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Volumn 1, Issue 2, 2005, Pages

Shiga toxins: Potent poisons, pathogenicity determinants, and pharmacological agents

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EID: 84894270096     PISSN: None     EISSN: 23246200     Source Type: Journal    
DOI: 10.1128/ecosalplus.8.7.8     Document Type: Article
Times cited : (5)

References (165)
  • 1
    • 0041382714 scopus 로고
    • Über freie Receptoren von Typhus- und Dysenterie-Bazillen und über das Dysenterie Toxin
    • Neisser M, Shiga K. 1903. Über freie Receptoren von Typhus- und Dysenterie-Bazillen und über das Dysenterie Toxin. Dtsch Med Wochenschr 29: 61-62.
    • (1903) Dtsch Med Wochenschr , vol.29 , pp. 61-62
    • Neisser, M.1    Shiga, K.2
  • 2
    • 0004336983 scopus 로고
    • Über Iosliche, durch asptische Autolyse erhaltene Giftstoffe von Ruhr- und Typhus-Bazillen
    • Conradi H. 1903. Über Iosliche, durch asptische Autolyse erhaltene Giftstoffe von Ruhr- und Typhus-Bazillen. Dtsch Med Wochenschr 29: 26-28.
    • (1903) Dtsch Med Wochenschr , vol.29 , pp. 26-28
    • Conradi, H.1
  • 3
    • 0020442890 scopus 로고
    • Production of Shigella dysenteriae type 1-like cytotoxin by Escherichia coli
    • O'Brien AD, LaVeck GD, Thompson MR, Formal SB. 1982. Production of Shigella dysenteriae type 1-like cytotoxin by Escherichia coli. J Infect Dis 146: 763-769.
    • (1982) J Infect Dis , vol.146 , pp. 763-769
    • O'Brien, A.D.1    LaVeck, G.D.2    Thompson, M.R.3    Formal, S.B.4
  • 4
    • 0020537151 scopus 로고
    • Purification and characterization of a Shigella dysenteriae 1-like toxin produced by Escherichia coli
    • O'Brien AD, LaVeck GD. 1983. Purification and characterization of a Shigella dysenteriae 1-like toxin produced by Escherichia coli. Infect Immun 40: 675-683.
    • (1983) Infect Immun , vol.40 , pp. 675-683
    • O'Brien, A.D.1    LaVeck, G.D.2
  • 5
    • 0020657059 scopus 로고
    • Sporadic cases of haemolytic-uraemic syndrome associated with faecal cytotoxin and cytotoxin-producing Escherichia coli in stools
    • Karmali MA, Steele BT, Petric M, Lim C. 1983. Sporadic cases of haemolytic-uraemic syndrome associated with faecal cytotoxin and cytotoxin-producing Escherichia coli in stools. Lancet 1: 619-620.
    • (1983) Lancet , vol.1 , pp. 619-620
    • Karmali, M.A.1    Steele, B.T.2    Petric, M.3    Lim, C.4
  • 6
    • 0017698198 scopus 로고
    • Vero response to a cytotoxin of Escherichia coli
    • Konowalchuk J, Speirs JI, Stavric S. 1977. Vero response to a cytotoxin of Escherichia coli. Infect Immun 18: 775-779.
    • (1977) Infect Immun , vol.18 , pp. 775-779
    • Konowalchuk, J.1    Speirs, J.I.2    Stavric, S.3
  • 7
    • 0020662906 scopus 로고
    • Escherichia coli O157:H7 strains associated with haemorrhagic colitis in the United States produce a Shigella dysenteriae 1 (Shiga) like cytotoxin
    • O'Brien AD, Lively TA, Chen ME, Rothman SW, Formal SB. 1983. Escherichia coli O157:H7 strains associated with haemorrhagic colitis in the United States produce a Shigella dysenteriae 1 (Shiga) like cytotoxin. Lancet 1: 702.
    • (1983) Lancet , vol.1 , pp. 702
    • O'Brien, A.D.1    Lively, T.A.2    Chen, M.E.3    Rothman, S.W.4    Formal, S.B.5
  • 8
    • 0021946215 scopus 로고
    • The association between idiopathic hemolytic uremic syndrome and infection by verotoxin-producing Escherichia coli
    • Karmali MA, Petric M, Lim C, Fleming PC, Arbus GS, Lior H. 1985. The association between idiopathic hemolytic uremic syndrome and infection by verotoxin-producing Escherichia coli. J Infect Dis 151: 775-782.
    • (1985) J Infect Dis , vol.151 , pp. 775-782
    • Karmali, M.A.1    Petric, M.2    Lim, C.3    Fleming, P.C.4    Arbus, G.S.5    Lior, H.6
  • 10
    • 0023631217 scopus 로고
    • Iron regulation of Shigalike toxin expression in Escherichia coli is mediated by the fur locus
    • Calderwood SB, Mekalanos JJ. 1987. Iron regulation of Shigalike toxin expression in Escherichia coli is mediated by the fur locus. J Bacteriol 169: 4759-4764.
    • (1987) J Bacteriol , vol.169 , pp. 4759-4764
    • Calderwood, S.B.1    Mekalanos, J.J.2
  • 11
    • 0000475753 scopus 로고
    • Preparation and properties of Shiga toxin and toxoid
    • Dubos RJ, Geiger JW. 1946. Preparation and properties of Shiga toxin and toxoid. J Exp Med 84: 143-156.
    • (1946) J Exp Med , vol.84 , pp. 143-156
    • Dubos, R.J.1    Geiger, J.W.2
  • 12
    • 3643133568 scopus 로고
    • The neurotoxin of Shigella shigae 3. The effect of iron on production of the toxin.
    • van Heyningen WE, Gladstone GP. 1953. The neurotoxin of Shigella shigae. 3. The effect of iron on production of the toxin. Br J Exp Pathol 34: 221-229.
    • (1953) Br J Exp Pathol , vol.34 , pp. 221-229
    • van Heyningen, W.E.1    Gladstone, G.P.2
  • 13
    • 0034764394 scopus 로고    scopus 로고
    • Isolation of a lysogenic bacteriophage carrying the stx1OX3 gene, which is closely associated with Shiga toxin-producing Escherichia coli strains from sheep and humans
    • Koch C, Hertwig S, Lurz R, Appel B, Beutin L. 2001. Isolation of a lysogenic bacteriophage carrying the stx1OX3 gene, which is closely associated with Shiga toxin-producing Escherichia coli strains from sheep and humans. J Clin Microbiol 39: 3992-3998.
    • (2001) J Clin Microbiol , vol.39 , pp. 3992-3998
    • Koch, C.1    Hertwig, S.2    Lurz, R.3    Appel, B.4    Beutin, L.5
  • 14
    • 0028854221 scopus 로고
    • Heterogeneity of the amino-acid sequences of Escherichia coli Shiga-like toxin type-I operons
    • Paton AW, Beutin L, Paton JC. 1995. Heterogeneity of the amino-acid sequences of Escherichia coli Shiga-like toxin type-I operons. Gene 153: 71-74.
    • (1995) Gene , vol.153 , pp. 71-74
    • Paton, A.W.1    Beutin, L.2    Paton, J.C.3
  • 15
    • 0142058583 scopus 로고    scopus 로고
    • Genetic and immunological analysis of a novel variant of Shiga toxin 1 from bovine Escherichia coli strains and development of bead-ELISA to detect the variant toxin
    • Ohmura-Hoshino M, Ho ST, Kurazono H, Igarashi K, Yamasaki S, Takeda Y. 2003. Genetic and immunological analysis of a novel variant of Shiga toxin 1 from bovine Escherichia coli strains and development of bead-ELISA to detect the variant toxin. Microbiol Immunol 47: 717-725.
    • (2003) Microbiol Immunol , vol.47 , pp. 717-725
    • Ohmura-Hoshino, M.1    Ho, S.T.2    Kurazono, H.3    Igarashi, K.4    Yamasaki, S.5    Takeda, Y.6
  • 16
    • 0029035804 scopus 로고
    • Comparative toxicity and virulence of Escherichia coli clones expressing variant and chimeric Shiga-like toxin type II operons
    • Paton AW, Bourne AJ, Manning PA, Paton JC. 1995. Comparative toxicity and virulence of Escherichia coli clones expressing variant and chimeric Shiga-like toxin type II operons. Infect Immun 63: 2450-2458.
    • (1995) Infect Immun , vol.63 , pp. 2450-2458
    • Paton, A.W.1    Bourne, A.J.2    Manning, P.A.3    Paton, J.C.4
  • 17
    • 0035189614 scopus 로고    scopus 로고
    • Characterization of a Shiga toxin-encoding temperate bacteriophage of Shigella sonnei
    • Strauch E, Lurz R, Beutin L. 2001. Characterization of a Shiga toxin-encoding temperate bacteriophage of Shigella sonnei. Infect Immun 69: 7588-7595.
    • (2001) Infect Immun , vol.69 , pp. 7588-7595
    • Strauch, E.1    Lurz, R.2    Beutin, L.3
  • 18
    • 0027323297 scopus 로고
    • Sequence of a variant Shiga-like toxin type-I operon of Escherichia coli O111:H-
    • Paton AW, Paton JC, Goldwater PN, Heuzenroeder MW, Manning PA. 1993. Sequence of a variant Shiga-like toxin type-I operon of Escherichia coli O111:H-. Gene 129: 87-92.
