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Volumn 46, Issue 2, 2014, Pages 77-84

Methylglyoxal impairs GLUT4 trafficking and leads to increased glucose uptake in L6 myoblasts

Author keywords

diabetes mellitus; glucose transporter 4; impaired glucose transport; insulin; methylglyoxal; oxidative stress

Indexed keywords

4-CHLORO-7-NITROBENZOFURAZAN; ANIMALS; APOPTOSIS; BIOLOGICAL TRANSPORT; CELL LINE; CELL MEMBRANE; DEOXYGLUCOSE; GLUCOSE; GLUCOSE TRANSPORTER TYPE 4; INSULIN; MUSCLE, SKELETAL; MYOBLASTS; OXIDATIVE STRESS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PYRUVALDEHYDE; RATS; SIGNAL TRANSDUCTION;

EID: 84894272539     PISSN: 00185043     EISSN: 14394286     Source Type: Journal    
DOI: 10.1055/s-0033-1357121     Document Type: Article
Times cited : (18)

References (56)
  • 1
    • 0034820785 scopus 로고    scopus 로고
    • Dicarbonyls increase in the postprandial period and reflect the degree of hyperglycemia
    • Beisswenger P. J., Howell S. K., O'Dell R. M., Wood M. E., Touchette A. D., Szwergold B. S. alpha-Dicarbonyls increase in the postprandial period and reflect the degree of hyperglycemia. Diabetes Care: 2001; 24 726 732 (Pubitemid 32888855)
    • (2001) Diabetes Care , vol.24 , Issue.4 , pp. 726-732
    • Beisswenger, P.J.1    Howell, S.K.2    O'Dell, R.M.3    Wood, M.E.4    Touchette, A.D.5    Szwergold, B.S.6
  • 2
    • 46049093457 scopus 로고    scopus 로고
    • Methylglyoxal: Its presence and potential scavengers
    • 01
    • Tan D., Wang Y., Lo C. Y., Ho C. T. Methylglyoxal: its presence and potential scavengers. Asia Pac J Clin Nutr: 2008; 17 01 261 264
    • (2008) Asia Pac J Clin Nutr , vol.17 , pp. 261-264
    • Tan, D.1    Wang, Y.2    Lo, C.Y.3    Ho, C.T.4
  • 3
    • 43449094351 scopus 로고    scopus 로고
    • Protein and nucleotide damage by glyoxal and methylglyoxal in physiological systems - Role in ageing and disease
    • Thornalley P. J. Protein and nucleotide damage by glyoxal and methylglyoxal in physiological systems - role in ageing and disease. Drug Metabol Drug Interact: 2008; 23 125 150 (Pubitemid 351669568)
    • (2008) Drug Metabolism and Drug Interactions , vol.23 , Issue.1-2 , pp. 125-150
    • Thornalley, P.J.1
  • 4
    • 79957557698 scopus 로고    scopus 로고
    • Differences in glyoxal and methylglyoxal metabolism determine cellular susceptibility to protein carbonylation and cytotoxicity
    • Yang K., Qiang D., Delaney S., Mehta R., Bruce W. R., O'Brien P. J. Differences in glyoxal and methylglyoxal metabolism determine cellular susceptibility to protein carbonylation and cytotoxicity. Chem Biol Interact: 2011; 191 322 329
    • (2011) Chem Biol Interact , vol.191 , pp. 322-329
    • Yang, K.1    Qiang, D.2    Delaney, S.3    Mehta, R.4    Bruce, W.R.5    O'Brien, P.J.6
  • 5
    • 34248162057 scopus 로고    scopus 로고
    • Methylglyoxal, oxidative stress, and hypertension
    • DOI 10.1139/Y06-077
    • Chang T., Wu L. Methylglyoxal, oxidative stress, and hypertension. Can J Physiol Pharmacol: 2006; 84 1229 1238 (Pubitemid 46707370)
    • (2006) Canadian Journal of Physiology and Pharmacology , vol.84 , Issue.12 , pp. 1229-1238
    • Chang, T.1    Wu, L.2
  • 6
    • 34250704858 scopus 로고    scopus 로고
    • Methylglyoxal and advanced glycation endproducts: New therapeutic horizons?
