Two distinct binding sites for globotriaosyl ceramide on verotoxins: Identification by molecular modelling and confirmation using deoxy analogues and a new glycolipid receptor for all verotoxins

Chemistry and Biology

Volumn 3, Issue 4, 1996, Pages 263-275

  Nyholm, Per Georg ^a   Magnusson, Göran ^b   Zheng, Zhiyuan ^b   Norel, Raquel ^c   Binnington Boyd, Beth ^d   Lingwood, Clifford A ^d,e  

^a UNIVERSITY OF TORONTO   (Canada)

^b LUND UNIVERSITY   (Sweden)

^c TEL AVIV UNIVERSITY   (Israel)

^d HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^e UNIVERSITY OF TORONTO   (Canada)

Author keywords

Carbohydrate protein docking; Glycolipid conformation; Molecular recognition; Shiga like toxin B subunit

Indexed keywords

ESCHERICHIA COLI;

BACTERIAL TOXIN; CELL SURFACE RECEPTOR; GLOBOTRIAOSYL LYSOSPHINGOLIPID; GLYCOLIPID; GLYCOLIPID RECEPTOR; SPHINGOLIPID; VEROTOXIN 1;

ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; METABOLISM;

BACTERIAL TOXINS; BINDING SITES; GLYCOLIPIDS; HUMANS; MODELS, MOLECULAR; RECEPTORS, CELL SURFACE; SHIGA-LIKE TOXIN I; SPHINGOLIPIDS;

EID: 0030113327     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(96)90106-4     Document Type: Article

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