Elevated serum copper and ceruloplasmin levels in Alzheimer's disease

Asia-Pacific Psychiatry

Volumn 6, Issue 1, 2014, Pages 38-45

  Park, Jun Hyun ^a   Lee, Dong Woo ^a   Park, Kyung Soo ^b  

^a Inje University College of Medicine   (South Korea)

^b Korea Institute of Science and Technology   (South Korea)

Author keywords

Alzheimer's disease; Ceruloplasmin; Copper; Heavy metal toxicity; Oxidation reduction

Indexed keywords

ALZHEIMER'S DISEASE; CERULOPLASMIN; COPPER; HEAVY METAL TOXICITY; OXIDATION-REDUCTION;

AGED; ALZHEIMER DISEASE; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CERULOPLASMIN; COGNITION; COPPER; FEMALE; HUMANS; MALE; PSYCHOLOGICAL TESTS;

EID: 84894309053     PISSN: 17585864     EISSN: 17585872     Source Type: Journal    
DOI: 10.1111/appy.12077     Document Type: Article

References (44)

1. Adlard P.A., Bush A.I. (2006) Metals and Alzheimer's disease. J Alzheimers Dis. 10(2-3), 145-163.
2. Arnal N., Cristalli D.O., de Alaniz M.J., Marra C.A. (2010) Clinical utility of copper, ceruloplasmin, and metallothionein plasma determinations in human neurodegenerative patients and their first-degree relatives. Brain Res. 1319, 118-130.
3. Aston-Jones G., Rajkowski J., Cohen J. (1999) Role of locus coeruleus in attention and behavioral flexibility Biol Psychiatry. 46, 1309-1320.
4. Atwood C.S., Huang X., Moir R.D., Tanzi R.E., Bush A.I. (1999) Role of free radicals and metal ions in the pathogenesis of Alzheimer's disease. Met Ions Biol Syst. 36, 309-364.
5. Behl C. (1997) Amyloid β-protein toxicity and oxidative stress in Alzheimer's disease. Cell Tissue Res. 290, 471-480.
6. Bouret S., Sara S.J. (2004) Reward expectation, orientation of attention and locus coeruleus-medial frontal cortex interplay during learning. Eur J Neurosci. 20, 791-802.
7. Brenner S. (2003) Elevation of serum copper levels in Alzheimer's disease. Neurology. 60, 1559.
8. Brewer G.J., Kanzer S.H., Zimmerman E.A., Celmins D.F., Heckman S.M., Dick R. (2010) Copper and ceruloplasmin abnormalities in Alzheimers disease. Am J Alzheimers Dis Other Demen. 25, 490-497.
9. Bush A.I. (2003) Copper, zinc, and the metallobiology of Alzheimer disease. Alzheimer Dis Assoc Disord. 17, 147.
10. Capo C.R., Arciello M., Squitti R., etal. (2008) Features of ceruloplasmin in the cerebrospinal fluid of Alzheimer's disease patients. Biometals. 21, 367-372.
11. Casado A., Encarnación López-Fernández M., Concepción Casado M., Torre R. (2008) Lipid peroxidation and antioxidant enzyme activities in vascular and Alzheimer dementias. Neurochem Res. 33, 450-458.
12. Chorsky R., Yaghmai F., Hill W., Stopa E. (2001) Alzheimer's disease: a review concerning immune response and microischemia. Med Hypotheses. 56, 124-127.
13. Coull J. (1994) Pharmacological manipulations of the alpha 2-noradrenergic system. Effects on cognition. Drugs Aging. 5, 116.
14. Coull J., Büchel C., Friston K., Frith C. (1999) Noradrenergically mediated plasticity in a human attentional neuronal network. Neuroimage. 10, 705-715.
15. De Luigi A., Fragiacomo C., Lucca U., Quadri P., Tettamanti M., Grazia De Simoni M. (2001) Inflammatory markers in Alzheimer's disease and multi-infarct dementia. Mech Ageing Dev. 122, 1985-1995.
16. Delibas N., Ozcankaya R., Altuntas I. (2002) Clinical importance of erythrocyte malondialdehyde levels as a marker for cognitive deterioration in patients with dementia of Alzheimer type: a repeated study in 5-year interval. Clin Biochem. 35, 137-141.
17. Dietrich A., Glindemann D., Pizarro F., etal. (2004) Health and aesthetic impacts of copper corrosion on drinking water. Water Sci Technol. 49, 55.
18. Gerhardsson L., Lundh T., Minthon L., Londos E. (2008) Metal concentrations in plasma and cerebrospinal fluid in patients with Alzheimer's disease. Dement Geriatr Cogn Disord. 25, 508-515.
19. Gonzalez C., Martin T., Cacho J., etal. (1999) Serum zinc, copper, insulin and lipids in Alzheimer's disease epsilon 4 apolipoprotein E allele carriers. Eur J Clin Invest. 29, 637-642.
20. Halliwell B., Gutteridge J. (1999) The chemistry of free radicals and related "reactive species". Free Radic Biol Med. 3, 36-104.