    • Desai K., Wu L. Methylglyoxal and advanced glycation endproducts: new therapeutic horizons? Recent Pat Cardiovasc Drug Discov: 2007; 2 89 99 (Pubitemid 46957320)
    • (2007) Recent Patents on Cardiovascular Drug Discovery , vol.2 , Issue.2 , pp. 89-99
    • Desai, K.1    Wu, L.2
  • 7
    • 0032703938 scopus 로고    scopus 로고
    • Methylglyoxal in living organisms - Chemistry, biochemistry, toxicology and biological implications
    • DOI 10.1016/S0378-4274(99)00160-5, PII S0378427499001605
    • Kalapos M. P. Methylglyoxal in living organisms: chemistry, biochemistry, toxicology and biological implications. Toxicol Lett: 1999; 110 145 175 (Pubitemid 29528251)
    • (1999) Toxicology Letters , vol.110 , Issue.3 , pp. 145-175
    • Kalapos, M.P.1
  • 8
    • 0026603415 scopus 로고
    • The metabolism of aminoacetone to methylglyoxal by semicarbazide- sensitive amine oxidase in human umbilical artery
    • Lyles G. A., Chalmers J. The metabolism of aminoacetone to methylglyoxal by semicarbazide-sensitive amine oxidase in human umbilical artery. Biochem Pharmacol: 1992; 43 1409 1414
    • (1992) Biochem Pharmacol , vol.43 , pp. 1409-1414
    • Lyles, G.A.1    Chalmers, J.2
  • 9
    • 0028908348 scopus 로고
    • Advanced protein glycosylation in diabetes and aging
    • Brownlee M. Advanced protein glycosylation in diabetes and aging. Annu Rev Med: 1995; 46 223 234
    • (1995) Annu Rev Med , vol.46 , pp. 223-234
    • Brownlee, M.1
  • 12
    • 0035135246 scopus 로고    scopus 로고
    • Advanced glycation end-products: A review
    • DOI 10.1007/s001250051591
    • Singh R., Barden A., Mori T., Beilin L. Advanced glycation end-products: a review. Diabetologia: 2001; 44 129 146 (Pubitemid 32156196)
    • (2001) Diabetologia , vol.44 , Issue.2 , pp. 129-146
    • Singh, R.1    Barden, A.2    Mori, T.3    Beilin, L.4
  • 13
    • 77952866159 scopus 로고    scopus 로고
    • Diabetic cardiomyopathy - To take a long story serious
    • Stratmann B., Gawlowski T., Tschoepe D. Diabetic cardiomyopathy - to take a long story serious. Herz: 2010; 35 161 168
    • (2010) Herz , vol.35 , pp. 161-168
    • Stratmann, B.1    Gawlowski, T.2    Tschoepe, D.3
  • 14
    • 34948816643 scopus 로고    scopus 로고
    • Plasma methylglyoxal and glyoxal are elevated and related to early membrane alteration in young, complication-free patients with Type 1 diabetes
    • DOI 10.1007/s11010-007-9535-1
    • Han Y., Randell E., Vasdev S., Gill V., Gadag V., Newhook L. A., Grant M., Hagerty D. Plasma methylglyoxal and glyoxal are elevated and related to early membrane alteration in young, complication-free patients with Type 1 diabetes. Mol Cell Biochem: 2007; 305 123 131 (Pubitemid 47517175)
    • (2007) Molecular and Cellular Biochemistry , vol.305 , Issue.1-2 , pp. 123-131
    • Han, Y.1    Randell, E.2    Vasdev, S.3    Gill, V.4    Gadag, V.5    Newhook, L.A.6    Grant, M.7    Hagerty, D.8
  • 15
    • 0026786580 scopus 로고
    • The assay of methylglyoxal in biological systems by derivatization with 1,2-diamino-4,5-dimethoxybenzene
    • McLellan A. C., Phillips S. A., Thornalley P. J. The assay of methylglyoxal in biological systems by derivatization with 1,2-diamino-4,5- dimethoxybenzene. Anal Biochem: 1992; 206 17 23
    • (1992) Anal Biochem , vol.206 , pp. 17-23
    • McLellan, A.C.1    Phillips, S.A.2    Thornalley, P.J.3
  • 16
    • 0023950461 scopus 로고
    • Advanced glycosylation end products in tissue and the biochemical basis of diabetic complications
    • Brownlee M., Cerami A., Vlassara H. Advanced glycosylation end products in tissue and the biochemical basis of diabetic complications. N Engl J Med: 1988; 318 1315 1321
    • (1988) N Engl J Med , vol.318 , pp. 1315-1321
    • Brownlee, M.1    Cerami, A.2    Vlassara, H.3
  • 17
    • 10644282357 scopus 로고    scopus 로고
    • Importance of advanced glycation end products in diabetes-associated cardiovascular and renal disease
    • DOI 10.1016/j.amjhyper.2004.08.021, PII S0895706104010003
    • Cooper M. E. Importance of advanced glycation end products in diabetes-associated cardiovascular and renal disease. Am J Hypertens: 2004; 17 31S 38S (Pubitemid 39647569)
    • (2004) American Journal of Hypertension , vol.17 , Issue.SUPPL.
