Mechanisms and mediators of psychological stress-induced rise in core temperature

Psychosomatic Medicine

Volumn 63, Issue 3, 2001, Pages 476-486

  Oka, Takakazu ^a,b   Oka, Kae ^a,b   Hori, Tetsuro ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b HARVARD INSTITUTES OF MEDICINE   (United States)

Author keywords

Emotional hyperthermia; Fever; Fever of unknown origin; Psychogenic fever; Stress; Stress induced hyperthermia

Indexed keywords

BENZODIAZEPINE DERIVATIVE; LIPOPOLYSACCHARIDE; PROSTAGLANDIN; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE INHIBITOR; SEROTONIN; SEROTONIN 1A AGONIST;

ANXIETY; ARTICLE; CONDITIONING; CONTROLLED STUDY; CORE TEMPERATURE; DISEASE ASSOCIATION; ENVIRONMENTAL FACTOR; FEVER; HYPERTHERMIA; LOCOMOTION; MENTAL STRESS; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PYREXIA IDIOPATHICA; RAT; STIMULUS RESPONSE; TEMPERATURE DEPENDENCE; THERMOREGULATION;

EID: 0035012146     PISSN: 00333174     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006842-200105000-00018     Document Type: Article

References (130)

1. Mackowiak PA. Normal "body" temperature. In: Mackowiak PA, editor. Fever: basic mechanisms and management. 2nd ed. Philadelphia: Lippincott-Raven Publishers; 1997. p. 207-13.
2. Kleitman N. The effect of motion pictures on body temperature. Science 1945;101:507-8.
3. Renbourn ET. Body temperature and pulse rate in boys and young men prior to sporting contests. A study of emotional hvperthermia: with a review of the literature. J Psychosom Res 1960;4:149-75.
4. Briese E. Emotional hyperthermia and performance in humans. Physiol Behav 1995;58:615-8.
5. Gotsev T, Ivanov A. Psychogenic elevation of body temperature in healthy persons. Acta Physiol Hung 1950;1:53-62.
6. Marazziti D, DiMuro A, Castrogivanni P. Psychological stress and body temperature changes in humans. Physiol Behav 1992; 52:393-5.
7. Wynn FB. The psychic factor as an element in temperature disturbance shown by some observations in the selected draft. JAMA 1919;73:31-4.
8. Falcon-Lesses M, Proger SH. Psychogenic fever. N Engl J Med 1930;203:1034-6.
9. Kintner AR, Rowntree LG. Long continued, low grade, idiopathic fever. JAMA 1934;102:889-92.
10. Reimann HA. The problem of long, continued, low grade fever. JAMA 1936;107:1089-94.
11. Ziegler LH, Cash PT. A study of the influence of emotions and affects on the surface temperature of the human body. Am J Psychiatr 1938;95:677-96.
12. Malleson N. Panic and phobia: a possible method of treatment. Lancet 1959;1:225-7.
13. Sheldon DWS. Psychogenic fever. Lancet 1959;1:835-6.
14. Henderson R, Stephenson R. Panic and phobia. Lancet 1959;1: 1049.
15. Petersdorf RG, Beeson PB. Fever of unexplained origin: report on 100 cases. Medicine (Baltimore) 1961;40:1-30.
16. Meyer R, Beck D. Psychodynamics of psychogenic fever. Z Psychosom Med Psychoanal 1976;22:169-76.
17. O'Toole JK, Dyck G. Report of psychogenic fever in catatonia responding to electroconvulsive therapy. Dis Nerv Syst 1977; 38:852-3.
18. Hasan MK, White AC. Psychogenic fever: entity or nonentity? Postgrad Med 1979;66:152-4.
19. McNeil GN, Leighton LH, Elkins AM. Possible psychogenic fever of 103.5 degrees F in a patient with borderline personality disorder. Am J Psychiatry 1984;141:896-7.
20. Weinstein L. Clinically benign fever of unknown origin: a personal retrospective. Rev Infect Dis 1985;7:692-9.
21. Ihara N. Psychogenic fever. Shouni Naika 1991;23(Suppl): 296-9.