    • (1993) Gene , vol.129 , pp. 87-92
    • Paton, A.W.1    Paton, J.C.2    Goldwater, P.N.3    Heuzenroeder, M.W.4    Manning, P.A.5
  • 19
    • 0036211836 scopus 로고    scopus 로고
    • Identification, characterization, and distribution of a Shiga toxin 1 gene variant (stx1c) in Escherichia coli strains isolated from humans
    • Zhang W, Bielaszewska M, Kuczius T, Karch H. 2002. Identification, characterization, and distribution of a Shiga toxin 1 gene variant (stx1c) in Escherichia coli strains isolated from humans. J Clin Microbiol 40: 1441-1446.
    • (2002) J Clin Microbiol , vol.40 , pp. 1441-1446
    • Zhang, W.1    Bielaszewska, M.2    Kuczius, T.3    Karch, H.4
  • 20
    • 0038628867 scopus 로고    scopus 로고
    • Identification and characterization of a new variant of Shiga toxin 1 in Escherichia coli ONT:H19 of bovine origin
    • Burk C, Dietrich R, Acar G, Moravek M, Bulte M, Martlbauer E. 2003. Identification and characterization of a new variant of Shiga toxin 1 in Escherichia coli ONT:H19 of bovine origin. J Clin Microbiol 41: 2106-2112.
    • (2003) J Clin Microbiol , vol.41 , pp. 2106-2112
    • Burk, C.1    Dietrich, R.2    Acar, G.3    Moravek, M.4    Bulte, M.5    Martlbauer, E.6
  • 21
    • 0023984847 scopus 로고    scopus 로고
    • Optimal alignments in linear space
    • Myers EW, Miller W. 1998. Optimal alignments in linear space. Comput Appl Biosci 4: 11-17.
    • (1998) Comput Appl Biosci , vol.4 , pp. 11-17
    • Myers, E.W.1    Miller, W.2
  • 22
    • 0026458378 scopus 로고
    • Amino acid substitution matrices from protein blocks
    • Henikoff S, Henikoff JG. 1992. Amino acid substitution matrices from protein blocks. Proc Natl Acad Sci USA 89: 10915-10919.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 10915-10919
    • Henikoff, S.1    Henikoff, J.G.2
  • 23
    • 0022512195 scopus 로고
    • Two toxin-converting phages from Escherichia coli O157:H7 strain 933 encode antigenically distinct toxins with similar biologic activities
    • Strockbine NA, Marques LR, Newland JW, Smith HW, Holmes RK, O'Brien AD. 1986. Two toxin-converting phages from Escherichia coli O157:H7 strain 933 encode antigenically distinct toxins with similar biologic activities. Infect Immun 53: 135-140.
    • (1986) Infect Immun , vol.53 , pp. 135-140
    • Strockbine, N.A.1    Marques, L.R.2    Newland, J.W.3    Smith, H.W.4    Holmes, R.K.5    O'Brien, A.D.6
  • 24
    • 0023740567 scopus 로고
    • Isolation and characterization of monoclonal antibodies to Shiga-like toxin II of enterohemorrhagic Escherichia coli and use of the monoclonal antibodies in a colony enzyme-linked immunosorbent assay
    • Perera LP, Marques LR, O'Brien AD. 1988. Isolation and characterization of monoclonal antibodies to Shiga-like toxin II of enterohemorrhagic Escherichia coli and use of the monoclonal antibodies in a colony enzyme-linked immunosorbent assay. J Clin Microbiol 26: 2127-2131.
    • (1988) J Clin Microbiol , vol.26 , pp. 2127-2131
    • Perera, L.P.1    Marques, L.R.2    O'Brien, A.D.3
  • 25
    • 0023840545 scopus 로고
    • Cloning and sequencing of the genes for Shiga toxin from Shigella dysenteriae type 1
    • Strockbine NA, Jackson MP, Sung LM, Holmes RK, O'Brien AD. 1988. Cloning and sequencing of the genes for Shiga toxin from Shigella dysenteriae type 1. J Bacteriol 170: 1116-1122.
    • (1988) J Bacteriol , vol.170 , pp. 1116-1122
    • Strockbine, N.A.1    Jackson, M.P.2    Sung, L.M.3    Holmes, R.K.4    O'Brien, A.D.5
  • 27
    • 0026027180 scopus 로고
    • Two copies of Shigalike toxin II-related genes common in enterohemorrhagic Escherichia coli strains are responsible for the antigenic heterogeneity of the O157:H- strain E32511
    • Schmitt CK, McKee ML, O'Brien AD. 1991. Two copies of Shigalike toxin II-related genes common in enterohemorrhagic Escherichia coli strains are responsible for the antigenic heterogeneity of the O157:H- strain E32511. Infect Immun 59: 1065-1073.
    • (1991) Infect Immun , vol.59 , pp. 1065-1073
    • Schmitt, C.K.1    McKee, M.L.2    O'Brien, A.D.3
  • 28
    • 0031671439 scopus 로고    scopus 로고
    • Identification of new verocytotoxin type 2 variant B-subunit genes in human and animal Escherichia coli isolates
    • Pierard D, Muyldermans G, Moriau L, Stevens D, Lauwers S. 1998. Identification of new verocytotoxin type 2 variant B-subunit genes in human and animal Escherichia coli isolates. J Clin Microbiol 36: 3317-3322.
    • (1998) J Clin Microbiol , vol.36 , pp. 3317-3322
    • Pierard, D.1    Muyldermans, G.2    Moriau, L.3    Stevens, D.4    Lauwers, S.5
  • 29
    • 0026922176 scopus 로고
    • Cloning and nucleotide sequence of a variant Shiga-like toxin II gene from Escherichia coli OX3:H21 isolated from a case of sudden infant death syndrome
    • Paton AW, Paton JC, Heuzenroeder MW, Goldwater PN, Manning PA. 1992. Cloning and nucleotide sequence of a variant Shiga-like toxin II gene from Escherichia coli OX3:H21 isolated from a case of sudden infant death syndrome. Microb Pathog 13: 225-236.
    • (1992) Microb Pathog , vol.13 , pp. 225-236
    • Paton, A.W.1    Paton, J.C.2    Heuzenroeder, M.W.3    Goldwater, P.N.4    Manning, P.A.5
  • 30
    • 0027296098 scopus 로고
    • Polymerase chain reaction amplification, cloning and sequencing of variant Escherichia coli Shiga-like toxin type II operons
    • Paton AW, Paton JC, Manning PA. 1993. Polymerase chain reaction amplification, cloning and sequencing of variant Escherichia coli Shiga-like toxin type II operons. Microb Pathog 15: 77-82.
    • (1993) Microb Pathog , vol.15 , pp. 77-82
    • Paton, A.W.1    Paton, J.C.2    Manning, P.A.3
  • 31
    • 0025333838 scopus 로고
    • Cloning and nucleotide sequencing of Vero toxin 2 variant genes from Escherichia coli O91:H21 isolated from a patient with the hemolytic uremic syndrome
    • Ito H, Terai A, Kurazono H, Takeda Y, Nishibuchi M. 1990. Cloning and nucleotide sequencing of Vero toxin 2 variant genes from Escherichia coli O91:H21 isolated from a patient with the hemolytic uremic syndrome. Microb Pathog 8: 47-60.
    • (1990) Microb Pathog , vol.8 , pp. 47-60
    • Ito, H.1    Terai, A.2    Kurazono, H.3    Takeda, Y.4    Nishibuchi, M.5
  • 32
    • 0029874043 scopus 로고    scopus 로고
    • Activation of Shiga-like toxins by mouse and human intestinal mucus correlates with virulence of enterohemorrhagic Escherichia coli O91:H21 isolates in orally infected, streptomycin-treated mice
    • Melton-Celsa AR, Darnell SC, O'Brien AD. 1996. Activation of Shiga-like toxins by mouse and human intestinal mucus correlates with virulence of enterohemorrhagic Escherichia coli O91:H21 isolates in orally infected, streptomycin-treated mice. Infect Immun 64: 1569-1576.
    • (1996) Infect Immun , vol.64 , pp. 1569-1576
    • Melton-Celsa, A.R.1    Darnell, S.C.2    O'Brien, A.D.3
  • 33
    • 2042500663 scopus 로고    scopus 로고
    • Toxin activation by intestinal mucus correlates with the virulence of Shiga toxin-producing Escherichia coli in orally-infected mice
    • Melton-Celsa AR, O'Brien AD. 1998. Toxin activation by intestinal mucus correlates with the virulence of Shiga toxin-producing Escherichia coli in orally-infected mice. Zentbl Bakteriol 29(Suppl.):192-199.
    • (1998) Zentbl Bakteriol , vol.29 , pp. 192-199
    • Melton-Celsa, A.R.1    O'Brien, A.D.2
  • 34
    • 0024375644 scopus 로고
    • Globotetraosylceramide is recognized by the pig edema disease toxin
    • De Grandis S, Law H, Brunton J, Gyles C, Lingwood CA. 1989. Globotetraosylceramide is recognized by the pig edema disease toxin. J Biol Chem 264: 12520-12525.