21. Indi S., Rao K. (2007) Copper-and iron-induced differential fibril formation in [alpha]-synuclein: TEM study. Neurosci Lett. 424, 78-82.
22. Institute S. (1999) SAS Procedures Guide, Version 8. 1: SAS Publishing, Cary.
23. Johnson P.E., Milne D.B., Lykken G.I. (1992) Effects of age and sex on copper absorption, biological half-life, and status in humans. Am J Clin Nutr. 56, 917-925.
24. Jorm A., Korten A., Henderson A. (1987) The prevalence of dementia: a quantitative integration of the literature. Acta Psychiatr Scand. 76, 465-479.
25. Kessler H., Pajonk F.G., Meisser P., etal. (2006) Cerebrospinal fluid diagnostic markers correlate with lower plasma copper and ceruloplasmin in patients with Alzheimer's disease. J Neural Transm. 113, 1763-1769.
26. Lee J.H., Lee K.U., Lee D.Y., etal. (2002) Development of the Korean Version of the Consortium to Establish a Registry for Alzheimer's Disease Assessment Packet (CERAD-K). J Gerontol B Psychol Sci Soc Sci. 57, P47-P53.
27. Lin C.J., Huang H.C., Jiang Z.F. (2010) Cu(II) interaction with amyloid-beta peptide: a review of neuroactive mechanisms in AD brains. Brain Res Bull. 82(5-6), 235-242.
28. McKhann G., Drachman D., Folstein M., Katzman R., Price D., Stadlan E.M. (1984) Clinical diagnosis of Alzheimer's disease Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 34, 939-939.
29. Molina J.A., Jimenez-Jimenez F.J., Aguilar M.V., etal. (1998) Cerebrospinal fluid levels of transition metals in patients with Alzheimer's disease. J Neural Transm. 105(4-5), 479-488.
30. Multhaup G., Masters C. (1999) Metal binding and radical generation of proteins in human neurological diseases and aging. Met Ions Biol Syst. 36, 365.
31. Orr C., Rowe D., Halliday G. (2002) An inflammatory review of Parkinson's disease. Prog Neurobiol. 68, 325-340.
32. Ozcankaya R., Delibas N. (2002) Malondialdehyde, superoxide dismutase, melatonin, iron, copper, and zinc blood concentrations in patients with Alzheimer disease: cross-sectional study. Croat Med J. 43, 28-32.
33. Ritchie C.W., Bush A.I., Mackinnon A., etal. (2003) Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting A {beta} amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial. Arch Neurol. 60, 1685.
34. Sayre L.M., Perry G., Harris P.L.R., Liu Y., Schubert K.A., Smith M.A. (2000) In situ oxidative catalysis by neurofibrillary tangles and senile plaques in Alzheimer's disease. J Neurochem. 74, 270-279.
35. Schoonjans F. (2003) Medcalc statistics for biomedical research: software manual [computer program]. Mariakerke: Medcalc Statistical Software.
36. Snaedal J., Kristinsson J., Gunnarsdottir S., Olafsdottir K, Baldvinsson M., Johannesson T. (1998) Copper, ceruloplasmin and superoxide dismutase in patients with Alzheimer's disease. a case-control study. Dement Geriatr Cogn Disord. 9, 239-242.
37. Squitti R., Pasqualetti P., Dal Forno G., etal. (2005) Excess of serum copper not related to ceruloplasmin in Alzheimer disease. Neurology. 64, 1040-1046.
38. Squitti R., Barbati G., Rossi L., etal. (2006) Excess of nonceruloplasmin serum copper in AD correlates with MMSE, CSF (beta)-amyloid, and h-tau. Neurology. 67, 76-82.
39. Squitti R., Bressi F., Pasqualetti P., etal. (2009) Longitudinal prognostic value of serum "free" copper in patients with Alzheimer disease. Neurology. 72, 50-55.
40. Strozyk D., Launer L.J., Adlard P.A., etal. (2009) Zinc and copper modulate Alzheimer A(beta) levels in human cerebrospinal fluid. Neurobiol Aging. 30, 1069-1077.
41. Walshe J. (2003) Wilson's disease: the importance of measuring serum caeruloplasmin non-immunologically. Ann Clin Biochem. 40, 115-121.
42. Wilson S.A.K. (1997) Progressive lenticular degeneration: a familial nervous disease associated with cirrhosis of the liver1. Neurol Classics. 165, 295-509.
43. Zatta P., Drago D., Zambenedetti P., etal. (2008) Accumulation of copper and other metal ions, and metallothionein I/II expression in the bovine brain as a function of aging. J Chem Neuroanat. 36, 1-5.
44. Zecca L., Stroppolo A., Gatti A., etal. (2004) The role of iron and copper molecules in the neuronal vulnerability of locus coeruleus and substantia nigra during aging. Proc Natl Acad Sci U S A. 101, 9843-9848.