22. Oka T, Mishima N, Nakagawa T, Oka K. Studies on the usefulness of Kampo medicines for psychogenic fever. J Jpn Assoc Orient Psychosom Med 1991;6:32-6.
23. Timmerman RJ, Thompson J, Noordzij HM, van der Meer JW. Psychogenic periodic fever. Neth J Med 1992;41:158-60.
24. Sugawara H, Oka T, Kubo C. Psychogenic fever. Jpn J Clin Exp Med 1995;72:2446-9.
25. Miric D, Venet R, Aproh E, Nguyen-Duc H. Psychogenic fever or psychogenic hyperthermia? J Am Geriatr Soc 1997;45: 1287-8.
26. Oka T, Araki T, Oka K, Kanemitsu Y, Azuma T, Akamine M, Matsuura T, Kubo C. A case of psychogenic fever effectively treated with Rikkunshi-to. J Jpn Assoc Orient Psychosom Med 1998;13:74-8.
27. Araki T, Oka T, Akamine M, Oyama N, Kubo C. Effectiveness of drawing therapy in patients with psychogenic fever [abstract]. Jpn J Psychosom Med 1998;38(Suppl):135.
28. Oka T, Oka K, Hori T, Kubo C. Studies on the mechanisms of fever in patients with psychogenic fever: are proinflammatory cytokines involved in psychogenic fever [abstract]? Jpn J Psychosom Med 1998;38(Suppl):135.
29. IUPS Thermal Commission. Glossary of terms for thermal physiology. Second edition. Pflugers Arch 1987;410:567-87.
30. Gordon CJ. A review of terms for regulated vs. forced, neurochemical-induced changes in body temperature. Life Sci 1983; 32:1285-95.
31. Britt BA. Malignant hyperthermia - a review. In: Schoenbaum E. Lomax P. editors. Thermoregulation: pathology, pharmacology, and therapy. New York: Pergamon Press; 1991. p. 179-292.
32. Kluger MJ. Fever: role of pyrogens and cryogens. Physiol Rev 1991;71:93-127.
33. Watkins LR, Maier SF, Goehler LE. Cytokine-to-brain communication: a review and analysis of alternative mechanisms. Life Sci 1995;57:1011-26.
34. 2: a putative fever mediator. In: Mackowiak PA, editor. Fever: basic mechanisms and management. Philadelphia: Lippincott-Raven; 1997. p. 117-45.
35. Hori T, Katafuchi T, Ota K, Matsuda T, Oka T, Oka K. Evidence for the involvement of AV3V in the circulating IL-1β-to-brain communication. J Thermal Biol 2000;25:29-33.
36. Hori T, Katafuchi T. Cell biology and the functions of thermosensitive neurons in the brain. Prog Brain Res 1998;115:9-23.
37. Hori T, Kiyohara T, Shibata M, Oomura Y, Nishino H, Aou S, Fujita I. Responsiveness of monkey preoptic thermosensitive neurons to non-thermal emotional stimuli. Brain Res Bull 1986;17:75-82.
38. Ogawa T. Thermal influence on palmar sweating and mental influence on generalized sweating in man. Jpn J Physiol 1975; 25:525-36.
39. Stewart J, Eikelboom R. Stress masks the hypothermic effect of naloxone in rats. Life Sci 1979;25:1165-72.
40. Singer R, Harker CT, Vander AJ, Kluger MJ. Hyperthermia induced by open-field stress is blocked by salicylate. Physiol Behav 1986;36:1179-82.
41. Briese E, De Quijada MG. Colonic temperature of rats during handling. Acta Physiol Lat Am 1970;20:97-102.
42. Blasig J, Hollt V, Bauerle U, Herz A. Involvement of endorphins in emotional hyperthermia of rats. Life Sci 1978;23:2525-31.
43. Morley RM, Conn CA, Kluger MJ, Vander AJ. Temperature regulation in biotelemetered spontaneously hypertensive rats. Am J Physiol 1990;258:R1064-9.
44. Borsini F, Lecci A, Volterra G, Meli A. A model to measure anticipatory anxiety in mice? Psychopharmacology (Berl) 1989; 98:207-11.
45. Zethof TJ, Van der Heyden JA, Tolboom JT, Olivier B. Stress-induced hyperthermia in mice: a methodological study. Physiol Behav 1994;55:109-15.