    • (1989) J Biol Chem , vol.264 , pp. 12520-12525
    • De Grandis, S.1    Law, H.2    Brunton, J.3    Gyles, C.4    Lingwood, C.A.5
  • 35
    • 0025191006 scopus 로고
    • Comparison of the glycolipid receptor specificities of Shigalike toxin type II and Shiga-like toxin type II variants
    • Samuel JE, Perera LP, Ward S, O'Brien AD, Ginsburg V, Krivan HC. 1990. Comparison of the glycolipid receptor specificities of Shigalike toxin type II and Shiga-like toxin type II variants. Infect Immun 58: 611-618.
    • (1990) Infect Immun , vol.58 , pp. 611-618
    • Samuel, J.E.1    Perera, L.P.2    Ward, S.3    O'Brien, A.D.4    Ginsburg, V.5    Krivan, H.C.6
  • 37
    • 0025313405 scopus 로고
    • Molecular cloning and nucleotide sequence of another variant of the Escherichia coli Shiga-like toxin II family
    • Gannon VP, Teerling C, Masri SA, Gyles CL. 1990. Molecular cloning and nucleotide sequence of another variant of the Escherichia coli Shiga-like toxin II family. J Gen Microbiol 136(Pt 6):1125-1135.
    • (1990) J Gen Microbiol , vol.136 , Issue.Pt 6 , pp. 1125-1135
    • Gannon, V.P.1    Teerling, C.2    Masri, S.A.3    Gyles, C.L.4
  • 39
    • 0028357335 scopus 로고
    • The shigella paradigm and colitis due to enterohaemorrhagic Escherichia coli
    • Acheson DW, Keusch GT. 1994. The shigella paradigm and colitis due to enterohaemorrhagic Escherichia coli. Gut 35: 872-874.
    • (1994) Gut , vol.35 , pp. 872-874
    • Acheson, D.W.1    Keusch, G.T.2
  • 40
    • 0000047520 scopus 로고
    • Escherichia coli O157:H7 and other enterohemorrhagic Escherichia coli
    • Blaser MJ, Smith PD, Ravdin JI, Greenberg HB, and Guerrant RL (ed), Raven Press, New York, N.Y
    • Griffin PM. 1995. Escherichia coli O157:H7 and other enterohemorrhagic Escherichia coli, p 739-761. In Blaser MJ, Smith PD, Ravdin JI, Greenberg HB, and Guerrant RL (ed), Infections of the Gastrointestinal Tract. Raven Press, New York, N.Y.
    • (1995) Infections of the Gastrointestinal Tract , pp. 739-761
    • Griffin, P.M.1
  • 45
    • 0344061522 scopus 로고    scopus 로고
    • Characterization of the baboon responses to Shiga-like toxin: descriptive study of a new primate model of toxic responses to Stx-1
    • Taylor FB Jr, Tesh VL, DeBault L, Li A, Chang AC, Kosanke SD, Pysher TJ, Siegler RL. 1999. Characterization of the baboon responses to Shiga-like toxin: descriptive study of a new primate model of toxic responses to Stx-1. Am J Pathol 154: 1285-1299.
    • (1999) Am J Pathol , vol.154 , pp. 1285-1299
    • Taylor, F.B.1    Tesh, V.L.2    DeBault, L.3    Li, A.4    Chang, A.C.5    Kosanke, S.D.6    Pysher, T.J.7    Siegler, R.L.8
  • 47
    • 0025280956 scopus 로고
    • Recent advances in understanding the pathogenesis of the hemolytic uremic syndromes
    • Kaplan BS, Cleary TG, Obrig TG. 1990. Recent advances in understanding the pathogenesis of the hemolytic uremic syndromes. Pediatr Nephrol 4: 276-283.
    • (1990) Pediatr Nephrol , vol.4 , pp. 276-283
    • Kaplan, B.S.1    Cleary, T.G.2    Obrig, T.G.3
  • 48
    • 0034820680 scopus 로고    scopus 로고
    • Pathogenesis of Shiga toxin-induced hemolytic uremic syndrome
    • Ray PE, Liu X-H. 2001. Pathogenesis of Shiga toxin-induced hemolytic uremic syndrome. Pediatr Nephrol 16: 823-839.
    • (2001) Pediatr Nephrol , vol.16 , pp. 823-839
    • Ray, P.E.1    Liu, X.-H.2
  • 50
    • 0037080046 scopus 로고    scopus 로고
    • ABO and P1 blood group antigen expression and the Stx genotype and outcome of childhood Escherichia coli O157:H7 infections
    • Jelacic JK, Wobbe CL, Boster DR, Ciol MA, Watkins SL, Tarr PI, Stapleton AE. 2002. ABO and P1 blood group antigen expression and the Stx genotype and outcome of childhood Escherichia coli O157:H7 infections. J Infect Dis 185: 214-219.
    • (2002) J Infect Dis , vol.185 , pp. 214-219
    • Jelacic, J.K.1    Wobbe, C.L.2    Boster, D.R.3    Ciol, M.A.4    Watkins, S.L.5    Tarr, P.I.6    Stapleton, A.E.7
  • 51
    • 0024369158 scopus 로고
    • Toxin genotypes and plasmid profiles as determinants of systemic sequelae in Escherichia coli O157:H7 infections
    • Ostroff SM, Tarr PI, Neill MA, Lewis JH, Hargrett-Bean N, Kobayashi JM. 1989. Toxin genotypes and plasmid profiles as determinants of systemic sequelae in Escherichia coli O157:H7 infections. J Infect Dis 160: 994-998.
    • (1989) J Infect Dis , vol.160 , pp. 994-998
    • Ostroff, S.M.1    Tarr, P.I.2    Neill, M.A.3    Lewis, J.H.4    Hargrett-Bean, N.5    Kobayashi, J.M.6
  • 52
    • 0023546211 scopus 로고
    • Properties of strains of Escherichia coli belonging to serogroup O157 with special reference to production of Vero cytotoxins VT1 and VT2
    • Scotland SM, Willshaw GA, Smith HR, Rowe B. 1987. Properties of strains of Escherichia coli belonging to serogroup O157 with special reference to production of Vero cytotoxins VT1 and VT2. Epidemiol Infect 99: 613-624.
    • (1987) Epidemiol Infect , vol.99 , pp. 613-624
    • Scotland, S.M.1    Willshaw, G.A.2    Smith, H.R.3    Rowe, B.4
  • 54
    • 0028889506 scopus 로고
    • Specific interaction of Escherichia coli O157:H7-derived Shiga-like toxin II with human renal endothelial cells
    • Louise CB, Obrig TG. 1995. Specific interaction of Escherichia coli O157:H7-derived Shiga-like toxin II with human renal endothelial cells. J Infect Dis 172: 1397-1401.
    • (1995) J Infect Dis , vol.172 , pp. 1397-1401
    • Louise, C.B.1    Obrig, T.G.2
  • 55
    • 0023787493 scopus 로고
    • The histopathology of the hemolytic uremic syndrome associated with verocytotoxin-producing Escherichia coli infections
    • Richardson SE, Karmali MA, Becker LE, Smith CR. 1988. The histopathology of the hemolytic uremic syndrome associated with verocytotoxin-producing Escherichia coli infections. Hum Pathol 19: 1102-1108.
    • (1988) Hum Pathol , vol.19 , pp. 1102-1108
    • Richardson, S.E.1    Karmali, M.A.2    Becker, L.E.3    Smith, C.R.4
  • 56
    • 1342284069 scopus 로고    scopus 로고
    • Interaction of Shiga toxin from Escherichia coli with human intestinal epithelial cell lines and explants: Stx2 induces epithelial damage in organ culture
    • Schuller S, Frankel G, Philips AD. 2004. Interaction of Shiga toxin from Escherichia coli with human intestinal epithelial cell lines and explants: Stx2 induces epithelial damage in organ culture. Cell Microbiol 6: 289-301.
    • (2004) Cell Microbiol , vol.6 , pp. 289-301
    • Schuller, S.1    Frankel, G.2    Philips, A.D.3
  • 58
    • 0027214127 scopus 로고
    • Virulence of enterohemorrhagic Escherichia coli O91:H21 clinical isolates in an orally infected mouse model
    • Lindgren SW, Melton AR, O'Brien AD. 1993. Virulence of enterohemorrhagic Escherichia coli O91:H21 clinical isolates in an orally infected mouse model. Infect Immun 61: 3832-3842.
    • (1993) Infect Immun , vol.61 , pp. 3832-3842
    • Lindgren, S.W.1    Melton, A.R.2    O'Brien, A.D.3
  • 59
    • 0032407577 scopus 로고    scopus 로고
    • Virulence of Shiga toxin-producing Escherichia coli (STEC) in orally-infected mice correlates with the type of toxin produced by the infecting strain
    • Melton-Celsa AR, Rogers JE, Schmitt CK, Darnell SC, O'Brien AD. 1998. Virulence of Shiga toxin-producing Escherichia coli (STEC) in orally-infected mice correlates with the type of toxin produced by the infecting strain. Jpn J Med Sci Biol 51(Suppl.):S108-S114.