    • Cooper, M.E.1
  • 18
    • 0033567419 scopus 로고    scopus 로고
    • Accumulation of α-oxoaldehydes during oxidative stress: A role in cytotoxicity
    • DOI 10.1016/S0006-2952(99)00132-X, PII S000629529900132X
    • Abordo E. A., Minhas H. S., Thornalley P. J. Accumulation of alpha-oxoaldehydes during oxidative stress: a role in cytotoxicity. Biochem Pharmacol: 1999; 58 641 648 (Pubitemid 29296884)
    • (1999) Biochemical Pharmacology , vol.58 , Issue.4 , pp. 641-648
    • Abordo, E.A.1    Minhas, H.S.2    Thornalley, P.J.3
  • 20
    • 0027454552 scopus 로고
    • The glyoxalase system in health and disease
    • Thornalley P. J. The glyoxalase system in health and disease. Mol Aspects Med: 1993; 14 287 371
    • (1993) Mol Aspects Med , vol.14 , pp. 287-371
    • Thornalley, P.J.1
  • 21
    • 0347419281 scopus 로고    scopus 로고
    • Glyoxalase I - Structure, function and a critical role in the enzymatic defence against glycation
    • Thornalley P. J. Glyoxalase I - structure, function and a critical role in the enzymatic defence against glycation. Biochem Soc Trans: 2003; 31 1343 1348 (Pubitemid 38030973)
    • (2003) Biochemical Society Transactions , vol.31 , Issue.6 , pp. 1343-1348
    • Thornalley, P.J.1
  • 22
    • 10644266855 scopus 로고    scopus 로고
    • Methylglyoxal-induced nitric oxide and peroxynitrite production in vascular smooth muscle cells
    • DOI 10.1016/j.freeradbiomed.2004.10.034, PII S0891584904008834
    • Chang T., Wang R., Wu L. Methylglyoxal-induced nitric oxide and peroxynitrite production in vascular smooth muscle cells. Free Radic Biol Med: 2005; 38 286 293 (Pubitemid 39656138)
    • (2005) Free Radical Biology and Medicine , vol.38 , Issue.2 , pp. 286-293
    • Chang, T.1    Wang, R.2    Wu, L.3
  • 23
    • 38749130432 scopus 로고    scopus 로고
    • The tandem of free radicals and methylglyoxal
    • Kalapos M. P. The tandem of free radicals and methylglyoxal. Chem Biol Interact: 2008; 171 251 271
    • (2008) Chem Biol Interact , vol.171 , pp. 251-271
    • Kalapos, M.P.1
  • 26
    • 0035966052 scopus 로고    scopus 로고
    • Hydrogen peroxide generated during cellular insulin stimulation is integral to activation of the distal insulin signaling cascade in 3T3-L1 adipocytes
    • Mahadev K., Wu X., Zilbering A., Zhu L., Lawrence J. T., Goldstein B. J. Hydrogen peroxide generated during cellular insulin stimulation is integral to activation of the distal insulin signaling cascade in 3T3-L1 adipocytes. J Biol Chem: 2001; 276 48662 48669
    • (2001) J Biol Chem , vol.276 , pp. 48662-48669
    • Mahadev, K.1    Wu, X.2    Zilbering, A.3    Zhu, L.4    Lawrence, J.T.5    Goldstein, B.J.6
  • 28
    • 10344236432 scopus 로고    scopus 로고
    • Regulated membrane trafficking of the insulin-responsive glucose transporter 4 in adipocytes
    • DOI 10.1210/er.2003-0011
    • Watson R. T., Kanzaki M., Pessin J. E. Regulated membrane trafficking of the insulin-responsive glucose transporter 4 in adipocytes. Endocr Rev: 2004; 25 177 204 (Pubitemid 38501393)
    • (2004) Endocrine Reviews , vol.25 , Issue.2 , pp. 177-204
    • Watson, R.T.1    Kanzaki, M.2    Pessin, J.E.3
  • 29
    • 48149100986 scopus 로고    scopus 로고
    • Insulin action on glucose transporters through molecular switches, tracks and tethers
    • Zaid H., Antonescu C. N., Randhawa V. K., Klip A. Insulin action on glucose transporters through molecular switches, tracks and tethers. Biochem J: 2008; 413 201 215