46. Yokoi Y. Effect of ambient temperature upon emotional hyperthermia and hypothermia in rabbits. J Appl Physiol 1966;21: 1795-8.
47. Snow AE, Horita A. Interaction of apomorphine and stressors in the production of hyperthermia in the rabbit. J Pharmacol Exp Ther 1982;220:335-9.
48. Cabanac M, Gosselin F. Emotional fever in the lizard Callopistes maculatus (Teiidae). Anim Behav 1993;46:200-2.
49. Kluger MJ, O'Reilly B, Shope TR, Vander AJ. Further evidence that stress hyperthermia is a fever. Physiol Behav 1987;39: 763-6.
50. Briese E, Cabanac M. Emotional fever and salicylate. In: Szelenyi Z, Szekely M, editors. Contributions to thermal physiology. Vol 32: Advances in physiological sciences. Oxford: Pergamon Press; 1980. p. 161-3.
51. Morimoto A, Watanabe T, Morimoto K, Nakamori T, Murakami N. Possible involvement of prostaglandins in psychological stress-induced responses in rats. J Physiol (Lond) 1991;443: 421-9.
52. Parrott RF, Lloyd DM. Restraint, but not frustration, induces prostaglandin-mediated hyperthermia in pigs. Physiol Behav 1995;57:1051-5.
53. Vellucci SV, Parrott RF. Prostaglandin-dependent c-Fos expression in the median preoptic nucleus of pigs subjected to restraint: correlation with hyperthermia. Neurosci Lett 1995; 198:49-51.
54. Nakane H, Shimizu N, Hori T. Stress-induced norepinephrine release in the rat prefrontal cortex measured by microdialysis. Am J Physiol 1994;267:R1559-66.
55. Abercrombie ED, Jacobs BL. Single-unit response of noradrenergic neurons in the locus coeruleus of freely moving cats. II. Adaptation to chronically presented stressful stimuli. J Neurosci 1987;7:2844-8.
56. Glavin GB. Stress and brain noradrenaline: a review. Neurosci Biobehav Rev 1985;9:233-43.
57. 2 in the preoptic area of guinea pigs. Am J Physiol 1996;271:R528-36.
58. 2 during lipopolysaccharide-induced fever in guinea pigs. Brain Res Bull 1996;39:391-9.
59. Briese E, Cabanac M. Stress hyperthermia: physiological arguments that it is a fever. Physiol Behav 1991;49:1153-7.
60. Kluger MJ, Kozal W, Leon LR, Soszynski D, Conn CA. Cytokines and fever. Neuroimmunomodulation 1995;2:216-23.
61. Leon LR, Conn CA, Glaccum M, Kluger MJ, IL-1 type I receptor mediates acute phase response to turpentine, but not lipopolysaccharide, in mice. Am J Physiol 1996;271:R1668-75.
62. Kozak W, Kluger MJ, Soszynski D, Conn CA, Rudolph K, Leon LR, Zheng H. IL-6 and IL-1 beta in fever: studies using cytokine-deficient (knockout) mice. Ann N Y Acad Sci 1998;856: 33-47.
63. Long NC, Kluger MJ, Vander AJ. Antiserum against mouse IL-1 alpha does not block stress hyperthermia or LPS fever in the rat. In: Lomax P, Schonbaum E, editors. Thermoregulation: research and clinical applications. Basel: Karger; 1989. p. 78-84.
64. Long NC, Vander AJ, Kunkel SL, Kluger MJ. Antiserum against tumor necrosis factor increases stress hyperthermia in rats. Am J Physiol 1990;258:R591-5.
65. LeMay LG, Otterness IG, Vander AJ, Kluger MJ. In vivo evidence that the rise in plasma IL 6 following injection of a fever-inducing dose of LPS is mediated by IL 1 beta. Cytokine 1990;2:199-204.
66. LeMay LG, Vander AJ, Kluger MJ. The effects of psychological stress on plasma interleukin-6 activity in rats. Physiol Behav 1990;47:957-61.
67. Soszynski D, Kozak W, Conn CA, Rudolph K, Kluger MJ. Beta-adrenoceptor antagonists suppress elevation in body temperature and increase in plasma IL-6 in rats exposed to open field. Neuroendocrinology 1996;63:459-67.