    • (1998) Jpn J Med Sci Biol , vol.51 , pp. S108-S114
    • Melton-Celsa, A.R.1    Rogers, J.E.2    Schmitt, C.K.3    Darnell, S.C.4    O'Brien, A.D.5
  • 61
    • 0023880395 scopus 로고
    • Effects of iron and temperature on Shiga-like toxin I production by Escherichia coli
    • Weinstein DL, Holmes RK, O'Brien AD. 1988. Effects of iron and temperature on Shiga-like toxin I production by Escherichia coli. Infect Immun 56: 106-111.
    • (1988) Infect Immun , vol.56 , pp. 106-111
    • Weinstein, D.L.1    Holmes, R.K.2    O'Brien, A.D.3
  • 63
    • 0025044083 scopus 로고
    • Analyses of transcription of the Shiga-like toxin type II and Shiga-like toxin type II variant operons of Escherichia coli
    • Sung LM, Jackson MP, O'Brien AD, Holmes RK. 1990. Analyses of transcription of the Shiga-like toxin type II and Shiga-like toxin type II variant operons of Escherichia coli. J Bacteriol 172: 6386-6395.
    • (1990) J Bacteriol , vol.172 , pp. 6386-6395
    • Sung, L.M.1    Jackson, M.P.2    O'Brien, A.D.3    Holmes, R.K.4
  • 64
    • 0035126514 scopus 로고    scopus 로고
    • Human neutrophils and their products induce Shiga toxin production by enterohemorrhagic Escherichia coli
    • Wagner PL, Acheson DW, Waldor MK. 2001. Human neutrophils and their products induce Shiga toxin production by enterohemorrhagic Escherichia coli. Infect Immun 69: 1934-1937.
    • (2001) Infect Immun , vol.69 , pp. 1934-1937
    • Wagner, P.L.1    Acheson, D.W.2    Waldor, M.K.3
  • 65
    • 0023780698 scopus 로고
    • Cloning and sequencing of a Shiga-like toxin type II variant from Escherichia coli strain responsible for edema disease of swine
    • Weinstein DL, Jackson MP, Samuel JE, Holmes RK, O'Brien AD. 1988. Cloning and sequencing of a Shiga-like toxin type II variant from Escherichia coli strain responsible for edema disease of swine. J Bacteriol 170: 4223-4230.
    • (1988) J Bacteriol , vol.170 , pp. 4223-4230
    • Weinstein, D.L.1    Jackson, M.P.2    Samuel, J.E.3    Holmes, R.K.4    O'Brien, A.D.5
  • 66
    • 0034056335 scopus 로고    scopus 로고
    • Quinolone antibiotics induce Shiga toxinencoding bacteriophages, toxin production, and death in mice
    • Zhang X, McDaniel AD, Wolf LE, Keusch GT, Waldor MK, Acheson DW. 2000. Quinolone antibiotics induce Shiga toxinencoding bacteriophages, toxin production, and death in mice. J Infect Dis 181: 664-670.
    • (2000) J Infect Dis , vol.181 , pp. 664-670
    • Zhang, X.1    McDaniel, A.D.2    Wolf, L.E.3    Keusch, G.T.4    Waldor, M.K.5    Acheson, D.W.6
  • 67
    • 0022615278 scopus 로고
    • Cloning and expression of the genes specifying Shiga-like toxin production in Escherichia coli H19
    • Huang A, De Grandis S, Friesen J, Karmali M, Petric M, Congi R, Brunton JL. 1986. Cloning and expression of the genes specifying Shiga-like toxin production in Escherichia coli H19. J Bacteriol 166: 375-379.
    • (1986) J Bacteriol , vol.166 , pp. 375-379
    • Huang, A.1    De Grandis, S.2    Friesen, J.3    Karmali, M.4    Petric, M.5    Congi, R.6    Brunton, J.L.7
  • 68
    • 0021683078 scopus 로고
    • Shiga-like toxin-converting phages from Escherichia coli strains that cause hemorrhagic colitis or infantile diarrhea
    • O'Brien AD, Newland JW, Miller SF, Holmes RK, Smith HW, Formal SB. 1984. Shiga-like toxin-converting phages from Escherichia coli strains that cause hemorrhagic colitis or infantile diarrhea. Science 226: 694-696.
    • (1984) Science , vol.226 , pp. 694-696
    • O'Brien, A.D.1    Newland, J.W.2    Miller, S.F.3    Holmes, R.K.4    Smith, H.W.5    Formal, S.B.6
  • 69
    • 0021056172 scopus 로고
    • Vero cell toxins in Escherichia coli and related bacteria: transfer by phage and conjugation and toxic action in laboratory animals, chickens and pigs
    • Smith HW, Green P, Parsell Z. 1983. Vero cell toxins in Escherichia coli and related bacteria: transfer by phage and conjugation and toxic action in laboratory animals, chickens and pigs. J Gen Microbiol 129(Pt 10):3121-3137.
    • (1983) J Gen Microbiol , vol.129 , Issue.Pt 10 , pp. 3121-3137
    • Smith, H.W.1    Green, P.2    Parsell, Z.3
  • 71
    • 0031746606 scopus 로고    scopus 로고
    • Functional and genetic analysis of regulatory regions of coliphage H-19B: location of Shiga-like toxin and lysis genes suggest a role for phage functions in toxin release
    • Neely MN, Friedman DI. 1998. Functional and genetic analysis of regulatory regions of coliphage H-19B: location of Shiga-like toxin and lysis genes suggest a role for phage functions in toxin release. Mol Microbiol 28: 1255-1267.
    • (1998) Mol Microbiol , vol.28 , pp. 1255-1267
    • Neely, M.N.1    Friedman, D.I.2
  • 72
    • 0035101012 scopus 로고    scopus 로고
    • Role for a phage promoter in Shiga toxin 2 expression from a pathogenic Escherichia coli strain
    • Wagner PL, Neely MN, Zhang X, Acheson DW, Waldor MK, Friedman DI. 2001. Role for a phage promoter in Shiga toxin 2 expression from a pathogenic Escherichia coli strain. J Bacteriol 183: 2081-2085.
    • (2001) J Bacteriol , vol.183 , pp. 2081-2085
    • Wagner, P.L.1    Neely, M.N.2    Zhang, X.3    Acheson, D.W.4    Waldor, M.K.5    Friedman, D.I.6
  • 74
    • 0034027928 scopus 로고    scopus 로고
    • Identification and characterization of Escherichia coli strains of O157 and non-O157 serogroups containing three distinct Shiga toxin genes
    • Furst S, Scheef J, Bielaszewski M, Russmann H, Karch H. 2000. Identification and characterization of Escherichia coli strains of O157 and non-O157 serogroups containing three distinct Shiga toxin genes. J Med Microbiol 49: 383-386.
    • (2000) J Med Microbiol , vol.49 , pp. 383-386
    • Furst, S.1    Scheef, J.2    Bielaszewski, M.3    Russmann, H.4    Karch, H.5
  • 76
    • 0038104900 scopus 로고    scopus 로고
    • Nonpathogenic Escherichia coli can contribute to the production of Shiga toxin
    • Gamage SD, Strasser JE, Chalk CL, Weiss AA. 2003. Nonpathogenic Escherichia coli can contribute to the production of Shiga toxin. Infect Immun 71: 3107-3115.
    • (2003) Infect Immun , vol.71 , pp. 3107-3115
    • Gamage, S.D.1    Strasser, J.E.2    Chalk, C.L.3    Weiss, A.A.4
  • 78
    • 3843148925 scopus 로고    scopus 로고
    • Possession, use, and transfer of select agents and toxins; interim final rule
    • Centers for Disease Control Prevention. 2002. Possession, use, and transfer of select agents and toxins; interim final rule. Fed Regist 240: 76886-76905.
    • (2002) Fed Regist , vol.240 , pp. 76886-76905
  • 79
    • 0028367338 scopus 로고
    • Crystal structure of the holotoxin from Shigella dysenteriae at 2.5 Å resolution
    • Fraser ME, Chernaia MM, Kozlov YV, James MN. 1994. Crystal structure of the holotoxin from Shigella dysenteriae at 2.5 Å resolution. Nat Struct Biol 1: 59-64.
    • (1994) Nat Struct Biol , vol.1 , pp. 59-64
    • Fraser, M.E.1    Chernaia, M.M.2    Kozlov, Y.V.3    James, M.N.4
  • 81
    • 0028174549 scopus 로고
    • Evidence that the A2 fragment of Shiga-like toxin type I is required for holotoxin integrity
    • Austin PR, Jablonski PE, Bohach GA, Dunker AK, Hovde CJ. 1994. Evidence that the A2 fragment of Shiga-like toxin type I is required for holotoxin integrity. Infect Immun 62: 1768-1775.
    • (1994) Infect Immun , vol.62 , pp. 1768-1775
    • Austin, P.R.1    Jablonski, P.E.2    Bohach, G.A.3    Dunker, A.K.4    Hovde, C.J.5
  • 82
    • 0027492707 scopus 로고
    • Comparison of the B-pentamers of heat-labile enterotoxin and verotoxin-1: two structures with remarkable similarity and dissimilarity
    • Sixma TK, Stein PE, Hol WG, Read RJ. 1993. Comparison of the B-pentamers of heat-labile enterotoxin and verotoxin-1: two structures with remarkable similarity and dissimilarity. Biochemistry 32: 191-198.
