT2C receptors. World J. Biol. Psychiatry 2011, 12:574-587.
37. Saper C.B., Scammell T.E., Lu J. Hypothalamic regulation of sleep and circadian rhythms. Nature 2005, 437:1257-1263.
38. Seeman T.E., McEwen B.S., Singer B.H., Albert M.S., Rowe J.W. Increase in urinary cortisol excretion and memory declines: MacArthur studies of successful aging. J. Clin. Endocrinol. Metab. 1997, 82:2458-2465.
39. Sgoifo A., Koolhaas J.M., Musso E., De Boer S.F. Different sympathovagal modulation of heart rate during social and nonsocial stress episodes in wild-type rats. Physiol. Behav. 1999, 67:733-738.
40. Souetre E., Salvati E., Wehr T.A., Sack D.A., Krebs B., Darcourt G. Twenty-four-hour profiles of body temperature and plasma TSH in bipolar patients during depression and during remission and in normal control subjects. Am. J. Psychiatry 1988, 145:1133-1137.
41. Stöhr W. Heart rate of tree shrews and its persistent modification by social contact. Biological Factors in Cardiovascular Disease 1986, 492-499. Springer Verlag, Berlin. T.H. Schmidt, T.M. Dembrowski, G. Blümchen (Eds.).
42. Tardito D., Milanese M., Bonifacino T., Musazzi L., Grilli M., Mallei A., Mocaer E., Gabriel-Gracia C., Racagni G., Popoli M., Bonanno G. Blockade of stress-induced increase of glutamate release in the rat prefrontal/frontal cortex by agomelatine involves synergy between melatonergic and 5-HT2C receptor-dependent pathways. BMC Neurosci 2010, 11:68.
43. Tardito D., Molteni R., Popoli M., Racagni G. Synergistic mechanisms involved in the antidepressant effects of agomelatine. Eur. Neuropsychopharmacol. 2012, 22(Suppl. 3):482-486.
44. Tuma J., Strubbe J.H., Mocaer E., Koolhaas J.M. S20098 affects the free-running rhythms of body temperature and activity and decreases light-induced phase delays of circadian rhythms of the rat. Chronobiol. Int 2001, 18:781-799.
45. van der Hart M.G., Czéh B., de Biurrun G., Michaelis T., Watanabe T., Natt O., Frahm J., Fuchs E Substance P receptor antagonist and clomipramine prevent stress-induced alterations in cerebral metabolites, cytogenesis in the dentate gyrus and hippocampal volume. Mol. Psychiatry 2002, 7:933-941.
46. Van der Heyden J.A., Zethof T.J., Olivier B. Stress-induced hyperthermia in singly housed mice. Physiol. Behav. 1997, 62:463-470.
47. Vinkers C.H., van Bogaert M.J., Klanker M., Korte S.M., Oosting R., Hanania T., Hopkins S.C., Olivier B., Groenink L. Translational aspects of pharmacological research into anxiety disorders: the stress-induced hyperthermia (SIH) paradigm. Eur. J. Pharmacol. 2008, 585:407-425.
48. Watson S., Gallagher P., Del-Estal D., Hearn A., Ferrier I.N., Young A.H. Hypothalamic-pituitary-adrenal axis function in patients with chronic depression. Psychol. Med. 2002, 32:1021-1028.
49. Willner P., Mitchell P.J. The validity of animal models of predisposition to depression. Behav. Pharmacol. 2002, 13:169-188.
50. Winckelmann G., Maass G., Schmidt H., Lohner J. Vegetative hyperthermia: a thermoregulation disorder or a variant from the norm?. Dtsch. Med. Wochenschr. 1986, 111:1590-1594.