68. Oka K, Takaki A, Yagi S, Hori T. Changes of rectal temperature and plasma IL-6 level in mice induced non-inflammatory stress [abstract]. Jpn J Physiol 1997;47:S228.
69. Takaki A, Shioda S, Ito K, Maeda M, Kanemitsu Y, Yagi S, Arimura A, Hori T. Non-inflammatory stress and brain-gutliver-immune axis. In: Oomura Y, Hori T, editors. Brain and biodefence. Tokyo: Japan Scientific Societies Press; 1998. p. 155-60.
70. Long NC, Kunkel SL, Vander AJ, Kluger MJ. Antiserum against tumor necrosis factor enhances lipopolysaccharide fever in rats. Am J Physiol 1990;258:R332-7.
71. Blatteis CM, Xin L, Quan N. Neuromodulation of fever: apparent involvement of opioids. Brain Res Bull 1991;26:219-23.
72. Romanovsky AA, Shido O, Ungar AL, Blatteis CM. Peripheral naloxone attenuates lipopolysaccharide fever in guinea pigs by an action outside the blood-brain barrier. Am J Physiol 1994; 266:R1824-31.
73. Zawada WM, Clarke J, Ruwe WD. Naloxone differentially alters fevers induced by cytokines. Neurochem Int 1997;30:441-8.
74. Handler CM, Price RW, Geller EB, Adler MW. Effect of mu-selective opioid antagonists on MIP-1 beta and IL-1 beta-induced fever. Ann N Y Acad Sci 1998;856:270-3.
75. Nakashima T, Hori T, Kuriyama K, Matsuda T. Effects of interferon-alpha on the activity of preoptic thermosensitive neurons in tissue slices. Brain Res 1988;454:361-7.
76. Nakashima T, Murakami T, Murai Y, Hori T, Miyata S, Kiyohara T. Naloxone suppresses the rising phase of fever induced by interferon-alpha. Brain Res Bull 1995;37:61-6.
77. Hori T, Katafuchi T, Take S, Shimizu N. Neuroimmunomodulatory actions of hypothalamic interferon-alpha. Neuroimmunomodulation 1998;5:172-7.
78. Blasig J, Bauerle U, Herz A. Endorphin-induced hyperthermia: characterization of the exogenously and endogenously induced effects. Naunyn Schmiedebergs Arch Pharmacol 1979;309: 137-43.
79. Millan MJ, Millan MH, Herz A. The role of the ventral noradrenergic bundle in relation to endorphins in the control of core temperature, open-field and ingestive behaviour in the rat. Brain Res 1983;263:283-94.
80. Pae YS, Lai H, Horita A. Hyperthermia in the rat from handling stress blocked by naltrexone injected into the preoptic-anterior hypothalamus. Pharmacol Biochem Behav 1985;22:337-9.
81. Vidal C, Suaudeau C, Jacob J. Hyper-and hypothermia induced by non-noxious stress: effects of naloxone, diazepam and gamma-acetylenic GABA. Life Sci 1983;33:587-90.
82. Watanabe T, Morimoto A, Sakata Y, Murakami N. ACTH response induced by interleukin-1 is mediated by CRF secretion stimulated by hypothalamic PGE. Experientia 1990;46:481-4.
83. Rothwell NJ. Central effects of CRF on metabolism and energy balance. Neurosci Biobehav Rev 1990;14:263-71.
84. Morimoto A, Nakamori T, Morimoto K, Tan N, Murakami N. The central role of corticotrophin-releasing factor (CRF-41) in psychological stress in rats. J Physiol (Lond) 1993;460:221-9.
85. Nakamori T, Morimoto A, Murakami N. Effect of a central CRF antagonist on cardiovascular and thermoregulatory responses induced by stress or IL-1 beta. Am J Physiol 1993;265:R834-9.
86. Morrow LE, McClellan JL, Conn CA, Kluger MJ. Glucocorticoids alter fever and IL-6 responses to psychological stress and to lipopolysaccharide. Am J Physiol 1993;264:R1010-6.
