The effects of minocycline on extracellular matrix in patients with chronic venous leg ulcers

Acta Phlebologica

Volumn 14, Issue 3, 2013, Pages 99-107

  Serra, R ^a   Grande, R ^a   Buffone, G ^a   Gallelli, L ^a   De Franciscis, S ^a  

^a UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

Author keywords

Metalloproteinases; Therapy; Varicose ulcers

Indexed keywords

EID: 84894266140     PISSN: 1593232X     EISSN: 18271766     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Serra R, Buffone G, Costanzo G, Montemurro R, Perri P, Damiano R et al. Varicocele in younger as risk factor for inguinal hernia and for chronic venous disease in older: preliminary results of a prospective cohort study. Ann Vasc Surg 2013;27:329-31.
2. Serra R, Buffone G, de Franciscis A, Mastrangelo D, Molinari V, Montemurro R et al. A genetic study of chronic venous insufficiency. Ann Vasc Surg 2012;26:636-42.
3. Serra R, Buffone G, Molinari V, Montemurro R, Perri P, Stillitano DM et al. Low molecular weight heparin improves healing of chronic venous ulcers especially in the elderly. Int Wound J 2013:10.1111/iwj.12071.
4. Burgess JK. The role of the extracellular matrix and specific growth factors in the regulation of inflammation and remodelling in asthma. Pharmacol Ther 2009;122:19-29.
5. Eklöf B, Rutherford RB, Bergan JJ, Carpentier PH, Gloviczki P, Kistner RL et al.; American Venous Forum International Ad Hoc Committee for Revision of the CEAP Classification. Revision of the CEAP classification for chronic venous disorders: consensus statement. J Vasc Surg 2004;40:1248-52. (Pubitemid 40037299)
6. Serra R, Buffone G, de Franciscis A, Mastrangelo D, Vitagliano T, Greco M et al. Skin grafting followed by low-molecular-weight heparin long-term therapy in chronic venous leg ulcers. Ann Vasc Surg 2012;26:190-7.
7. Serra R, Buffone G, Falcone D, Molinari V, Scaramuzzino M, Gallelli L et al. Chronic venous leg ulcers are associated with high levels of metalloproteinases-9 and neutrophil gelatinase-associated lipocalin. Wound Repair Regen 2013;21:395-401.
8. Serra R, Gallelli L, Buffone G, Molinari V, Stillitano DM, Palmieri C et al. Doxycycline speeds up healing of chronic venous ulcers. Int Wound J 2013 [Epub ahead of print].
9. Garrido-Mesa N, Zarzuelo A, Gálvez J. What is behind the non-antibiotic properties of minocycline? Pharmacol Res 2013;67:18-30.
10. Zarogoulidis P, Papanas N, Kioumis I, Chatzaki E, Maltezos E, Zarogoulidis K. Macrolides: from in vitro anti-inflammatory and immunomodulatory properties to clinical practice in respiratory diseases. Eur J Clin Pharmacol 2012;68:479-503.
11. Gu Y, Lee HM, Sorsa T, Salminen A, Ryan ME, Slepian MJ et al. Non-antibacterial tetracyclines modulate mediators of periodontitis and atherosclerotic cardiovascular disease: a mechanistic link between local and systemic inflammation. Pharmacol Res 2011;64:573-9.
12. Fragomeni G, Merola A, Serra R, de Franciscis S, Amato F. A nonlinear lumped parameters model to analyze the dynamics of venous reflux. Conf Proc IEEE Eng Med Biol Soc 2008;2008:1407-10.
13. de Franciscis S, De Sarro G, Longo P, Buffone G, Molinari V, Stillitano DM et al. Hyperhomocysteinaemia and chronic venous ulcers. Int Wound J 2013 [Epub ahead of print].
14. Preianò M, Pasqua L, Gallelli L, Galasso O, Gasparini G, Savino R et al. Simultaneous extraction and rapid visualization of peptidomic and lipidomic body fluids fingerprints by using mesoporous aluminosilicate and MALDI-TOF MS. Proteomics 2012;12:3286-94.
15. Pelaia G, Gallelli L, D'Agostino B, Vatrella A, Cuda G, Fratto D et al. Effects of TGFbeta and glucocorticoids on map kinase phosphorylation, IL-6/IL-11 secretion and cell proliferation in primary cultures of human lung fibroblasts. J Cell Physiol 2007;210:489-97. (Pubitemid 44956894)
16. Gallelli L, Falcone D, Pelaia G, Renda T, Terracciano R, Malara N et al. Interleukin-6 receptor superantagonist Sant7 inhibits TGF-induced proliferation of human lung fibroblasts. Cell Prolif 2008;41:393-407. (Pubitemid 351692954)