    • (2008) Biochem J , vol.413 , pp. 201-215
    • Zaid, H.1    Antonescu, C.N.2    Randhawa, V.K.3    Klip, A.4
  • 30
    • 79953841907 scopus 로고    scopus 로고
    • Endocytosis, recycling, and regulated exocytosis of glucose transporter 4
    • Foley K., Boguslavsky S., Klip A. Endocytosis, recycling, and regulated exocytosis of glucose transporter 4. Biochemistry: 2011; 50 3048 3061
    • (2011) Biochemistry , vol.50 , pp. 3048-3061
    • Foley, K.1    Boguslavsky, S.2    Klip, A.3
  • 31
    • 27844435600 scopus 로고    scopus 로고
    • Minireview: Recent developments in the regulation of glucose transporter-4 traffic: New signals, locations, and partners
    • DOI 10.1210/en.2005-0850
    • Ishiki M., Klip A. Minireview: recent developments in the regulation of glucose transporter-4 traffic: new signals, locations, and partners. Endocrinology: 2005; 146 5071 5078 (Pubitemid 41653019)
    • (2005) Endocrinology , vol.146 , Issue.12 , pp. 5071-5078
    • Ishiki, M.1    Klip, A.2
  • 32
    • 34548436875 scopus 로고    scopus 로고
    • GLUT4 translocation: The last 200 nanometers
    • DOI 10.1016/j.cellsig.2007.06.003, PII S0898656807001787
    • Watson R. T., Pessin J. E. GLUT4 translocation: the last 200 nanometers. Cell Signal: 2007; 19 2209 2217 (Pubitemid 47361681)
    • (2007) Cellular Signalling , vol.19 , Issue.11 , pp. 2209-2217
    • Watson, R.T.1    Pessin, J.E.2
  • 34
    • 28544450844 scopus 로고    scopus 로고
    • Glucose transporter 4: Cycling, compartments and controversies
    • DOI 10.1038/sj.embor.7400584, PII 7400584
    • Dugani C. B., Klip A. Glucose transporter 4: cycling, compartments and controversies. EMBO Rep: 2005; 6 1137 1142 (Pubitemid 41741696)
    • (2005) EMBO Reports , vol.6 , Issue.12 , pp. 1137-1142
    • Dugani, C.B.1    Klip, A.2
  • 35
    • 0033942001 scopus 로고    scopus 로고
    • Insulin action and insulin resistance in human skeletal muscle
    • Zierath J. R., Krook A., Wallberg-Henriksson H. Insulin action and insulin resistance in human skeletal muscle. Diabetologia: 2000; 43 821 835 (Pubitemid 30463160)
    • (2000) Diabetologia , vol.43 , Issue.7 , pp. 821-835
    • Zierath, J.R.1    Krook, A.2    Wallberg-Henriksson, H.3
  • 37
    • 35548952654 scopus 로고    scopus 로고
    • Accumulation of endogenous methylglyoxal impaired insulin signaling in adipose tissue of fructose-fed rats
    • DOI 10.1007/s11010-007-9563-x
    • Jia X., Wu L. Accumulation of endogenous methylglyoxal impaired insulin signaling in adipose tissue of fructose-fed rats. Mol Cell Biochem: 2007; 306 133 139 (Pubitemid 350001825)
    • (2007) Molecular and Cellular Biochemistry , vol.306 , Issue.1-2 , pp. 133-139
    • Jia, X.1    Wu, L.2
  • 38
    • 33745312600 scopus 로고    scopus 로고
    • Methylglyoxal impairs the insulin signaling pathways independently of the formation of intracellular reactive oxygen species
    • DOI 10.2337/db05-0857
    • Riboulet-Chavey A., Pierron A., Durand I., Murdaca J., Giudicelli J., Van Obberghen E. Methylglyoxal impairs the insulin signaling pathways independently of the formation of intracellular reactive oxygen species. Diabetes: 2006; 55 1289 1299 (Pubitemid 44195367)
    • (2006) Diabetes , vol.55 , Issue.5 , pp. 1289-1299
    • Riboulet-Chavey, A.1    Pierron, A.2    Durand, I.3    Murdaca, J.4    Giudicelli, J.5    Van Obberghen, E.6
  • 39
    • 0029777417 scopus 로고    scopus 로고
    • Insulin resistance in non-insulin dependent diabetes mellitus. A review
    • DOI 10.1007/s005920050013