87. Morrow LE, McClellan JL, Klir JJ, Kluger MJ. The CNS site of glucocorticoid negative feedback during LPS-and psychological stress-induced fevers. Am J Physiol 1996;271:R732-7.
88. McClellan JL, Klir JJ, Morrow LE, Kluger MJ. Central effects of glucocorticoid receptor antagonist RU-38486 on lipopolysaccharide and stress-induced fever. Am J Physiol 1994;267: R705-11.
89. Reul JM, de Kloet ER. Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation. Endocrinology 1985;117:2505-11.
90. Beckman AL. Effect of intrahypothalamic norepinephrine on thermoregulatory responses in the rat. Am J Physiol 1970;218: 1596-604.
91. Zeisberger E, Bruck K. Central effects of noradrenaline on the control of body temperature in the guinea-pig. Pflugers Arch 1971;322:152-66.
92. Hori T, Nakayama T. Effects of biogenic amines on central thermoresponsive neurones in the rabbit. J Physiol (Lond) 1973;232:71-85.
93. Hori T, Kiyohara T, Nakashima T, Shibata M. Responses of preoptic thermosensitive neurons to medial forebrain bundle stimulation. Brain Res Bull 1982;8:667-75.
94. Nakamori T, Morimoto A, Morimoto K, Tan N, Murakami N. Effects of alpha-and beta-adrenergic antagonists on rise in body temperature induced by psychological stress in rats. Am J Physiol 1993;264:R156-61.
95. Crawshaw LI. Effects of intracerebral 5-hydroxytryptamine injection on thermoregulation in rat. Physiol Behav 1972;9: 133-40.
96. Myers RD. Impairment of thermoregulation, food and water intakes in the rat after hypothalamic injections of 5,6-dihydroxytryptamine. Brain Res 1975;94:491-506.
97. Komiskey HL, Rudy TA. Serotonergic influences on brain stem thermoregulatory mechanisms in the cat. Brain Res 1977;134: 297-315.
98. Abdel-Fattah AF, Matsumoto K, el-Hady KA, Watanabe H. 5-HT1A and 5-HT2 receptors mediate hypo-and hyperthermic effects of tryptophan in pargyline-pretreated rats. Pharmacol Biochem Behav 1995;52:379-84.
99. Mazzola-Pomietto P, Aulakh CS, Wozniak KM, Hill JL. Murphy DL. Evidence that 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)-induced hyperthermia in rats is mediated by stimulation of 5-HT2A receptors. Psychopharmacology (Berl) 1995;117:193-9.
100. Mazzola-Pomietto P, Aulakh CS, Murphy DL. Temperature, food intake, and locomotor activity effects of a 5-HT3 receptor agonist and two 5-HT3 receptor antagonists in rats. Psychopharmacology (Berl) 1995;121:488-93.
101. Aulakh CS, Mazzola-Pomietto P, Murphy DL. Long-term anti-depressant treatments alter 5-HT2A and 5-HT2C receptor-mediated hyperthermia in Fawn-Hooded rats. Eur J Pharmacol 1995;282:65-70.
102. Zethof TJ, Van der Heyden JA, Tolboom JT, Olivier B. Stress-induced hyperthermia as a putative anxiety model. Eur J Pharmacol 1995;294:125-35.
103. Groenink L, Compaan J, van der Gugten J, Zethof T, van der Heyden J, Olivier B. Stress-induced hyperthermia in mice: pharmacological and endocrinological aspects. Ann N Y Acad Sci 1995;771:252-6.
104. Lecci A, Borsini F, Volterra G, Meli A. Pharmacological validation of a novel animal model of anticipatory anxiety in mice. Psychopharmacology (Berl) 1990;101:255-61.
105. Lecci A, Borsini F, Mancinelli A, D'Aranno V, Stasi MA, Volterra G, Meli A. Effect of serotoninergic drugs on stress-induced hyperthermia (SIH) in mice. J Neural Transm 1990;82: 219-30.
106. Lecci A, Borsini F, Gragnani L, Volterra G, Meli A. Effect of psychotomimetics and some putative anxiolytics on stress-induced hyperthermia. J Neural Transm 1991;83:67-76.
