Screen for abnormal mitochondrial phenotypes in mouse embryonic stem cells identifies a model for succinyl-CoA ligase deficiency and mtDNA depletion

DMM Disease Models and Mechanisms

Volumn 7, Issue 2, 2014, Pages 271-280

  Donti, Taraka R ^a   Stromberger, Carmen ^a,b   Ge, Ming ^a   Eldin, Karen W ^a   Craigen, William J ^a   Graham, Brett H ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Gene trap; Mitochondria; Mitochondrial DNA depletion; TCA cycle

Indexed keywords

METHYLMALONIC ACID; MITOCHONDRIAL DNA; SUCCINYL COENZYME A SYNTHETASE; SUCLA2 PROTEIN, MOUSE;

ALLELE; ANIMAL; ANIMAL EMBRYO; ANTIBODY SPECIFICITY; BIOLOGICAL MODEL; BONE MINERALIZATION; DEFICIENCY; EMBRYO DEATH; EMBRYONIC STEM CELL; ENZYMOLOGY; FEMALE; FIBROBLAST; GENE EXPRESSION REGULATION; GENETIC SCREENING; GENETICS; METABOLISM; MITOCHONDRION; MOUSE; MUTATION; PATHOLOGY; PHENOTYPE; PLACENTA; PREGNANCY;

ALLELES; ANIMALS; CALCIFICATION, PHYSIOLOGIC; DNA, MITOCHONDRIAL; EMBRYO LOSS; EMBRYO, MAMMALIAN; EMBRYONIC STEM CELLS; FEMALE; FIBROBLASTS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENETIC TESTING; METHYLMALONIC ACID; MICE; MITOCHONDRIA; MODELS, BIOLOGICAL; MUTATION; ORGAN SPECIFICITY; PHENOTYPE; PLACENTA; PREGNANCY; SUCCINATE-COA LIGASES;

EID: 84894301649     PISSN: 17548403     EISSN: 17548411     Source Type: Journal    
DOI: 10.1242/dmm.013466     Document Type: Article

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