    • Alzaid A. A. Insulin resistance in non-insulin-dependent diabetes mellitus. A review. Acta Diabetol: 1996; 33 87 99 (Pubitemid 26270983)
    • (1996) Acta Diabetologica , vol.33 , Issue.2 , pp. 87-99
    • Alzaid, A.A.1
  • 41
    • 84878131295 scopus 로고    scopus 로고
    • Impact of GLO1 knock down on GLUT4 trafficking and glucose uptake in L6 myoblasts
    • Engelbrecht B., Stratmann B., Hess C., Tschoepe D., Gawlowski T. Impact of GLO1 knock down on GLUT4 trafficking and glucose uptake in L6 myoblasts. PLoS One: 2013; 8 e65195
    • (2013) PLoS One , vol.8
    • Engelbrecht, B.1    Stratmann, B.2    Hess, C.3    Tschoepe, D.4    Gawlowski, T.5
  • 42
    • 84860850082 scopus 로고    scopus 로고
    • High-mobility group box 1 protein is implicated in advanced glycation end products-induced vascular endothelial growth factor A production in the rat retinal ganglion cell line RGC-5
    • Lee J. J., Hsiao C. C., Yang I. H., Chou M. H., Wu C. L., Wei Y. C., Chen C. H., Chuang J. H. High-mobility group box 1 protein is implicated in advanced glycation end products-induced vascular endothelial growth factor A production in the rat retinal ganglion cell line RGC-5. Mol Vis: 2012; 18 838 850
    • (2012) Mol Vis , vol.18 , pp. 838-850
    • Lee, J.J.1    Hsiao, C.C.2    Yang, I.H.3    Chou, M.H.4    Wu, C.L.5    Wei, Y.C.6    Chen, C.H.7    Chuang, J.H.8
  • 43
    • 0028292698 scopus 로고
    • Glyoxalase system in clinical diabetes mellitus and correlation with diabetic complications
    • McLellan A. C., Thornalley P. J., Benn J., Sonksen P. H. Glyoxalase system in clinical diabetes mellitus and correlation with diabetic complications. Clin Sci (Lond): 1994; 87 21 29 (Pubitemid 24220267)
    • (1994) Clinical Science , vol.87 , Issue.1 , pp. 21-29
    • McLellan, A.C.1    Thornalley, P.J.2    Benn, J.3    Sonksen, P.H.4
  • 44
    • 17644387768 scopus 로고    scopus 로고
    • Measurement of methylglyoxal in rat tissues by electrospray ionization mass spectrometry and liquid chromatography
    • DOI 10.1016/j.vascn.2004.08.005
    • Randell E. W., Vasdev S., Gill V. Measurement of methylglyoxal in rat tissues by electrospray ionization mass spectrometry and liquid chromatography. J Pharmacol Toxicol Meth: 2005; 51 153 157 (Pubitemid 40568606)
    • (2005) Journal of Pharmacological and Toxicological Methods , vol.51 , Issue.2 , pp. 153-157
    • Randell, E.W.1    Vasdev, S.2    Gill, V.3
  • 45
    • 0242468729 scopus 로고    scopus 로고
    • Quantitative screening of advanced glycation endproducts in cellular and extracellular proteins by tandem mass spectrometry
    • DOI 10.1042/BJ20030763
    • Thornalley P. J., Battah S., Ahmed N., Karachalias N., Agalou S., Babaei-Jadidi R., Dawnay A. Quantitative screening of advanced glycation endproducts in cellular and extracellular proteins by tandem mass spectrometry. Biochem J: 2003; 375 581 592 (Pubitemid 37433506)
    • (2003) Biochemical Journal , vol.375 , Issue.3 , pp. 581-592
    • Thornalley, P.J.1    Battah, S.2    Ahmed, N.3    Karachalias, N.4    Agalou, S.5    Babaei-Jadidi, R.6    Dawnay, A.7
  • 46
    • 0028826421 scopus 로고
    • Cloning, chromosomal localization and expression analysis of the mouse Akt2 oncogene
    • Altomare D. A., Guo K., Cheng J. Q., Sonoda G., Walsh K., Testa J. R. Cloning, chromosomal localization and expression analysis of the mouse Akt2 oncogene. Oncogene: 1995; 11 1055 1060
    • (1995) Oncogene , vol.11 , pp. 1055-1060