17. Gallelli L, Pelaia G, Fratto D, Muto V, Falcone D, Vatrella A et al. Effects of budesonide on P38 MAPK activation, apoptosis and IL-8 secretion, induced by TNF-alpha and Haemophilus influenzae in human bronchial epithelial cells. Int J Immunopathol Pharmacol 2010;23:471-9.
18. Pelaia G, Gallelli L, Renda T, Fratto D, Falcone D, Caraglia M et al. Effects of statins and farnesyl transferase inhibitors on ERK phosphorylation, apoptosis and cell viability in non small lung cancer cells. Cell Prolif 2012;11:25-31.
19. Gallelli L, Pelaia G, D'Agostino B, Cuda G, Vatrella A, Fratto D et al. Endothelin-1 induces proliferation of human lung fibroblasts and IL-11 secretion through an ET(A) receptor-dependent activation of map kinases. J CellBiochem 2005;96:858-68. (Pubitemid 41567556)
20. Pelaia G, Cuda G, Vatrella A, Gallelli L, Fratto D, Gioffre V et al. Effects of hydrogen peroxide on MAPK activation, IL-8 production and cell viability in primary cultures of human bronchial epithelial cells. J Cell Biochem 2004;93:142-52.
21. Falcone D, Gallelli L, Di Virgilio A, Tucci L, Scaramuzzino M, Terracciano R et al. Effects of simvastatin and rosuvastatin on RAS protein, matrix metalloproteinases and NF-κB in lung cancer and in normal pulmonary tissues. Cell Prolif 2013;46:172-82.
22. Yong VW, Wells J, Giuliani F, Casha S, Power C, Metz LM. The promise of minocycline in neurology. Lancet Neurol 2004;3:744-51. (Pubitemid 39535260)
23. Good ML, Hussey DL. Minocycline: stain devil? Br J Dermatol 2003;149:237-9. (Pubitemid 37100246)
24. Klein NC, Cunha BA. Tetracyclines. Med Clin North Am 1995;79:789-801.
25. Timmerman MF, van der Weijden GA, van Steenbergen TJ, Mantel MS, de Graaff J, van der Velden U. Evaluation of the long-term efficacy and safety of locally-applied minocycline in adult periodontitis patients. J Clin Periodontol 1996;23:707-16. (Pubitemid 126732020)
26. Lu HK, Chei CJ. Efficacy of subgingivally applied minocycline in the treatment of chronic periodontitis. J Periodontal Res 2005;40:20-7.
27. Bland PS, Goodson JM, Gunsolley JC, Grossi SG, Otomo-Corgel J, Doherty F et al. Association of antimicrobial and clinical efficacy: periodontitis therapy with minocycline microspheres. J Int Acad Periodontol 2010;12:11-9.
28. Babich H, Tipton DA. In vitro response of human gingival epithelioid S-G cells to minocycline. Toxicol In Vitro 2002;16:11-21. (Pubitemid 34112632)
29. Whiteman M, Halliwell B. Prevention of peroxynitrite-dependent tyrosine nitration and inactivation of alpha1-antiproteinase by antibiotics. Free Radic Res 1997;26:49-56. (Pubitemid 27060128)
30. Nagase H, Woessner JF Jr. Matrix metalloproteinases. J Biol Chem 1999;274:21491-4. (Pubitemid 129519680)
31. Spinale FG. Matrix metalloproteinases: regulation and dysregulation in the failing heart. Circ Res 2002;90:520-30. (Pubitemid 34640901)
32. Yu Jr LP, Smith Jr GN, Hasty KA, Brandt KD. Doxycycline inhibits type XI collagenolytic activity of extracts from human osteoarthritic cartilage and of gelatinase. J Rheumatol 1991;18:1450-2.
33. Smith Jr GN, Brandt KD, Hasty KA. Procollagenase is reduced to inactive fragments upon activation in the presence of doxycycline. Ann N Y Acad Sci 1994;732:436-8.
34. Huang T-Y, Chu H-C, Lin Y-L, Lin C-K, Hsieh T-Y, Chang W-K et al. Minocycline attenuates experimental colitis in mice by blocking expression of inducible nitric oxide synthase and matrix metalloproteinases. Toxicol Appl Pharmacol 2009;237:69-82.
35. Sadowski T, Steinmeyer J. Effects of tetracyclines on the production of matrix metalloproteinases and plasminogen activators as well as of their natural inhibitors, tissue inhibitor of metalloproteinases-1 and plasminogen activator inhibitor-1. Inflamm Res 2001;50:175-82. (Pubitemid 32242707)
36. Creemers EE, Cleutjens JP, Smits JF, Daemen MJ. Matrix metalloproteinase inhibition after myocardial infarction: a new approach to prevent heart failure? Circulation Research 2001;89:201-10. (Pubitemid 34132679)
37. DeClerck YA, Imren S. Protease inhibitors: role and potential therapeutic use in human cancer. Eur J Cancer 1994;30A:2170-80.