    • (1993) Biochemistry , vol.32 , pp. 191-198
    • Sixma, T.K.1    Stein, P.E.2    Hol, W.G.3    Read, R.J.4
  • 83
    • 0026543155 scopus 로고
    • Crystal structure of the cell-binding B oligomer of verotoxin-1 from E coli.
    • Stein PE, Boodhoo A, Tyrrell GJ, Brunton JL, Read RJ. 1992. Crystal structure of the cell-binding B oligomer of verotoxin-1 from E. coli. Nature 355: 748-750.
    • (1992) Nature , vol.355 , pp. 748-750
    • Stein, P.E.1    Boodhoo, A.2    Tyrrell, G.J.3    Brunton, J.L.4    Read, R.J.5
  • 84
    • 0042572519 scopus 로고    scopus 로고
    • Thermodynamic analysis of the structural stability of the Shiga toxin B-subunit
    • Pina DG, Gomez J, Villar E, Johannes L, Shnyrov VL. 2003. Thermodynamic analysis of the structural stability of the Shiga toxin B-subunit. Biochemistry 42: 9498-9506.
    • (2003) Biochemistry , vol.42 , pp. 9498-9506
    • Pina, D.G.1    Gomez, J.2    Villar, E.3    Johannes, L.4    Shnyrov, V.L.5
  • 85
    • 0026244229 scopus 로고
    • MOLSCRIPT: a program to produce both detailed and schematic plots of protein
    • Kraulis P. 1991. MOLSCRIPT: a program to produce both detailed and schematic plots of protein. J Appl Crystallogr 24: 946-950.
    • (1991) J Appl Crystallogr , vol.24 , pp. 946-950
    • Kraulis, P.1
  • 86
    • 0030815133 scopus 로고    scopus 로고
    • Raster3D: photorealistic molecular graphics
    • Merritt E, Bacon D. 1997. Raster3D: photorealistic molecular graphics. Methods Enzymol 277: 505-524.
    • (1997) Methods Enzymol , vol.277 , pp. 505-524
    • Merritt, E.1    Bacon, D.2
  • 89
    • 0034819738 scopus 로고    scopus 로고
    • Shiga toxin translocation across intestinal epithelial cells is enhanced by neutrophil transmigration
    • Hurley BP, Thorpe CM, Acheson DWK. 2001. Shiga toxin translocation across intestinal epithelial cells is enhanced by neutrophil transmigration. Infect Immun 69: 6148-6155.
    • (2001) Infect Immun , vol.69 , pp. 6148-6155
    • Hurley, B.P.1    Thorpe, C.M.2    Acheson, D.W.K.3
  • 90
    • 0028141671 scopus 로고
    • Evidence that verotoxins (Shiga-like toxins) from Escherichia coli bind to P blood group antigens of human erythrocytes in vitro
    • Bitzan M, Richardson S, Huang C, Boyd B, Petric M, Karmali MA. 1994. Evidence that verotoxins (Shiga-like toxins) from Escherichia coli bind to P blood group antigens of human erythrocytes in vitro. Infect Immun 62: 3337-3347.
    • (1994) Infect Immun , vol.62 , pp. 3337-3347
    • Bitzan, M.1    Richardson, S.2    Huang, C.3    Boyd, B.4    Petric, M.5    Karmali, M.A.6
  • 92
    • 0035874529 scopus 로고    scopus 로고
    • Platelet activation by Shiga toxin and circulatory factors as a pathogenetic mechanism in the hemolytic uremic syndrome
    • Karpman D, Papadopoulou D, Nilsson K, Sjogren AC, Mikaelsson C, Lethagen S. 2001. Platelet activation by Shiga toxin and circulatory factors as a pathogenetic mechanism in the hemolytic uremic syndrome. Blood 97: 3100-3108.
    • (2001) Blood , vol.97 , pp. 3100-3108
    • Karpman, D.1    Papadopoulou, D.2    Nilsson, K.3    Sjogren, A.C.4    Mikaelsson, C.5    Lethagen, S.6
  • 93
    • 0025190414 scopus 로고
    • The expression of blood group P1 in post-enteropathic haemolytic uraemic syndrome
    • Taylor CM, Milford DV, Rose PE, Roy TC, Rowe B. 1990. The expression of blood group P1 in post-enteropathic haemolytic uraemic syndrome. Pediatr Nephrol 4: 59-61.
    • (1990) Pediatr Nephrol , vol.4 , pp. 59-61
    • Taylor, C.M.1    Milford, D.V.2    Rose, P.E.3    Roy, T.C.4    Rowe, B.5
  • 96
    • 0032962143 scopus 로고    scopus 로고
    • The detection of Shiga toxins in the kidney of a patient with hemolytic uremic syndrome
    • Uchida H, Kiyokawa N, Horie H, Fujimoto J, Takeda T. 1999. The detection of Shiga toxins in the kidney of a patient with hemolytic uremic syndrome. Pediatr Res 45: 133-137.
    • (1999) Pediatr Res , vol.45 , pp. 133-137
    • Uchida, H.1    Kiyokawa, N.2    Horie, H.3    Fujimoto, J.4    Takeda, T.5
  • 97
    • 0022508584 scopus 로고
    • Pathogenesis of Shigella diarrhea XI. Isolation of a Shigella toxin-binding glycolipid from rabbit jejunum and HeLa cells and its identification as globotriaosylceramide.
    • Jacewicz M, Clausen H, Nudelman E, Donohue-Rolfe A, Keusch GT. 1986. Pathogenesis of Shigella diarrhea. XI. Isolation of a Shigella toxin-binding glycolipid from rabbit jejunum and HeLa cells and its identification as globotriaosylceramide. J Exp Med 163: 1391-1404.
    • (1986) J Exp Med , vol.163 , pp. 1391-1404
    • Jacewicz, M.1    Clausen, H.2    Nudelman, E.3    Donohue-Rolfe, A.4    Keusch, G.T.5
  • 99
    • 0029786680 scopus 로고    scopus 로고
    • Importance of glycolipid synthesis for butyric acid-induced sensitization to Shiga toxin and intracellular sorting of toxin in A431 cells
    • Sandvig K, Garred O, van Helvoort A, van Meer G, van Deurs B. 1996. Importance of glycolipid synthesis for butyric acid-induced sensitization to Shiga toxin and intracellular sorting of toxin in A431 cells. Mol Biol Cell 7: 1391-1404.
    • (1996) Mol Biol Cell , vol.7 , pp. 1391-1404
    • Sandvig, K.1    Garred, O.2    van Helvoort, A.3    van Meer, G.4    van Deurs, B.5
  • 100
    • 0033520914 scopus 로고    scopus 로고
    • Activation of Src family kinase Yes induced by Shiga toxin binding to Globotriaosyl ceramide (Gb3/CD77) in low density, detergent-insoluble microdomains
    • Katagiri YU, Mori T, Nakajima H, Katagiri C, Taguchi T, Takeda T, Kiyokawa N, Fujimoto J. 1999. Activation of Src family kinase Yes induced by Shiga toxin binding to Globotriaosyl ceramide (Gb3/CD77) in low density, detergent-insoluble microdomains. J Biol Chem 274: 35278-35282.
    • (1999) J Biol Chem , vol.274 , pp. 35278-35282
    • Katagiri, Y.U.1    Mori, T.2    Nakajima, H.3    Katagiri, C.4    Taguchi, T.5    Takeda, T.6    Kiyokawa, N.7    Fujimoto, J.8
  • 102
    • 0028352977 scopus 로고
    • Retrograde transport from the Golgi complex to the ER of both Shiga toxin and the nontoxic Shiga B-fragment is regulated by butyric acid and cAMP
    • Sandvig K, Ryd M, Garred O, Schweda E, Holm PK, van Deurs B. 1994. Retrograde transport from the Golgi complex to the ER of both Shiga toxin and the nontoxic Shiga B-fragment is regulated by butyric acid and cAMP. J Cell Biol 126: 53-64.
    • (1994) J Cell Biol , vol.126 , pp. 53-64
    • Sandvig, K.1    Ryd, M.2    Garred, O.3    Schweda, E.4    Holm, P.K.5    van Deurs, B.6
  • 103
    • 0035168061 scopus 로고    scopus 로고
    • Targeting of Shiga toxin Bsubunit to retrograde transport route in association with detergentresistant membranes
    • Falguieres T, Mallard F, Baron C, Hanau D, Lingwood C, Goud B, Salamero J, Johannes L. 2001. Targeting of Shiga toxin Bsubunit to retrograde transport route in association with detergentresistant membranes. Mol Biol Cell 12: 2453-2468.