107. Scott IM, Boulant JA. Dopamine effects on thermosensitive neurons in hypothalamic tissue slices. Brain Res 1984;306: 157-63.
108. Shibata H, Nagasaka T. Contribution of nonshivering thermogenesis to stress-induced hyperthermia in rats. Jpn J Physiol 1982;32:991-5.
109. Poole S, Stephenson JD. Core temperature: some shortcomings of rectal temperature measurements. Physiol Behav 1977;18: 203-5.
110. Eikelboom R. Learned anticipatory rise in body temperature due to handling. Physiol Behav 1986;37:649-53.
111. Gollnick PD, lanuzzo CD. Colonic temperature response of rats during exercise. J Appl Physiol 1968;24:747-50.
112. Bermant RI, Reeves DL, Levinson DM, Justesen DR. Classical conditioning of microwave-induced hyperthermia in rats. Radio Sci 1979;14:201-7.
113. Amir S, Stewart I. Resetting of the circadian clock by a conditioned stimulus. Nature 1996;379:542-5.
114. Eikelboom R, Stewart J. Conditioned temperature effects using morphine as the unconditioned stimulus. Psychopharmacology (Berl) 1979;61:31-8.
115. Cunningham CL, Crabbe JC, Rigter H. Pavlovian conditioning of drug-induced changes in body temperature. Pharmacol Ther 1983;23:365-91.
116. Schwarz KS, Cunningham CL. Conditioned stimulus control of morphine hyperthermia. Psychopharmacology (Berl) 1990;101: 77-84.
117. Schwarz-Stevens KS, Cunningham CL. Pavlovian conditioning of heart rate and body temperature with morphine: effects of CS duration. Behav Neurosci 1993;107:1039-48.
118. Broadbent J, Cunningham CL. Pavlovian conditioning of morphine hyperthermia: assessment of interstimulus interval and CS-US overlap. Psychopharmacology (Berl) 1996;126:156-64.
119. Bull DF, Brown R, King MG, Husband AJ. Modulation of body temperature through taste aversion conditioning. Physiol Behav 1991;49:1229-33.
120. Bull DF, Exton MS, Husband AJ. Acute-phase immune response: lipopolysaccharide-induced fever and sleep alterations are not simultaneously conditionable in the rat during the inactive (light) phase. Physiol Behav 1994;56:143-9.
121. Bull DF, Husband AJ, Munro KI, Exton MS, Pfister HP, King MG. Inhibition of endotoxin-induced temperature change by behavioral conditioning using alpha-melanocyte-stimulating hormone as an unconditioned stimulus. Peptides 1994;15: 139-42.
122. Long NC, Vander AJ, Kluger MJ. Stress-induced rise of body temperature in rats is the same in warm and cool environments. Physiol Behav 1990;47:773-5.
123. Cabanac M. Plaisir ou deplaisir de la sensation thermique et homeothermie. Physiol Behav 1969;4:354-69.
124. Cabanac M, Massonnet B, Belaiche R. Preferred skin temperature as a function of internal and mean skin temperature. J Appl Physiol 1972;33:699-703.
125. Soszynski D, Kozak W, Kluger MJ. Endotoxin tolerance does not alter open field-induced fever in rats. Physiol Behav 1998; 63:689-92.
126. Briese E. Cold increases and warmth diminishes stress-induced rise of colonic temperature in rats. Physiol Behav 1992;51:881-3.
127. Davatelis G, Wolpe SD, Sherry B, Dayer JM, Chicheportiche R, Cerami A. Macrophage inflammatory protein-1: a prostaglandin-independent endogenous pyrogen. Science 1989;243: 1066-8.
128. Ashman RB, Mullbacher A. Infectious disease, fever, and the immune response. Immunol Today 1984;5:268-71.
129. Roberts NJ Jr. Impact of temperature elevation on immunologic defenses. Rev Infect Dis 1991;13:462-72.
130. Huey RB, Slatkin M. Cost and benefits of lizard thermoregulation. Q Rev Biol 1976;51:363-84.