Use of eculizumab and plasma exchange in successful combined liver-kidney transplantation in a case of atypical HUS associated with complement factor H mutation

Pediatric Nephrology

Volumn 29, Issue 3, 2014, Pages 477-480

  Tran, Ha ^a   Chaudhuri, Abanti ^a   Concepcion, Waldo ^a   Grimm, Paul C ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

Atypical HUS; Combined liver kidney transplant; Eculizumab; Factor H mutation; Plasma exchange

Indexed keywords

ANTIBODIES, MONOCLONAL, HUMANIZED; COMPLEMENT FACTOR H; DNA MUTATIONAL ANALYSIS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HEMOLYTIC-UREMIC SYNDROME; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INFANT; KIDNEY DISEASES; KIDNEY TRANSPLANTATION; LIVER TRANSPLANTATION; MUTATION; PHENOTYPE; PLASMA EXCHANGE; TIME FACTORS; TREATMENT OUTCOME;

EID: 84894264000     PISSN: 0931041X     EISSN: 1432198X     Source Type: Journal    
DOI: 10.1007/s00467-013-2630-5     Document Type: Article

References (16)

1. Saland JM, Ruggenenti P, Remuzzi G, Consensus Study G (2009) liver-kidney transplantation to cure atypical hemolytic uremic syndrome. J Am Soc Nephrol 20:940-949
2. Nester C, Stewart Z, Myers D, Jetton J, Nair R, Reed A, Thomas C, Smith R, Brophy P (2011) Pre-emptive eculizumab and plasmapheresis for renal transplant in atypical hemolytic uremic syndrome. Clin J Am Soc Nephrol 6:1488-1494
3. Loirat C, Noris M, Fremeaux-Bacchi V (2008) Complement and the atypical hemolytic uremic syndrome in children. Pediatr Nephrol 23:1957-1972
4. Landau D, Shalev H, Levy-Finer G, Polonsky A, Segev Y, Katchko L (2001) Familial hemolytic uremic syndrome associated with complement factor H deficiency. J Pediatr 138:412-417 (Pubitemid 32207148)
5. Zimmerhackl LB, Scheiring J, Prufer F, Taylor CM, Loirat C (2007) Renal transplantation in HUS patients with disorders of complement regulation. Pediatr Nephrol 22:10-16 (Pubitemid 46138353)
6. Davin JC, Strain L, Goodship TH (2008) Plasma therapy in atypical haemolytic uremic syndrome: lessons from a family with a factor H mutation. Pediatr Nephrol 23:1517-1521
7. Hirt-Minkowski P, Schaub S, Mayr M, Schifferli JA, Dickenmann M, Fremeaux-Bacchi V, Steiger J (2009) Haemolytic uraemic syndrome caused by factor H mutation: is single kidney transplantation under intensive plasmatherapy an option? Nephrol Dial Transplant 24:3548-3551
8. Wilson C, Torpey N, Jaques B, Strain L, Talbot D, Manas D, Goodship T (2011) Successful simultaneous liver-kidney transplant in an adult with atypical hemolytic uremic syndrome associated with a mutation in complement factor H. Am J Kidney Dis 58:109-112
9. Zimmerhackl LB, Hofer J, Cortina G, Mark W, Wurzner R, Jungraithmayr TC, Khursigara G, Kliche KO, Radauer W (2010) Prophylactic eculizumab after renal transplantation in atypical hemolytic-uremic syndrome. N Eng J Med 362:1746-1748
10. Davin JC, Gracchi V, Bouts A, Groothoff J, Strain L, Goodship T (2010) Maintenance of kidney function following treatment with eculizumab and discontinuation of plasma exchange after a third kidney transplant for atypical hemolytic uremic syndrome associated with a CFH mutation. Am J Kidney Dis 55:708-711
11. Albertazzi V, Bonucchi D, De Amicis S, Americo C, Ghiandai G, Cappelli G (2010) A favorable 3-year outcome of kidney transplantation in atypical hemolytic uremic syndrome associated with a factor H mutation: case report. Transplant Proc 42:1352-1354
12. Remuzzi G, Ruggenenti P, Colledan M, Gridelli B, Bertani A, Bettinaglio P, Bucchioni S, Sonzogni A, Bonanomi E, Sonzogni V, Platt JL, Perico N, Noris M (2005) Hemolytic uremic syndrome: a fatal outcome after kidney and liver transplantation performed to correct factor h gene mutation. Am J Transplant 5:1146-1150 (Pubitemid 40571267)
13. Saland JM, Emre SH, Shneider BL, Benchimol C, Ames S, Bromberg JS, Remuzzi G, Strain L, Goodship TH (2006) Favorable long-term outcome after liver-kidney transplant for recurrent hemolytic uremic syndrome associated with a factor H mutation. Am J Transplant 6:1948-1952 (Pubitemid 44024968)
14. De Vries B, Matthijsen RA, Wolfs TG, Van Bijnen AA, Heeringa P, Buurman WA (2003) Inhibition of complement factor C5 protects against renal ischemia-reperfusion injury: inhibition of late apoptosis and inflammation. Transplantation 75:375-382 (Pubitemid 36222966)
15. Zhou W, Farrar CA, Abe K, Pratt JR, Marsh JE, Wang Y, Stahl GL, Sacks SH (2000) Predominant role for C5b-9 in renal ischemia/reperfusion injury. J Clin Invest 105:1363-1371 (Pubitemid 30322402)
16. de Vries DK, van der Pol P, van Anken GE, van Gijlswijk DJ, Damman J, Lindeman JH, Reinders ME, Schaapherder AF, Kooten C (2013) Acute but transient release of terminal complement complex after reperfusion in clinical kidney transplantation. Transplantation 95:816-820