    • (2001) Mol Biol Cell , vol.12 , pp. 2453-2468
    • Falguieres, T.1    Mallard, F.2    Baron, C.3    Hanau, D.4    Lingwood, C.5    Goud, B.6    Salamero, J.7    Johannes, L.8
  • 104
    • 0031773458 scopus 로고    scopus 로고
    • Intracellular targeting of the endoplasmic reticulum/nuclear envelope by retrograde transport may determine cell hypersensitivity to verotoxin via globotriaosyl ceramide fatty acid isoform traffic
    • Arab S, Lingwood CA. 1998. Intracellular targeting of the endoplasmic reticulum/nuclear envelope by retrograde transport may determine cell hypersensitivity to verotoxin via globotriaosyl ceramide fatty acid isoform traffic. J Cell Physiol 177: 646-660.
    • (1998) J Cell Physiol , vol.177 , pp. 646-660
    • Arab, S.1    Lingwood, C.A.2
  • 105
    • 0344375094 scopus 로고    scopus 로고
    • Verotoxin 1 binding to intestinal crypt epithelial cells results in localization to lysosomes and abrogation of toxicity
    • Hoey EDE, Sharp L, Currie C, Lingwood CA, Gally DL, Smith DGE. 2003. Verotoxin 1 binding to intestinal crypt epithelial cells results in localization to lysosomes and abrogation of toxicity. Cell Microbiol 5: 85-97.
    • (2003) Cell Microbiol , vol.5 , pp. 85-97
    • Hoey, E.D.E.1    Sharp, L.2    Currie, C.3    Lingwood, C.A.4    Gally, D.L.5    Smith, D.G.E.6
  • 106
    • 0025028971 scopus 로고
    • Induction of verotoxin sensitivity in receptor-deficient cell lines using the receptor glycolipid globotriosylceramide
    • Waddell T, Cohen A, Lingwood CA. 1990. Induction of verotoxin sensitivity in receptor-deficient cell lines using the receptor glycolipid globotriosylceramide. Proc Natl Acad Sci USA 87: 7898-7901.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 7898-7901
    • Waddell, T.1    Cohen, A.2    Lingwood, C.A.3
  • 107
    • 0033062483 scopus 로고    scopus 로고
    • The identification of three biologically relevant globotriaosyl ceramide receptor binding sites on the Verotoxin 1 B subunit
    • Bast DJ, Banerjee L, Clark C, Read RJ, Brunton JL. 1999. The identification of three biologically relevant globotriaosyl ceramide receptor binding sites on the Verotoxin 1 B subunit. Mol Microbiol 32: 953-960.
    • (1999) Mol Microbiol , vol.32 , pp. 953-960
    • Bast, D.J.1    Banerjee, L.2    Clark, C.3    Read, R.J.4    Brunton, J.L.5
  • 109
    • 0030113327 scopus 로고    scopus 로고
    • Two distinct binding sites for globotriaosyl ceramide on verotoxins: identification by molecular modelling and confirmation using deoxy analogues and a new glycolipid receptor for all verotoxins
    • Nyholm PG, Magnusson G, Zheng Z, Norel R, Binnington-Boyd B, Lingwood CA. 1996. Two distinct binding sites for globotriaosyl ceramide on verotoxins: identification by molecular modelling and confirmation using deoxy analogues and a new glycolipid receptor for all verotoxins. Chem Biol 3: 263-275.
    • (1996) Chem Biol , vol.3 , pp. 263-275
    • Nyholm, P.G.1    Magnusson, G.2    Zheng, Z.3    Norel, R.4    Binnington-Boyd, B.5    Lingwood, C.A.6
  • 110
    • 0032483135 scopus 로고    scopus 로고
    • Solution structure of the complex between the B-subunit homopentamer of verotoxin VT-1 from Escherichia coli and the trisaccharide moiety of globotriaosylceramide
    • Shimizu H, Field RA, Homans SW, Donohue-Rolfe A. 1998. Solution structure of the complex between the B-subunit homopentamer of verotoxin VT-1 from Escherichia coli and the trisaccharide moiety of globotriaosylceramide. Biochemistry 37: 11078-11082.
    • (1998) Biochemistry , vol.37 , pp. 11078-11082
    • Shimizu, H.1    Field, R.A.2    Homans, S.W.3    Donohue-Rolfe, A.4
  • 111
    • 0028596536 scopus 로고
    • Interaction of the Shiga-like toxin type 1 B-subunit with its carbohydrate receptor
    • St. Hilaire PM, Boyd MK, Toone EJ. 1994. Interaction of the Shiga-like toxin type 1 B-subunit with its carbohydrate receptor. Biochemistry 33: 14452-14463.
    • (1994) Biochemistry , vol.33 , pp. 14452-14463
    • St Hilaire, P.M.1    Boyd, M.K.2    Toone, E.J.3
  • 112
    • 0026684124 scopus 로고
    • Retrograde transport of endocytosed Shiga toxin to the endoplasmic reticulum
    • Sandvig K, Garred O, Prydz K, Kozlov JV, Hansen SH, van Deurs B. 1992. Retrograde transport of endocytosed Shiga toxin to the endoplasmic reticulum. Nature 358: 510-512.
    • (1992) Nature , vol.358 , pp. 510-512
    • Sandvig, K.1    Garred, O.2    Prydz, K.3    Kozlov, J.V.4    Hansen, S.H.5    van Deurs, B.6
  • 114
    • 0028171126 scopus 로고
    • Capping and receptor-mediated endocytosis of cell-bound verotoxin (Shiga-like toxin) 1. Chemical identification of an amino acid in the B subunit necessary for efficient receptor glycolipid binding and cellular internalization.
    • Khine AA, Lingwood CA. 1994. Capping and receptor-mediated endocytosis of cell-bound verotoxin (Shiga-like toxin). 1. Chemical identification of an amino acid in the B subunit necessary for efficient receptor glycolipid binding and cellular internalization. J Cell Physiol 161: 319-332.
    • (1994) J Cell Physiol , vol.161 , pp. 319-332
    • Khine, A.A.1    Lingwood, C.A.2
  • 115
    • 0034669117 scopus 로고    scopus 로고
    • Entry of ricin and Shiga toxin into cells: molecular mechanisms and medical prospectives
    • Sandvig K, van Deurs B. 2000. Entry of ricin and Shiga toxin into cells: molecular mechanisms and medical prospectives. EMBO J 19: 5943-5950.
    • (2000) EMBO J , vol.19 , pp. 5943-5950
    • Sandvig, K.1    van Deurs, B.2
  • 116
    • 0345490781 scopus 로고    scopus 로고
    • The intracellular voyage of cholera toxin: going retro
    • Lencer WI, Tsai B. 2003. The intracellular voyage of cholera toxin: going retro. Trends Biochem Sci 28: 639-645.
    • (2003) Trends Biochem Sci , vol.28 , pp. 639-645
    • Lencer, W.I.1    Tsai, B.2
  • 117
    • 0035937408 scopus 로고    scopus 로고
    • Protein disulfide isomerase acts a redox-dependent chaperone to unfold cholera toxin
    • Tsai B, Rodighiero C, Lencer WI, Rapoport TA. 2001. Protein disulfide isomerase acts a redox-dependent chaperone to unfold cholera toxin. Cell 104: 937-948.
    • (2001) Cell , vol.104 , pp. 937-948
    • Tsai, B.1    Rodighiero, C.2    Lencer, W.I.3    Rapoport, T.A.4
  • 118
    • 0023664263 scopus 로고
    • The mechanism of action of ricin and related toxic lectins on eukaryotic ribosomes The site and the characteristics of the modification in 28 S ribosomal RNA caused by the toxins.
    • Endo Y, Mitsui K, Motizuki M, Tsurugi K. 1987. The mechanism of action of ricin and related toxic lectins on eukaryotic ribosomes. The site and the characteristics of the modification in 28 S ribosomal RNA caused by the toxins. J Biol Chem 262: 5908-5912.
    • (1987) J Biol Chem , vol.262 , pp. 5908-5912
    • Endo, Y.1    Mitsui, K.2    Motizuki, M.3    Tsurugi, K.4
  • 119
    • 2042422489 scopus 로고    scopus 로고
    • Shiga toxins of Shigella dysenteriae and Escherichia coli
    • Aktories K and Just I (ed), Springer-Verlag, Berlin, Germany
    • Melton-Celsa AR, O'Brien AD. 2000. Shiga toxins of Shigella dysenteriae and Escherichia coli, p 385-406. In Aktories K and Just I (ed), Handbook of Experimental Pharmacology, vol. 145. Springer-Verlag, Berlin, Germany.
    • (2000) Handbook of Experimental Pharmacology , vol.145 , pp. 385-406
    • Melton-Celsa, A.R.1    O'Brien, A.D.2
  • 121
    • 0027494536 scopus 로고
    • The role of tyrosine-114 in the enzymatic activity of the Shiga-like toxin I A-chain
    • Deresiewicz RL, Austin PR, Hovde CJ. 1993. The role of tyrosine-114 in the enzymatic activity of the Shiga-like toxin I A-chain. Mol Gen Genet 241: 467-473.
    • (1993) Mol Gen Genet , vol.241 , pp. 467-473
    • Deresiewicz, R.L.1    Austin, P.R.2    Hovde, C.J.3
  • 123
    • 0026185113 scopus 로고
    • Importance of arginine at position 170 of the A subunit of Vero toxin 1 produced by enterohemorrhagic Escherichia coli for toxin activity
    • Yamasaki S, Furutani M, Ito K, Igarashi K, Nishibuchi M, Takeda Y. 1991. Importance of arginine at position 170 of the A subunit of Vero toxin 1 produced by enterohemorrhagic Escherichia coli for toxin activity. Microb Pathog 11: 1-9.