    • Altomare, D.A.1    Guo, K.2    Cheng, J.Q.3    Sonoda, G.4    Walsh, K.5    Testa, J.R.6
  • 47
    • 2342565881 scopus 로고    scopus 로고
    • Advances in protein kinase B signalling: AKTion on multiple fronts
    • DOI 10.1016/j.tibs.2004.03.006, PII S096800040400074X
    • Brazil D. P., Yang Z. Z., Hemmings B. A. Advances in protein kinase B signalling: AKTion on multiple fronts. Trends Biochem Sci: 2004; 29 233 242 (Pubitemid 38591317)
    • (2004) Trends in Biochemical Sciences , vol.29 , Issue.5 , pp. 233-242
    • Brazil, D.P.1    Yang, Z.-Z.2    Hemmings, B.A.3
  • 49
    • 66349098674 scopus 로고    scopus 로고
    • Insulin-modulated Akt subcellular localization determines Akt isoform-specific signaling
    • Gonzalez E., McGraw T. E. Insulin-modulated Akt subcellular localization determines Akt isoform-specific signaling. Proc Natl Acad Sci USA: 2009; 106 7004 7009
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 7004-7009
    • Gonzalez, E.1    McGraw, T.E.2
  • 50
    • 41449087811 scopus 로고    scopus 로고
    • Rapid Activation of Akt2 Is Sufficient to Stimulate GLUT4 Translocation in 3T3-L1 Adipocytes
    • DOI 10.1016/j.cmet.2008.02.008, PII S1550413108000429
    • Ng Y., Ramm G., Lopez J. A., James D. E. Rapid activation of Akt2 is sufficient to stimulate GLUT4 translocation in 3T3-L1 adipocytes. Cell Metab: 2008; 7 348 356 (Pubitemid 351455217)
    • (2008) Cell Metabolism , vol.7 , Issue.4 , pp. 348-356
    • Ng, Y.1    Ramm, G.2    Lopez, J.A.3    James, D.E.4
  • 52
    • 77952203721 scopus 로고    scopus 로고
    • Hydrogen peroxide stimulates glucose uptake in myotube cells via the insulin signaling pathway
    • Mazlan M., Mansor R., Ngah W. Hydrogen peroxide stimulates glucose uptake in myotube cells via the insulin signaling pathway. Sains Malaysiana: 2010; 39 315 320
    • (2010) Sains Malaysiana , vol.39 , pp. 315-320
    • Mazlan, M.1    Mansor, R.2    Ngah, W.3
  • 54
    • 0030176306 scopus 로고    scopus 로고
    • Pharmacology of methylglyoxal: Formation, modification of proteins and nucleic acids, and enzymatic detoxification - A role in pathogenesis and antiproliferative chemotherapy
    • DOI 10.1016/0306-3623(95)02054-3
    • Thornalley P. J. Pharmacology of methylglyoxal: formation, modification of proteins and nucleic acids, and enzymatic detoxification - a role in pathogenesis and antiproliferative chemotherapy. Gen Pharmacol: 1996; 27 565 573 (Pubitemid 26233322)
    • (1996) General Pharmacology , vol.27 , Issue.4 , pp. 565-573
    • Thornalley, P.J.1
  • 55
    • 78649441939 scopus 로고    scopus 로고
    • Methylglyoxal scavengers attenuate endothelial dysfunction induced by methylglyoxal and high concentrations of glucose
    • Dhar A., Dhar I., Desai K. M., Wu L. Methylglyoxal scavengers attenuate endothelial dysfunction induced by methylglyoxal and high concentrations of glucose. Br J Pharmacol: 2010; 161 1843 1856
    • (2010) Br J Pharmacol , vol.161 , pp. 1843-1856
    • Dhar, A.1    Dhar, I.2    Desai, K.M.3    Wu, L.4
  • 56
    • 24044468429 scopus 로고    scopus 로고
    • Turning signals on and off: GLUT4 traffic in the insulin-signaling highway
    • Thong F. S., Dugani C. B., Klip A. Turning signals on and off: GLUT4 traffic in the insulin-signaling highway. Physiology (Bethesda): 2005; 20 271 284 (Pubitemid 41215201)
    • (2005) Physiology , Issue.4 , pp. 271-284
    • Thong, F.S.L.1    Dugani, C.B.2    Klip, A.3


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