    • (1991) Microb Pathog , vol.11 , pp. 1-9
    • Yamasaki, S.1    Furutani, M.2    Ito, K.3    Igarashi, K.4    Nishibuchi, M.5    Takeda, Y.6
  • 124
    • 0032581041 scopus 로고    scopus 로고
    • Shiga toxin attacks bacterial ribosomes as effectively as eucaryotic ribosomes
    • Suh JK, Hovde CJ, Robertus JD. 1998. Shiga toxin attacks bacterial ribosomes as effectively as eucaryotic ribosomes. Biochemistry 37: 9394-9398.
    • (1998) Biochemistry , vol.37 , pp. 9394-9398
    • Suh, J.K.1    Hovde, C.J.2    Robertus, J.D.3
  • 128
    • 0032528349 scopus 로고    scopus 로고
    • Shiga toxin type 1 activates tumor necrosis factor-a gene transcription and nuclear translocation of the transcriptional activators nuclear factor-kB and activator protein-1
    • Sakiri R, Ramegowda B, Tesh VL. 1998. Shiga toxin type 1 activates tumor necrosis factor-a gene transcription and nuclear translocation of the transcriptional activators nuclear factor-kB and activator protein-1. Blood 92: 558-566.
    • (1998) Blood , vol.92 , pp. 558-566
    • Sakiri, R.1    Ramegowda, B.2    Tesh, V.L.3
  • 129
    • 0029957125 scopus 로고    scopus 로고
    • Effects of verocytotoxin-1 on nonadherent human monocytes: binding characteristics, protein synthesis, and induction of cytokine release
    • van Setten PA, Monnens LAH, Verstraten RGG, van Den Heuvel LP, van Hinsbergh VW. 1996. Effects of verocytotoxin-1 on nonadherent human monocytes: binding characteristics, protein synthesis, and induction of cytokine release. Blood 88: 174-183.
    • (1996) Blood , vol.88 , pp. 174-183
    • van Setten, P.A.1    Monnens, L.A.H.2    Verstraten, R.G.G.3    van Den Heuvel, L.P.4    van Hinsbergh, V.W.5
  • 130
    • 0025946126 scopus 로고
    • Shiga toxin-associated hemolyticuremic syndrome: combined cytotoxic effects of Shiga toxin, interleukin-1 beta, and tumor necrosis factor alpha on human vascular endothelial cells in vitro
    • Louise CB, Obrig TG. 1991. Shiga toxin-associated hemolyticuremic syndrome: combined cytotoxic effects of Shiga toxin, interleukin-1 beta, and tumor necrosis factor alpha on human vascular endothelial cells in vitro. Infect Immun 59: 4173-4179.
    • (1991) Infect Immun , vol.59 , pp. 4173-4179
    • Louise, C.B.1    Obrig, T.G.2
  • 131
    • 0025800056 scopus 로고
    • Evaluation of the role of Shiga and Shiga-like toxins in mediating direct damage to human vascular endothelial cells
    • Tesh VL, Samuel JE, Perera LP, Sharefkin JB, O'Brien AD. 1991. Evaluation of the role of Shiga and Shiga-like toxins in mediating direct damage to human vascular endothelial cells. J Infect Dis 164: 344-352.
    • (1991) J Infect Dis , vol.164 , pp. 344-352
    • Tesh, V.L.1    Samuel, J.E.2    Perera, L.P.3    Sharefkin, J.B.4    O'Brien, A.D.5
  • 132
    • 0032603531 scopus 로고    scopus 로고
    • Verotoxin induces apoptosis and the complete, rapid, long-term elimination of human astrocytoma xenografts in nude mice
    • Arab S, Rutka J, Lingwood C. 1999. Verotoxin induces apoptosis and the complete, rapid, long-term elimination of human astrocytoma xenografts in nude mice. Oncol Res 11: 33-39.
    • (1999) Oncol Res , vol.11 , pp. 33-39
    • Arab, S.1    Rutka, J.2    Lingwood, C.3
  • 133
    • 0842311700 scopus 로고    scopus 로고
    • Verotoxin sensitivity of ECV304 cells in vitro and in vivo in a xenograft tumour model: VT1 as a tumour neovascular marker
    • Heath-Engel HM, Lingwood CA. 2003. Verotoxin sensitivity of ECV304 cells in vitro and in vivo in a xenograft tumour model: VT1 as a tumour neovascular marker. Angiogenesis 6: 129-141.
    • (2003) Angiogenesis , vol.6 , pp. 129-141
    • Heath-Engel, H.M.1    Lingwood, C.A.2
  • 136
    • 0037220584 scopus 로고    scopus 로고
    • Antiviral activity of Shiga toxin requires enzymatic activity and is associated with increased permeability of the target cells
    • Basu I, Ferens WA, Stone DM, Hovde CJ. 2003. Antiviral activity of Shiga toxin requires enzymatic activity and is associated with increased permeability of the target cells. Infect Immun 71: 327-334.
    • (2003) Infect Immun , vol.71 , pp. 327-334
    • Basu, I.1    Ferens, W.A.2    Stone, D.M.3    Hovde, C.J.4
  • 137
    • 0033943684 scopus 로고    scopus 로고
    • Antiviral activity of Shiga toxin 1:suppression of bovine leukemia virus-related spontaneous lymphocyte proliferation
    • Ferens WA, Hovde CJ. 2000. Antiviral activity of Shiga toxin 1:suppression of bovine leukemia virus-related spontaneous lymphocyte proliferation. Infect Immun 68: 4462-4469.
    • (2000) Infect Immun , vol.68 , pp. 4462-4469
    • Ferens, W.A.1    Hovde, C.J.2
  • 138
    • 0031175179 scopus 로고    scopus 로고
    • Predictors of hemolytic uremic syndrome in children during a large outbreak of Escherichia coli O157:H7 infections
    • Bell BP, Griffin PM, Lozano P, Christie DL, Kobayashi JM, Tarr PI. 1997. Predictors of hemolytic uremic syndrome in children during a large outbreak of Escherichia coli O157:H7 infections. Pediatrics 100: E12.
    • (1997) Pediatrics , vol.100 , pp. E12
    • Bell, B.P.1    Griffin, P.M.2    Lozano, P.3    Christie, D.L.4    Kobayashi, J.M.5    Tarr, P.I.6
  • 140
    • 84943208932 scopus 로고
    • Infections with Escherichia coli O157:H7 in Washington State The first year of statewide disease surveillance.
    • Ostroff SM, Kobayashi JM, Lewis JH. 1989. Infections with Escherichia coli O157:H7 in Washington State. The first year of statewide disease surveillance. JAMA 262: 355-359.
    • (1989) JAMA , vol.262 , pp. 355-359
    • Ostroff, S.M.1    Kobayashi, J.M.2    Lewis, J.H.3
  • 141
    • 0002077144 scopus 로고
    • Subinhibitory concentrations of antibiotics modulate amount of Shiga-like toxin produced by Escherichia coli
    • Adam D, Hahn H, and Opferkuch W (ed, Springer-Verlag, Berlin, Germany
    • Karch H, Goroncy-Termes P, Opferkuch W, Kroll H-P, O'Brien A. 1985. Subinhibitory concentrations of antibiotics modulate amount of Shiga-like toxin produced by Escherichia coli, p 239-245. In Adam D, Hahn H, and Opferkuch W (ed), The Influence of Antibiotics on the Host-Parasite Relationship II. Springer-Verlag, Berlin, Germany.
    • (1985) The Influence of Antibiotics on the Host-Parasite Relationship II , pp. 239-245
    • Karch, H.1    Goroncy-Termes, P.2    Opferkuch, W.3    Kroll, H.-P.4    O'Brien, A.5
  • 142
    • 0032932223 scopus 로고    scopus 로고
    • Induction of prophages of enterohemorrhagic Escherichia coli O157:H7 with norfloxacin
    • Matsushiro A, Sato K, Miyamoto H, Yamamura T, Honda T. 1999. Induction of prophages of enterohemorrhagic Escherichia coli O157:H7 with norfloxacin. J Bacteriol 181: 2257-2260.
    • (1999) J Bacteriol , vol.181 , pp. 2257-2260
    • Matsushiro, A.1    Sato, K.2    Miyamoto, H.3    Yamamura, T.4    Honda, T.5
  • 143
    • 0037190067 scopus 로고    scopus 로고
    • Antimicrobial therapy in patients with Escherichia coli O157:H7 infection
    • Molbak K, Mead PS, Griffin PM. 2002. Antimicrobial therapy in patients with Escherichia coli O157:H7 infection. JAMA 288: 1014-1016.
    • (2002) JAMA , vol.288 , pp. 1014-1016
    • Molbak, K.1    Mead, P.S.2    Griffin, P.M.3
  • 144
    • 0034729744 scopus 로고    scopus 로고
    • The risk of the hemolytic-uremic syndrome after antibiotic treatment of Escherichia coli O157:H7 infections
    • Wong CS, Jelacic S, Habeeb RL, Watkins SL, Tarr PI. 2000. The risk of the hemolytic-uremic syndrome after antibiotic treatment of Escherichia coli O157:H7 infections. N Engl J Med 342: 1930-1936.
    • (2000) N Engl J Med , vol.342 , pp. 1930-1936
    • Wong, C.S.1    Jelacic, S.2    Habeeb, R.L.3    Watkins, S.L.4    Tarr, P.I.5
  • 145
    • 0032753465 scopus 로고    scopus 로고
    • Effect of early fosfomycin treatment on prevention of hemolytic uremic syndrome accompanying Escherichia coli O157:H7 infection
    • Ikeda K, Ida O, Kimoto K, Takatorige T, Nakanishi N, Tatara K. 1999. Effect of early fosfomycin treatment on prevention of hemolytic uremic syndrome accompanying Escherichia coli O157:H7 infection. Clin Nephrol 52: 357-362.
    • (1999) Clin Nephrol , vol.52 , pp. 357-362
    • Ikeda, K.1    Ida, O.2    Kimoto, K.3    Takatorige, T.4    Nakanishi, N.5    Tatara, K.6
  • 146
    • 0025749699 scopus 로고
    • Investigation of Shiga-like toxin binding to chemically synthesized oligosaccharide sequences
    • Armstrong GD, Fodor E, Vanmaele R. 1991. Investigation of Shiga-like toxin binding to chemically synthesized oligosaccharide sequences. J Infect Dis 164: 1160-1167.
    • (1991) J Infect Dis , vol.164 , pp. 1160-1167
    • Armstrong, G.D.1    Fodor, E.2    Vanmaele, R.3
  • 147
    • 0041411080 scopus 로고    scopus 로고
    • Effect of an oral Shiga toxin-binding agent on diarrhea-associated hemolytic uremic syndrome in children: a randomized controlled trial
    • Trachtman H, Cnaan A, Christen E, Gibbs K, Zhao S, Acheson DW, Weiss R, Kaskel FJ, Spitzer A, Hirschman GH. 2003. Effect of an oral Shiga toxin-binding agent on diarrhea-associated hemolytic uremic syndrome in children: a randomized controlled trial. JAMA 290: 1337-1344.
    • (2003) JAMA , vol.290 , pp. 1337-1344
    • Trachtman, H.1    Cnaan, A.2    Christen, E.3    Gibbs, K.4    Zhao, S.5    Acheson, D.W.6    Weiss, R.7    Kaskel, F.J.8    Spitzer, A.9    Hirschman, G.H.10
  • 150
    • 0037442497 scopus 로고    scopus 로고
    • Assessment in mice of the therapeutic potential of tailored, multivalent Shiga toxin carbohydrate ligands
    • Mulvey GL, Marcato P, Kitov PI, Sadowska J, Bundle DR, Armstrong GD. 2003. Assessment in mice of the therapeutic potential of tailored, multivalent Shiga toxin carbohydrate ligands. J Infect Dis 187: 640-649.
    • (2003) J Infect Dis , vol.187 , pp. 640-649
    • Mulvey, G.L.1    Marcato, P.2    Kitov, P.I.3    Sadowska, J.4    Bundle, D.R.5    Armstrong, G.D.6
  • 154
    • 0038444124 scopus 로고    scopus 로고
    • Stx2-specific human monoclonal antibodies protect mice against lethal infection with Escherichia coli expressing Stx2 variants
    • Sheoran AS, Chapman S, Singh P, Donohue-Rolfe A, Tzipori S. 2003. Stx2-specific human monoclonal antibodies protect mice against lethal infection with Escherichia coli expressing Stx2 variants. Infect Immun 71: 3125-3130.
    • (2003) Infect Immun , vol.71 , pp. 3125-3130
    • Sheoran, A.S.1    Chapman, S.2    Singh, P.3    Donohue-Rolfe, A.4    Tzipori, S.5
  • 155
    • 0035884459 scopus 로고    scopus 로고
    • Efficacy of postinfection treatment with anti-Shiga toxin (Stx) 2 humanized monoclonal antibody TMA-15 in mice lethally challenged with Stx-producing Escherichia coli
    • Yamagami S, Motoki M, Kimura T, Izumi H, Takeda T, Katsuura Y, Matsumoto Y. 2001. Efficacy of postinfection treatment with anti-Shiga toxin (Stx) 2 humanized monoclonal antibody TMA-15 in mice lethally challenged with Stx-producing Escherichia coli. J Infect Dis 184: 738-742.
    • (2001) J Infect Dis , vol.184 , pp. 738-742
    • Yamagami, S.1    Motoki, M.2    Kimura, T.3    Izumi, H.4    Takeda, T.5    Katsuura, Y.6    Matsumoto, Y.7
  • 156
    • 0026078191 scopus 로고
    • Serological responses to the B subunit of Shiga-like toxin 1 and its peptide fragments indicate that the B subunit is a vaccine candidate to counter action of the toxin
    • Boyd B, Richardson S, Gariepy J. 1991. Serological responses to the B subunit of Shiga-like toxin 1 and its peptide fragments indicate that the B subunit is a vaccine candidate to counter action of the toxin. Infect Immun 59: 750-757.
    • (1991) Infect Immun , vol.59 , pp. 750-757
    • Boyd, B.1    Richardson, S.2    Gariepy, J.3
  • 157
    • 0030961347 scopus 로고    scopus 로고
    • Coexpression of the B subunit of Shiga toxin 1 and EaeA from enterohemorrhagic Escherichia coli in Vibrio cholerae vaccine strains
    • Butterton JR, Ryan ET, Acheson DW, Calderwood SB. 1997. Coexpression of the B subunit of Shiga toxin 1 and EaeA from enterohemorrhagic Escherichia coli in Vibrio cholerae vaccine strains. Infect Immun 65: 2127-2135.
    • (1997) Infect Immun , vol.65 , pp. 2127-2135
    • Butterton, J.R.1    Ryan, E.T.2    Acheson, D.W.3    Calderwood, S.B.4
  • 159
    • 0023903983 scopus 로고
    • Synthetic peptides of Shiga toxin B subunit induce antibodies which neutralize its biological activity
    • Harari I, Donohue-Rolfe A, Keusch G, Arnon R. 1988. Synthetic peptides of Shiga toxin B subunit induce antibodies which neutralize its biological activity. Infect Immun 56: 1618-1624.
    • (1988) Infect Immun , vol.56 , pp. 1618-1624
    • Harari, I.1    Donohue-Rolfe, A.2    Keusch, G.3    Arnon, R.4
  • 161
    • 84959058110 scopus 로고    scopus 로고
    • Synthesis and immunologic properties of O-specific polysaccharide-protein conjugate vaccines for prevention and treatment of infections with Escherichia coli O157 and other causes of hemolytic-uremic syndrome
    • Kaper JB and O'Brien AD (ed), ASM Press, Washington, D.C
    • Konadu E, Parke JC, Jr, Donohue-Rolfe A, Calderwood SB, Robbins JB, Szu SC. 1998. Synthesis and immunologic properties of O-specific polysaccharide-protein conjugate vaccines for prevention and treatment of infections with Escherichia coli O157 and other causes of hemolytic-uremic syndrome, p 419-424. In Kaper JB and O'Brien AD (ed), Escherichia coli O157:H7 and Other Shiga Toxin-Producing E. coli Strains. ASM Press, Washington, D.C.
    • (1998) Escherichia coli O157:H7 and Other Shiga Toxin-Producing E. coli Strains , pp. 419-424
    • Konadu, E.1    Parke, J.C.2    Donohue-Rolfe, A.3    Calderwood, S.B.4    Robbins, J.B.5    Szu, S.C.6
  • 162
    • 0242595620 scopus 로고    scopus 로고
    • Stx-liposome conjugates as candidate vaccines
    • Uchida T. 2003. Stx-liposome conjugates as candidate vaccines. Drugs Today 39: 673-693.
    • (2003) Drugs Today , vol.39 , pp. 673-693
    • Uchida, T.1
  • 163
    • 0003866334 scopus 로고    scopus 로고
    • U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Md
    • Army Medical Research Institute US of Infectious Diseases. 1998. Medical management of biological casualties: handbook. U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Md.
    • (1998) Medical management of biological casualties: handbook
  • 164
    • 0034696740 scopus 로고    scopus 로고
    • Biological and chemical terrorism: Strategic plan for preparedness and response
    • Centers for Disease Control Prevention. 2000. Biological and chemical terrorism: Strategic plan for preparedness and response. Morb Mortal Wkly Rep 49: 1-14.
    • (2000) Morb Mortal Wkly Rep , vol.49 , pp. 1-14
  • 165
    • 0344807652 scopus 로고    scopus 로고
    • NIAID biodefense research agenda for category B and C priority pathogens
    • National Institute of Allergy and Infectious Diseases, Bethesda, Md
    • National Institute of Allergy Infectious Diseases. 2003. NIAID biodefense research agenda for category B and C priority pathogens, p 1-58. U.S. Department of Health and Human Services report no 03-5315. National Institute of Allergy and Infectious Diseases, Bethesda, Md.
    • (2003) U.S. Department of Health and Human Services report no 03-5315 , pp. 1-58


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